Cornus mas

Common Names: Cornelian cherry, sorbet, cornejo macho

Ethnobotanical Studies

Clinical Trials

Extract from Aronia melanocarpa, Lonicera caerulea, and Vaccinium myrtillus Improves near Visual Acuity in People with Presbyopia.

Szumny D et al (2024).
Nutrients.
DOI:
10.3390/nu16070926
PubMed:
38612968

Effect of Cornus mas L. fruit extract on blood pressure, anthropometric and body composition indices in patients with non-alcoholic fatty liver disease: A double-blind randomized controlled trial.

Scientists studied the effect of Cornus mas L. fruit extract on blood pressure and body measurements in patients with NAFLD, suggesting it could potentially improve obesity and hypertension.

Yarhosseini F et al (2023).
Clin Nutr ESPEN.
DOI:
10.1016/j.clnesp.2023.04.018
PubMed:
37344070

The effect of Cornus mas fruit extract on vasomotor symptoms and sex hormones in postmenopausal women: a randomized, double-blind, clinical trial.

Study found that Cornus mas fruit has antioxidant and anti-inflammatory properties. It may help alleviate menopausal symptoms and modulate sex hormones in postmenopausal women.

Rimaz S et al (2023).
Menopause.
DOI:
10.1097/GME.0000000000002117
PubMed:
36696645

Studies

Hepatic changes following a high-fat diet: effects of Cornus mas and gold nanoparticles phytoreduced with Cornus mas on oxidative stress, inflammation, and histological damage.

Summary

"Study found HFD causes liver injury, CM and GNPsCM can protect against oxidative stress and inflammation. Important for potential treatment/prevention of liver damage from high fat diets."

Immunology
Zugravu DD et al (2024).
Med Pharm Rep.
DOI:
10.15386/mpr-2775
PubMed:
39234459

Antioxidant and Antidiabetic Activity of Cornus mas L. and Crataegus monogyna Fruit Extracts.

Summary

Three green extraction methods were evaluated for polyphenols and vitamin C extraction from fruit extracts, with ASE and LE showing highest yields and antioxidant and antidiabetic activities. These extracts stimulate insulin secretion and could be beneficial for metabolic disorders.

DiabetesImmunology
Paun G et al (2024).
Molecules.
DOI:
10.3390/molecules29153595
PubMed:
39125000

The Impact of Cornelian Cherry (Cornus mas L.) on Cardiometabolic Risk Factors: A Meta-Analysis of Randomised Controlled Trials.

Meta-Analysis
Frumuzachi O et al (2024).
Nutrients.
DOI:
10.3390/nu16132173
PubMed:
38999920

The Antimicrobial Effect of Cornus mas L. and Sorbus aucuparia L. Fruit Extracts against Resistant Uropathogens in Correlation with the Prevalence of Urinary Tract Infections in Companion Animals.

Summary

Study tested and fruit extracts on bacteria from pets with UTIs, finding strong antimicrobial activity. Potential alternative to antibiotics, combating antibiotic resistance.

Antimicrobial
Aurori M et al (2024).
Pharmaceuticals (Basel).
DOI:
10.3390/ph17060814
PubMed:
38931481

Comparison of the Antioxidant and Cytoprotective Properties of Extracts from Different Cultivars of Cornus mas L.

Immunology
Pomianek T et al (2024).
Int J Mol Sci.
DOI:
10.3390/ijms25105495
PubMed:
38791533

Investigating the Anti-Inflammatory Properties and Skin Penetration Ability of Cornelian Cherry (Cornus mas L.) Extracts.

Immunology
Zagórska-Dziok M et al (2024).
Int J Mol Sci.
DOI:
10.3390/ijms25094763
PubMed:
38731982

Wild Edible Plants Used in Dalmatian Zagora (Croatia).

Ninčević Runjić T et al (2024).
Plants (Basel).
DOI:
10.3390/plants13081079
PubMed:
38674488

Detection of morphological and eco-physiological traits of ornamental woody species to assess their potential Net O(3) uptake.

Manzini J et al (2024).
Environ Res.
DOI:
10.1016/j.envres.2024.118844
PubMed:
38579998

Therapeutic Potential of Cornus Genus: Navigating Phytochemistry, Pharmacology, Clinical Studies, and Advanced Delivery Approaches.

Phytochemistry
Badoni S et al (2024).
Chem Biodivers.
DOI:
10.1002/cbdv.202301888
PubMed:
38403786

The Health-Promoting Quality Attributes, Polyphenols, Iridoids and Antioxidant Activity during the Development and Ripening of Cornelian Cherry (Cornus mas L.).

Immunology
Przybylska D et al (2024).
Antioxidants (Basel).
DOI:
10.3390/antiox13020229
PubMed:
38397827

Effects of gold nanoparticles phytoreduced with Cornus mas L. extract on the aorta wall function in rats with hyperlipid diet - a study on isolated aortic rings.

Moldovan R et al (2024).
Med Pharm Rep.
DOI:
10.15386/mpr-2659
PubMed:
38344328

Health-Promoting Properties of Anthocyanins from Cornelian Cherry (Cornus mas L.) Fruits.

Review
Szot I et al (2024).
Molecules.
DOI:
10.3390/molecules29020449
PubMed:
38257363

Cornelian Cherry (Cornus mas L.) Fruit Extract Lowers SREBP-1c and C/EBPα in Liver and Alters Various PPAR-α, PPAR-γ, LXR-α Target Genes in Cholesterol-Rich Diet Rabbit Model.

Genetics
Danielewski M et al (2024).
Int J Mol Sci.
DOI:
10.3390/ijms25021199
PubMed:
38256272

Plant-derived natural medicines for the management of osteoporosis: A comprehensive review of clinical trials.

Summary

This study reviewed clinical evidence on using herbal medicine to manage osteoporosis, which is a chronic skeletal disease causing low bone density and increased fracture risk.

Review Arthritis
Karimi SM, Bayat M and Rahimi R (2023).
J Tradit Complement Med.
DOI:
10.1016/j.jtcme.2023.08.001
PubMed:
38223808

The effect of lyophilized dried cornelian cherry (Cornus mas L.) intake on anthropometric and biochemical parameters in women with insulin resistance: A randomized controlled trial.

Celık ZM et al (2023).
Food Sci Nutr.
DOI:
10.1002/fsn3.3725
PubMed:
38107130

The effect of Cornus mas extract on nıcotıne-ınduced oxıdatıve stress and ıntratestıcular damage ın male rats.

Öztekin Ü et al (2023).
Cell Mol Biol (Noisy-le-grand).
DOI:
10.14715/cmb/2023.69.11.37
PubMed:
38015512

Evaluation of the Biological Activity of Hydrogel with Cornus mas L. Extract and Its Potential Use in Dermatology and Cosmetology.

Dermatology
Zagórska-Dziok M et al (2023).
Molecules.
DOI:
10.3390/molecules28217384
PubMed:
37959803

The Nephroprotective Effect of Cornelian Cherry (Cornus mas L.) and Rowanberry (Sorbus aucuparia L.) in Gentamicin-Induced Nephrotoxicity on Wistar Rats with Emphasis on the Evaluation of Novel Renal Biomarkers and the Antioxidant Capacity in Correlation with Nitro-Oxidative Stress.

Immunology
Aurori M et al (2023).
Nutrients.
DOI:
10.3390/nu15204392
PubMed:
37892466

The Possibility of Using Fruit-Bearing Plants of Temperate Climate in the Treatment and Prevention of Diabetes.

Summary

This review suggests that alternative fruit species such as Cornelian cherry, mulberry, bird cherry, and sour cherry have potential health benefits, including antidiabetic effects attributed to polyphenols. These fruits could be used in the treatment of diabetes and related complications.

Review Diabetes
Łysiak GP and Szot I (2023).
Life (Basel).
DOI:
10.3390/life13091795
PubMed:
37763199

Iridoid- and flavonoid-enriched fractions of Cornus sanguinea and Cornus mas exert antioxidant and anti-inflammatory effects and inhibit key enzymes in the treatment of metabolic disorders.

ImmunologyPhytochemistry
Tenuta MC et al (2023).
Food Funct.
DOI:
10.1039/d3fo02987e
PubMed:
37694378

Comparative Study of Cytotoxicity and Antioxidant, Anti-Aging and Antibacterial Properties of Unfermented and Fermented Extract of Cornus mas L.

Summary

Dogwood extract and ferment have antioxidant, anti-aging properties, promote cell viability, and inhibit bacterial proliferation. Fermentation with kombucha yields valuable products, making them great ingredients for skincare.

Immunology
Zagórska-Dziok M et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms241713232
PubMed:
37686038

Effects of Cornus mas L. on anthropometric and biochemical parameters among metabolic associated fatty liver disease patients: Randomized clinical trial.

Bayram HM, Iliaz R and Gunes FE (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117068
PubMed:
37611681

New Data on Native and Alien Vascular Flora of Sicily (Italy): New Findings and Updates.

Cambria S et al (2023).
Plants (Basel).
DOI:
10.3390/plants12091743
PubMed:
37176800

A Multifaceted Evaluation Approach for Greek Native Neglected and Underutilized Forest Fruit Trees and Shrubs as Natural Sources of Antioxidants: Consolidating the Framework for Their Sustainable Agronomic Exploitation.

Karapatzak E et al (2023).
Plants (Basel).
DOI:
10.3390/plants12081642
PubMed:
37111865

Cornus mas L. Extract Targets the Specific Molecules of the Th17/Treg Developmental Pathway in TNBS-Induced Experimental Colitis in Rats.

Gastroenterology
Szandruk-Bender M et al (2023).
Molecules.
DOI:
10.3390/molecules28073034
PubMed:
37049797

Effects of Gold Nanoparticles Functionalized with Cornus mas L. Fruit Extract on the Aorta Wall in Rats with a High-Fat Diet and Experimental-Induced Diabetes Mellitus-An Imaging Study.

Diabetes
Moldovan R et al (2023).
Nanomaterials (Basel).
DOI:
10.3390/nano13061101
PubMed:
36985995

Improvement of Caciotta-like cheese nutritional value by means of enrichment with blackcurrant (Ribes nigrum) and Cornelian cherry (Cornus mas).

Andersen J et al (2023).
Front Nutr.
DOI:
10.3389/fnut.2022.1023490
PubMed:
36846023

Cornelian Cherry (Cornus mas L.) Iridoid and Anthocyanin-Rich Extract Reduces Various Oxidation, Inflammation, and Adhesion Markers in a Cholesterol-Rich Diet Rabbit Model.

Immunology
Danielewski M et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms24043890
PubMed:
36835296

Repeated stand structure inventory dataset in long abandoned deciduous forest reserves in Hungary.

Szegleti Z et al (2023).
Data Brief.
DOI:
10.1016/j.dib.2023.108929
PubMed:
36819895

Cornelian Cherry (Cornus mas) Powder as a Functional Ingredient for the Formulation of Bread Loaves: Physical Properties, Nutritional Value, Phytochemical Composition, and Sensory Attributes.

Phytochemistry
Šimora V et al (2023).
Foods.
DOI:
10.3390/foods12030593
PubMed:
36766122

Traditional Ethnobotanical Knowledge of the Central Lika Region (Continental Croatia)-First Record of Edible Use of Fungus Taphrina pruni.

Ethnobotany
Vitasović-Kosić I et al (2022).
Plants (Basel).
DOI:
10.3390/plants11223133
PubMed:
36432861

In Vitro Evaluation of Anti-Inflammatory and Protective Potential of an Extract from Cornus mas L. Fruit against H(2)O(2)-Induced Oxidative Stress in Human Skin Keratinocytes and Fibroblasts.

Immunology
Wójciak M et al (2022).
Int J Mol Sci.
DOI:
10.3390/ijms232213755
PubMed:
36430233

A Comparison of the Antiosteoporotic Effects of Cornelian Cherry (Cornus mas L.) Extracts from Red and Yellow Fruits Containing Different Constituents of Polyphenols and Iridoids in Osteoblasts and Osteoclasts.

Phytochemistry
Park E et al (2022).
Oxid Med Cell Longev.
DOI:
10.1155/2022/4122253
PubMed:
36225173

Efficacy and safety of dietary polyphenol supplementation in the treatment of non-alcoholic fatty liver disease: A systematic review and meta-analysis.

Summary

This study examines the use of dietary polyphenols to treat non-alcoholic fatty liver disease. There is limited evidence for its effectiveness, and this study aims to evaluate its therapeutic efficacy.

Meta-Analysis Phytochemistry
Yang K et al (2022).
Front Immunol.
DOI:
10.3389/fimmu.2022.949746
PubMed:
36159792

Co-Microencapsulation of Anthocyanins from Cornelian Cherry (Cornus mas L.) Fruits and Lactic Acid Bacteria into Antioxidant and Anti-Proliferative Derivative Powders.

Cancer
Enache IM et al (2022).
Nutrients.
DOI:
10.3390/nu14173458
PubMed:
36079716

"Improved quality assessment of cornelian cherry (Cornus mas L.) fruit with regard to their processing potential".

Gössinger M et al (2022).
J Food Sci Technol.
DOI:
10.1007/s13197-022-05370-y
PubMed:
35872725

Cornelian Cherry (Cornus mas L.) Extracts Exert Cytotoxicity in Two Selected Melanoma Cell Lines-A Factorial Analysis of Time-Dependent Alterations in Values Obtained with SRB and MTT Assays.

Lewandowski Ł et al (2022).
Molecules.
DOI:
10.3390/molecules27134193
PubMed:
35807436

Cornus mas L. Increases Glucose Uptake and the Expression of PPARG in Insulin-Resistant Adipocytes.

Małodobra-Mazur M et al (2022).
Nutrients.
DOI:
10.3390/nu14112307
PubMed:
35684107

Potential for Prebiotic Stabilized Cornus mas L. Lyophilized Extract in the Prophylaxis of Diabetes Mellitus in Streptozotocin Diabetic Rats.

Diabetes
Sip S et al (2022).
Antioxidants (Basel).
DOI:
10.3390/antiox11020380
PubMed:
35204262

Cornus mas and Cornus officinalis-A Comparison of Antioxidant and Immunomodulatory Activities of Standardized Fruit Extracts in Human Neutrophils and Caco-2 Models.

Immunology
Czerwińska ME et al (2021).
Plants (Basel).
DOI:
10.3390/plants10112347
PubMed:
34834710

Iridoids, Flavonoids, and Antioxidant Capacity of Cornus mas, C. officinalis, and C. mas × C. officinalis Fruits.

Phytochemistry
Klymenko S et al (2021).
Biomolecules.
DOI:
10.3390/biom11060776
PubMed:
34064234

Cornus mas L. Stones: A Valuable By-Product as an Ellagitannin Source with High Antioxidant Potential.

Przybylska D et al (2020).
Molecules.
DOI:
10.3390/molecules25204646
PubMed:
33053845

Cornus mas and Cornus Officinalis-Analogies and Differences of Two Medicinal Plants Traditionally Used.

Review
Czerwińska ME and Melzig MF (2018).
Front Pharmacol.
DOI:
10.3389/fphar.2018.00894
PubMed:
30210335

Cornus mas L. extract as a multifunctional material for manufacturing cosmetic emulsions.

Nizioł-Łukaszewska Z et al (2018).
Chin J Nat Med.
DOI:
10.1016/S1875-5364(18)30058-X
PubMed:
29703328

Cornus mas (L.) Fruit as a Potential Source of Natural Health-Promoting Compounds: Physico-Chemical Characterisation of Bioactive Components.

De Biaggi M et al (2018).
Plant Foods Hum Nutr.
DOI:
10.1007/s11130-018-0663-4
PubMed:
29671173

Cornus mas: a review on traditional uses and pharmacological properties.

Review
Hosseinpour-Jaghdani F et al (2017).
J Complement Integr Med.
DOI:
10.1515/jcim-2016-0137
PubMed:
28782352

Cornus mas L. (cornelian cherry), an important European and Asian traditional food and medicine: Ethnomedicine, phytochemistry and pharmacology for its commercial utilization in drug industry.

Review EthnobotanyPhytochemistry
Dinda B et al (2016).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2016.09.042
PubMed:
27705748