Cocculus hirsutus

Ethnobotanical Studies

Studies

Chemical profiling and simultaneous quantification of major bioactive constituents from Cocculus hirsutus by UPLC-QqQ-MS.

Tatapudi KK et al (2023).
J Pharm Biomed Anal.
DOI:
10.1016/j.jpba.2023.115675
PubMed:
37633166

Sinococuline, a bioactive compound of Cocculus hirsutus has potent anti-dengue activity.

Shukla R et al (2023).
Sci Rep.
DOI:
10.1038/s41598-023-27927-3
PubMed:
36658277

Phytochemicals of Cocculus hirsutus deciphered SARS-CoV-2 inhibition by targeting main proteases in molecular docking, simulation, and pharmacological analyses.

Summary

Researchers aimed to discover natural compounds with anti-COVID-19 properties by testing phytochemicals from a traditional medicine plant against the main proteases of the SARS-CoV-2 virus, which play a key role in replication and transcription. They used computer tools to identify the most promising compounds, and identified betulin, coclaurine, and quinic acid from the plant as showing significant binding affinity to the SARS-CoV-2 main proteases. These compounds could potentially serve as leads for developing specific anti-COVID-19 treatments.

COVID-19
Rajan M et al (2022).
J Biomol Struct Dyn.
DOI:
10.1080/07391102.2022.2121758
PubMed:
36099182

Phytochemicals as potential inhibitors for COVID-19 revealed by molecular docking, molecular dynamic simulation and DFT studies.

Summary

Researchers investigated the potential use of plant compounds for treating COVID-19 using molecular docking experiments. The compounds showed high binding affinity and two were further explored. Molecular mechanics-based calculations were used to re-rank the candidates, with two compounds being confirmed as stable in association with viral protease. The compounds' geometries, electrical properties, chemical reactivity, and intermolecular interactions were also studied. These in silico discoveries have identified potential COVID-19 inhibitors and could contribute to antiviral drug discovery.

COVID-19
Puthanveedu V and Muraleedharan K (2022).
Struct Chem.
DOI:
10.1007/s11224-022-01982-4
PubMed:
35729939

Clinical safety and pharmacokinetic evaluation of aqueous extract of Cocculus hirsutus, an anti-viral phytopharmacetical drug as a potential for the treatment of dengue and COVID-19.

Summary

Scientists have conducted a study on AQCH tablets as a potential treatment for dengue and COVID-19 infections. The study aimed to evaluate the safety and pharmacokinetics of AQCH in healthy human subjects. AQCH has shown to have anti-viral activity in in vitro and small animal studies. With no effective vaccine or drug available for dengue, this study brings hope for a potential treatment option. The results of this study suggest that AQCH tablets are safe and well-tolerated in humans, and could be a promising solution in the fight against dengue and COVID-19.

AntimicrobialCOVID-19
Dar SK et al (2022).
Heliyon.
DOI:
10.1016/j.heliyon.2022.e09416
PubMed:
35582330

Effect of "Murcchana samskara" on therapeutic efficacy of BhallatakadiGhrita.

Wayal SR et al (2022).
J Ayurveda Integr Med.
DOI:
10.1016/j.jaim.2022.100547
PubMed:
35219071

Efficacy and Safety of a Phytopharmaceutical Drug Derived from Cocculus hirsutus in Adults with Moderate COVID-19: a Phase 2, Open-label, Multicenter, Randomized Controlled Trial.

Summary

Researchers evaluated the effectiveness and safety of purified aqueous extract of Cocculus hirsutus (AQCH) combined with standard care in hospitalized patients with moderate COVID-19. AQCH has shown strong antiviral activity in laboratory studies. There is a critical need for a safe and effective oral therapy for COVID-19.

COVID-19
Joglekar S et al (2022).
Infect Dis Ther.
DOI:
10.1007/s40121-022-00604-0
PubMed:
35179709

Development of a bioanalytical method for the quantification of sinococuline in human plasma and its application in phase I clinical pharmacokinetic study.

Bhadaliya C et al (2022).
Biomed Chromatogr.
DOI:
10.1002/bmc.5337
PubMed:
35028959

Cocculus hirsutus-Derived Phytopharmaceutical Drug Has Potent Anti-dengue Activity.

Shukla R et al (2021).
Front Microbiol.
DOI:
10.3389/fmicb.2021.746110
PubMed:
34912307

Cocculus hirsutus (L.) W.Theob. (Menispermaceae): A Review on Traditional Uses, Phytochemistry and Pharmacological Activities.

Review Phytochemistry
Logesh R et al (2020).
Medicines (Basel).
DOI:
10.3390/medicines7110069
PubMed:
33182572

Cocculus hirsutus: Molecular Docking to Identify Suitable Targets for Hepatocellular Carcinoma by In silico Technique.

Thavamani BS, Mathew M and Dhanabal SP (2016).
Pharmacogn Mag.
DOI:
10.4103/0973-1296.185769
PubMed:
27563224

Anticancer activity of Cocculus hirsutus against Dalton's lymphoma ascites (DLA) cells in mice.

Cancer
Thavamani BS, Mathew M and Palaniswamy DS (2014).
Pharm Biol.
DOI:
10.3109/13880209.2013.871642
PubMed:
24920232

Nephroprotective activity of Cocculus hirsutus leaf extract in 5/6 nephrectomized rat model.

Gadapuram TK et al (2013).
J Basic Clin Physiol Pharmacol.
DOI:
10.1515/jbcpp-2013-0007
PubMed:
23729561

Antimicrobial activity of the roots of cocculus hirsutus.

Antimicrobial
Nayak S and Singhai AK (2003).
Anc Sci Life.
PubMed:
22557094