Researchers investigated the potential of crocin, a compound from saffron, to protect against Parkinson's disease. This could lead to new treatments for the neurodegenerative disorder.
Saffron supplementation for 8 weeks reduced fasting blood sugar, improved lipid profile, liver enzymes, and oxidative status in patients with type-2 diabetes. Further research needed for side effects and clinical recommendations.
C. sativus petal extract promotes cell survival, migration, and angiogenesis, upregulating COL1A1 and VEGF. It accelerates wound closure, making it a potential herbal treatment for diabetic wounds.
Crocins, from Crocus sativus L., with clozapine or risperidone, counteract cognitive deficits induced by NMDA receptor antagonists in rats. Crocins show potential as adjunctive therapy for schizophrenia.
Researchers have found that saffron may have benefits for depression and anxiety. This could lead to new natural treatments for mental health issues.
This review discusses how radiation exposure affects the brain and neurodegenerative diseases. Herbal medicines like Allium cepa and Centella asiatica show promise in protecting against neurological damage and may have potential in managing neurological illnesses.
Saffron contains safranal, which may help prevent seizures by reducing cell death and inflammation. Understanding this mechanism could lead to new epilepsy treatments.
Bimetallic Ag@ZnO NCs synthesized from Crocus sativus extract show promising anti-cancer properties against cervical cancer, outperforming other nanoparticles. Research may lead to improved cancer therapy methods.
Researchers found saffron and its compounds, especially crocin, show promise for treating neurological disorders like depression and Alzheimer's. They protect the brain by modulating neurotransmitters, reducing inflammation, and improving cognitive function. Consider using saffron-based therapies for brain health.
Researchers successfully synthesized bimetallic nanoparticles (CS-Pd/ZnO NCs) using a natural extract, assessing their antioxidant and anti-cancer properties. These nanoparticles showed potential for cervical cancer treatment by inducing cell death and apoptosis.
Saffron shows promise as a breast cancer treatment by inducing apoptosis and inhibiting cell division. Clinical trials indicate it may alleviate symptoms and enhance quality of life. Further research is needed.
Saffron, a popular food condiment, has various health benefits, including immune boosting, aphrodisiac, and liver protective properties. It is also known to have positive effects on mood and neurodegenerative disorders like dementia and Parkinson's.
Safranal, an active compound in saffron, reduces brain damage after ischemic stroke (IS) by reducing oxidative stress. It promotes neuron survival, stimulates neurogenesis, induces angiogenesis, and increases SIRT1 expression. Silencing SIRT1 reverses these effects. Safranal shows promise for restoring neural function after IS.
Saffron supplementation can reduce weight, BMI, and waist circumference in obese prediabetic adolescents, although not as effectively as metformin. It can also improve lipid profiles and has potential as a nutraceutical option for weight management in adolescents with obesity and prediabetes.
Researchers investigated the effects of social isolation on behavior in rats and the potential therapeutic effects of crocin. Social isolation caused anxiety, depression, obsessive-compulsive-like behavior, and hyperlocomotion. Crocin reversed these effects and increased BDNF expression, suggesting its potential as a therapeutic agent.
Researchers studied the main component in saffron, PCS-1, and its effect on a potential therapeutic target for depression called AMPK. They found that PCS-1 has antidepressive properties by activating AMPK. This suggests that targeting AMPK could be beneficial for treating depression.
Crocin from Crocus sativus L. can reduce oxidative stress and inflammation in diabetic nephropathy. However, the exact mechanism of action is unclear. Important for potential treatment of DN.
This study found that crocetin, an active ingredient in saffron, has a rapid antidepressant effect. It reduced depressive-like behaviors, neuroinflammation, and nerve injuries in mice by suppressing inflammatory cytokines and apoptosis through the PI3K/AKT signaling pathways. The effect lasted for at least 2 days after a single treatment.
Researchers used DNA barcoding, HPLC, and HPTLC to test saffron samples from 16 countries. 43% were adulterated, with DNA barcoding identifying the most cases. Adulterants included unsafe plants and synthetic safranal. Methods will aid in quality control and market surveillance.
Study evaluated saffron extracts for ADHD treatment, assessing effectiveness and safety. Important for lab decisions due to saffron's popularity and potential as a traditional plant remedy.
Researchers investigated the potential benefits of saffron extract (SF) as a monotherapy and in combination with methotrexate (MTX) for rheumatoid arthritis. Results showed that SF alone and in combination with MTX improved biometric, immunological, and biochemical parameters, suggesting SF's anti-arthritic and anti-inflammatory potential.
Nanoemulsions made from natural extracts can potentially be used as antimicrobial and anti-aflatoxigenic agents, making them effective for food preservation and safety. However, more research is needed to understand their mechanism of action.
Crocus sativus (saffron) has been used as herbal medicine for T2DM in Sri Lanka. Systematic reviews and meta-analysis support its effectiveness, validating traditional knowledge.
This review explores herbal treatments for ADHD, examining their effects on humans and animals and their potential to modify inflammation. It may offer non-pharmacological options with fewer side effects for ADHD treatment.
Plant-derived bioactive compounds, such as vitamin C, polyphenols, curcumin, and resveratrol, have antioxidant and neuroprotective properties, suggesting potential for treating oxidative stress-related diseases like MDD, ASD, ADHD, and neurodegenerative disorders. Additional clinical research is needed to confirm their therapeutic benefits.
This study examined the effects of saffron and its active ingredient, crocin, on an animal model of autism. Results showed that saffron and crocin reduced behavioral abnormalities and oxidative stress in the brain. These findings suggest that saffron and crocin could be potential treatments for autism. However, more research is needed to confirm their efficacy.
Network pharmacology was used to identify therapeutic pathways of Crocus sativus extract for PCOS. Prominent targets and signaling pathways were found, suggesting the extract can regulate multiple pathways. Carotenoids and apocarotenoids in the extract are bioavailable and non-toxic.
Saffron has shown analgesic activities in preclinical and clinical studies. It affects various pain-related targets and has been beneficial in chronic pain conditions as an adjunct therapy to commonly used analgesics.
The polysaccharide PCSPB from Crocus sativus petals inhibits tumor growth, induces tumor cell death and disrupts blood vessels. It also modulates immune cells to promote anti-tumor activity.
Saffron tepals have stronger anti-diabetic effects than stigmas. They inhibit carbohydrate digestion enzymes and glucose absorption, potentially preventing or managing diabetes.
Saffron and black seed have therapeutic effects on diseases by decreasing TNF-a levels, treating conditions such as hepatotoxicity, cancer, and non-alcoholic fatty liver. More research and clinical trials are needed.
Research is underway to find effective treatments for COVID-19. Scientists are exploring traditional systems like Unani formulation, which has been used in cholera and other epidemics. A review aims to analyze the potential of Unani formulation in preventing and controlling COVID-19.
A review of 41 studies found that adaptogens, particularly St. John's Wort and saffron, may be effective non-pharmacological strategies for depression. The studies suggest that adaptogens reduce allostatic load via the regulation of BDNF. However, there is limited research on combining adaptogens with physical exercise. The review provides support for the use of St. John's Wort and saffron in depression treatment and highlights the need for more research on the efficacy of other adaptogens and the combination of herbal extracts and resistance training.
Study evaluated the safety and effectiveness of dietary polyphenols for treating rheumatoid arthritis. Results may inform potential alternative treatments for RA.
Safranal, derived from Saffron, has anti-inflammatory properties. Its role in osteoporosis, a bone disease in menopause, and its effect on osteoclasts regulated by NF-κB signaling is unknown.
A new herbal formulation called Sailuotong (SLT) consisting of extracts from Panax ginseng, Ginkgo biloba, and Crocus sativus was developed and found to enhance cognition in patients with vascular dementia (VaD) in early clinical trials. A phase III clinical trial has been developed to confirm the efficacy and safety of SLT in 238 patients with mild to moderate VaD or VaD mixed with Alzheimer’s disease. Participants will be randomly allocated to receive SLT or placebo capsules for 52 weeks, and primary outcome measures include cognitive and functional assessments. The study aims to provide important data on this novel treatment approach to VaD.
Cholestasis has negative effects on brain function and memory, while crocin has been shown to be neuroprotective. This study evaluated the effect of crocin on spatial learning and memory in rats with cholestasis. Bile duct ligation was used to induce cholestasis, and crocin was administered for 30 days. The results showed that crocin partially reversed the negative effects of cholestasis on spatial memory and increased levels of important proteins in the hippocampus. Crocin may have a significant neuroprotective effect on memory impairment caused by cholestasis.
Researchers have discovered that crocetin, a natural antioxidant found in saffron, can counteract the process of programmed cell death, known as parthanatos, during an ischemic stroke. They found that crocetin reduces the production of reactive oxygen species and poly (ADP-ribose), both associated with parthanatos, at early stages of the process, and prevents the degradation of hexokinase-I, which helps maintain mitochondrial function, at later stages. The study suggests that crocetin may be a potential drug candidate for preventing and treating ischemic stroke.
A study tested the effects of extracts from Rosemary and Saffron, given individually and combined, on Alzheimer's neuroinflammation in rats. The rats were given extracts over 15 days and then tested for cognitive impairment, amyloid neuroproteins, oxidative stress, and other markers. The extracts showed significant improvement in all parameters compared to the control group and a better morphological appearance in the cortex and hippocampus. Computational analysis found the extracts may impede the activity of proteins regulating disease progression, suggesting these extracts could help treat Alzeheimer's.
Saffron has been traditionally used in Chinese and Islamic medicine to treat depression, and its aroma is known to have calming effects. Researchers studied the composition of saffron's volatile oil and found that it has properties that could potentially help with depression and anxiety. This suggests that saffron may have therapeutic benefits beyond its traditional use as a spice.
Safranal, a compound derived from Chinese herbal medicine, has anti-inflammatory properties and shows potential in stabilizing mast cells and inhibiting inflammatory mediator production in asthma and anaphylaxis models.
In this study, researchers investigated the effects of the medicinal plant Crocus Sativus L. on reactive oxygen-nitrogen species, which are produced during cellular reactions. They found that certain compounds in the plant were able to reduce these harmful species, potentially providing a protective effect against oxidative stress. This study highlights the potential benefits of using medicinal plants as natural remedies for oxidative stress-related diseases.
Saffron, a medicinal plant commonly used in Asia, has been shown to have various health benefits such as treatment for coronary artery diseases, hypertension, stomach disorders, dysmenorrhea, and learning and memory impairments. It also has anti-inflammatory, anti-atherosclerotic, antigenotoxic, and cytotoxic activities and shows promising results in antitussive, anticonvulsant, anti-Alzheimer, and depression treatments. The study found that saffron and its components increase glutamate and dopamine levels in the brain and interact with the opioid system to reduce withdrawal syndrome. The results suggest that saffron and its constituents could be promising agents in treating nervous system disorders.