Colebrookea oppositifolia

Ethnobotanical Studies

Studies

Dereplication Based Strategy for Rapid Identification and Isolation of a Novel Anti-inflammatory Flavonoid by LCMS/MS from Colebrookea oppositifolia.

Immunology
Sharma N et al (2021).
ACS Omega.
DOI:
10.1021/acsomega.1c01837
PubMed:
34805658

Acteoside isolated from Colebrookea oppositifolia attenuates I/R brain injury in Wistar rats via modulation of HIF-1α, NF-κB, and VEGF pathways.

Summary

Acteoside, isolated from C. oppositifolia, was studied for its anti-stroke activity in Wistar rats. Rats were pretreated with acteoside at different doses before being subjected to ischemia-reperfusion brain injury. Neurological, motor-cognitive functions were evaluated along with morphological, biochemical, histopathological, and gene expression studies. Results showed that acteoside had a protective effect against I/R induced brain injury, making it a potential therapeutic agent for stroke treatment.

Neuroscience
Viswanatha GL et al (2021).
Inflammopharmacology.
DOI:
10.1007/s10787-021-00851-6
PubMed:
34365555

Acteoside Isolated from Colebrookea oppositifolia Smith Attenuates Epilepsy in Mice Via Modulation of Gamma-Aminobutyric Acid Pathways.

Summary

Acteoside was evaluated for its anticonvulsant properties and mechanism of action in mice. It was found to have significant anticonvulsant activity in the pentylenetetrazole (PTZ) model, but not in the maximal electroshock (MES) or N-methyl-D-aspartic acid (NMDA) models. Studies on the PTZ model showed that acteoside restored altered antioxidant levels, GABA mRNA levels, and glutamate levels in the cortex and hippocampus regions of PTZ-treated mice. The anticonvulsant activity of acteoside was confirmed to be due to its GABAergic mechanism and was found to have no central side effects. The study concludes that acteoside and related compounds may be useful in the treatment of epilepsy.

Neuroscience
Viswanatha GL et al (2020).
Neurotox Res.
DOI:
10.1007/s12640-020-00267-0
PubMed:
32803629

Antioxidant potential and chemical characterization of bioactive compounds from a medicinal plant Colebrokea oppositifolia Sm.

Ishtiaq S et al (2020).
An Acad Bras Cienc.
DOI:
10.1590/0001-3765202020190387
PubMed:
32696843

Comprehensive Characterization of Secondary Metabolites from Colebrookea oppositifolia (Smith) Leaves from Nepal and Assessment of Cytotoxic Effect and Anti-Nf-κB and AP-1 Activities In Vitro.

Peron G et al (2020).
Int J Mol Sci.
DOI:
10.3390/ijms21144897
PubMed:
32664524

Foliar epidermal anatomy of Lamiaceae with special emphasis on their trichomes diversity using scanning electron microscopy.

Gul S et al (2019).
Microsc Res Tech.
DOI:
10.1002/jemt.23157
PubMed:
30633436

Corrigendum to "Chemical characterization and cerebroprotective effect of methanolic root extract of Colebrookea oppositifolia in rats" [J. Ethnopharmacol. 223 15 (2018) 63-75].

Ethnobotany
Viswanatha GL et al (2019).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2018.07.020
PubMed:
30093213

Chemical characterization and cerebroprotective effect of methanolic root extract of Colebrookea oppositifolia in rats.

Viswanatha GL et al (2018).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2018.05.009
PubMed:
29777902

Antimicrobial, Anthelmintic, and Antiviral Activity of Plants Traditionally Used for Treating Infectious Disease in the Similipal Biosphere Reserve, Odisha, India.

Antimicrobial
Panda SK et al (2017).
Front Pharmacol.
DOI:
10.3389/fphar.2017.00658
PubMed:
29109684

Ameliorative potential of Colebrookea oppositifolia methanolic root extract against experimental models of epilepsy: Possible role of GABA mediated mechanism.

Summary

Colebrookea oppositifolia Smith plant is used by various folk medicine groups in sub-Himalayan regions of India to treat epilepsy.

Neuroscience
Viswanatha GL, Venkataranganna MV and Prasad NBL (2017).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2017.03.078
PubMed:
28391167