Crataegus pinnatifida

Common Names: Chinese haw, Chinese hawthorn

Ethnobotanical Studies

Gelao ethnic minority, North Guizhou, China

Uses: Diarrhea

DOI:: 10.3389/fphar.2023.1217599
PubMed:: 37719846

Clinical Trials

Efficacy of Crataegus Extract Mixture on Body Fat and Lipid Profiles in Overweight Adults: A 12-Week, Randomized, Double-Blind, Placebo-Controlled Trial.

Researchers conducted a study on overweight adults taking Crataegus Extract Mixture (CEM). Results showed CEM decreased body fat, weight, and improved lipid profiles with no adverse events. CEM may be an effective and safe treatment for obesity and dyslipidemia.

Song J et al (2024).; Nutrients.
DOI:: 10.3390/nu16040494
PubMed:: 38398818

Studies

Exploring the Molecular Mechanisms of Herbs in the Treatment of Hyperlipidemia Based on Network Pharmacology and Molecular Docking.

Cheng X et al (2024).; J Med Food.
DOI:: 10.1089/jmf.2024.k.0098
PubMed:: 39149800

Transposable elements in Rosaceae: insights into genome evolution, expression dynamics, and syntenic gene regulation.

Genetics

Yu Z et al (2024).; Hortic Res.
DOI:: 10.1093/hr/uhae118
PubMed:: 38919560

Effect of apigetrin in pseudo-SARS-CoV-2-induced inflammatory and pulmonary fibrosis in vitro model.

Summary

Researchers developed a model of ARDS and PF caused by SARS-CoV-2 in cells. HIF-1α knockdown and apigetrin showed promise in reducing inflammation and fibrosis, suggesting potential for SARS-CoV-2 treatment.

COVID-19 Immunology

Han H, Kim JE and Lee HJ (2024).; Sci Rep.
DOI:: 10.1038/s41598-024-65447-w
PubMed:: 38914619

The Effects of Crataegus pinnatifida and Wolfiporia extensa Combination on Diet-Induced Obesity and Gut Microbiota.

Summary

Study showed CP and WE combo improved metabolic health, reduced obesity from HFD, improved glucose/insulin/lipid levels. Altered gut microbiota, promising obesity combat approach.

Gastroenterology Obesity

Yuan J et al (2024).; Foods.
DOI:: 10.3390/foods13111633
PubMed:: 38890862

High-density genetic map and quantitative trait loci map of skin color in hawthorn (Crataegus pinnatifida bge. Var. major N.E.Br.).

Wang D, Cheng B and Zhang J (2024).; Front Genet.
DOI:: 10.3389/fgene.2024.1405604
PubMed:: 38873113

Hawthorn (Crataegus pinnatifida) berries ripeness induced pectin diversity: A comparative study in physicochemical properties, structure, function and fresh-keeping potential.

Phytochemistry

Wei X et al (2024).; Food Chem.
DOI:: 10.1016/j.foodchem.2024.139703
PubMed:: 38823132

An ethnobotanical survey on the medicinal and edible plants used by the Daur people in China.

Ethnobotany

Bi Y et al (2024).; J Ethnobiol Ethnomed.
DOI:: 10.1186/s13002-024-00695-8
PubMed:: 38790060

Study on the hypotensive effect and mechanism of hawthorn (Crataegus pinnatifida) fruits and hyperoside in spontaneously hypertensive rats.

Chi B et al (2024).; Food Funct.
DOI:: 10.1039/d3fo02641h
PubMed:: 38722076

ANTIBACTERIAL EFFECT OF CRATAEGUS PINNATIFIDA EXTRACT AGAINST ENTROCOCCUS FAECALIS A ROOT CANAL DISEASE-CAUSING BACTERIA.

Choi YR, Yu SB and Nam SH (2024).; Georgian Med News.
PubMed:: 38609104

10.

A study on the treatment effects of Crataegus pinnatifida polysaccharide on non-alcoholic fatty liver in mice by modulating gut microbiota.

Gastroenterology

Hao P et al (2024).; Front Vet Sci.
DOI:: 10.3389/fvets.2024.1383801
PubMed:: 38601914

11.

Structurally diverse 1,2-diarylpropanes from the fruit of Crataegus pinnatifida and the investigation on their mirror-image ECD spectra with the same absolute configurations.

Lv TM et al (2024).; Phytochemistry.
DOI:: 10.1016/j.phytochem.2024.114067
PubMed:: 38583852

12.

Potential Phytotherapy of DSS-Induced Colitis: Ameliorating Reactive Oxygen Species-Mediated Necroptosis and Gut Dysbiosis with a New Crataegus pinnatifida Bunge Variety-Daehong.

Gastroenterology

Lee KI et al (2024).; Antioxidants (Basel).
DOI:: 10.3390/antiox13030340
PubMed:: 38539873

13.

Naodesheng decoction regulating vascular function via G-protein-coupled receptors: network analysis and experimental investigations.

Chen S et al (2024).; Front Pharmacol.
DOI:: 10.3389/fphar.2024.1355169
PubMed:: 38533257

14.

Hawthorn leaf flavonoids alleviate the deterioration of atherosclerosis by inhibiting SCAP-SREBP2-LDLR pathway through sPLA2-ⅡA signaling in macrophages in mice.

Immunology Phytochemistry

Bai X et al (2024).; J Ethnopharmacol.
DOI:: 10.1016/j.jep.2024.118006
PubMed:: 38442806

15.

Isolation, structural properties and bioactivities of polysaccharides from Crataegus pinnatifida.

Review

Sun Y et al (2023).; J Ethnopharmacol.
DOI:: 10.1016/j.jep.2023.117688
PubMed:: 38159827

16.

Four pairs of neolignan enantiomers with distinctive isochroman moiety from the fruits of Crataegus pinnatifida and their protective activities against H(2)O(2)-induced SH-SY5Y cells.

Zhao P et al (2023).; Phytochemistry.
DOI:: 10.1016/j.phytochem.2023.113933
PubMed:: 38029952

17.

Comprehensive metabolomic variations of hawthorn before and after insect infestation based on the combination analysis of (1)H NMR and UPLC-MS.

Summary

Scientists analyzed the metabolites in hawthorn before and after insect infestation. They identified 57 differential biomarkers that can detect infestation and ensure food safety. This study provides insights for future research on infestation mechanisms and safe storage monitoring.

Phytochemistry

Cheng Y et al (2023).; Curr Res Food Sci.
DOI:: 10.1016/j.crfs.2023.100616
PubMed:: 37881336

18.

Folium crataegi boosts skin regeneration for burn injury in rats through multiple ways.

Deng Z et al (2023).; Biomed Pharmacother.
DOI:: 10.1016/j.biopha.2023.115457
PubMed:: 37690389

19.

Hyperoside Prevents Aβ42-Induced Neurotoxicity in PC12 Cells and Caenorhabditis elegans.

Neuroscience

Wang K et al (2023).; Mol Neurobiol.
DOI:: 10.1007/s12035-023-03521-6
PubMed:: 37535309

20.

First Report of Fire Blight on Chinese hawthorn (Crataegus pinnatifida Bunge) Caused by Erwinia amylovora in Korea.

Lim YJ et al (2023).; Plant Dis.
DOI:: 10.1094/PDIS-04-23-0703-PDN
PubMed:: 37430478

21.

Research progress on the structural characterization, biological activity and product application of polysaccharides from Crataegus pinnatifida.

Review

Jing Y et al (2023).; Int J Biol Macromol.
DOI:: 10.1016/j.ijbiomac.2023.125408
PubMed:: 37343606

22.

In Vivo Effects of Crataegus pinnatifida Extract for Healthy Longevity.

Yu IS et al (2023).; J Microbiol Biotechnol.
DOI:: 10.4014/jmb.2302.02022
PubMed:: 37218439

23.

Hyperoside prevents high-fat diet-induced obesity by increasing white fat browning and lipophagy via CDK6-TFEB pathway.

Summary

Hyperoside, found in Hypericum perforatum and Crataegus pinnatifida, has potential to treat obesity and metabolic diseases, but more research is needed.

Obesity

Cheng S et al (2023).; J Ethnopharmacol.
DOI:: 10.1016/j.jep.2023.116259
PubMed:: 36781055

24.

Structural characterization of a heteropolysaccharide from the fruit of Crataegus pinnatifida and its bioactivity on the gut microbiota of immunocompromised mice.

Gastroenterology

Jing Y et al (2023).; Food Chem.
DOI:: 10.1016/j.foodchem.2023.135658
PubMed:: 36780857

25.

Characterize the physicochemical properties and microstructure of pectin from high-pressure and thermal processed cloudy hawthorn (Crataegus pinnatifida) juice based on acid heating extraction.

Phytochemistry

Tian H et al (2023).; Food Chem.
DOI:: 10.1016/j.foodchem.2022.135199
PubMed:: 36521389

26.

Neuroprotective effects of hawthorn leaf flavonoids in Aβ(25-35) -induced Alzheimer's disease model.

Neuroscience Phytochemistry

Xu Y et al (2023).; Phytother Res.
DOI:: 10.1002/ptr.7690
PubMed:: 36447359

27.

Crataegus pinnatifida: A botanical, ethnopharmacological, phytochemical, and pharmacological overview.

Review Phytochemistry

Li R et al (2023).; J Ethnopharmacol.
DOI:: 10.1016/j.jep.2022.115819
PubMed:: 36228891

28.

Botany, traditional uses, phytochemistry and pharmacological activity of Crataegus pinnatifida (Chinese hawthorn): a review.

Review Phytochemistry

Zhang SY et al (2022).; J Pharm Pharmacol.
DOI:: 10.1093/jpp/rgac050
PubMed:: 36179124

29.

Lignans with neuroprotective activity from the fruits of Crataegus pinnatifida.

Neuroscience Phytochemistry

Xin BS et al (2022).; Fitoterapia.
DOI:: 10.1016/j.fitote.2022.105216
PubMed:: 35569638

30.

Hyperoside: A Review of Its Structure, Synthesis, Pharmacology, Pharmacokinetics and Toxicity.

Review

Xu S et al (2022).; Molecules.
DOI:: 10.3390/molecules27093009
PubMed:: 35566359

31.

Hyperoside: A review on its sources, biological activities, and molecular mechanisms.

Review

Wang Q et al (2022).; Phytother Res.
DOI:: 10.1002/ptr.7478
PubMed:: 35561084

32.

Crataegus pinnatifida polysaccharide alleviates colitis via modulation of gut microbiota and SCFAs metabolism.

Gastroenterology

Guo C et al (2021).; Int J Biol Macromol.
DOI:: 10.1016/j.ijbiomac.2021.03.137
PubMed:: 33774071

33.

The effects of Crataegus pinnatifida (Chinese hawthorn) on metabolic syndrome: A review.

Review

Dehghani S, Mehri S and Hosseinzadeh H (2019).; Iran J Basic Med Sci.
DOI:: 10.22038/IJBMS.2019.31964.7678
PubMed:: 31217924

34.

Crataegus pinnatifida: chemical constituents, pharmacology, and potential applications.

Review

Wu J et al (2014).; Molecules.
DOI:: 10.3390/molecules19021685
PubMed:: 24487567

35.

Polyphenolic profile and biological activity of Chinese hawthorn (Crataegus pinnatifida BUNGE) fruits.

Review

Jurikova T et al (2012).; Molecules.
DOI:: 10.3390/molecules171214490
PubMed:: 23222867