Crataegus monogyna

Common Names: oneseed hawthorn, singleseed hawthorn

Ethnobotanical Studies

Marmilla Subregion, Sardinia, Italy

Uses: Against hypertension, cardiac, cardiac neurosis and angina pectoris, antispasmodic ad against anxiety and insomnia, febrifuge

DOI:: 10.3390/plants11223165
PubMed:: 36432894

Shouf Biosphere Reserve, Lebanon

Uses: spasms, cardiovascular diseases, chronic diarrhea, hypertensive, nerve sedative, insomnia, palpitation

DOI:: 10.1186/s13002-022-00568-y
PubMed:: 36572929

Lika-Senj County, Croatia

Uses: in brandy; tea as a medicine against atherosclerosis, hypertension, to strengthen heart function and to soothe, for nervousness

DOI:: 10.3390/plants11223133
PubMed:: 36432861

Studies

Antioxidant and Antidiabetic Activity of Cornus mas L. and Crataegus monogyna Fruit Extracts.

Summary

Three green extraction methods were evaluated for polyphenols and vitamin C extraction from fruit extracts, with ASE and LE showing highest yields and antioxidant and antidiabetic activities. These extracts stimulate insulin secretion and could be beneficial for metabolic disorders.

Diabetes Immunology

Paun G et al (2024).; Molecules.
DOI:: 10.3390/molecules29153595
PubMed:: 39125000

The investigation of selected bioactive compounds and antioxidant properties of Crataegus monogyna L.

Immunology

Čulum D, Čopra-Janićijević A and Vidic D (2024).; Nat Prod Res.
DOI:: 10.1080/14786419.2024.2367009
PubMed:: 38949524

Phenolic Composition of Crataegus monogyna Jacq. Extract and Its Anti-Inflammatory, Hepatoprotective, and Antileukemia Effects.

Summary

Study investigated potential benefits of plant () in traditional medicine: anti-inflammatory, hepatoprotective, and anticancer properties. Promising results suggest further exploration for liver damage, inflammation, and leukemia treatment.

Immunology Phytochemistry

Ez-Zahra Amrati F et al (2024).; Pharmaceuticals (Basel).
DOI:: 10.3390/ph17060786
PubMed:: 38931453

Assessing monofloral bee pollens from Türkiye: Palynological verification, phenolic profile, and antioxidant activity.

Summary

This study analyzed various monofloral bee pollen samples for their palynological analysis, antioxidant activity, phenolic profiles, and color. Different species had varying phenolic compositions and higher levels of TPC and antioxidant activity. This helps authenticate and ensure the quality of bee pollen products for the food industry.

Immunology Phytochemistry

Çobanoğlu DN et al (2024).; J Food Sci.
DOI:: 10.1111/1750-3841.16928
PubMed:: 38235995

Species traits related to the invasion of woody plants in Patagonian deciduous forests.

Lediuk KD et al (2024).; Plant Biol (Stuttg).
DOI:: 10.1111/plb.13609
PubMed:: 38230841

A new endophytic species of Microthecium (Melanosporales, Sordariomycetes, Pezizomycotina, Ascomycota) from Mallorca (Balearic Islands, Spain).

Stchigel AM, Cano-Lira JF and Pintos-Amengual Á (2024).; Rev Iberoam Micol.
DOI:: 10.1016/j.riam.2023.10.002
PubMed:: 38176988

Exploring the potential of phenolic and antioxidant compounds in new Rosaceae fruits.

Immunology Phytochemistry

Razola-Díaz MDC et al (2023).; J Sci Food Agric.
DOI:: 10.1002/jsfa.13255
PubMed:: 38160248

Plants under Siege: Investigating the Relevance of 'Ca. P. solani' Cixiid Vectors through a Multi-Test Study.

Kosovac A et al (2023).; Plants (Basel).
DOI:: 10.3390/plants12244157
PubMed:: 38140484

Physicochemical, Antioxidant, and Antimicrobial Properties of Three Medicinal Plants from the Western Part of the Rhodope Mountains, Bulgaria.

Summary

Study finds thyme, cotton thistle, and hawthorn extracts have various properties. Thyme is rich in protein, vitamin C, and antioxidants; cotton thistle is high in moisture and carbohydrates. Extracts can combat bacteria but have limited effect on fungi.

Antimicrobial Immunology Phytochemistry

Parzhanova A et al (2023).; Life (Basel).
DOI:: 10.3390/life13122237
PubMed:: 38137839

10.

Forgotten Perfumery Plants - Part II: New Insights into the Development of Novel Fragrant Ingredients - Hawthorn Case Study.

Bouville AS et al (2023).; Chem Biodivers.
DOI:: 10.1002/cbdv.202301020
PubMed:: 37815162

11.

Optimization and bio-fabrication of phyto-mediated silver nanoparticles (Ag-NPs) for antibacterial potential.

Mehmood A et al (2023).; J Biomol Struct Dyn.
DOI:: 10.1080/07391102.2023.2242960
PubMed:: 37793992

12.

Quality control, phytochemical profile, and biological activities of Crataegus monogyna Jacq. and Crataegus laciniata Ucria fruits aqueous extracts.

Summary

Both fruit extracts, rich in polyphenols, show antioxidant, antihyperglycemic effects, and antimicrobial activity against specific bacteria, suggesting their potential use in pharmaceuticals.

Phytochemistry

Zahrae Radi F et al (2023).; Saudi Pharm J.
DOI:: 10.1016/j.jsps.2023.101753
PubMed:: 37705878

13.

Effect of Plant Extracts Combinations on TNF-α, IL-6 and IL-10 Levels in Serum of Rats Exposed to Acute and Chronic Stress.

Summary

This study examines the effects of combined plant extracts rich in flavonoids on cytokine levels in stressed rats. The extracts, Antistress I and Antistress II, showed potential in reducing pro-inflammatory cytokines (TNF-α and IL-6) and increasing anti-inflammatory cytokine (IL-10) levels. The combinations were more effective than individual extracts.

Immunology

Kandilarov I et al (2023).; Plants (Basel).
DOI:: 10.3390/plants12173049
PubMed:: 37687297

14.

The pro-oxidant action of high-oxygen MAP on beef patties can be counterbalanced by antioxidant compounds from common hawthorn and rose hips.

Immunology

Vallejo-Torres C et al (2023).; Meat Sci.
DOI:: 10.1016/j.meatsci.2023.109282
PubMed:: 37473715

15.

Wild Fruits of Crataegus monogyna Jacq. and Sorbus aria (L.) Crantz: From Traditional Foods to Innovative Sources of Pigments and Antioxidant Ingredients for Food Products.

Immunology

Tamayo-Vives C et al (2023).; Foods.
DOI:: 10.3390/foods12122427
PubMed:: 37372638

16.

Anti-Obesity Actions of Two Separated Aqueous Extracts From Arbutus (Arbutus unedo) and Hawthorn (Crataegus monogyna) Fruits Against High-Fat Diet in Rats via Potent Antioxidant Target.

Summary

In a study, two extracts from fruits of A and C plants reduced weight and adipose tissue in obese rats and improved metabolic and biochemical markers. These extracts have potential for preventing and treating obesity.

Immunology Obesity

Wahabi S et al (2023).; Dose Response.
DOI:: 10.1177/15593258231179904
PubMed:: 37275393

17.

Comprehensive Evaluation of Three Important Herbs for Kombucha Fermentation.

Tefon Öztürk BE et al (2023).; Food Technol Biotechnol.
DOI:: 10.17113/ftb.61.01.23.7789
PubMed:: 37200785

18.

Therapeutic effects of Crataegus monogyna inhibitors against breast cancer.

Summary

A recent study combines data mining, network pharmacology, and docking analysis to potentially revolutionize breast cancer treatment. By exploring prestigious phytochemicals, the study identifies bioactive compounds in a particular plant that may alter target genes implicated in breast cancer. Docking analysis and simulation studies support these findings. The study proposes six key compounds that contribute to breast cancer development by affecting specific proteins. This integration of network pharmacology and bioinformatics provides convincing evidence for the potential of this plant to alleviate breast cancer and paves the way for further experimental research.

Cancer

Basavarajappa GM et al (2023).; Front Pharmacol.
DOI:: 10.3389/fphar.2023.1187079
PubMed:: 37180727

19.

Commodity risk assessment of Crataegus monogyna plants from the UK.

EFSA Panel on Plant Health (PLH) et al (2023).; EFSA J.
DOI:: 10.2903/j.efsa.2023.8003
PubMed:: 37101683

20.

Correlation Between Toxic Elements and Pesticide Residues in Medicinal Herbs Available in Pharmaceutical Market.

Bratu MM et al (2023).; Biol Trace Elem Res.
DOI:: 10.1007/s12011-023-03642-y
PubMed:: 36964813

21.

Traditional Ethnobotanical Knowledge of the Central Lika Region (Continental Croatia)-First Record of Edible Use of Fungus Taphrina pruni.

Ethnobotany

Vitasović-Kosić I et al (2022).; Plants (Basel).
DOI:: 10.3390/plants11223133
PubMed:: 36432861

22.

Extraction with Acidified Methanol-An Easy and Effective Method of Methyl Chlorogenate Formation, as Studied by ESI-MS.

Szymborska K, Frański R and Beszterda-Buszczak M (2022).; Molecules.
DOI:: 10.3390/molecules27217543
PubMed:: 36364364

23.

Biotechnological Potential of Different Organs of Mistletoe (Viscum album L.) Collected from Various Host Tree Species in an Urban Area.

Skrypnik L et al (2022).; Plants (Basel).
DOI:: 10.3390/plants11202686
PubMed:: 36297709

24.

Medicinal Herbs in the Relief of Neurological, Cardiovascular, and Respiratory Symptoms after COVID-19 Infection A Literature Review.

Summary

COVID-19 can cause neurological complications, including anxiety, depression, MAD, and irreversible dementia, which can harm respiratory, circulatory, and heart function. Clinical trials suggest that phytotherapy, using natural plant materials like valeranon and apigenin, can aid these conditions. The study presents plant materials and their active compounds that can reduce post-COVID-19 complications, particularly those impacting the nervous system.

Review COVID-19 Cardiology

Nawrot J et al (2022).; Cells.
DOI:: 10.3390/cells11121897
PubMed:: 35741026

25.

Volatile Constituents of Some Selected Plant Species Traditionally Used as Tea in the Sharri Mountains (Kosovo).

Hajdari A et al (2022).; ScientificWorldJournal.
DOI:: 10.1155/2022/2594195
PubMed:: 35615222

26.

Mapping nectar-rich pollinator floral resources using airborne multispectral imagery.

Barnsley SL, Lovett AA and Dicks LV (2022).; J Environ Manage.
DOI:: 10.1016/j.jenvman.2022.114942
PubMed:: 35421693

27.

The essential oil compositions of three Sicilian accessions of Viscum album L. growing on three different host trees.

Phytochemistry

Geraci A et al (2022).; Nat Prod Res.
DOI:: 10.1080/14786419.2022.2058940
PubMed:: 35357239

28.

Botanical, Phytochemical, Anti-Microbial and Pharmaceutical Characteristics of Hawthorn (Crataegusmonogyna Jacq.), Rosaceae.

Review Antimicrobial Phytochemistry

Martinelli F et al (2021).; Molecules.
DOI:: 10.3390/molecules26237266
PubMed:: 34885847

29.

Development of an Optimized Drying Process for the Recovery of Bioactive Compounds from the Autumn Fruits of Berberis vulgaris L. and Crataegus monogyna Jacq.

Moldovan C et al (2021).; Antioxidants (Basel).
DOI:: 10.3390/antiox10101579
PubMed:: 34679714

30.

Setup of an Ultrasonic-Assisted Extraction to Obtain High Phenolic Recovery in Crataegus monogyna Leaves.

Phytochemistry

Martín-García B et al (2021).; Molecules.
DOI:: 10.3390/molecules26154536
PubMed:: 34361687

31.

Chemical composition, antioxidant and antibacterial activity of Crataegus monogyna leaves' extracts.

Belabdelli F et al (2022).; Nat Prod Res.
DOI:: 10.1080/14786419.2021.1958215
PubMed:: 34334069

32.

Plants in the management of male infertility.

Review

Abarikwu SO, Onuah CL and Singh SK (2020).; Andrologia.
DOI:: 10.1111/and.13509
PubMed:: 31989693

33.

Polyphenolic Composition of Crataegus monogyna Jacq.: From Chemistry to Medical Applications.

Review Phytochemistry

Nabavi SF et al (2015).; Nutrients.
DOI:: 10.3390/nu7095361
PubMed:: 26378574

34.

Crataegus monogyna fruit aqueous extract as a protective agent against doxorubicin-induced reproductive toxicity in male rats.

Shalizar Jalali A and Hasanzadeh S (2013).; Avicenna J Phytomed.
PubMed:: 25050270

35.

Attenuation of Cyclosporine-Induced Sperm Impairment and Embryotoxicity by Crataegus monogyna Fruit Aqueous Extract.

Zahra A et al (2013).; Cell J.
PubMed:: 24027659

36.

Crataegus monogyna aqueous extract ameliorates cyclophosphamide-induced toxicity in rat testis: stereological evidences.

Jalali AS, Hasanzadeh S and Malekinejad H (2012).; Acta Med Iran.
PubMed:: 22267371

37.

Hawthorn--Crataegus monogyna (common hawthorn) or Crataegus laevigata (midland hawthorn; Crataegus oxyacantha); also known as haw, thornapple, maythorn, whitethorn.

Genetics

Rasmussen P et al (2011).; J Prim Health Care.
PubMed:: 21359265

38.

Hawthorn.

Review

Fong HH and Bauman JL (2002).; J Cardiovasc Nurs.
PubMed:: 12597258