Cirsium maackii

Ethnobotanical Studies

Studies

Korean Thistle (Cirsium japonicum var. maackii (Maxim.) Matsum.): A Potential Dietary Supplement against Diabetes and Alzheimer's Disease.

Summary

Researchers investigated the activity of different parts of Korean thistle for their potential to inhibit diabetes and Alzheimer's disease. Ethyl acetate and dichloromethane fractions of the leaf extract showed α-glucosidase and BACE1 inhibitory activity, respectively. Luteolin, an isolated compound, also exhibited non-competitive inhibition against both α-glucosidase and BACE1. Docking studies showed that luteolin formed a strong hydrogen bond with the peripheral binding amino acid residues and hydrophobic interactions with the enzymes. Korean thistle may be a dietary supplement against these diseases, especially the leaves, due to the preponderance of active luteolin. This promising candidate warrants further in vitro and in vivo studies.

DiabetesNeuroscience
Wagle A et al (2019).
Molecules.
DOI:
10.3390/molecules24030649
PubMed:
30759846

Protective effects of flavonoids isolated from Korean milk thistle Cirsium japonicum var. maackii (Maxim.) Matsum on tert-butyl hydroperoxide-induced hepatotoxicity in HepG2 cells.

Phytochemistry
Jung HA et al (2017).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2017.07.027
PubMed:
28735729

Inhibition of advanced glycation endproducts formation by Korean thistle, Cirsium maackii.

Jung HA et al (2015).
Asian Pac J Trop Med.
DOI:
10.1016/S1995-7645(14)60178-4
PubMed:
25901916

Quantitative HPLC analysis of two key flavonoids and inhibitory activities against aldose reductase from different parts of the Korean thistle, Cirsium maackii.

Phytochemistry
Jung HA, Kim YS and Choi JS (2009).
Food Chem Toxicol.
DOI:
10.1016/j.fct.2009.08.014
PubMed:
19733610