Codonopsis pilosula

Common Names: bellflower

Ethnobotanical Studies

Studies

Effect of Continuous Cropping on Growth and Lobetyolin Synthesis of the Medicinal Plant Codonopsis pilosula (Franch.) Nannf. Based on the Integrated Analysis of Plant-Metabolite-Soil Factors.

Xu L et al (2024).
J Agric Food Chem.
DOI:
10.1021/acs.jafc.4c03664
PubMed:
39196612

Modulating butyric acid-producing bacterial community abundance and structure in the intestine of immunocompromised mice with neutral polysaccharides extracted from Codonopsis pilosula.

Rong X and Shu Q (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.134959
PubMed:
39179083

Shenqi Fuzheng Injection Reduces Cisplatin-Induced Kidney Injury via cGAS/STING Signaling Pathway in Breast Cancer Mice Model.

Summary

SQFZ, a traditional Chinese medicine, when combined with chemotherapy, can enhance treatment effectiveness and reduce side effects. Its specific mechanism in reducing cisplatin-induced kidney injury requires further study.

Cancer
Ma Y et al (2024).
Breast Cancer (Dove Med Press).
DOI:
10.2147/BCTT.S475860
PubMed:
39165276

MiR-221 on protective oxidative induced by selenium modified Codonopsis pilosula polysaccharide.

Qin T et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.134815
PubMed:
39154690

Targeted mutagenesis in Arabidopsis and medicinal plants using transposon-associated TnpB.

Lv Z et al (2024).
J Integr Plant Biol.
DOI:
10.1111/jipb.13758
PubMed:
39109980

Metabolomics combined with network pharmacology reveals the potential development value of Campanumoea javanica Bl. and its metabolite differences with Codonopsis Radix.

Peng J et al (2024).
BMC Plant Biol.
DOI:
10.1186/s12870-024-05401-0
PubMed:
39020306

Cooperative effects of three preservatives on physiological quality, endophytic bacterial community and volatile organic compounds of postharvest Codonopsis pilosula var. modesta roots.

Wang Y et al (2024).
J Sci Food Agric.
DOI:
10.1002/jsfa.13694
PubMed:
39007367

Heterologous expression of BACE1 and its interaction with Codonopsis pilosula polysaccharides and Lobetyolin.

Zhao F et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.133440
PubMed:
38944075

Paraphoma chrysanthemicola Affects the Carbohydrate and Lobetyolin Metabolism Regulated by Salicylic Acid in the Soilless Cultivation of Codonopsis pilosula.

Sun W et al (2024).
Biology (Basel).
DOI:
10.3390/biology13060408
PubMed:
38927288

Preparation, characterization and evaluation of microwave-assisted synthesized selenylation Codonopsis pilosula polysaccharides.

Peng K et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.133228
PubMed:
38897504

Soil Organic Matter and Total Nitrogen Reshaped Root-Associated Bacteria Community and Synergistic Change the Stress Resistance of Codonopsis pilosula.

Huo X et al (2024).
Mol Biotechnol.
DOI:
10.1007/s12033-024-01217-3
PubMed:
38890219

A systematic review of the mechanism of action and potential medicinal value of codonopsis pilosula in diseases.

Review
Guo H et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2024.1415147
PubMed:
38803438

Lobetyolin protects mice against LPS-induced sepsis by downregulating the production of inflammatory cytokines in macrophage.

Immunology
Chen Z et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2024.1405163
PubMed:
38799158

Efficacy of substances containing 3 types of active ingredients-saponins, flavones, and alkaloids in regulation of cytokines in autoimmune diseases a systematic review and Meta-analysis based on animal studies.

Summary

Scientists tested the effectiveness of saponins, flavones, and alkaloids on animals with autoimmune diseases. Results may help develop new treatments for AIDs in humans.

Meta-Analysis Phytochemistry
Ruifang Z et al (2024).
J Tradit Chin Med.
DOI:
10.19852/j.cnki.jtcm.20240402.003
PubMed:
38767625

Integrated metabolomic and transcriptomic analysis of triterpenoid accumulation in the roots of Codonopsis pilosula var. modesta (Nannf.) L.T.Shen at different altitudes.

Wang ZX et al (2024).
Phytochem Anal.
DOI:
10.1002/pca.3362
PubMed:
38764207

Codonopsis pilosula-derived glycopeptide dCP1 promotes the polarization of tumor-associated macrophage from M2-like to M1 phenotype.

Summary

Glycopeptide dCP1 from Codonopsis pilosula extracts can convert tumor-promoting M2-like tumor-associated macrophages (TAM) into tumor-suppressive M1 phenotype, potential for tumor treatment.

CancerImmunology
Liu H, Yao M and Ren J (2024).
Cancer Immunol Immunother.
DOI:
10.1007/s00262-024-03694-6
PubMed:
38743074

Effects of Klebsiella michiganensis LDS17 on Codonopsis pilosula growth, rhizosphere soil enzyme activities, and microflora, and genome-wide analysis of plant growth-promoting genes.

Summary

PGPB strain LDS17 isolated from rhizosphere promotes plant growth, inhibits fungi, increases enzyme activity, microbial diversity, and heavy metal resistance. Potential use in microbial fertilizers for sustainable plant growth and stress tolerance. Important for improving agricultural practices and environmental sustainability.

Genetics
Jin T et al (2024).
Microbiol Spectr.
DOI:
10.1128/spectrum.04056-23
PubMed:
38563743

Research on the brewing technology of Dangshen Huangjiu with low biogenic amines and high functional factors.

Gao Y et al (2024).
J Sci Food Agric.
DOI:
10.1002/jsfa.13503
PubMed:
38563388

Network pharmacology-based investigation of the effects of Shenqi Fuzheng injection on glioma proliferation and migration via the SRC/PI3K/AKT signaling pathway.

Li S et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118128
PubMed:
38561056

An inulin-type fructan CP-A from Codonopsis pilosula attenuates experimental colitis in mice by promoting autophagy-mediated inactivation of NLRP3 inflammasome.

Gastroenterology
Zhou J et al (2024).
Chin J Nat Med.
DOI:
10.1016/S1875-5364(24)60556-X
PubMed:
38553192

Oxidative Stress in Spinocerebellar Ataxia Type 3 and Its Attenuation by Herbal Remedies in Traditional Chinese Medicine: A Systematic Review.

Summary

Herbal remedies in traditional Chinese medicine show promise in managing SCA3 by targeting oxidative stress. Preclinical studies support their therapeutic roles, suggesting potential alternative treatments to delay disease progression.

Review Immunology
Mohd Hisam NS and Wong KH (2024).
Antioxidants (Basel).
DOI:
10.3390/antiox13030375
PubMed:
38539908

Isolation, purification, and structural characterization of polysaccharides from Codonopsis pilosula and its therapeutic effects on non-alcoholic fatty liver disease in vitro and in vivo.

Ma K et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.130988
PubMed:
38518942

Codonopsis pilosula water extract delays D-galactose-induced aging of the brain in mice by activating autophagy and regulating metabolism.

Summary

Researchers studied the anti-aging effects of Codonopsis pilosula on the brain. Results suggest potential benefits for brain health, supporting traditional medicinal uses. Important for future research in neuroprotection and cognitive function.

Neuroscience
Wang X et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118016
PubMed:
38462027

Improvement in the quality and productivity of Codonopsis pilosula seedlings by dazomet soil fumigation.

Wang H et al (2024).
Sci Rep.
DOI:
10.1038/s41598-024-56093-3
PubMed:
38443552

Effect of Codonopsis pilosula polysaccharide on the quality of sheep semen preservation at 4°C.

Wang Y et al (2024).
Anim Biosci.
DOI:
10.5713/ab.23.0258
PubMed:
38271972

Occurrence of Leaf Spot on Elaeocarpus decipiens Caused by Alternaria alternata, a new disease in China.

Liu J et al (2024).
Plant Dis.
DOI:
10.1094/PDIS-10-23-2044-PDN
PubMed:
38268177

Efficacy and safety of traditional plant-based medicines for preventing chronic oxaliplatin-induced peripheral neurotoxicity in patients with colorectal cancer: A systematic review and meta-analysis with core herb contribution.

Summary

Researchers studied the use of traditional plant-based medicines to prevent nerve damage caused by chemotherapy. Results are unclear due to different medicine combinations and lack of understanding of their mechanisms.

Review CancerGastroenterologyNeuroscience
Han J et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.117735
PubMed:
38211824

An inulin-type fructan CP-A from Codonopsis pilosula alleviates TNBS-induced ulcerative colitis based on serum-untargeted metabolomics.

Gastroenterology
Zhou J et al (2024).
Am J Physiol Gastrointest Liver Physiol.
DOI:
10.1152/ajpgi.00214.2023
PubMed:
38193197

Drying kinetics prediction and quality effect of ultrasonic synergy vacuum far-infrared drying of Codonopsis pilosula.

Wang T et al (2023).
J Food Sci.
DOI:
10.1111/1750-3841.16890
PubMed:
38161279

Impact of Codonopsis decoction on cerebral blood flow and cognitive function in rats with chronic cerebral ischemia.

Summary

Researchers investigated the use of Codonopsis decoction, a traditional Chinese medicine made from the dried roots of certain species of Codonopsis, in treating chronic cerebral ischemia (CCI). CCI is associated with qi and blood deficiencies and fluid depletion. This study explores the potential benefits and medicinal properties of Codonopsis in CCI treatment.

CardiologyNeuroscience
Wang J et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117585
PubMed:
38159825

Exploration of Postharvest Conditions for Codonopsis pilosula Nannf. var. modesta (Nannf.) L. T. Shen Roots Based on Sensory Quality, Active Components, Antioxidant Capacity and Physiological Changes at Different Storage Temperatures.

Immunology
Wen L et al (2023).
Foods.
DOI:
10.3390/foods12244418
PubMed:
38137223

[Screening and expression analysis of transcription factors involved in genuineness of Codonopsis pilosula in Shanxi].

Zhai YJ et al (2023).
Zhongguo Zhong Yao Za Zhi.
DOI:
10.19540/j.cnki.cjcmm.20230727.101
PubMed:
38114173

Codonopsis pilosula polysaccharide alleviates rotenone-induced murine brain organoids death through downregulation of gene body DNA methylation modification in the ZIC4/PGM5/CAMTA1 axis.

Summary

Codonopsis pilosula polysaccharide (CpP) protected mouse brain organoids from rotenone damage by reducing cytotoxicity and promoting cell cycle progression through demethylation modifications.

GeneticsNeuroscience
Chen H et al (2023).
Biochem Biophys Rep.
DOI:
10.1016/j.bbrep.2023.101593
PubMed:
38074999

The Mechanism of Core Chinese Medicine Combination in Treating Salivation.

Wang Y and Zhang Y (2023).
Stud Health Technol Inform.
DOI:
10.3233/SHTI230899
PubMed:
38007798

Study on environmental factors affecting the quality of codonopsis radix based on MaxEnt model and all-in-one functional factor.

Wang Z et al (2023).
Sci Rep.
DOI:
10.1038/s41598-023-46546-6
PubMed:
38007505

Fabrication of porous adsorbents from eco-friendly aqueous foam for high-efficient removal of cationic dyes and sustainable utilization assessment.

Duan F et al (2024).
J Environ Sci (China).
DOI:
10.1016/j.jes.2022.11.024
PubMed:
37980025

[Effect of Continuous Cropping on the Physicochemical Properties, Microbial Activity, and Community Characteristics of the Rhizosphere Soil of Codonopsis pilosula].

Summary

Continuous cropping changes soil properties, microbial activity, and community characteristics, leading to increased organic carbon, phosphorus, nitrogen, and salt, while pH decreases. Bacterial diversity declines, but fungi diversity increases. Microbial community stability is disrupted. Bacterial community characteristics are influenced by phosphorus, potassium, carbon-nitrogen ratio, and soil respiration, while nitrogen, potassium, phosphorus, and soil respiration affect fungal community characteristics.

Phytochemistry
Yang Y et al (2023).
Huan Jing Ke Xue.
DOI:
10.13227/j.hjkx.202211100
PubMed:
37973120

Systemic Immunomodulatory Effects of Codonopsis pilosula Glucofructan on S180 Solid-Tumor-Bearing Mice.

Summary

Researchers investigated the effects of an immunopotentiator called CPG on the immune response in tumor-bearing mice. Results showed that CPG inhibited tumor growth, enhanced immune responses, and induced tumor cell death. These findings contribute to our understanding of the immune system's role in fighting tumors.

CancerImmunology
Fan Y et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms242115598
PubMed:
37958581

Integrated widely targeted metabolomics and network pharmacology revealed quality disparities between Guizhou and conventional producing areas of Codonopsis Radix.

Zhang K et al (2023).
Front Nutr.
DOI:
10.3389/fnut.2023.1271817
PubMed:
37915621

Genomic Characteristics and Comparative Genomics Analysis of the Endophytic Fungus Paraphoma chrysanthemicola DS-84 Isolated from Codonopsis pilosula Root.

Sun W et al (2023).
J Fungi (Basel).
DOI:
10.3390/jof9101022
PubMed:
37888278

Multi-omics revealed the mechanisms of Codonopsis pilosula aqueous extract in improving UC through blocking abnormal activation of PI3K/Akt signaling pathway.

Li F et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117220
PubMed:
37820998

Sheng-Mai-Yin inhibits doxorubicin-induced ferroptosis and cardiotoxicity through regulation of Hmox1.

Meng P et al (2023).
Aging (Albany NY).
DOI:
10.18632/aging.205062
PubMed:
37770231

A Pectic Polysaccharide from Codonopsis pilosula Alleviates Inflammatory Response and Oxidative Stress of Aging Mice via Modulating Intestinal Microbiota-Related Gut-Liver Axis.

GastroenterologyImmunology
Zou Y et al (2023).
Antioxidants (Basel).
DOI:
10.3390/antiox12091781
PubMed:
37760084

Codonopsis pilosula polysaccharides promote osteogenic differentiation and inhibit lipogenic differentiation of rat bone marrow stem cells by activating β-catenin.

Liu J et al (2023).
Chem Biol Interact.
DOI:
10.1016/j.cbi.2023.110721
PubMed:
37739048

Guben Xiezhuo decoction inhibits M1 polarization through the Raf1/p-Elk1 signaling axis to attenuate renal interstitial fibrosis.

Liu Y et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117189
PubMed:
37716490

Investigation on the lubrication component and mechanism for a biolubricant isolated from the agro-waste resource of Codonopsis pilosula.

Xie M et al (2023).
Sci Total Environ.
DOI:
10.1016/j.scitotenv.2023.166014
PubMed:
37541498

Characterization of Codonopsis pilosula subsp. tangshen plastome and comparative analysis of Codonopsis species.

Yue J et al (2022).
PLoS One.
DOI:
10.1371/journal.pone.0271813
PubMed:
35913971

Codonopsis pilosula polysaccharides attenuate Escherichia coli-induced acute lung injury in mice.

Gong Z et al (2022).
Food Funct.
DOI:
10.1039/d2fo01221a
PubMed:
35818994

Integration of network pharmacology and molecular docking technology reveals the mechanism of the herbal pairing of Codonopsis Pilosula (Franch.) Nannf and Astragalus Membranaceus (Fisch.) Bge on chronic heart failure.

Cardiology
Xu J et al (2021).
Ann Palliat Med.
DOI:
10.21037/apm-21-1469
PubMed:
34353081

Codonopsis pilosula Polysaccharides Alleviate Aβ (1-40)-Induced PC12 Cells Energy Dysmetabolism via CD38/NAD+ Signaling Pathway.

Hu YR et al (2021).
Curr Alzheimer Res.
DOI:
10.2174/1567205018666210608103831
PubMed:
34102973

The Adjuvant Effects on Vaccine and the Immunomodulatory Mechanisms of Polysaccharides From Traditional Chinese Medicine.

Review Immunology
Wang D, Liu Y and Zhao W (2021).
Front Mol Biosci.
DOI:
10.3389/fmolb.2021.655570
PubMed:
33869288

New pectic polysaccharides from Codonopsis pilosula and Codonopsis tangshen: structural characterization and cellular antioxidant activities.

Immunology
Zou YF et al (2021).
J Sci Food Agric.
DOI:
10.1002/jsfa.11261
PubMed:
33857333

Extraction, purification, structural characteristics and biological properties of the polysaccharides from Codonopsis pilosula: A review.

Review
Luan F et al (2021).
Carbohydr Polym.
DOI:
10.1016/j.carbpol.2021.117863
PubMed:
33766352

Chemical constituents comparison of Codonopsis tangshen, Codonopsis pilosula var. modesta and Codonopsis pilosula.

Lin LC, Tsai TH and Kuo CL (2013).
Nat Prod Res.
DOI:
10.1080/14786419.2013.778849
PubMed:
23506253