Codonopsis lanceolata

Ethnobotanical Studies

Studies

Oxidative and carbonyl stress induced AMD and Codonopsis lanceolata ameliorates AMD via controlling oxidative and carbonyl stress.

Lee SY et al (2024).
Sci Rep.
DOI:
10.1038/s41598-024-67044-3
PubMed:
39009704

An outlook on the versatility of plant saponins: A review.

Summary

Saponin-rich plants are eco-friendly alternatives to synthetic surfactants and medications. Studies show high potential for sustainable, ethical, and economical use in commercial products, benefiting human health and the environment.

Review Phytochemistry
Jolly A, Hour Y and Lee YC (2024).
Fitoterapia.
DOI:
10.1016/j.fitote.2024.105858
PubMed:
38365071

Codonopsis lanceolata polysaccharide ameliorates high-fat diet induced-postpartum hypogalactia via stimulating prolactin receptor-mediated Jak2/Stat5 signaling.

Summary

Researchers found that Codonopsis lanceolata polysaccharide improved weight gain, liver health, metabolic abnormalities, mammary gland development, and lactation performance in mice with hypogalactia induced by a high-fat diet. This suggests a potential use of traditional Chinese medicine for treating hypogalactia.

Immunology
Chen S et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2023.129114
PubMed:
38181915

Codonopsis lanceolata Extract Restores Smooth Muscle Vasorelaxation in Rat Carotid Arteries Even under High Extracellular K(+) Concentrations.

Kim U et al (2023).
Nutrients.
DOI:
10.3390/nu15173791
PubMed:
37686823

In silico guided screening of active components of C. lanceolata as 3-chymotrypsin-like protease inhibitors of novel coronavirus.

Summary

Researchers conducted computational screening of phytoconstituents from a specific plant to identify potential antiviral hit candidates against 3CLpro, a target for COVID-19 treatment. Stigmasterol showed the highest binding affinity and exhibited stable interactions. This study suggests as a potential drug candidate for further development against the virus.

COVID-19
Sharma G et al (2023).
3 Biotech.
DOI:
10.1007/s13205-023-03745-2
PubMed:
37663751

Fermented Sprouts of Codonopsis lanceolata Suppress LPS-Induced Inflammatory Responses by Inhibiting NF-κB Signaling Pathway in RAW 264.7 Macrophages and CD1 Mice.

Immunology
Choi SH et al (2023).
Pharmaceutics.
DOI:
10.3390/pharmaceutics15071793
PubMed:
37513980

Recent bioanalytical methods for the isolation of bioactive natural products from genus Codonopsis.

Review
Dar AA et al (2023).
Phytochem Anal.
DOI:
10.1002/pca.3253
PubMed:
37316180

De Novo Transcriptome Sequencing of Codonopsis lanceolata for Identification of Triterpene Synthase and Triterpene Acetyltransferase.

Genetics
Choi HB et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms24065769
PubMed:
36982844

The chromosome-level genome assembly of lance asiabell (Codonopsis lanceolata), a medicinal and vegetable plant of the Campanulaceae family.

Genetics
Jang W et al (2023).
Front Genet.
DOI:
10.3389/fgene.2023.1100819
PubMed:
36816041

UPLC-QTOF-MS-Based Metabolomics and Antioxidant Capacity of Codonopsis lanceolata from Different Geographical Origins.

Nam M et al (2023).
Foods.
DOI:
10.3390/foods12020267
PubMed:
36673357

Lancemaside A from Codonopsis lanceolata: Studies on Antiviral Activity and Mechanism of Action against SARS-CoV-2 and Its Variants of Concern.

Summary

Scientists evaluated Codonopsis lanceolata as a potential treatment for COVID-19 and found that the plant extract and its active compound, lancemaside A (LA), effectively blocked SARS-CoV-2 infection by altering membrane cholesterol and blocking membrane fusion between the virus and host cells. LA also impeded the entry pathways of several SARS-CoV-2 variants, including Omicron. Researchers suggest that LA has broad-spectrum anti-SARS-CoV-2 activity and may serve as a potential therapeutic option.

AntimicrobialCOVID-19
Kim TY et al (2022).
Antimicrob Agents Chemother.
DOI:
10.1128/aac.01201-22
PubMed:
36374087

The efficacy and safety of Codonopsis lanceolata water extract for sarcopenia: A study protocol for randomized, double-blind, placebo-controlled clinical trial.

Park J et al (2022).
Medicine (Baltimore).
DOI:
10.1097/MD.0000000000030773
PubMed:
36181010

Codonopsis lanceolata and its active component Tangshenoside I ameliorate skeletal muscle atrophy via regulating the PI3K/Akt and SIRT1/PGC-1α pathways.

Kim TY, Park KT and Choung SY (2022).
Phytomedicine.
DOI:
10.1016/j.phymed.2022.154058
PubMed:
35349834

Polyacetylenes from Codonopsis lanceolata Root Induced Apoptosis of Human Lung Adenocarcinoma Cells and Improved Lung Dysbiosis.

Wang MC et al (2022).
Biomed Res Int.
DOI:
10.1155/2022/7713355
PubMed:
35224100

Codonopsis lanceolata ameliorates sarcopenic obesity via recovering PI3K/Akt pathway and lipid metabolism in skeletal muscle.

Obesity
Han MJ and Choung SY (2022).
Phytomedicine.
DOI:
10.1016/j.phymed.2021.153877
PubMed:
35026519

Complete genome sequence of Codonopsis torradovirus A, a novel torradovirus infecting Codonopsis lanceolata in South Korea.

Genetics
Belete MT et al (2021).
Arch Virol.
DOI:
10.1007/s00705-021-05244-2
PubMed:
34605994

Slippery flowers as a mechanism of defence against nectar-thieving ants.

Takeda K, Kadokawa T and Kawakita A (2021).
Ann Bot.
DOI:
10.1093/aob/mcaa168
PubMed:
33410906

Codonopsis lanceolata Contributes to Ca2+ Homeostasis by Mediating SOCE and PLC/IP3 Pathways in Vascular Endothelial and Smooth Muscle Cells.

Kim MK et al (2020).
Planta Med.
DOI:
10.1055/a-1214-6718
PubMed:
32731264

Codonopsis lanceolata polysaccharide CLPS alleviates high fat/high sucrose diet-induced insulin resistance via anti-oxidative stress.

Zhang Y et al (2020).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2019.09.185
PubMed:
31669275

Codonopsis lanceolata: A Review of Its Therapeutic Potentials.

Review
Hossen MJ et al (2016).
Phytother Res.
DOI:
10.1002/ptr.5553
PubMed:
26931614