Citrus aurantium

Common Names: sour orange

Ethnobotanical Studies

Clinical Trials

Comparison of Aromatherapy with Citrus aurantium and Lavender on Sexual Satisfaction in Breastfeeding Women: A Randomized Controlled Trial.

Sharifipour F, Heydarpour S and Salari N (2023).
Breastfeed Med.
PubMed:
36603110

The Effects of Lavender and Citrus aurantium on Anxiety and Agitation of the Conscious Patients in Intensive Care Units: A Parallel Randomized Placebo-Controlled Trial.

Karimzadeh Z et al (2021).
Biomed Res Int.
PubMed:
34222473

Studies

Eriodictyol regulates white adipose tissue browning and hepatic lipid metabolism in high fat diet-induced obesity mice via activating AMPK/SIRT1 pathway.

Summary

Researchers studied eriodictyol, a compound in Citrus aurantium L. var. amara Engl., known for anti-obesity potential. Understanding its effects can lead to new treatments for obesity.

Lin SX et al (2024).
J Ethnopharmacol.
PubMed:
39216775

Mechanism of Jizhi syrup's prevention and treatment of acute bronchitis based on LPS-iNOS inflammatory mediators' signalling pathway.

Han M et al (2024).
J Ethnopharmacol.
PubMed:
39197804

Exploring stachydrine: from natural occurrence to biological activities and metabolic pathways.

Review
He Z et al (2024).
Front Plant Sci.
PubMed:
39170783

Metabolomic profiles and differential metabolites of volatile components in Citrus aurantium Changshan-huyou pericarp during different growth and development stages.

Cui Q et al (2024).
Food Chem X.
PubMed:
39130723

Comparative Analysis of Hydrosol Volatile Components of Citrus × Aurantium 'Daidai' and Citrus × Aurantium L. Dried Buds with Different Extraction Processes Using Headspace-Solid-Phase Microextraction with Gas Chromatography-Mass Spectrometry.

Xie X et al (2024).
Molecules.
PubMed:
39124903

Dose-dependent responses: a preliminary investigation into the olfactory effects of essential oil concentrations on canine behavior.

Haverbeke A et al (2024).
Vet Res Commun.
PubMed:
39066825

Neural Circuit Mechanisms of Sinisan formula for the Treatment of adolescent Depression: prefrontal cortex to dorsal raphe nucleus.

Summary

Researchers investigated the Sinisan formula's impact on neuron activity and circuits for treating depression. Understanding its mechanisms can lead to improved treatment options for depression.

Zhou L et al (2024).
J Ethnopharmacol.
PubMed:
38972528

Sour orange (Citrus aurantium) seed, a rich source of protein isolate and hydrolysate - A thorough investigation.

Rownaghi M and Niakousari M (2024).
Heliyon.
PubMed:
38952368

Simultaneous Determination of 23 Pyrrolizidine and Tropane Alkaloids in Infusions from Dry Edible Flowers Using Optimized μSPEed(®) Microextraction Prior to Their Analysis by UHPLC-IT-MS/MS.

Fernández-Pintor B, Morante-Zarcero S and Sierra I (2024).
Foods.
PubMed:
38890967

Differential distribution of characteristic constituents in peel and pulp of Aurantii Fructus Immaturus (Citrus aurantium L.) using MALDI mass spectrometry imaging.

Cai W et al (2024).
Fitoterapia.
PubMed:
38857834

Unraveling the antifungal composition of bitter orange decoction against the melon pathogen Fusarium jinanense.

Summary

Researchers analyzed the antifungal properties of bitter orange peel decoction, identifying coumarins and flavones as key inhibitors of a melon phytopathogen. This study provides insights for utilizing unexplored food sources in drug development.

de Freitas MD et al (2024).
Food Chem.
PubMed:
38843716

An integrated multi-system to screen quality markers of blossom of Citrus aurantium L. var. amara Engl. via combining lipid-lowering and expectorant assays.

Zeng W et al (2024).
Biomed Chromatogr.
PubMed:
38806448

Real-world Chinese herbal medicine for Parkinson's disease: a hospital-based retrospective analysis of electronic medical records.

Summary

Chinese medicine therapies show promise in treating Parkinson's disease in controlled settings. However, real-world usage and patient demographics remain unclear. Understanding this can aid in better utilization of these therapies.

Lyu S et al (2024).
Front Aging Neurosci.
PubMed:
38756536

Standardization parameters and synergism of source plant materials for the antidiabetic efficacy of the Rauvolfia-Citrus tea.

Summary

TL;DR: Standardized herbal RC-tea from Rauvolfia-Citrus treats T2D with blood glucose control and lipid reduction. Mix of both plants essential for best results, avoiding hypoglycemia or hyperglycemia. Ideal, cost-effective alternative to GLP-1 treatments in low-income areas with rising T2D rates.

Campbell-Tofte J et al (2024).
Fitoterapia.
PubMed:
38744382

Da-Chai-Hu-Tang Formula inhibits the progression and metastasis in HepG2 cells through modulation of the PI3K/AKT/STAT3-induced cell cycle arrest and apoptosis.

Duan ZW et al (2024).
J Ethnopharmacol.
PubMed:
38705430

Ethnobotany and diversity of Citrus spp. (Rutaceae) as a source of "Kem-kem" traditional medicine used among the Karo sub-ethnic in North Sumatra, Indonesia.

Rahayu M et al (2024).
Heliyon.
PubMed:
38694125

Antidiabetic action of the Chinese formula Shouhuitongbian and the underlying mechanism associated with alteration of gut microbiota.

Summary

The traditional Chinese formula Shouhuitongbian (SHTB), containing herbs like Aloe vera and Cassia obtusifolia, may have antidiabetic effects due to its role in improving insulin resistance. This could lead to new treatments for type 2 diabetes.

Wang T et al (2024).
Phytomedicine.
PubMed:
38636179

Therapeutic potential of hypnotic herbal medicines: A comprehensive review.

Review
Ghasemzadeh Rahbardar M and Hosseinzadeh H (2024).
Phytother Res.
PubMed:
38595123

Scavenging Glyoxal and Methylglyoxal by Synephrine and Neohesperidin from Flowers of Citrus aurantium L. var. amara Engl. in Mice and Humans.

Liang Y et al (2024).
J Agric Food Chem.
PubMed:
38529939

Mycorrhiza-induced resistance in citrus against Tetranychus urticae is plant-species dependent and inversely correlated to basal immunity.

Manresa-Grao M et al (2024).
Pest Manag Sci.
PubMed:
38446401

Scavenging Glyoxal and Methylglyoxal by Synephrine Alone or in Combination with Neohesperidin at High Temperatures.

Liang Y et al (2024).
J Agric Food Chem.
PubMed:
38442256

Mechanism insights into the pleiotropic effects of nobiletin as a potential therapeutic agent on non-alcoholic fatty liver disease (NAFLD).

Review
Ran Q et al (2024).
Biomed Pharmacother.
PubMed:
38401524

The Effect of Opuntia ficus Mucilage Pectin and Citrus aurantium Extract Added to a Food Matrix on the Gut Microbiota of Lean Humans and Humans with Obesity.

Summary

Scientists studied how a food gel with certain compounds affected gut bacteria. The gel increased beneficial bacteria growth in lean individuals, but decreased growth in those with obesity. This may impact gut health differently based on weight.

Estrada-Sierra NA et al (2024).
Foods.
PubMed:
38397564

Synergistic effects of essential oils and phenolic extracts on antimicrobial activities using blends of Artemisia campestris, Artemisia herba alba, and Citrus aurantium.

Summary

This study explores synergistic antibacterial effects of plant extracts against foodborne bacteria. Different combinations of extracts were tested and found to have synergistic effects. The study emphasizes the importance of finding optimal proportions for effective antibacterial activity in food preservation systems.

Benamar-Aissa B et al (2024).
Biomol Concepts.
PubMed:
38353049

Elder (Sambucus nigra), identified by high-content screening, counteracts foam cell formation without promoting hepatic lipogenesis.

Steinbauer S et al (2024).
Sci Rep.
PubMed:
38347122

Comparative Activities of Three Compounds from Citrus aurantium L. var. amara Engl. to Improve Oxidized Low-Density Lipoprotein-Induced Lipid Deposition.

Hao KX et al (2024).
ACS Omega.
PubMed:
38343915

Untargeted Metabolomic Analyses and Antilipidemic Effects of Citrus Physiological Premature Fruit Drop.

Wang C et al (2024).
Int J Mol Sci.
PubMed:
38339154

Application and mechanisms of Sanhua Decoction in the treatment of cerebral ischemia-reperfusion injury.

Summary

Sanhua Decoction, a traditional Chinese medicinal formulation, shows potential in treating cerebral ischemia-reperfusion injury. It acts through antioxidant, anti-inflammatory, and neurotransmitter regulatory pathways to protect nerve cells and reduce cerebral edema. Studying its mechanisms can improve understanding and future clinical application.

Review Cardiology
Wang YK et al (2024).
World J Clin Cases.
PubMed:
38322692

Variation of the essential oil components of Citrus aurantium leaves upon using different distillation techniques and evaluation of their antioxidant, antidiabetic, and neuroprotective effect against Alzheimer's disease.

Summary

Bitter orange leaves were extracted using different methods to compare their chemical composition. The essential oils showed antioxidant and antidiabetic activities, making them potential sources for future drugs.

Elhawary EA et al (2024).
BMC Complement Med Ther.
PubMed:
38308284

Citrus aurantium L. and synephrine improve brown adipose tissue function in adolescent mice programmed by early postnatal overfeeding.

Guimarães AC et al (2024).
Front Nutr.
PubMed:
38274208

The Population Dynamics and Parasitism Rates of Ceratitis capitata, Anastrepha fraterculus, and Drosophila suzukii in Non-Crop Hosts: Implications for the Management of Pest Fruit Flies.

Buonocore-Biancheri MJ et al (2024).
Insects.
PubMed:
38249067

Flavonoid extracts of Citrus aurantium L. var. amara Engl. Promote browning of white adipose tissue in high-fat diet-induced mice.

Summary

Researchers investigated the potential of Citrus aurantium L. var. amara Engl. (CAVA) blossom in combating obesity by enhancing the browning of white adipose tissue (WAT). The study builds on previous findings indicating CAVA's anti-obesity potential.

Lin SX et al (2024).
J Ethnopharmacol.
PubMed:
38219880

Identification of Volatile Molecules and Bioactivity of Gruyt Craft Beer Enriched with Citrus aurantium var. dulcis L. Essential Oil.

Taiti C et al (2023).
Int J Mol Sci.
PubMed:
38203520

Chemical characterization and discovery of novel quality markers in Citrus aurantium L. fruit from traditional cultivation areas in China using GC-MS-based cuticular waxes analysis.

Li Y et al (2023).
Food Chem X.
PubMed:
38144759

Antidepressant effects of a Persian herbal formula on mice with chronic unpredictable mild stress.

Summary

A survey assessed the effects of a Persian herbal formula on mice with chronic stress. Herbal medicine may offer an alternative therapy for depression, addressing limitations in current medication options.

Gavzan H et al (2023).
Avicenna J Phytomed.
PubMed:
38089415

Activity of Citrus aurantium and Lavandula angustifolia in Alzheimer's Disease Symptoms in Male Wistar Rats.

Summary

This study investigated the effects of hydro-alcoholic extracts on Alzheimer's Disease (AD) and antioxidant problems. It provides insights into potential treatments for AD, which could be relevant for your lab's research on neurodegenerative disorders.

Arasteh A et al (2023).
Avicenna J Med Biotechnol.
PubMed:
38078339

Evaluation of acute, subacute, and subchronic toxicity of a hepatoprotective herbal formulation.

Bemidinezhad A et al (2023).
Toxicol Rep.
PubMed:
38045604

Biological Activities of Citrus aurantium Leaf Extract by Optimized Ultrasound-Assisted Extraction.

Wang GH et al (2023).
Molecules.
PubMed:
37959671

Effects of Interaction of Protein Hydrolysate and Arbuscular Mycorrhizal Fungi Effects on Citrus Growth and Expressions of Stress-Responsive Genes (Aquaporins and SOSs) under Salt Stress.

Summary

Protein hydrolysates and arbuscular mycorrhizal fungi improve crop growth and reduce damage from salt stress. They enhance nutrient absorption, sodium effluxion, and the expression of stress-responsive genes in citrus plants. The combined application of both is more effective.

Lu Q et al (2023).
J Fungi (Basel).
PubMed:
37888239

Extending shelf life and optimizing effective parameters by using clove oil (Syzygium aromaticum oleum)/orange oil (Citrus aurantium var dulcis oleum) in bread: thermal, morphological and sensory approach.

Şahin Fİ and Acaralı N (2023).
J Food Sci Technol.
PubMed:
37786596

Zhisou powder displays therapeutic effect on chronic bronchitis through inhibiting PI3K/Akt/HIF-1α/VEGFA signaling pathway and reprograming metabolic pathway of arachidonic acid.

Dong Y et al (2023).
J Ethnopharmacol.
PubMed:
37673198

Metabolic profiling of the flower of Citrus aurantium L. var. amara Engl. in rats using ultra-high-performance liquid chromatography coupled to quadrupole time-of-flight tandem mass spectrometry with data mining strategy.

Summary

Researchers have studied the chemical components of Citrus aurantium L. var. amara Engl. (FCAVA) and are now investigating its in vivo substances to discover potential anti-obesity ingredients.

Zhou H et al (2023).
Rapid Commun Mass Spectrom.
PubMed:
37580848

The Effect of Aromatherapy with Citrus aurantium Aroma on Pain after Orthopedic Surgery: A Randomized Clinical Trial.

Summary

This study investigates how aromatherapy with essential oils affects pain levels after orthopedic surgery, offering potential alternative methods for pain management.

Bargi S et al (2023).
J Caring Sci.
PubMed:
37469751

Comparison of Chemical Compositions and Antioxidant Activities for the Immature Fruits of Citrus changshan-huyou Y.B. Chang and Citrus aurantium L.

Zhang Q et al (2023).
Molecules.
PubMed:
37446717

Essential oils for treating anxiety: a systematic review of randomized controlled trials and network meta-analysis.

Summary

Study compares efficacy of essential oils (EOs) for treating anxiety, aiming to clarify discrepancies in previous research. Researchers analyze results of multiple RCTs to provide insights into potential benefits of EOs.

Meta-Analysis Neuroscience
Tan L et al (2023).
Front Public Health.
PubMed:
37325306

Nutritional, biological, and structural properties of bioactive peptides from bellflower, Persian-willow, and bitter-orange pollens.

Sarabandi K et al (2023).
J Food Sci.
PubMed:
37282747

Variation in microbial feature perception in the Rutaceae family with immune receptor conservation in citrus.

Trinh J et al (2023).
Plant Physiol.
PubMed:
37144828

Sanhua decoction: Current understanding of a traditional herbal recipe for stroke.

Summary

Sanhua decoction (SHD), a traditional Chinese medicine with over 40 bioactive compounds, shows promise in treating ischemic stroke by suppressing inflammation, protecting the blood brain barrier, inhibiting apoptosis, scavenging oxygen free radicals, and more. Large-scale clinical trials are needed to confirm its efficacy and understand its mechanisms.

Zheng L et al (2023).
Front Neurosci.
PubMed:
37123364

Preliminary exploration of method for screening efficacy markers compatibility in TCM prescriptions based on Q-markers: Anti-inflammatory activity of Dachaihu decoction as an example.

Bi S et al (2023).
J Ethnopharmacol.
PubMed:
37088240

Evaluation of a combination of Citrus aurantium var. Dulcis essential oil and albendazole for the treatment of sheep gastrointestinal nematodes.

Mesquita-Sousa D et al (2023).
Vet Parasitol.
PubMed:
37080069

Effect of Citrus aurantium juice as a disinfecting agent on quality and bacterial communities of striped catfish steaks stored at -20 °C.

Dabsantai K and Mahidsanan T (2023).
PeerJ.
PubMed:
37065691

Systematic review on the anxiolytic and hypnotic effects of flower extracts in in vivo pre-clinical studies published from 2010 to 2020.

Summary

Researchers conducted a systematic review of scientific articles published between 2010 and 2020 that evaluated the anxiolytic, sedative, and/or hypnotic effects of flower extracts in pre-clinical animal models. They found that some flower extracts have an anxiolytic effect comparable to diazepam, but their therapeutic utility in anxiety disorders needs more investigation. The study compiled the characteristics of anxiety studies in animal models, evaluated locomotor activity, and the hypnotic effect of the extracts. The study revealed that matricaria chamomilla had a sedative effect, and 23 other flower plants had anxiolytic effects. However, more reliable behavioral tests and better experimental designs are needed to obtain more conclusive evidence with clinical significance.

Meneses C et al (2023).
Phytother Res.
PubMed:
37039741

Laboratory evaluation of the life history of hibiscus mealybug, Nipaecocus viridis (Hemiptera: Pseudococcidae), on selected citrus and potential non-citrus hosts in Florida.

Olabiyi D, Stelinski LL and Diepenbrock LM (2023).
J Econ Entomol.
PubMed:
37030011

Potential bio-functional properties of Citrus aurantium L. leaf: chemical composition, antiviral activity on herpes simplex virus type-1, antiproliferative effects on human lung and colon cancer cells and oxidative protection.

Mejri H et al (2023).
Int J Environ Health Res.
PubMed:
37029956

Abundance and distribution of arbuscular mycorrhizal fungi associated with oil-yielding plants.

Yadav A et al (2023).
J Basic Microbiol.
PubMed:
37010016

"Drying effect" of fructus aurantii components and the mechanism of action based on network pharmacology and in vitro pharmacodynamic validation.

Zhu J et al (2023).
Front Pharmacol.
PubMed:
36969872

Discovery of Brassica Yellows Virus and Porcine Reproductive and Respiratory Syndrome Virus in Diaphorina citri and Changes in Virome Due to Infection with 'Ca. L. asiaticus'.

Lu J et al (2023).
Microbiol Spectr.
PubMed:
36943045

Establishment of angiotensin-converting enzyme 2 and cluster of differentiation 147 dual target cell membrane chromatography based on SNAP-tag technology for screening anti severe acute respiratory syndrome coronavirus 2 active components.

Summary

Researchers have developed a screening system that uses dual-targeted cell membrane chromatography and liquid chromatography-mass spectroscopy to analyze receptors for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This method was used to identify antiviral components in Citrus aurantium extracts, including hesperidin, neohesperidin, nobiletin, and tangeretin. In vitro experiments showed these components can inhibit virus entry into cells and interact with host-virus receptors. The study provides new insight into drug-receptor interactions and may lead to the development of new antiviral drugs.

Wang H et al (2023).
J Chromatogr A.
PubMed:
36870232

Development of Dairy Products Fortified with Plant Extracts: Antioxidant and Phenolic Content Characterization.

Kandyliari A et al (2023).
Antioxidants (Basel).
PubMed:
36830058

The effect of cognitive-behavioral counseling with or without Citrus aurantium essential oil on sleep quality in pregnant women: a randomized controlled trial.

Summary

This study examined the effect of cognitive-behavioral counseling and aromatherapy with essential oil on sleep quality, anxiety, and quality of life in 75 pregnant women. The intervention groups received counseling with either essential oil or a placebo, while the control group received routine prenatal care. After the intervention, both intervention groups had significantly lower anxiety and higher quality of life scores than the control group, but there was no significant difference in sleep quality. This suggests that non-pharmacological treatments, such as counseling, may benefit pregnant women with sleep disorders. However, further research is needed to confirm these results.

Rahmani N et al (2023).
Sleep Biol Rhythms.
PubMed:
36778981

Ovicidal toxicity of plant essential oils and their major constituents against two mosquito vectors and their non-target aquatic predators.

Moungthipmalai T et al (2023).
Sci Rep.
PubMed:
36746998

Linalool controls the viability of Escherichia coli by regulating the synthesis and modification of lipopolysaccharide, the assembly of ribosome, and the expression of substrate transporting proteins.

Gao Z et al (2023).
Food Res Int.
PubMed:
36737930

Prokinetic effects of Citrus reticulata and Citrus aurantium extract with/without Bupleurum chinense using multistress-induced delayed gastric emptying models.

Gong Y et al (2023).
Pharm Biol.
PubMed:
36728913

The Effect of Citrus aurantium on Non-Small-Cell Lung Cancer: A Research Based on Network and Experimental Pharmacology.

Yao L et al (2023).
Biomed Res Int.
PubMed:
36726839

Fruits and their phytochemicals in mitigating the ill effects of ionizing radiation: review on the existing scientific evidence and way forward.

Raghu SV et al (2023).
Food Funct.
PubMed:
36688345

Effect of Emulsion Particle Size on the Encapsulation Behavior and Oxidative Stability of Spray Microencapsulated Sweet Orange Oil (Citrus aurantium var. dulcis).

Peng Q et al (2022).
Foods.
PubMed:
36613332

An approach of pectin from Citrus aurantium L. for superabsorbent resin with superior quality for hygiene products: Salt resistance, antibacterial, nonirritant and biodegradability.

Zhou P et al (2023).
Int J Biol Macromol.
PubMed:
36539172

In-vitro anti-sickling potential of baicalin and naringenin isolated from Oroxylum indicum and Citrus aurantium on human sickle red blood cells.

Lone BA et al (2023).
Nat Prod Res.
PubMed:
36525466

Neohesperidin and spike RBD interaction in omicron and its sub-variants: In silico, structural and simulation studies.

Singh JK et al (2023).
Comput Biol Med.
PubMed:
36502697

Health Risk and Metal Contamination Assessment in Orange (Citrus aurantium) of Pakistan: a Multivariate Study.

Rashid UA et al (2023).
Biol Trace Elem Res.
PubMed:
36477658

Polarity-extended composition profiling via LC-MS-based metabolomics approaches: A key to functional investigation of Citrus aurantium L.

Miao W et al (2023).
Food Chem.
PubMed:
36435109

Total glucosides of paeony alleviates scleroderma by inhibiting type I interferon responses.

Li S et al (2023).
J Ethnopharmacol.
PubMed:
36334818

Citrus aurantium L. Active Constituents, Biological Effects and Extraction Methods. An Updated Review.

Review
Maksoud S et al (2021).
Molecules.
PubMed:
34641373

Effects of Citrus aurantium L. on Gastrointestinal Motility and Gastric Cancer Cell Proliferation.

Gao M and Yang W (2023).
Cancer Biother Radiopharm.
PubMed:
33112653

Pharmacology of Herbal Sexual Enhancers: A Review of Psychiatric and Neurological Adverse Effects.

Review
Brunetti P et al (2020).
Pharmaceuticals (Basel).
PubMed:
33066617

Hepatoprotective Effect of Citrus aurantium L. Against APAP-induced Liver Injury by Regulating Liver Lipid Metabolism and Apoptosis.

Shu Y et al (2020).
Int J Biol Sci.
PubMed:
32071546

Clinical Pharmacology of Citrus aurantium and Citrus sinensis for the Treatment of Anxiety.

Review
Mannucci C et al (2018).
Evid Based Complement Alternat Med.
PubMed:
30622597

An Overview on Citrus aurantium L.: Its Functions as Food Ingredient and Therapeutic Agent.

Review
Suntar I et al (2018).
Oxid Med Cell Longev.
PubMed:
29854097

Safety, Efficacy, and Mechanistic Studies Regarding Citrus aurantium (Bitter Orange) Extract and p-Synephrine.

Review
Stohs SJ et al (2017).
Phytother Res.
PubMed:
28752649