Coreopsis tinctoria

Common Names: plains coreopsis, golden tickseed, Atkinson's tickseed

Ethnobotanical Studies

Studies

Anti-photoaging effect and the mechanism of Coreopsis tinctoria okanin against UVB-induced skin damage in mice.

Sun S et al (2024).
Int Immunopharmacol.
DOI:
10.1016/j.intimp.2024.112657
PubMed:
39024749

Optimizing Coreopsis tinctoria Flower Extraction and Inhibiting CML Activity: Box-Behnken Design.

Chen X, Zhou X and Gao Y (2024).
Anticancer Agents Med Chem.
DOI:
10.2174/0118715206299886240620070011
PubMed:
38919005

Marein, a novel natural product for restoring chemo-sensitivity to cancer cells through competitive inhibition of ABCG2 function.

Summary

Marein from Coreopsis tinctoria Nutt can sensitize drug resistant cancer cells by inhibiting ABCG2 transporter, increasing drug accumulation, and binding to critical site F439. Potential implications for treating ABCG2-expressing tumors with chemotherapeutic drugs.

Cancer
Li Y et al (2024).
Biochem Pharmacol.
DOI:
10.1016/j.bcp.2024.116219
PubMed:
38643907

Coreopsis tinctoria improves energy metabolism in obese hyperglycemic mice.

Summary

This study shows that Chinese trumpet creeper (CT) can improve energy metabolism and lower blood glucose levels in obese mice by targeting the liver. Kaempferol, a compound in CT, plays a significant role in this process.

DiabetesObesity
Huangfu B et al (2024).
Heliyon.
DOI:
10.1016/j.heliyon.2024.e27449
PubMed:
38496841

Marein Ameliorates Myocardial Fibrosis by Inhibiting HIF-1α and TGF-β1/Smad2/3 Signaling Pathway in Isoproterenol-stimulated Mice and TGF-β1-stimulated Cardiac Fibroblasts.

Summary

Researchers studied the role of myocardial fibrosis in heart failure. Understanding this connection is important for making informed decisions in the lab regarding the disease.

Cardiology
Niu G et al (2023).
Curr Pharm Des.
DOI:
10.2174/0113816128282062231218075341
PubMed:
38151839

UPLC-quadrupole time-of-flight-tandem mass spectrometry combined with chemometrics and network pharmacology to differentiate Coreopsis tinctoria Nutt.

Zhou X et al (2023).
Biomed Chromatogr.
DOI:
10.1002/bmc.5797
PubMed:
38084786

First report of powdery mildew caused by Podosphaera fusca on Coreopsis tinctoria in China.

Xu D et al (2023).
Plant Dis.
DOI:
10.1094/PDIS-10-23-2089-PDN
PubMed:
38050401

Optimization of preparation method of hepatoprotective active components from Coreopsis tinctoria Nutt. and its action mechanism in vivo.

Abdurehman D et al (2023).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2023.115590
PubMed:
37776638

Neuroprotection of isookanin against MPTP-induced cell death of SH-SY5Y cells via BCL2/BAX and PI3K/AKT pathways.

Zhang R et al (2023).
Psychopharmacology (Berl).
DOI:
10.1007/s00213-023-06383-x
PubMed:
37256377

Inhibition Effect of Okanin Toward Human Cytochrome P450 3A4 and 2D6 with Multi-spectroscopic Studies and Molecular Docking.

Wang S et al (2023).
J Fluoresc.
DOI:
10.1007/s10895-023-03258-4
PubMed:
37191827

Marein reduces lipid levels via modulating the PI3K/AKT/mTOR pathway to induce lipophagy.

Zhang PP et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116523
PubMed:
37080364

Isolation, Bioactive Potential, and Application of Essential Oils and Terpenoid-Rich Extracts as Effective Antioxidant and Antimicrobial Agents in Meat and Meat Products.

Review AntimicrobialImmunology
Šojić B et al (2023).
Molecules.
DOI:
10.3390/molecules28052293
PubMed:
36903538

Pollen morphological investigation of selected species of family Asteraceae from Pakistan by using light and scanning electron microscopy.

Hayat K et al (2023).
Microsc Res Tech.
DOI:
10.1002/jemt.24308
PubMed:
36876588

Aromatase inhibitors isolated from a flowering tea, snow Chrysanthemum (the capitula of Coreopsis tinctoria Nutt.).

Luo F et al (2023).
J Nat Med.
DOI:
10.1007/s11418-022-01678-3
PubMed:
36630026

Okanin from Coreopsis tinctoria Nutt. alleviates cognitive impairment in bilateral common carotid artery occlusion mice by regulating the miR-7/NLRP3 axis in microglia.

Summary

Researchers investigated the effects of okanin, the main active ingredient in Nutt. flower, on cognitive impairment following stroke. They found that okanin was able to improve cognitive impairment, inhibit microglial activation, decrease inflammasome activation, and increase miR-7 expression. Okanin was also able to suppress NLRP3 inflammasome activation in stimulated microglia and prevent microglia-induced neuronal injury. These results suggest that okanin could be a potential functional food for stroke recovery.

Neuroscience
Mi Y et al (2023).
Food Funct.
DOI:
10.1039/d2fo01476a
PubMed:
36511396

Corrigendum: Protective Effects of Anthocyanins from Coreopsis tinctoria against Oxidative Stress Induced by Hydrogen Peroxide in MIN6 Cells.

Immunology
Liu J et al (2023).
Chem Biodivers.
DOI:
10.1002/cbdv.202201106
PubMed:
36482062

Development of an LC/MS/MS Method for Simultaneous Detection of 11 Polyphenols in Rat Plasma and Its Pharmacokinetic Application after Oral Administration of Coreopsis tinctoria Extract.

Han H et al (2023).
Chem Biodivers.
DOI:
10.1002/cbdv.202200574
PubMed:
36382445

Impact of Coreopsis tinctoria Nutt. Essential oil microcapsules on the formation of biogenic amines and quality of smoked horsemeat sausage during ripening.

Phytochemistry
Li Y et al (2023).
Meat Sci.
DOI:
10.1016/j.meatsci.2022.109020
PubMed:
36334510

Protective Effect of Effective Components of Coreopsis tinctoria Nutt on Retinopathy of db/db Diabetic Mice.

Diabetes
Hui L, Tao Y and Xinmin M (2021).
Evid Based Complement Alternat Med.
DOI:
10.1155/2021/9948609
PubMed:
34691233

Marein ameliorates diabetic nephropathy by inhibiting renal sodium glucose transporter 2 and activating the AMPK signaling pathway in db/db mice and high glucose-treated HK-2 cells.

Diabetes
Guo Y et al (2020).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2020.110684
PubMed:
33152903

Okanin in Coreopsis tinctoria Nutt is a major quorum-sensing inhibitor against Chromobacterium violaceum.

Mu Y, Zeng H and Chen W (2020).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2020.113017
PubMed:
32464313

Coreopsis tinctoria Nutt ameliorates high glucose-induced renal fibrosis and inflammation via the TGF-β1/SMADS/AMPK/NF-κB pathways.

Immunology
Yao L et al (2019).
BMC Complement Altern Med.
DOI:
10.1186/s12906-018-2410-7
PubMed:
30630477

Flavonoids furom Coreopsis tinctoria adjust lipid metabolism in hyperlipidemia animals by down-regulating adipose differentiation-related protein.

Phytochemistry
Li Y et al (2014).
Lipids Health Dis.
DOI:
10.1186/1476-511X-13-193
PubMed:
25512113