Cinnamomum cassia

Ethnobotanical Studies

Clinical Trials

Efficacy and safety of CKD-495 in acute and chronic gastritis: A Phase III superiority clinical trial.

Seo SY et al (2023).
Medicine (Baltimore).
DOI:
10.1097/MD.0000000000035926
PubMed:
38065906

Cinnamon (Cinnamomum cassia) water extract improves diarrhea symptoms by changing the gut environment: a randomized controlled trial.

Cinnamon water extract (CWE) improved diarrhea symptoms, increased colonic transit time, and altered gut microbiota composition by increasing certain metabolites and changing microbial groups.

Park SY et al (2023).
Food Funct.
DOI:
10.1039/d2fo01835g
PubMed:
36655542

Cinnamomum zeylanicum (Ceylon cinnamon) as a potential pharmaceutical agent for type-2 diabetes mellitus: study protocol for a randomized controlled trial.

This study investigates the potential anti-diabetic effects of Sri Lankan cinnamon extract in patients with type-2 diabetes, which has not been explored before.

Ranasinghe P et al (2017).
Trials.
DOI:
10.1186/s13063-017-2192-0
PubMed:
28962661

Studies

Identification of procyanidins as α-glucosidase inhibitors, pancreatic lipase inhibitors, and antioxidants from the bark of Cinnamomum cassia by multi-bioactivity-labeled molecular networking.

Dai J et al (2024).
Food Res Int.
DOI:
10.1016/j.foodres.2024.114833
PubMed:
39147522

Cinnamon extracts, trans-cinnamaldehyde and trans-cinnamic acid inhibit HDAC 1 activity.

Koyu H et al (2024).
Food Funct.
DOI:
10.1039/d4fo02764g
PubMed:
39145543

Jin-Xin-Kang alleviates heart failure by mitigating mitochondrial dysfunction through the Calcineurin/Dynamin-Related Protein 1 signaling pathway.

Summary

JXK, a traditional Chinese herbal formula, effectively treats chronic heart failure (CHF) with seven medicinal herbs. While its clinical efficacy is proven, the specific mechanisms remain unknown. Further research is needed for potential cardiac treatment advancements.

Cardiology
Lin L et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118685
PubMed:
39127116

Evaluation of different drying methods on the quality of Cinnamomum cassia barks by analytic hierarchy process method.

Li L et al (2024).
Heliyon.
DOI:
10.1016/j.heliyon.2024.e34608
PubMed:
39114071

Antioxidant and Anti-Apoptotic Neuroprotective Effects of Cinnamon in Imiquimod-Induced Lupus.

Summary

Study investigated cinnamomum cassia for antioxidant potential in lupus redox pathways. Potential novel therapy for lupus due to antioxidant properties, may impact disease activity.

DermatologyImmunologyNeuroscience
Maalouly G et al (2024).
Antioxidants (Basel).
DOI:
10.3390/antiox13070880
PubMed:
39061948

Anticandidal effect of cinnamic acid characterized from Cinnamomum cassia bark against the fluconazole resistant strains of Candida.

Kannan KP and As SG (2024).
Braz J Microbiol.
DOI:
10.1007/s42770-024-01469-w
PubMed:
39046694

Advances in pharmacological effects and mechanism of action of cinnamaldehyde.

Review
Guo J et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2024.1365949
PubMed:
38903995

Antileishmanial and Antifungal Activities of Volatile Oils from Cinnamomum cassia Bark and Schinus molle Leaves.

Summary

Researchers studied the antiparasitic and antifungal properties of Schinus molle and Cinnamomum cassia essential oils, as well as their blends. Results show promising activity against Leishmania and Candida, indicating potential for new treatments.

Antimicrobial
da Silva ASR et al (2024).
Chem Biodivers.
DOI:
10.1002/cbdv.202401076
PubMed:
38899851

Effects of benzoic acid synthesized from Cinnamomum cassia by green chemistry on valproic acid-induced neurotoxicity in zebrafish embryos.

Summary

Researchers studied the effects of green-synthesized benzoic acid on autism-related gene expression in zebrafish embryos exposed to Valproic acid toxicity. Benzoic acid improved gene expression and antioxidant balance, showing potential for autism treatment.

Neuroscience
Cansız D et al (2024).
Toxicol Mech Methods.
DOI:
10.1080/15376516.2024.2364899
PubMed:
38888055

Exploring the Metabolic Effects of a Herbal Remedy of Asarum sieboldii, Platycodon grandiflorum, and Cinnamomum cassia Extracts: Unraveling Its Therapeutic Potential as a Topical Application for Atopic Dermatitis Treatment.

Dermatology
Lee G et al (2024).
Antioxidants (Basel).
DOI:
10.3390/antiox13050563
PubMed:
38790668

Identification of a cinnamoyl-CoA reductase from Cinnamomum cassia involved in trans-cinnamaldehyde biosynthesis.

Ye P et al (2024).
Planta.
DOI:
10.1007/s00425-024-04419-w
PubMed:
38687380

Cinnamaldehyde: An effective component of Cinnamomum cassia inhibiting Helicobacter pylori.

Li CY et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118222
PubMed:
38663778

An in vitro study elucidating the synergistic effects of aqueous cinnamon extract and an anti-TNF-α biotherapeutic: implications for a complementary and alternative therapy for non-responders.

Khedkar S and Khan MA (2024).
BMC Complement Med Ther.
DOI:
10.1186/s12906-024-04438-w
PubMed:
38521924

A Systematic Review Evaluating Cinnamon's Effects on Glucose Utilizing a Ranking System to Assess Bias and Study Quality.

Bakhach H et al (2024).
J Med Food.
DOI:
10.1089/jmf.2023.0277
PubMed:
38466959

Effect of cinnamon essential oil/ γ-cyclodextrin inclusion complex on papaya quality and shelf-life.

Phytochemistry
Phan C et al (2024).
J Sci Food Agric.
DOI:
10.1002/jsfa.13443
PubMed:
38445761

Determination of higenamine in common natural spices by ultrahigh-performance liquid chromatography-tandem mass spectrometry.

Phytochemistry
Du J et al (2024).
Drug Test Anal.
DOI:
10.1002/dta.3672
PubMed:
38440922

LanGui tea, an herbal medicine formula, protects against binge alcohol-induced acute liver injury by activating AMPK-NLRP3 signaling.

Gu M et al (2024).
Chin Med.
DOI:
10.1186/s13020-024-00906-0
PubMed:
38439080

Long COVID-19 gastrointestinal related disorders and traditional Chinese medicine: A network target-based approach.

Summary

Research reviewed nutraceuticals from Traditional Chinese Medicine for relieving Long COVID-19 gastrointestinal symptoms. Identified plants such as Cinnamomum cassia and Salvia miltiorrhiza show promise in reducing inflammation and oxidative stress. These natural remedies may offer multi-target therapeutic benefits for Long COVID-19 complications.

Review COVID-19
Mattioli LB et al (2024).
Phytother Res.
DOI:
10.1002/ptr.8163
PubMed:
38421118

Immunomodulatory Role of Plants and Their Constituents on the Management of Metabolic Disorders: An Evidence-Based Review.

Summary

Plant-derived bioactive compounds show promise in improving metabolic and immune functions in patients with metabolic disorders. This review highlights the therapeutic potential of phytochemical formulations in alleviating conditions like obesity and diabetes. Further research and clinical trials are needed for validation.

Review Immunology
Febriyanti RM, Levita J and Diantini A (2024).
Drug Des Devel Ther.
DOI:
10.2147/DDDT.S442566
PubMed:
38415194

Essential oils extracted from nine different plants exhibit differential effects on skin antioxidation and elasticity.

Kim DS et al (2024).
FEBS Open Bio.
DOI:
10.1002/2211-5463.13778
PubMed:
38409906

Cinnamaldehyde protects cardiomyocytes from oxygen-glucose deprivation/reoxygenation-induced lipid peroxidation and DNA damage via activating the Nrf2 pathway.

Genetics
Li YG et al (2024).
Chem Biol Drug Des.
DOI:
10.1111/cbdd.14489
PubMed:
38404216

Uncovering the Mechanisms of Cinnamic Acid Treating Diabetic Nephropathy Based on Network Pharmacology, Molecular Docking, and Experimental Validation.

Summary

Cinnamic acid from Cinnamomum cassia can improve diabetic nephropathy, but we need more understanding of how it works and its potential targets for better treatment.

Diabetes
Dai L et al (2024).
Curr Comput Aided Drug Des.
DOI:
10.2174/0115734099286283240130115111
PubMed:
38347789

Chinese herb couple against diabetes: integrating network pharmacology and mechanism study.

Summary

Cassia twig-Astragalus is a Chinese herb couple used to treat diabetes. This study identified its active ingredients and targets, showing potential in improving glucose tolerance and reducing inflammation in diabetic rats.

Diabetes
Li J et al (2024).
J Biomol Struct Dyn.
DOI:
10.1080/07391102.2024.2314263
PubMed:
38345075

Integrated transcriptomics and metabolomics analysis provides insights into aromatic volatiles formation in Cinnamomum cassia bark at different harvesting times.

Genetics
Yao S et al (2024).
BMC Plant Biol.
DOI:
10.1186/s12870-024-04754-w
PubMed:
38308239

Integrated metabolomic and transcriptomic analyses revealed metabolite variations and regulatory networks in Cinnamomum cassia Presl from four growth years.

Gao H et al (2024).
Front Plant Sci.
DOI:
10.3389/fpls.2023.1325961
PubMed:
38269138

A comprehensive "quality-quantity-activity" approach based on portable near-infrared spectrometer and membership function analysis to systematically evaluate spice quality: Cinnamomum cassia as an example.

Zou Z et al (2023).
Food Chem.
DOI:
10.1016/j.foodchem.2023.138142
PubMed:
38081096

Essential Oils of Mentha arvensis and Cinnamomum cassia Exhibit Distinct Antibacterial Activity at Different Temperatures In Vitro and on Chicken Skin.

Vepštaitė-Monstavičė I et al (2023).
Foods.
DOI:
10.3390/foods12213938
PubMed:
37959057

Repellent effects of Chinese cinnamon oil on nymphal ticks of Haemaphysalis longicornis, Rhipicephalus haemaphysaloides, and Hyalomma asiaticum.

Zhou Y et al (2023).
Exp Appl Acarol.
DOI:
10.1007/s10493-023-00855-7
PubMed:
37870735

Essential oils of Pinus sylvestris, Citrus limon and Origanum vulgare exhibit high bactericidal and anti-biofilm activities against Neisseria gonorrhoeae and Streptococcus suis.

Jurado P et al (2023).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2023.115703
PubMed:
37857249

Interpretation of the anti-influenza active ingredients and potential mechanisms of Ge Gen Decoction based on spectrum-effect relationships and network analysis.

Liu X et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117290
PubMed:
37806538

Cinnamon (Cinnamomum cassia) hot water extract improves inflammation and tight junctions in the intestine in vitro and in vivo.

Immunology
Park TG et al (2023).
Food Sci Biotechnol.
DOI:
10.1007/s10068-023-01292-3
PubMed:
37781063

Enrichment of cinnamaldehyde from Cinnamomum cassia by electroosmotic coupled particle-assisted solvent flotation.

Yan C et al (2023).
J Chromatogr A.
DOI:
10.1016/j.chroma.2023.464411
PubMed:
37778100

Deciphering the antifungal mechanism and functional components of cin-namomum cassia essential oil against Candida albicans through integration of network-based metabolomics and pharmacology, the greedy algorithm, and molecular docking.

Summary

Researchers investigated the antifungal activity of Cinnamomum cassia, a plant used in traditional Chinese medicine. This study highlights its potential as a source for new antifungal agents, offering hope for combating deadly fungal infections.

AntimicrobialPhytochemistry
Gu K et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117156
PubMed:
37729978

Exploring the effects and mechanisms of Guizhigancao Decoction on heart failure using an integrated approach based on experimental support and network pharmacology strategy.

Summary

Researchers aimed to understand the mechanisms and effective treatments for heart failure (HF), a major cause of death and clinical problem. The study highlights the need for an urgently developed strategy to combat HF.

Cardiology
Qu J et al (2023).
J Tradit Complement Med.
DOI:
10.1016/j.jtcme.2023.03.010
PubMed:
37693095

Linking traditional medicine to modern phytotherapy: Chemical characterization and assessment of antioxidant and anticholinesterase effects in vitro of a natural Persian remedy for dementia.

Summary

An improved formulation from Traditional Persian Medicine (TPM) containing a mixture of plants exhibits antioxidant and anti-cholinesterase properties, potentially making it a useful natural remedy for dementia. Further studies are needed for safety and efficacy.

ImmunologyNeuroscience
Peron G et al (2023).
J Pharm Biomed Anal.
DOI:
10.1016/j.jpba.2023.115674
PubMed:
37634357

Comparative pharmacokinetics and tissue distribution of polydatin, resveratrol, and emodin after oral administration of Huzhang and Huzhang-Guizhi herb-pair extracts to rats.

Yang J et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117010
PubMed:
37557937

Short communication: Antibacterial effects of essential oils from Cinnamomum cassia bark and Eucalyptus globulus leaves-The involvements of major constituents.

Nguyen HTT et al (2023).
PLoS One.
DOI:
10.1371/journal.pone.0288787
PubMed:
37450504

Ling-Gui-Qi-Hua formula alleviates left ventricular myocardial fibrosis in rats with heart failure with preserved ejection fraction by blocking the transforming growth factor-β1 /Smads signaling pathway.

Summary

The researchers studied the LGQH decoction, a traditional Chinese medicine formula, and found it has cardioprotective effects on heart failure. The active ingredients and anti-fibrotic mechanism are still unknown.

Cardiology
Shi Y et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116849
PubMed:
37385575

Development of species-specific ISSR-derived SCAR marker for early discrimination between Cinnamomum verum and Cinnamomum cassia.

Gangwar H et al (2023).
Mol Biol Rep.
DOI:
10.1007/s11033-023-08578-z
PubMed:
37306873

Cinnamomum cassia on Arterial Stiffness and Endothelial Dysfunction in Type 2 Diabetes Mellitus: Outcomes of a Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

Summary

This study examined the effects of for patients with type 2 diabetes. It found that administration reduced body weight, BMI, and HbAc, but had no significant impact on arterial stiffness, endothelial dysfunction, blood pressure, glucose, and lipids.

CardiologyDiabetes
Delgadillo-Centeno JS et al (2023).
J Med Food.
DOI:
10.1089/jmf.2022.0089
PubMed:
37262194

Anti-inflammatory effect and metabolic mechanism of BS012, a mixture of Asarum sieboldii, Platycodon grandiflorum, and Cinnamomum cassia extracts, on atopic dermatitis in vivo and in vitro.

DermatologyImmunology
Lee G et al (2023).
Phytomedicine.
DOI:
10.1016/j.phymed.2023.154818
PubMed:
37187105

Chemical Profile Determination and Quantitative Analysis of Components in Oryeong-san Using UHPLC-Q-Orbitrap-MS and UPLC-TQ-MS/MS.

Jang S, Lee A and Hwang YH (2023).
Molecules.
DOI:
10.3390/molecules28093685
PubMed:
37175095

Fumigant toxicity and behavioral alterations of six plant essential oils against the red fire ant (Solenopsis invicta Buren).

Fu J et al (2023).
Environ Sci Pollut Res Int.
DOI:
10.1007/s11356-023-27329-y
PubMed:
37126171

Impact of dietary supplementation with Cinnamomum cassia essential oil on silver catfish (Rhamdia quelen): Toxicological effects and muscle antioxidant and fatty acid profiles.

ImmunologyPhytochemistry
Rossato Viana A et al (2023).
J Toxicol Environ Health A.
DOI:
10.1080/15287394.2023.2198564
PubMed:
37010980

An Analysis of the Toxicity, Antioxidant, and Anti-Cancer Activity of Cinnamon Silver Nanoparticles in Comparison with Extracts and Fractions of Cinnamomum Cassia at Normal and Cancer Cell Levels.

Cancer
El-Baz YG et al (2023).
Nanomaterials (Basel).
DOI:
10.3390/nano13050945
PubMed:
36903823

Identification of Differential Compositions of Aqueous Extracts of Cinnamomi Ramulus and Cinnamomi Cortex.

Wang P et al (2023).
Molecules.
DOI:
10.3390/molecules28052015
PubMed:
36903261

Cinnamomum cassia and Rosa laevigata Mixture Improves Benign Prostatic Hyperplasia in Rats by Regulating Androgen Receptor Signaling and Apoptosis.

Endocrinology
Kim M et al (2023).
Nutrients.
DOI:
10.3390/nu15040818
PubMed:
36839177

Bioactive Piperazic Acid-Bearing Cyclodepsipeptides, Lydiamycins E-H, from an Endophytic Streptomyces sp. Associated with Cinnamomum cassia.

Wang W et al (2023).
J Nat Prod.
DOI:
10.1021/acs.jnatprod.2c00902
PubMed:
36812487

Cinnamaldehyde Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice by Modulating TLR4/NF-κB Signaling Pathway and NLRP3 Inflammasome Activation.

Gastroenterology
Tan X et al (2023).
Chem Biodivers.
DOI:
10.1002/cbdv.202200089
PubMed:
36653304

Essential Oil Trunk Injection Into Orchard Trees: Consequences on the Performance and Preference of Hemipteran Pests.

Phytochemistry
Denoirjean T et al (2023).
J Econ Entomol.
DOI:
10.1093/jee/toac203
PubMed:
36634219

Rapid and non-destructive cinnamon authentication by NIR-hyperspectral imaging and classification chemometrics tools.

Cruz-Tirado JP et al (2023).
Spectrochim Acta A Mol Biomol Spectrosc.
DOI:
10.1016/j.saa.2022.122226
PubMed:
36512964

Microwave-assisted extraction of polysaccharide from Cinnamomum cassia with anti-hyperpigmentation properties: Optimization and characterization studies.

Al-Ajalein AAS et al (2023).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2022.12.023
PubMed:
36502951

Safety and efficacy of a feed additive consisting of an essential oil from Cinnamomum cassia (L.) J. Presl (cassia leaf oil) for use in all animal species (FEFANA asbl).

Phytochemistry
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) et al (2022).
EFSA J.
DOI:
10.2903/j.efsa.2022.7600
PubMed:
36274981

Chemical profiling and identification of anti-osteoporosis chemical-markers of Cinnamomum cassia (L.) presl extracts using GC-MS and spectrum-activity analyses.

Arthritis
Zhao S et al (2023).
Nat Prod Res.
DOI:
10.1080/14786419.2022.2123480
PubMed:
36098221

Natural Plants Compounds as Modulators of Epithelial-to-Mesenchymal Transition.

Review
Avila-Carrasco L et al (2019).
Front Pharmacol.
DOI:
10.3389/fphar.2019.00715
PubMed:
31417401

Volatiles from Cinnamomum cassia buds.

Sandner D, Krings U and Berger RG (2018).
Z Naturforsch C J Biosci.
DOI:
10.1515/znc-2017-0087
PubMed:
29145172

An Overview of Herbal Products and Secondary Metabolites Used for Management of Type Two Diabetes.

Review Diabetes
Ota A and Ulrih NP (2017).
Front Pharmacol.
DOI:
10.3389/fphar.2017.00436
PubMed:
28729836

Herbal medicine for the management of polycystic ovary syndrome (PCOS) and associated oligo/amenorrhoea and hyperandrogenism; a review of the laboratory evidence for effects with corroborative clinical findings.

Review Endocrinology
Arentz S et al (2014).
BMC Complement Altern Med.
DOI:
10.1186/1472-6882-14-511
PubMed:
25524718

Cinnamon for diabetes mellitus.

Summary

Animal studies suggest cinnamon may improve glycaemic control in diabetes. Human studies have not been extensively reviewed, limiting our understanding of its potential benefits for managing diabetes.

Meta-Analysis Diabetes
Leach MJ and Kumar S (2012).
Cochrane Database Syst Rev.
DOI:
10.1002/14651858.CD007170.pub2
PubMed:
22972104