Conium maculatum

Common Names: deadly hemlock, poison hemlock, poison parsley, poison-hemlock

Ethnobotanical Studies

Studies

Mass Spectrometry Imaging of Coniine and Other Hemlock Alkaloids after On-Tissue Derivatization Reveals Distinct Alkaloid Distributions in the Plant.

Phytochemistry
Barrera-Adame DA, Schuster S and Niedermeyer THJ (2024).
J Nat Prod.
DOI:
10.1021/acs.jnatprod.4c00445
PubMed:
38904441

Identification of Potential Phytochemical Inhibitors From Conium maculatum Targeting the Epidermal Growth Factor Receptor in Metastatic Colorectal Cancer via Molecular Docking Analysis.

Summary

Scientists screened phytochemicals from a plant as potential inhibitors of EGFR in metastatic colorectal cancer (mCRC). 25 compounds had favorable drug-like properties, with 12 showing high affinity for EGFR. Seven compounds were predicted to be safe and effective, warranting further investigation and optimization.

CancerGastroenterologyPhytochemistry
Venkateswaran S et al (2023).
Cureus.
DOI:
10.7759/cureus.48000
PubMed:
38034159

Vertigoheel promotes rodent cognitive performance in multiple memory tests.

Summary

A study was conducted to assess the potential cognitive benefits of VH-04, a drug that has been used for decades to treat vertigo. The researchers investigated its effects on memory and explored the biological mechanisms behind its activity. Cognitive impairment in older individuals and those with brain disorders can be debilitating, and current therapies only offer temporary improvement. This research aims to find new, safe, and effective therapeutics to reverse or delay cognitive impairment. By repurposing VH-04, a drug with a proven safety record, there is hope for developing a more successful treatment option.

Neuroscience
Ott K et al (2023).
Front Neurosci.
DOI:
10.3389/fnins.2023.1183023
PubMed:
37325043

"Retraction Notice to 'Evaluation of therapeutic and toxic levels of Conium maculatum L. extract in gestation and foetal development of adult albino rats" [Journal of Ayurveda and Integrtaive Medicine 13 (2022)100621].

Genetics
Konanki S et al (2023).
J Ayurveda Integr Med.
DOI:
10.1016/j.jaim.2023.100700
PubMed:
36813681

Poisonous Piperidine Plants and the Biodiversity of Norditerpenoid Alkaloids for Leads in Drug Discovery: Experimental Aspects.

Review Phytochemistry
Qasem AMA, Rowan MG and Blagbrough IS (2022).
Int J Mol Sci.
DOI:
10.3390/ijms232012128
PubMed:
36292987

Evaluation of therapeutic and toxic levels of Conium maculatum L. extract in gestation and foetal development of adult albino rats.

Konanki S et al (2022).
J Ayurveda Integr Med.
DOI:
10.1016/j.jaim.2022.100621
PubMed:
35961155

Physiological Effects of Conium Maculatum.

(1845).
Buffalo Med J Mon Rev Med Surg Sci.
PubMed:
35374052

High throughput phenotyping of cross-sectional morphology to assess stalk lodging resistance.

Oduntan YA, Stubbs CJ and Robertson DJ (2022).
Plant Methods.
DOI:
10.1186/s13007-021-00833-3
PubMed:
34983578

What Socrates drank? Comparative chemical investigation of two Greek Conium taxa exhibiting diverse chemical profiles.

Vlassi A et al (2022).
Phytochemistry.
DOI:
10.1016/j.phytochem.2021.113060
PubMed:
34952367

Mild-to-severe poisoning due to Conium maculatum as toxic herb: A case series.

Boskabadi J et al (2021).
Clin Case Rep.
DOI:
10.1002/ccr3.4509
PubMed:
34322257

Characterization of Phytoconstituents from Alcoholic Extracts of Four Woody Species and Their Potential Uses for Management of Six Fusarium oxysporum Isolates Identified from Some Plant Hosts.

Salem MZM et al (2021).
Plants (Basel).
DOI:
10.3390/plants10071325
PubMed:
34209682

Vertigoheel induced psychosis: A patient case report.

O'Connell M, Hunt E and VandenBerg A (2021).
Ment Health Clin.
DOI:
10.9740/mhc.2021.01.031
PubMed:
33505824

Study of Immunotropic Properties of Water-Soluble Polysaccharides Isolated from Conium maculatum Grass.

Ligacheva AA et al (2020).
Bull Exp Biol Med.
DOI:
10.1007/s10517-020-05033-y
PubMed:
33263855

Diversity of Secondary Metabolites in Roots from Conium maculatum L.

Chizzola R and Lohwasser U (2020).
Plants (Basel).
DOI:
10.3390/plants9080939
PubMed:
32722223

Conium maculatum intoxication: Literature review and case report on hemlock poisoning.

Karakasi MV et al (2019).
Forensic Sci Rev.
PubMed:
30594904

Polyketide synthases from poison hemlock (Conium maculatum L.).

Hotti H et al (2015).
FEBS J.
DOI:
10.1111/febs.13410
PubMed:
26260860

Anticancer potential of Conium maculatum extract against cancer cells in vitro: Drug-DNA interaction and its ability to induce apoptosis through ROS generation.

CancerGenetics
Mondal J, Panigrahi AK and Khuda-Bukhsh AR (2014).
Pharmacogn Mag.
DOI:
10.4103/0973-1296.139792
PubMed:
25298670

Nicotinic plant poisoning.

Summary

Plants containing nicotinic and nicotinic-like alkaloids can be toxic to humans and have similar symptoms. This review focuses on the taxonomy and principal alkaloids of these plants, their mechanisms of toxicity, and how to manage poisoning. The study provides valuable information for healthcare professionals to identify and treat plant-related toxicities in patients.

Review Neuroscience
Schep LJ, Slaughter RJ and Beasley DM (2009).
Clin Toxicol (Phila).
DOI:
10.1080/15563650903252186
PubMed:
19778187

Poison hemlock (Conium maculatum L.).

Review
Vetter J et al (2004).
Food Chem Toxicol.
PubMed:
15234067

Biochemistry of hemlock (Conium maculatum L.) alkaloids and their acute and chronic toxicity in livestock. A review.

Review Phytochemistry
López TA, Cid MS and Bianchini ML (1999).
Toxicon.
PubMed:
10340826