Crataegus azarolus

Common Names: azarole, Mediterranean-medlar

Ethnobotanical Studies

Clinical Trials

Antihypertensive Indigenous Lebanese Plants: Ethnopharmacology and a Clinical Trial.

This study documents the traditional use of antihypertensive medicinal plants in Lebanon and clinically tests the effectiveness of three commonly used plant species. Results show significant reductions in blood pressure, indicating their potential as a treatment for mild hypertension. Further research is needed.

Samaha AA et al (2019).
Biomolecules.
DOI:
10.3390/biom9070292
PubMed:
31330767

Studies

Phytochemical Properties of Crataegus azarolus Berries Decoction Extract and Evaluation of its Protective Activity Against Acetic Acid-Induced Ulcerative Colitis in Rats.

Summary

The researchers found that the extract from berries had a protective effect against ulcerative colitis induced by acetic acid in rats. The extract showed antioxidant activity and reduced damage to the colon by stimulating mucus secretion and reducing inflammation. This suggests that the extract could be a potential treatment for ulcerative colitis.

GastroenterologyPhytochemistry
Sammari H et al (2024).
Dose Response.
DOI:
10.1177/15593258241226890
PubMed:
38223297

Uterodilation effect of unripe fruit extract of Crataegus azarolus var. aronia L. on rat uterine smooth muscles.

Ameen AAM et al (2023).
Prostaglandins Other Lipid Mediat.
DOI:
10.1016/j.prostaglandins.2023.106783
PubMed:
37726053

The Impact of Procyanidin Extracted from Crataegus azarolus on Rats with Induced Heart Failure.

Cardiology
Z Rashid B and Dizaye KF (2022).
Cell Mol Biol (Noisy-le-grand).
DOI:
10.14715/cmb/2022.68.9.28
PubMed:
36905256

Protective effects of Crataegus azarolus L. berries aqueous extract against castor oil-induced diarrhea, oxidative stress, and inflammation in rat.

Immunology
Sammari H et al (2021).
Neurogastroenterol Motil.
DOI:
10.1111/nmo.14065
PubMed:
33320393

Characterization of Polysaccharides Extracted from Pulps and Seeds of Crataegus azarolus L. var. aronia: Preliminary Structure, Antioxidant, Antibacterial, α-Amylase, and Acetylcholinesterase Inhibition Properties.

Summary

Researchers extracted polysaccharides from the pulps and seeds of L. var. through a hot water method and characterized them using various methods. The polysaccharides were found to have antioxidant, -amylase and antiacetylcholinesterase activity and displayed antibacterial effects against seven microorganisms, particularly Gram-positive bacteria. The highest total carbohydrate and uronic acid contents were found in the polysaccharides from pulp (CAP). These results indicate that polysaccharides from L. var. may be a new source of antioxidants and useful in the food and pharmaceutical industries as enzyme inhibitory agents.

Neuroscience
Rjeibi I, Zaabi R and Jouida W (2020).
Oxid Med Cell Longev.
DOI:
10.1155/2020/1903056
PubMed:
32566076

A New Ursane-type Triterpenoid and Other Constituents from the Leaves of Crataegus azarolus var. aronia.

Mahmud SA et al (2016).
Nat Prod Commun.
PubMed:
30475495

Chemical Composition, Antioxidant, Anti-Inflammatory, and Antiproliferative Activities of the Plant Lebanese Crataegus Azarolus L.

CancerImmunology
Kallassy H et al (2017).
Med Sci Monit Basic Res.
PubMed:
28769026

Valorization of Crataegus azarolus stones for the removal of textile anionic dye by central composite rotatable design using cubic model: optimization, isotherm, and kinetic studies.

Boudechiche N et al (2017).
Environ Sci Pollut Res Int.
DOI:
10.1007/s11356-017-9606-0
PubMed:
28681299

Antihypertensive Effects of Hydroalcoholic Extract of Crataegus Azarolus Subspecies Aronia Fruit in Rats with Renovascular Hypertension: An Experimental Mechanistic Study.

Cardiology
Haydari MR et al (2017).
Iran J Med Sci.
PubMed:
28533575

Therapeutic potentials of Crataegus azarolus var. eu- azarolus Maire leaves and its isolated compounds.

Abu-Gharbieh E and Shehab NG (2017).
BMC Complement Altern Med.
DOI:
10.1186/s12906-017-1729-9
PubMed:
28420354

Crataegus azarolus Leaves Induce Antiproliferative Activity, Cell Cycle Arrest, and Apoptosis in Human HT-29 and HCT-116 Colorectal Cancer Cells.

Cancer
Mustapha N et al (2016).
J Cell Biochem.
DOI:
10.1002/jcb.25416
PubMed:
26495895

Compounds isolated from the aerial part of Crataegus azarolus inhibit growth of B16F10 melanoma cells and exert a potent inhibition of the melanin synthesis.

Mustapha N et al (2015).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2014.11.010
PubMed:
25661350

Aqueous extract of Crataegus azarolus protects against DNA damage in human lymphoblast Cell K562 and enhances antioxidant activity.

Genetics
Mustapha N et al (2014).
Appl Biochem Biotechnol.
DOI:
10.1007/s12010-013-0667-3
PubMed:
24347159

Comparative analysis of Tunisian wild Crataegus azarolus (yellow azarole) and Crataegus monogyna (red azarole) leaf, fruit, and traditionally derived syrup: phenolic profiles and antioxidant and antimicrobial activities of the aqueous-acetone extracts.

AntimicrobialPhytochemistry
Belkhir M et al (2013).
J Agric Food Chem.
DOI:
10.1021/jf402874z
PubMed:
24070066

Effect of O/W process parameters on Crataegus azarolus L nanocapsule properties.

Esmaeili A, Rahnamoun S and Sharifnia F (2013).
J Nanobiotechnology.
DOI:
10.1186/1477-3155-11-16
PubMed:
23718829