Coptis chinensis

Ethnobotanical Studies

Clinical Trials

Efficacy and safety of mixture of ivy leaf extract and coptidis rhizome in the treatment of acute bronchitis: multicenter, randomized, double-blinded, active-controlled, parallel, therapeutic confirmatory clinical trial.

Han KI et al (2024).
Curr Med Res Opin.
DOI:
10.1080/03007995.2024.2362273
PubMed:
38889376

Studies

Composite microneedles loaded with Astragalus membranaceus polysaccharide nanoparticles promote wound healing by curbing the ROS/NF-κB pathway to regulate macrophage polarization.

Immunology
Liu X et al (2024).
Carbohydr Polym.
DOI:
10.1016/j.carbpol.2024.122574
PubMed:
39227108

Natural Coptidis Rhizoma Nanoparticles Improved the Oral Delivery of Docetaxel.

Ye D et al (2024).
Int J Nanomedicine.
DOI:
10.2147/IJN.S470853
PubMed:
39176130

Coptis Chinensis Franch: Substance Basis, Mechanism of Action and Quality Control Standard Revealed Based on the Q-marker Concept and New Strategy of Systemic Pharmacology and Biosynthesis Research.

Zheng Y et al (2024).
Curr Top Med Chem.
DOI:
10.2174/0115680266305274240723120426
PubMed:
39136504

Cyberpharmacology uncover the mechanism of the total Rhizoma Coptidis extracts ameliorate chronic atrophic gastritis.

Ma Z et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118644
PubMed:
39094758

In vivo and in vitro chemical composition and biological activity of traditional vs. dispensing granule decoctions of Coptidis Rhizoma: A comparative study.

Wang P et al (2024).
Biomed Chromatogr.
DOI:
10.1002/bmc.5960
PubMed:
38992861

Rhizoma coptidis can inhibit the excessive proliferation, inflammation, and transformation of lung fibroblasts into myofibroblasts.

Summary

Researchers studied the effects of Rhizoma coptidis on pulmonary fibrosis. COP showed potential as a treatment for the disease due to its anti-inflammatory properties.

Immunology
Yang J et al (2024).
Allergol Immunopathol (Madr).
DOI:
10.15586/aei.v52i4.1111
PubMed:
38970260

Molecular insights into chronic atrophic gastritis treatment: Coptis chinensis Franch studied via network pharmacology, molecular dynamics simulation and experimental analysis.

Hu C et al (2024).
Comput Biol Med.
DOI:
10.1016/j.compbiomed.2024.108804
PubMed:
38941899

Revealing microbial diversity in buffalo milk with high somatic cell counts: implications for mastitis diagnosis and treatment.

Jiang H et al (2024).
Vet Res Commun.
DOI:
10.1007/s11259-024-10438-5
PubMed:
38874832

Effects of three Huanglian-derived polysaccharides on the gut microbiome and fecal metabolome of high-fat diet/streptozocin-induced type 2 diabetes mice.

Summary

Study showed that polysaccharides from three Huanglian plants improved T2DM in mice by balancing gut microbiota, increasing SCFAs, and affecting metabolic pathways. Gut health is crucial for managing T2DM.

DiabetesGastroenterology
Wang J et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.133060
PubMed:
38871107

Multidirectional Intervention of Chinese Herbal Medicine in the Prevention and Treatment of Atherosclerosis: From Endothelial Protection to Immunomodulation.

Li JN et al (2024).
Am J Chin Med.
DOI:
10.1142/S0192415X24500381
PubMed:
38798151

Discovery of Nine Dipeptidyl Peptidase-4 Inhibitors from Coptis chinensis Using Virtual Screening, Bioactivity Evaluation, and Binding Studies.

Zhao Z et al (2024).
Molecules.
DOI:
10.3390/molecules29102304
PubMed:
38792165

Untargeted serum and gastric metabolomics and network pharmacology analysis reveal the superior efficacy of zingiberis rhizoma recens-/euodiae fructus-processed Coptidis Rhizoma on gastric ulcer rats.

Gastroenterology
Zhang Z et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118376
PubMed:
38782310

Coptidis rhizoma extract alleviates oropharyngeal candidiasis by gC1qR-EGFR/ERK/c-fos axis-induced endocytosis of oral epithelial cells.

Bao M et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118305
PubMed:
38729536

Revealing the mechanism of Dahuang Huanglian Xiexin Decoction attenuates dysbiosis via IL-17 signaling pathway based on network pharmacology and experimental validation.

Immunology
Ren T et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118267
PubMed:
38688354

Mechanism of the components compatibility of Scutellariae Radix and Coptidis Rhizoma on mice with hyperlipidemia by regulating the Cyp4a family.

Gao Y et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118263
PubMed:
38677575

Sangbaipi Decoction exerted in vitro and in vivo anti-Influenza Effect through inhibiting viral proteins.

Shi T et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118258
PubMed:
38663783

Antipathogenic Activities of Volatile Organic Compounds Produced by Bacillus velezensis LT1 against Sclerotium rolfsii LC1, the Pathogen of Southern Blight in Coptis chinensis.

Tang T et al (2024).
J Agric Food Chem.
DOI:
10.1021/acs.jafc.4c00984
PubMed:
38657235

A breakthrough in phytochemical profiling: ultra-sensitive surface-enhanced Raman spectroscopy platform for detecting bioactive components in medicinal and edible plants.

Phytochemistry
Yang C et al (2024).
Mikrochim Acta.
DOI:
10.1007/s00604-024-06360-x
PubMed:
38652378

Huang Lian Jie Du Decoction enhances the anti-tumor efficacy of immune checkpoint inhibitors by activating TLR7/8 signalling in melanoma.

Summary

Researchers studied how the traditional Chinese medicine HLJD can enhance the effectiveness of ICIs in melanoma treatment. Understanding this may improve cancer immunotherapy outcomes by overcoming drug resistance.

Cancer
Liu S et al (2024).
BMC Complement Med Ther.
DOI:
10.1186/s12906-024-04444-y
PubMed:
38605368

The Scutellaria-Coptis herb couple and its active small-molecule ingredient wogonoside alleviate cytokine storm by regulating the CD39/NLRP3/GSDMD signaling pathway.

Immunology
Wang H et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118155
PubMed:
38593962

The Mechanism of Polygonum Hydropiper L-Coptis Chinensis in the Treatment of Ulcerative Colitis Based on Network Pharmacology and Experimental Validation.

Gastroenterology
Zhu F et al (2024).
Front Biosci (Landmark Ed).
DOI:
10.31083/j.fbl2903093
PubMed:
38538280

Advancing green extraction of bioactive compounds using deep eutectic solvent-based ultrasound-assisted matrix solid-phase dispersion: Application to UHPLC-PAD analysis of alkaloids and organic acids in Coptidis rhizoma.

Phytochemistry
Han M et al (2024).
Talanta.
DOI:
10.1016/j.talanta.2024.125983
PubMed:
38537350

The anti-cholestatic effects of Coptis chinensis Franch. alone and combined with Tetradium ruticarpum (A. Jussieu) T. G. Hartley: dual effects on fecal metabolism and microbial diversity.

Han J et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2024.1372527
PubMed:
38523644

Biomarkers and coptis chinensis activity for rituximab-resistant diffuse large B-cell lymphoma: Combination of bioinformatics analysis, network pharmacology and molecular docking.

Immunology
Zhao Q et al (2024).
Technol Health Care.
DOI:
10.3233/THC-230738
PubMed:
38517810

Bacillus velezensis LT1: a potential biocontrol agent for southern blight on Coptis chinensis.

Tang T et al (2024).
Front Microbiol.
DOI:
10.3389/fmicb.2024.1337655
PubMed:
38500587

Epiberberine inhibits bone metastatic breast cancer-induced osteolysis.

Summary

Researchers studied epiberberine, a compound from Coptidis Rhizoma, for its anti-tumor and anti-inflammatory properties on breast cancer and metastatic breast cancer-induced osteolysis. Results show promising potential for future treatments.

Cancer
Wei C et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118039
PubMed:
38479545

A network pharmacology method explores the molecular mechanism of Coptis chinensis for the treatment of Alzheimer's disease.

Summary

Network pharmacology predicted molecular mechanisms of Coptis chinensis in Alzheimer's treatment, revealing active ingredients, targets, and a drug-component-disease-target network. Main signaling pathways involved PI3K-Akt, AGE-RAGE, MAPK, HIF-1, TNF, and relaxin. Berberine demonstrated strong affinity, informing future clinical research.

Neuroscience
Qian Q and Luo WL (2024).
Medicine (Baltimore).
DOI:
10.1097/MD.0000000000037103
PubMed:
38306514

Primary study on the effects and mechanisms of separate and combined decoctions of Scutellaria baicalensis Georgi - Coptis chinensis Franch extracts in relieving acute alcoholic liver injury in rats.

Shen Y et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.117790
PubMed:
38253276

Transcriptome analysis reveals cadmium exposure enhanced the isoquinoline alkaloid biosynthesis and disease resistance in Coptis chinensis.

Summary

Study identifies molecular mechanisms behind cadmium accumulation in medicinal herb Coptis chinensis, offers strategies to control and mitigate accumulation, enhance resistance, and promote synthesis of secondary metabolites.

GeneticsPhytochemistry
Li X et al (2024).
Ecotoxicol Environ Saf.
DOI:
10.1016/j.ecoenv.2024.115940
PubMed:
38218103

Protective Effect of Berberine on Acute Gastric Ulcer by Promotion of Tricarboxylic Acid Cycle-Mediated Arachidonic Acid Metabolism.

Gastroenterology
Guo Q et al (2024).
J Inflamm Res.
DOI:
10.2147/JIR.S436653
PubMed:
38193042

A rapid localization and analysis method for isoquinoline alkaloids with fluorescence in Coptis chinensis Franch. By fabricating the nano-silver sol as a substrate for surface-enhanced Raman spectroscopy.

Summary

Scientists developed a fast and sensitive method using surface-enhanced Raman spectroscopy to analyze traditional Chinese medicines (TCMs). This method overcomes limitations of traditional detection methods and helps ensure the quality and safety of TCMs.

Phytochemistry
Xie M et al (2024).
Anal Chim Acta.
DOI:
10.1016/j.aca.2023.342067
PubMed:
38182374

Study on anti-inflammatory effect of Shangkehuangshui in vitro and in vivo based on TLR4/TLR2-NF-κB signaling pathway.

Summary

Shangkehuangshui is a traditional Chinese medicine used for treating injuries. Despite its effectiveness, we still don't know how it works.

Immunology
Zhang B et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.117709
PubMed:
38181931

Coptisine inhibits aggressive and proliferative actions of fibroblast like synoviocytes and exerts a therapeutic potential for rheumatoid arthritis.

Summary

Coptisine, a compound from Chinese herb, has anti-tumor effect but its impact on rheumatoid arthritis (RA) is unclear. This study investigates coptisine's ability to control synovial proliferation in RA and its mechanism(s).

ArthritisCancer
Xu F et al (2024).
Int Immunopharmacol.
DOI:
10.1016/j.intimp.2023.111433
PubMed:
38181676

Identification and drug resistance of pathogen of ulcerative skin disease and its immune responses and protective efficacy after vaccination in a giant spiny frog, Quasipaa spinosa.

Wang Y and Xie Z (2023).
Microb Pathog.
DOI:
10.1016/j.micpath.2023.106526
PubMed:
38163491

Green fluorescent carbon dots for sensing of quercetin and pH and cell imaging.

Zhang Y, Cheng S and Zhang Y (2023).
Luminescence.
DOI:
10.1002/bio.4638
PubMed:
38083837

Systematic screening of hepatoprotective components from traditional Chinese medicine: Zuojin Pill as an example.

Wang D et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117556
PubMed:
38072292

N6-methyladenosine modification of TSC1 mRNA contributes to macrophage polarization regulated by Coptisine in DSS-induced ulcerative colitis.

Summary

This study investigates how coptisine (COP), derived from Coptis chinensis, inhibits macrophage inflammation in ulcerative colitis (UC). COP's protective mechanism against UC in mice induced with dextran sulfate sodium (DSS) is explored.

GastroenterologyGeneticsImmunology
Zhao M et al (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2023.155153
PubMed:
38014839

Chemical Characterization of the Precipitate Found in and Its Effect on Drug Release of the Scutellaria baicalensis -Coptis chinensis Extract.

Kim HY and Kim JH (2023).
Chem Biodivers.
DOI:
10.1002/cbdv.202301461
PubMed:
37961037

Coptisine, the Characteristic Constituent from Coptis chinensis, Exhibits Significant Therapeutic Potential in Treating Cancers, Metabolic and Inflammatory Diseases.

Immunology
Lu Q et al (2023).
Am J Chin Med.
DOI:
10.1142/S0192415X2350091X
PubMed:
37930333

Neuroprotective Properties of Berberine: Molecular Mechanisms and Clinical Implications.

Summary

Berberine (BBR), a natural compound found in certain plants, has various beneficial effects on the brain. It protects against oxidative stress, inflammation, and cell death, and regulates enzyme activity, neurotransmitter levels, and gut bacteria. By targeting multiple signaling pathways, BBR shows promise for neuroprotection.

Review Neuroscience
Tian E, Sharma G and Dai C (2023).
Antioxidants (Basel).
DOI:
10.3390/antiox12101883
PubMed:
37891961

Berberrubine is a novel and selective IMPDH2 inhibitor that impairs the growth of colorectal cancer.

Summary

Researchers discovered that a compound called berberrubine, found in Coptis chinensis, selectively inhibits IMPDH2, a protein highly expressed in colorectal cancer. Berberrubine impairs cancer cell growth and reduces tumor size in cells and mouse models, indicating potential for CRC treatment.

CancerGastroenterology
He X et al (2023).
Biochem Pharmacol.
DOI:
10.1016/j.bcp.2023.115868
PubMed:
37871880

Efficacy and safety of berberine for premature ventricular contractions: a meta-analysis and systematic review of randomized controlled trials.

Meta-Analysis
Qiao M et al (2023).
Pharm Biol.
DOI:
10.1080/13880209.2023.2248167
PubMed:
37855412

Herb pairs containing Curcumae Rhizoma (Ezhu): A review of bio-active constituents, compatibility effects and t-copula function analysis.

Review
Lin L et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117199
PubMed:
37844744

Berberine protects against neomycin-induced ototoxicity by reducing ROS generation and activating the PI3K/AKT pathway.

Zhang J et al (2023).
Neurosci Lett.
DOI:
10.1016/j.neulet.2023.137518
PubMed:
37844727

Berberine hydrochloride ameliorates PM2.5-induced pulmonary fibrosis in mice through inhibiting oxidative stress and inflammatory.

Immunology
Zhao J et al (2023).
Chem Biol Interact.
DOI:
10.1016/j.cbi.2023.110731
PubMed:
37839514

Nucleic acid strand displacement for indirect determination of foodborne bacteria by capillary electrophoresis and its application in antagonism and bacteriostasis studies.

Zhang S et al (2024).
Electrophoresis.
DOI:
10.1002/elps.202300155
PubMed:
37824215

Maintaining immune homeostasis with Coptis Chinensis water extract to mitigate sepsis severity via modulating gut microbiome and metabolism.

Gastroenterology
Meng H et al (2023).
J Pharm Biomed Anal.
DOI:
10.1016/j.jpba.2023.115719
PubMed:
37742503

Combining transcriptomics and network pharmacology to reveal the mechanism of Zuojin capsule improving spasmolytic polypeptide-expressing metaplasia.

Genetics
Xiong M et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117075
PubMed:
37625606

Combination of Coptis chinensis polysaccharides and berberine ameliorates ulcerative colitis by regulating gut microbiota and activating AhR/IL-22 pathway.

Gastroenterology
Wang X et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117050
PubMed:
37595814

Vitro UPLC analysis and mass method identification, and in vivo or cellular immune anti-inflammatory function of Sanhuang Xiexin Decoction (SHXD).

Summary

The researchers studied the effects of Sanhuang Xiexin Decoction (SHXD) on rat NK-cell phenotypes and its mechanism in treating inflammation induced by lipopolysaccharides (LPS).

Immunology
Gao Y et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117002
PubMed:
37544343

Huannao Yicong decoction ameliorates cognitive deficits in APP/PS1/tau triple transgenic mice by interfering with neurotoxic interaction of Aβ-tau.

Neuroscience
Zhang H et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116985
PubMed:
37532075

Identification of the therapeutic effect and molecular mechanism of Coptis chinensis Franch. and Magnolia officinalis var. biloba on chronic gastritis.

Song J et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116864
PubMed:
37393026

Coptis chinensis Franch polysaccharides provide a dynamically regulation on intestinal microenvironment, based on the intestinal flora and mucosal immunity.

Gastroenterology
Chen Q et al (2021).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2020.113542
PubMed:
33152428

Coptisine from Coptis chinensis exerts diverse beneficial properties: A concise review.

Review
Wu J et al (2019).
J Cell Mol Med.
DOI:
10.1111/jcmm.14725
PubMed:
31622015

UPLC-Q/TOF-MS-Based Serum Metabolomics Reveals Hypoglycemic Effects of Rehmannia glutinosa, Coptis chinensis and Their Combination on High-Fat-Diet-Induced Diabetes in KK-Ay Mice.

Diabetes
Qin Z et al (2018).
Int J Mol Sci.
DOI:
10.3390/ijms19123984
PubMed:
30544908

Berberine and Its Role in Chronic Disease.

Review
Cicero AF and Baggioni A (2016).
Adv Exp Med Biol.
PubMed:
27671811