Citrus sinensis

Ethnobotanical Studies

Clinical Trials

Bowel habits, faecal microbiota and faecal bile acid composition of healthy adults consuming fruit pomace fibres: two-arm, randomised, double-blinded, placebo-controlled trials.

The study investigated the effects of orange and apple pomaces on gastrointestinal outcomes in healthy adults. Pomace supplementation did not significantly affect bowel habits or microbiota diversity. However, baseline fiber intake was associated with changes in microbial genera.

Alexander C et al (2023).
Br J Nutr.
DOI:
10.1017/S0007114522002951
PubMed:
36102329

Clinical evaluation of Moro (Citrus sinensis (L.) Osbeck) orange juice supplementation for the weight management.

Cardile V, Graziano AC and Venditti A (2015).
Nat Prod Res.
DOI:
10.1080/14786419.2014.1000897
PubMed:
25588369

Studies

Antioxidant, anti-inflammatory and antibacterial activities of methanol extract and essential oil of two varieties of Citrus sinensis L. in Iran.

Summary

Study on antioxidant, anti-inflammatory, antifungal, antibacterial properties of two varieties of Iranian oranges. Northern orange skin had highest phenol and flavonoid content, antioxidant activity, anti-inflammatory effects, and positive impact on Gram-positive bacteria.

ImmunologyPhytochemistry
Bahramikia S, Habibi S and Shirzadi N (2024).
Nat Prod Res.
DOI:
10.1080/14786419.2024.2400232
PubMed:
39234994

Effector CLas0185 targets methionine sulphoxide reductase B1 of Citrus sinensis to promote multiplication of 'Candidatus Liberibacter asiaticus' via enhancing enzymatic activity of ascorbate peroxidase 1.

Zhang S et al (2024).
Mol Plant Pathol.
DOI:
10.1111/mpp.70002
PubMed:
39215961

Silver nanoparticles from orange peel extract: Colorimetric detection of Pb(2+) and Cd(2+) ions with a chemometric approach.

Zannotti M et al (2024).
Spectrochim Acta A Mol Biomol Spectrosc.
DOI:
10.1016/j.saa.2024.124881
PubMed:
39067363

The aroma profiles of dried gonggans: Characterization of volatile compounds in oven-dried and freeze-dried gonggan.

Liu D et al (2024).
Food Res Int.
DOI:
10.1016/j.foodres.2024.114716
PubMed:
39059964

Immunochromatographic strip for rapid and sensitive detection of bupirimate residues in peach, orange, and carrot.

Cheng Y et al (2024).
Food Chem.
DOI:
10.1016/j.foodchem.2024.140417
PubMed:
39003856

Curcumin-based residue-free and reusable photodynamic inactivation system for liquid foods and its application in freshly squeezed orange juice.

Liu Y et al (2024).
Food Chem.
DOI:
10.1016/j.foodchem.2024.140316
PubMed:
38968711

Effect of herbal irrigants on surface roughness of intraradicular dentin using quantitative method of 3D surface texture analysis.

Sobhy SM et al (2024).
Sci Rep.
DOI:
10.1038/s41598-024-65245-4
PubMed:
38965301

Deciphering the drug delivery potential of Type1 lipid transfer protein from Citrus sinensis for enhancing the therapeutic efficacy of drugs.

Rode S et al (2024).
Biochem Biophys Res Commun.
DOI:
10.1016/j.bbrc.2024.150253
PubMed:
38880080

Electrochemical detection of carbendazim using molecularly imprinted poly(3,4-ethylenedioxythiophene) on Co,N co-doped hollow carbon nanocage@CNTs-modified electrode.

Xue S et al (2024).
Food Chem.
DOI:
10.1016/j.foodchem.2024.140063
PubMed:
38878547

Effects of aluminum (Al) stress on the isoprenoid metabolism of two Citrus species differing in Al-tolerance.

Yang LT et al (2024).
Ecotoxicol Environ Saf.
DOI:
10.1016/j.ecoenv.2024.116545
PubMed:
38850709

Synergistic efficacy of ultrasound and ammonium persulfate in inactivating Escherichia coli O157:H7 in buffered peptone water and orange juice.

Lee SR et al (2024).
Int J Food Microbiol.
DOI:
10.1016/j.ijfoodmicro.2024.110749
PubMed:
38788343

A critical evaluation on the valorization strategies to reduce and reuse orange waste in bakery industry.

Review
Cirrincione F et al (2024).
Food Res Int.
DOI:
10.1016/j.foodres.2024.114422
PubMed:
38763672

Evaluation of the effect of Torulaspora delbrueckii on important volatile compounds in navel orange original brandy using E-nose combined with HS-SPME-GC-MS.

Liu J et al (2024).
Food Chem.
DOI:
10.1016/j.foodchem.2024.139625
PubMed:
38754349

Alicyclobacillus spp. in fruit-based products: Isolation, identification, quantitative assessment (SPME/GC-MS) of spoilage compounds and spore's resistance to thermal shocks.

do Prado-Silva L et al (2024).
Int J Food Microbiol.
DOI:
10.1016/j.ijfoodmicro.2024.110731
PubMed:
38733637

An antifouling electrochemical biosensor using self-signal for Salmonella typhimurium direct detection in food sample.

Gong L et al (2024).
Food Chem.
DOI:
10.1016/j.foodchem.2024.139536
PubMed:
38723569

Comparison of Insecticide Sprays in Alternate Rows and in All Rows on Asian Citrus Psyllid Control and Huanglongbing Progress in Sweet Orange Orchards.

Primiano IV, Barbosa Junior JT and Bassanezi RB (2024).
Plant Dis.
DOI:
10.1094/PDIS-03-24-0646-RE
PubMed:
38654535

N-acetylcysteine absorption and its potential dual effect improve fitness and fruit yield in Xylella fastidiosa infected plants.

Picchi SC et al (2024).
Pest Manag Sci.
DOI:
10.1002/ps.8137
PubMed:
38647195

Characterization and antioxidant activity of peel extracts from three varieties of citrus sinensis.

Summary

Study analyzed antioxidant properties of citrus peel extracts from different varieties. Results show high levels of bioactive compounds with antioxidant potential. Use of citrus peels could reduce environmental pollution and provide natural antioxidants for food and pharma industries.

Immunology
Ogo O et al (2024).
Heliyon.
DOI:
10.1016/j.heliyon.2024.e28456
PubMed:
38560209

Genotypic selection and trait variation in sweet orange (Citrus sinensis L. Osbeck) dataset of Bangladesh.

Khan MAH et al (2024).
Data Brief.
DOI:
10.1016/j.dib.2024.110333
PubMed:
38550231

Strategies for using magnetic beads in enhanced deep eutectic solvent-mechanochemical extraction of natural products from orange peels.

Wang Z et al (2024).
Food Chem.
DOI:
10.1016/j.foodchem.2024.139004
PubMed:
38492304

Nigella sativa, Anthemis hyaline and Citrus sinensis extracts reduce SARS-CoV-2 replication by fluctuating Rho GTPase, PI3K-AKT, and MAPK/ERK pathways in HeLa-CEACAM1a cells.

Summary

Anthemis hyaline, Nigella sativa, and Citrus sinensis extracts show promise in inhibiting coronavirus replication. Nigella sativa increases IL-8 levels and gene expression changes. Anthemis hyaline extract is the most effective in reducing viral load.

COVID-19Immunology
Bostancıklıoğlu M, İğci M and Ulaşlı M (2024).
Gene.
DOI:
10.1016/j.gene.2024.148366
PubMed:
38485035

Development of citrus peel by-product as a slice jam by using two-level factorial design.

Nowalid WFWM, Hamid HA and Giwa SH (2024).
Food Chem (Oxf).
DOI:
10.1016/j.fochms.2024.100196
PubMed:
38482042

Rapid and sensitive quantitation of amitraz in orange, tomato, and eggplant samples using immunochromatographic assay.

Lu Q et al (2024).
Food Chem.
DOI:
10.1016/j.foodchem.2024.138899
PubMed:
38452506

Production, acceptability, nutritional and pasting properties of orange-flesh sweet potato, cowpea and banana flour mix.

Olaniran AF et al (2024).
Sci Rep.
DOI:
10.1038/s41598-024-55312-1
PubMed:
38409312

Formulation of hesperidin-loaded in situ gel for ocular drug delivery: a comprehensive study.

Gözcü S et al (2024).
J Sci Food Agric.
DOI:
10.1002/jsfa.13407
PubMed:
38385802

Anti-Helicobacter pylori, anti-biofilm activity, and molecular docking study of citropten, bergapten, and its positional isomer isolated from Citrus sinensis L. leaves.

Mohammed HS et al (2024).
Heliyon.
DOI:
10.1016/j.heliyon.2024.e25232
PubMed:
38352786

Boron-mediated amelioration of copper toxicity in Citrus sinensis seedlings involved reduced concentrations of copper in leaves and roots and their cell walls rather than increased copper fractions in their cell walls.

Chen HH et al (2024).
J Hazard Mater.
DOI:
10.1016/j.jhazmat.2024.133738
PubMed:
38350317

Effects of the protective and therapeutic effect of yogurt enriched with Citrus sinensis essential oil against ibuprofen-induced gastric ulcer in elderly rats.

Summary

This study found that adding Citrus sinensis essential oil to yogurt increased acidity, total solids, and ash values. Rats fed with this functional yogurt had fewer gastric ulcer lesions compared to the control group. This suggests that yogurt with C. sinensis EO may help reduce the severity of ulcers and improve health.

GastroenterologyPhytochemistry
Polat Z et al (2024).
J Food Sci.
DOI:
10.1111/1750-3841.16937
PubMed:
38349052

Multiomics integrated with sensory evaluations to identify characteristic aromas and key genes in a novel brown navel orange (Citrus sinensis).

Genetics
Hu Z et al (2024).
Food Chem.
DOI:
10.1016/j.foodchem.2024.138613
PubMed:
38325085

Production of mannooligosaccharides from orange peel waste with β-mannanase expressed in Trichosporonoides oedocephalis.

Zhou T et al (2024).
Bioresour Technol.
DOI:
10.1016/j.biortech.2024.130373
PubMed:
38278453

Comparison of green solvents for the revalorization of orange by-products: Carotenoid extraction and in vitro antioxidant activity.

Immunology
Viñas-Ospino A et al (2024).
Food Chem.
DOI:
10.1016/j.foodchem.2024.138530
PubMed:
38271911

From food waste to eco-friendly functionalized polymer composites: Investigation of orange peels as active filler.

Pagliarini E et al (2024).
N Biotechnol.
DOI:
10.1016/j.nbt.2024.01.001
PubMed:
38253287

The CsAP2-09-CsWRKY25-CsRBOH2 cascade confers resistance against citrus bacterial canker by regulating ROS homeostasis.

Li Q et al (2024).
Plant J.
DOI:
10.1111/tpj.16623
PubMed:
38230828

Dietary fibre fractions rich in (poly)phenols from orange by-products and their metabolisation by in vitro digestion and colonic fermentation.

Núñez-Gómez V et al (2024).
Food Res Int.
DOI:
10.1016/j.foodres.2023.113718
PubMed:
38225107

Genome-wide identification of the GRF family in sweet orange (Citrus sinensis) and functional analysis of the CsGRF04 in response to multiple abiotic stresses.

Genetics
Fu MK et al (2024).
BMC Genomics.
DOI:
10.1186/s12864-023-09952-8
PubMed:
38184538

The greening-causing agent alters the behavioral and electrophysiological responses of the Asian citrus psyllid to a putative sex pheromone.

Volpe HXL et al (2024).
Sci Rep.
DOI:
10.1038/s41598-023-50983-8
PubMed:
38172384

Magnitude of Fruit Juice-Drug Interactions Due to Osmolality-Dependent Fluid Secretion: Differences among Apple, Orange, and Grapefruit Juices.

Takemura M et al (2024).
Biol Pharm Bull.
DOI:
10.1248/bpb.b23-00490
PubMed:
38171780

Peracetic acid residues in orange juice can lead to a 5-vinylguaiacol-induced clove-like off-flavor via Baeyer-Villiger oxidation of hesperidin.

Bauersachs E et al (2024).
Food Chem.
DOI:
10.1016/j.foodchem.2023.138252
PubMed:
38160594

Analysis of aroma components changes in Gannan navel orange at different growth stages by HS-SPME-GC-MS, OAV, and multivariate analysis.

Ye Y, Zheng S and Wang Y (2024).
Food Res Int.
DOI:
10.1016/j.foodres.2023.113622
PubMed:
38128975

Co-pyrolysis of orange peel and eggshell for oxygenated rich composite: Process optimization with response surface methodology.

Kumar N et al (2024).
J Environ Manage.
DOI:
10.1016/j.jenvman.2023.119786
PubMed:
38109824

Untargeted metabolomics analysis of Gannan navel orange at different storage periods under room temperature using HS-SPME-GC-MS and UPLC-Q-TOF/MS.

Yuan Y et al (2024).
Food Chem.
DOI:
10.1016/j.foodchem.2023.138186
PubMed:
38104456

Systematic analysis of the thioredoxin gene family in Citrus sinensis: identification, phylogenetic analysis, and gene expression patterns.

Genetics
Zuo X et al (2023).
Plant Signal Behav.
DOI:
10.1080/15592324.2023.2294426
PubMed:
38104280

CitrusUAT: A dataset of orange Citrus sinensis leaves for abnormality detection using image analysis techniques.

Gómez-Flores W, Garza-Saldaña JJ and Varela-Fuentes SE (2023).
Data Brief.
DOI:
10.1016/j.dib.2023.109908
PubMed:
38093853

A multidimensional evaluation of the effects of sweetener selection and UV-C treatment on orange juice and pectin-based confectionery gels.

Andreone A et al (2024).
J Sci Food Agric.
DOI:
10.1002/jsfa.13193
PubMed:
38053417

Sweet orange peel waste as a feed additive in growth promoting and protective effect against Aeromonas hydrophila of juvenile bagrid catfish Mystus nemurus.

See MS et al (2023).
J Environ Manage.
DOI:
10.1016/j.jenvman.2023.119677
PubMed:
38042084

Pyto-Architechture of Ag, Au and Ag-Au bi-metallic nanoparticles using waste orange peel extract for enable carcinogenic Congo red dye degradation.

Christina B et al (2024).
Environ Res.
DOI:
10.1016/j.envres.2023.117625
PubMed:
38007079

Analytical determination of tryptoquialanines A and B: Ensuring the quality and safety of orange juices.

Éder de Vilhena Araújo et al (2023).
Food Res Int.
DOI:
10.1016/j.foodres.2023.113607
PubMed:
37986534

Using Spectral Edge Frequency to Target Equivalent Brain States Under General Anesthesia Is Like Asking for Apples and Getting Oranges.

NeurosciencePain
Kreuzer M, Schneider G and García PS (2023).
Anesth Analg.
DOI:
10.1213/ANE.0000000000006615
PubMed:
37973136

Genome-wide identification, classification, and characterization of lectin gene superfamily in sweet orange (Citrus sinensis L.).

Genetics
Faysal Ahmed F et al (2023).
PLoS One.
DOI:
10.1371/journal.pone.0294233
PubMed:
37956187

Effect of citrus peeling (Citrus sinensis) on production performance, humoral immunity, nutrients, and energy utilization of broiler quails.

Ahmad F et al (2024).
Poult Sci.
DOI:
10.1016/j.psj.2023.103207
PubMed:
37931398

Influence of industrial blanching, cutting and freezing treatments on in vitro gastrointestinal digestion stability of orange (Citrus sinensis L.) and lemon (Citrus limon L.) peel polyphenols.

Ozdemirli N and Kamiloglu S (2023).
J Sci Food Agric.
DOI:
10.1002/jsfa.13101
PubMed:
37926555

The effect of adding pomace on the bioactive composition and flavor volatiles in fermented orange juice with Lactobacillus.

Xu H et al (2024).
J Sci Food Agric.
DOI:
10.1002/jsfa.13097
PubMed:
37922378

Solvothermal liquefaction of orange peels into biocrude: An experimental investigation of biocrude yield and energy compositional dependency on process variables.

Kariim I et al (2024).
Bioresour Technol.
DOI:
10.1016/j.biortech.2023.129928
PubMed:
37914051

Aggregation enhanced emissive orange carbon dots for information encryption and detection of Fe(3+) and tetracycline.

Li C, Liu L and Zhang D (2024).
Spectrochim Acta A Mol Biomol Spectrosc.
DOI:
10.1016/j.saa.2023.123504
PubMed:
37866262

Identification of Polymethoxyflavones (PMFs) from Orange Peel and Their Inhibitory Effects on the Formation of Trimethylamine (TMA) and Trimethylamine-N-oxide (TMAO) Using cntA/B and cutC/D Enzymes and Molecular Docking.

Lee H et al (2023).
J Agric Food Chem.
DOI:
10.1021/acs.jafc.3c04462
PubMed:
37851928

The effect of apple pomace powder and calcium ions on selected physicochemical properties of freeze-dried carrot-orange-ginger snacks.

Phytochemistry
Karwacka M, Galus S and Janowicz M (2024).
J Sci Food Agric.
DOI:
10.1002/jsfa.13058
PubMed:
37851851

Prebiotic potential of pectin and cello-oligosaccharides from apple bagasse and orange peel produced by high-pressure homogenization and enzymatic hydrolysis.

Manthei A et al (2024).
Food Chem.
DOI:
10.1016/j.foodchem.2023.137583
PubMed:
37804723

Screening the Citrus Greek National Germplasm Collection for fruit quality and metabolic footprint.

Michailidis M et al (2024).
Food Chem.
DOI:
10.1016/j.foodchem.2023.137573
PubMed:
37769559

Active site determination of novel plant versatile peroxidase extracted from Citrus sinensis and bioconversion of β-naphthol.

Hoque RA et al (2023).
3 Biotech.
DOI:
10.1007/s13205-023-03758-x
PubMed:
37719748

Effects of irradiation on the aging and sensory quality of navel orange distilled spirits.

Qu S et al (2024).
J Sci Food Agric.
DOI:
10.1002/jsfa.12985
PubMed:
37715570

Roles of citrus fruits on energy expenditure, body weight management, and metabolic biomarkers: a comprehensive review.

Review
Aslan MN, Sukan-Karaçağıl B and Acar-Tek N (2024).
Nutr Rev.
DOI:
10.1093/nutrit/nuad116
PubMed:
37702528

Omics approaches to investigate the neuroprotective capacity of a Citrus sinensis (sweet orange) extract in a Caenorhabditis elegans Alzheimer's model.

Summary

New study finds PLE100, an extract from Citrus sinensis by-products, shows promise as a treatment for Alzheimer's disease due to its neuroprotective properties and positive effects on genes and metabolites involved in stress response and lipid metabolism.

Neuroscience
Sánchez-Martínez JD, Cifuentes A and Valdés A (2023).
Food Res Int.
DOI:
10.1016/j.foodres.2023.113128
PubMed:
37689893

CO(2)-responsive deep eutectic solvents for the enhanced extraction of hesperidin from Fertile orange peel.

Wang S et al (2023).
Food Chem.
DOI:
10.1016/j.foodchem.2023.137255
PubMed:
37643516

APLs and Oranges: Induction of T Cell Anergy by Altered Peptide Ligands.

Jarjour NN and Jameson SC (2023).
J Immunol.
DOI:
10.4049/jimmunol.2300225
PubMed:
37603860

Regulation on copper-tolerance in Citrus sinensis seedlings by boron addition: Insights from root exudates, related metabolism, and gene expression.

Genetics
Chen HH et al (2023).
J Hazard Mater.
DOI:
10.1016/j.jhazmat.2023.132277
PubMed:
37591167

The adaptation of root cell wall pectin to copper toxicity in two citrus species differing in copper tolerance: remodeling and responding.

Lin ML et al (2023).
Tree Physiol.
DOI:
10.1093/treephys/tpad092
PubMed:
37490400

Genome-wide identification of GH9 gene family and the assessment of its role during fruit abscission zone formation in Vaccinium ashei.

Genetics
Wang Y et al (2023).
Plant Cell Rep.
DOI:
10.1007/s00299-023-03049-y
PubMed:
37474780

Electrohydrodynamic drying of citrus (Citrus sinensis L.) peel: Comparative evaluation on the physiochemical quality and volatile profiles.

Zhang AA et al (2023).
Food Chem.
DOI:
10.1016/j.foodchem.2023.136832
PubMed:
37453333

CsTPS21 encodes a jasmonate-responsive monoterpene synthase producing β-ocimene in citrus against Asian citrus psyllid.

Bin M et al (2023).
Plant Physiol Biochem.
DOI:
10.1016/j.plaphy.2023.107887
PubMed:
37442051

Enhanced sensitivity and accuracy via gold nanoparticles based multi-line lateral flow immunoassay strip for Salmonella typhimurium detection in milk and orange juice.

Gong L et al (2023).
Talanta.
DOI:
10.1016/j.talanta.2023.124929
PubMed:
37442004

Comprehensive genome-wide identification and transferability of chromosome-specific highly variable microsatellite markers from citrus species.

Genetics
Singh J et al (2023).
Sci Rep.
DOI:
10.1038/s41598-023-37024-0
PubMed:
37407627

When taking iron, a glass of orange juice a day keeps anemia away.

Powers JM and Auerbach M (2023).
Am J Hematol.
DOI:
10.1002/ajh.27017
PubMed:
37403430

Generation of the transgene-free canker-resistant Citrus sinensis using Cas12a/crRNA ribonucleoprotein in the T0 generation.

Su H et al (2023).
Nat Commun.
DOI:
10.1038/s41467-023-39714-9
PubMed:
37402755

A new formulation of Ni/Zn bi-metallic nanocomposite and evaluation of its applications for pollution removal, photocatalytic, electrochemical sensing, and anti-breast cancer.

Cancer
Li J et al (2023).
Environ Res.
DOI:
10.1016/j.envres.2023.116462
PubMed:
37352956

CO(2) uptake by activated hydrochar derived from orange peel (Citrus reticulata): Influence of carbonization temperature.

Deepak KR et al (2023).
J Environ Manage.
DOI:
10.1016/j.jenvman.2023.118350
PubMed:
37302173

Comparison of different drying technologies for brocade orange (Citrus sinensis) peels: Changes in color, phytochemical profile, volatile, and biological availability and activity of bioactive compounds.

Phytochemistry
Wang Z et al (2023).
Food Chem.
DOI:
10.1016/j.foodchem.2023.136539
PubMed:
37290238

Weighted gene coexpression correlation network analysis reveals the potential molecular regulatory mechanism of citrate and anthocyanin accumulation between postharvest 'Bingtangcheng' and 'Tarocco' blood orange fruit.

Genetics
Jin Y et al (2023).
BMC Plant Biol.
DOI:
10.1186/s12870-023-04309-5
PubMed:
37268922

Factors affecting aroma compounds in orange juice and their sensory perception: A review.

Review
Pan X et al (2023).
Food Res Int.
DOI:
10.1016/j.foodres.2023.112835
PubMed:
37254409

'Candidatus Liberibacter asiaticus' secretory protein SDE3 inhibits host autophagy to promote Huanglongbing disease in citrus.

Shi J et al (2023).
Autophagy.
DOI:
10.1080/15548627.2023.2213040
PubMed:
37249424

Effect of orange solid waste diet on flesh quality and metabolic profile of common carp (Cyprinus carpio).

Zhang J et al (2023).
Food Chem.
DOI:
10.1016/j.foodchem.2023.136427
PubMed:
37245462

Feeding on the Fruit Waste Orange Bagasse Modifies Immature Protein Content, Body Weight, Scent Bouquet Composition, and Copula Duration in Males of a Tephritid Frugivorous Fly.

Pascacio-Villafán C et al (2023).
Biology (Basel).
DOI:
10.3390/biology12050739
PubMed:
37237551

Multitargeted molecular docking and dynamics simulation studies of flavonoids and volatile components from the peel of Citrus sinensis L. (Osbeck) against specific tumor protein markers.

Summary

In this study, researchers investigated the potential medicinal properties of flavonoids and volatile components from the peel of (L.) Osbeck, commonly known as the sweet orange. Their findings suggest that flavonoids have a higher probability of being effective against certain anti-cancer drug targets compared to volatile components. The compound chlorogenic acid showed the strongest binding affinity to important anti-cancer targets, indicating its therapeutic potential. These results highlight the importance of flavonoids from sweet oranges and call for further research to optimize their use in medical treatments.

CancerPhytochemistry
Rajiv Gandhi G et al (2023).
J Biomol Struct Dyn.
DOI:
10.1080/07391102.2023.2212062
PubMed:
37203996

First Report of Postharvest Fruit Rot on Gannan Navel Orange Caused by Diaporthe unshiuensis in Jiangxi Province, China.

Yuan X et al (2023).
Plant Dis.
DOI:
10.1094/PDIS-04-23-0652-PDN
PubMed:
37189045

A novel photonic chemosensor for rapidly detecting synthetic dyes in orange juice using colorimetric and spectrophotometric methods.

Ahmadi S, Ghasempour Z and Hasanzadeh M (2023).
Food Chem.
DOI:
10.1016/j.foodchem.2023.136307
PubMed:
37178603

An effector of 'Candidatus Liberibacter asiaticus' manipulates autophagy to promote bacterial infection.

Shi H et al (2023).
J Exp Bot.
DOI:
10.1093/jxb/erad176
PubMed:
37166404

Nobiletin attenuates monocrotaline-induced pulmonary arterial hypertension through PI3K/Akt/STAT3 pathway.

Summary

This study examines the potential of nobiletin, found in orange peel, to relieve pulmonary arterial hypertension induced by monocrotaline and investigates how it works.

CardiologyImmunology
Yin Q et al (2023).
J Pharm Pharmacol.
DOI:
10.1093/jpp/rgad045
PubMed:
37158759

Boosting short-chain fatty acids production from co-fermentation of orange peel waste and waste activated sludge: Critical role of pH on fermentation steps and microbial function traits.

Shao Q et al (2023).
Bioresour Technol.
DOI:
10.1016/j.biortech.2023.129128
PubMed:
37137449

Molecular characterization of a flavanone 3-hydroxylase gene from citrus fruit reveals its crucial roles in anthocyanin accumulation.

Genetics
Ma G et al (2023).
BMC Plant Biol.
DOI:
10.1186/s12870-023-04173-3
PubMed:
37131162

Facile synthesis of carbon/titanium oxide quantum dots from lignocellulose-rich mandarin orange peel extract via microwave irradiation: Synthesis, characterization and bio-imaging application.

Rajendran K et al (2023).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2023.124546
PubMed:
37086766

A multifunctional true CCoAOMT enzyme participates in the biosynthesis of polymethoxylated flavones in citrus.

Liao Z et al (2023).
Plant Physiol.
DOI:
10.1093/plphys/kiad249
PubMed:
37086474

The Phytochemical and Pharmacological Properties of Citrus sinensis 'Maltese Half-Blood' Essential Oil Peels Extracted and Optimized by Response-Surface Methodology.

Phytochemistry
Kallel I et al (2023).
Curr Pharm Biotechnol.
DOI:
10.2174/1389201024666230405120520
PubMed:
37038662

Efficacy of an existing Ceratitis capitata (Diptera: Tephritidae) cold disinfestation treatment schedule for Ceratitis cosyra.

Manrakhan A et al (2023).
J Econ Entomol.
DOI:
10.1093/jee/toad063
PubMed:
37030002

Metabolomic profiles of not from concentrate orange juice after different sterilization treatments based on HS-SPME-GC-MS and UPLC-QTOF-MS.

Sun R et al (2023).
J Food Sci.
DOI:
10.1111/1750-3841.16549
PubMed:
37013965

Non-destructive, reverse iontophoretic extraction of phytochemicals from Mangifera indica, Centella asiatica, Punica granatum, and Citrus sinensis.

Eilstein J et al (2023).
Phytochem Anal.
DOI:
10.1002/pca.3219
PubMed:
36971356

The mystery behind dark-orange tomatoes: How can an exotic cleavage dioxygenase alter carotenoid flux?

Pereira L et al (2023).
Plant Physiol.
DOI:
10.1093/plphys/kiad164
PubMed:
36943255

The potential of different ripeness of blood oranges (Citrus sinensis L. Osbeck) for sale in advance after low-temperature storage: Anthocyanin enhancements, volatile compounds, and taste attributes.

Chen J et al (2023).
Food Chem.
DOI:
10.1016/j.foodchem.2023.135934
PubMed:
36940512

Lyotropic liquid crystal mesophases as transdermal delivery systems for lipophilic drugs: A comparative study.

de Araujo GRS et al (2023).
Int J Pharm.
DOI:
10.1016/j.ijpharm.2023.122853
PubMed:
36931537

Effects of ageing time on the properties of polysaccharide in tangerine peel and its bacterial community.

Yue F et al (2023).
Food Chem.
DOI:
10.1016/j.foodchem.2023.135812
PubMed:
36921363

Toxicity of insecticidal plant oils on the larval and adult stages of a major malaria vector (Anopheles gambiae Giles 1920).

Adelaja OJ et al (2023).
Parasitol Res.
DOI:
10.1007/s00436-023-07806-6
PubMed:
36890296

Valorization of orange peels exploiting fungal solid-state and lacto-fermentation.

Ricci A et al (2023).
J Sci Food Agric.
DOI:
10.1002/jsfa.12537
PubMed:
36860131

The journey of prochloraz pesticide in Citrus sinensis: Residual distribution, impact on transcriptomic profiling and reduction by plasma-activated water.

Lin Q et al (2023).
J Hazard Mater.
DOI:
10.1016/j.jhazmat.2023.130931
PubMed:
36860068

Distribution, migration and changes of typical chemical preservatives on orange during storage and processing.

Zhang M et al (2023).
Food Chem.
DOI:
10.1016/j.foodchem.2023.135728
PubMed:
36848835

Identification of novel inhibitor against Human Phosphoethanolamine Cytidylyl transferase from phytochemicals of Citrus sinensis peel extract by in vitro and in silico approach.

Phytochemistry
Victor PP et al (2023).
Biotechnol Appl Biochem.
DOI:
10.1002/bab.2453
PubMed:
36824047

Antioxidant capacity and antitumor activity of the bioactive protein prepared from orange peel residues as a by-product using fungal protease.

Immunology
Ahmed SA, Taie HAA and Abdel Wahab WA (2023).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2023.123578
PubMed:
36764344

Chitosan based encapsulation of Valeriana officinalis essential oil as edible coating for inhibition of fungi and aflatoxin B(1) contamination, nutritional quality improvement, and shelf life extension of Citrus sinensis fruits.

Phytochemistry
Das S et al (2023).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2023.123565
PubMed:
36740131

A prophage-encoded effector from "Candidatus Liberibacter asiaticus" targets ASCORBATE PEROXIDASE6 in citrus to facilitate bacterial infection.

Du J et al (2023).
Mol Plant Pathol.
DOI:
10.1111/mpp.13296
PubMed:
36692022

Suppression of citrus canker disease mediated by flagellin perception.

Andrade MO et al (2023).
Mol Plant Pathol.
DOI:
10.1111/mpp.13300
PubMed:
36691963

Activation of the phenylpropanoid pathway in Citrus sinensis collapsed vesicles during segment drying revealed by physicochemical and targeted metabolomics analysis.

Phytochemistry
Wang J et al (2023).
Food Chem.
DOI:
10.1016/j.foodchem.2022.135297
PubMed:
36623356

Microwave-assisted and chemically tailored chlorogenic acid-functionalized silver nanoparticles of Citrus sinensis in gel matrix aiding QbD design for the treatment of acne.

Dermatology
Alam A et al (2023).
J Cosmet Dermatol.
DOI:
10.1111/jocd.15611
PubMed:
36606381

Genome-wide identification, characterization, and expression profile ofNBS-LRRgene family in sweet orange (Citrussinensis).

Genetics
Yin T et al (2023).
Gene.
DOI:
10.1016/j.gene.2022.147117
PubMed:
36526123

Pyrolysis temperature affects the physiochemical characteristics of lanthanum-modified biochar derived from orange peels: Insights into the mechanisms of tetracycline adsorption by spectroscopic analysis and theoretical calculations.

Chen Z et al (2023).
Sci Total Environ.
DOI:
10.1016/j.scitotenv.2022.160860
PubMed:
36521614

Effect of commercial yeasts (Saccharomyces cerevisiae) on fermentation metabolites, phenolic compounds, and bioaccessibility of Brazilian fermented oranges.

Phytochemistry
Andrade Barreto SM et al (2023).
Food Chem.
DOI:
10.1016/j.foodchem.2022.135121
PubMed:
36521294

Health Risk and Metal Contamination Assessment in Orange (Citrus aurantium) of Pakistan: a Multivariate Study.

Rashid UA et al (2023).
Biol Trace Elem Res.
DOI:
10.1007/s12011-022-03515-w
PubMed:
36477658

Nobiletin and xanthohumol counteract the TNFα-mediated activation of endothelial cells through the inhibition of the NF-κB signaling pathway.

Corrado C et al (2023).
Cell Biol Int.
DOI:
10.1002/cbin.11963
PubMed:
36378586

Anti-Cryptosporidium efficacy of Citrus sinensis peel extract: Histopathological and ultrastructural experimental study.

Abd El Wahab WM et al (2022).
Exp Parasitol.
DOI:
10.1016/j.exppara.2022.108412
PubMed:
36374651

Stability of vitamin C, carotenoids, phenols, and antioxidant capacity of pasteurised orange juice with resistant maltodextrin storage.

Immunology
Arilla E et al (2024).
Food Sci Technol Int.
DOI:
10.1177/10820132221124200
PubMed:
36083164

Evaluation of antibacterial activity of compounds isolated from the peel of Newhall navel orange.

Liang Y et al (2023).
Nat Prod Res.
DOI:
10.1080/14786419.2022.2116580
PubMed:
36008769

Metabolite Signature and Differential Expression of Genes in Washington Navel Oranges (Citrus sinensis) Infected by Spiroplasma citri.

Genetics
McNeil CJ et al (2023).
Phytopathology.
DOI:
10.1094/PHYTO-05-22-0177-R
PubMed:
35984373

Effect of ultra violet (UV-C) and cold storage on orange juice quality.

Bazaraa WA et al (2023).
Food Sci Technol Int.
DOI:
10.1177/10820132221117750
PubMed:
35929082

Hesperidin hexosomal loaded nanodispersion: insights of its antimycobacterial, cytotoxic and anti-HCoV effects.

Summary

Valencia oranges contain hesperidin which has anti-TB and antiviral activity. Hesperidin was isolated and formulated as nanodispersions which showed a MIC of 0.19 µM against TB and significant interactions with the Mycobacterial Dihydrofolate reductase enzyme. The nanodispersions also had a cytotoxic effect against lung cancer at IC=33 µM and significant antiviral activity against Human Coronavirus 229E with IC=258.8 μM. This study suggests that Valencia orange peels could be a source of bioactive metabolites for treating diseases.

COVID-19
Elghani EMA et al (2023).
Nat Prod Res.
DOI:
10.1080/14786419.2022.2106484
PubMed:
35921497

Efficacy of ascorbic acid and different sources of orange peel on growth performance, gene expression, anti-oxidant status and microbial activity of growing rabbits under hot conditions.

Genetics
Hassan FA et al (2023).
Anim Biotechnol.
DOI:
10.1080/10495398.2022.2101114
PubMed:
35875862

In-silico studies on wild orange (Citrus macroptera Mont.) compounds against COVID-19 pro-inflammation targets.

Summary

A study investigated phytochemicals from for their potential to inhibit inflammatory proteins that remain active in some COVID-19 survivors. Molecular docking analysis found promising inhibitory potential of the phytochemicals against COX-2, NMDAR, and VCAM-1, and MM-GBSA binding free energy estimation showed one candidate, Limonene, displayed the highest binding efficacy with VCAM-1. The study suggests that these natural compounds could be further validated in pre-clinical and clinical trials for potential use in treating post-COVID inflammation complications.

COVID-19Immunology
Lala M et al (2023).
J Biomol Struct Dyn.
DOI:
10.1080/07391102.2022.2051744
PubMed:
35297321

Probiotic Characterization of Indigenous Kocuria flava Y4 Strain Isolated from Dioscorea villosa Leaves.

Barik A et al (2023).
Probiotics Antimicrob Proteins.
DOI:
10.1007/s12602-021-09877-2
PubMed:
34825308

Safety and efficacy of feed additives consisting of expressed sweet orange peel oil and its fractions from Citrus sinensis (L.) Osbeck for use in all animal species (FEFANA asbl).

EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) et al (2021).
EFSA J.
DOI:
10.2903/j.efsa.2021.6891
PubMed:
34824643

Bioactive compounds analysis in ethanolic extracts of Citrus maxima and Citrus sinensis exocarp and mesocarp.

Zareiyan F and Khajehsharifi H (2022).
Nat Prod Res.
DOI:
10.1080/14786419.2021.1986819
PubMed:
34622727

Citrus sinensis CBF1 Functions in Cold Tolerance by Modulating Putrescine Biosynthesis through Regulation of Arginine Decarboxylase.

Song J et al (2022).
Plant Cell Physiol.
DOI:
10.1093/pcp/pcab135
PubMed:
34478552

Comparative metabolic study of Citrus sinensis leaves cultivars based on GC-MS and their cytotoxic activity.

Kammoun AK, Altyar AE and Gad HA (2021).
J Pharm Biomed Anal.
DOI:
10.1016/j.jpba.2021.113991
PubMed:
33676167

Neuroprotective validation of pectin in T2DM-induced allodynia and hyperalgesia in diabetic peripheral neuropathic pain.

Summary

Researchers investigated whether pectin offers neuroprotective benefits against neuropathic pain in diabetic rodents. Results may inform potential treatment options for neuropathic pain in diabetic patients.

DiabetesNeurosciencePain
Srivastava R et al (2023).
Arch Physiol Biochem.
DOI:
10.1080/13813455.2021.1884725
PubMed:
33618606

Clinical Pharmacology of Citrus aurantium and Citrus sinensis for the Treatment of Anxiety.

Review
Mannucci C et al (2018).
Evid Based Complement Alternat Med.
DOI:
10.1155/2018/3624094
PubMed:
30622597