Curculigo orchioides

Ethnobotanical Studies

Studies

Curculigoside Regulates Apoptosis and Oxidative Stress Against Spinal Cord Injury by Modulating the Nrf-2/NQO-1 Signaling Pathway In Vitro and In Vivo.

Summary

Curculigoside (CUR) from Curculigo orchioides reduces apoptosis and oxidative stress in spinal cord injury, promoting tissue recovery and functional improvement through Nrf2/NQO1 signaling pathway. CUR shows promise for SCI treatment development.

Immunology
Hou Y et al (2024).
Mol Neurobiol.
DOI:
10.1007/s12035-024-04409-9
PubMed:
39230866

Lipid-lowering effect and oral transport characteristics study of curculigoside.

Wang A et al (2024).
Front Cardiovasc Med.
DOI:
10.3389/fcvm.2024.1426379
PubMed:
39015683

Unraveling the Mechanism of Curculiginis Rhizoma in Suppressing Cisplatin Resistance in Non-Small Cell Lung Cancer: An Experimental Study.

Summary

Study investigates Curculiginis Rhizoma (CR) mixed with cisplatin to combat chemoresistance in NSCLC. Results show potential to enhance drug sensitivity by targeting ABC transporters. Crucial for improving chemotherapy outcomes in lung cancer.

Cancer
Huang X et al (2024).
Onco Targets Ther.
DOI:
10.2147/OTT.S448636
PubMed:
38895133

Orcinol gentiobioside inhibits RANKL-induced osteoclastogenesis by promoting apoptosis and suppressing autophagy via the JNK1 signaling.

Lian C et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118060
PubMed:
38521429

Network pharmacology and experimental validation methods to reveal the active compounds and hub targets of Curculigo orchioides Gaertn in rheumatoid arthritis.

Arthritis
Liu X et al (2023).
J Orthop Surg Res.
DOI:
10.1186/s13018-023-04352-w
PubMed:
37957674

Curculigoside mitigates dextran sulfate sodium‑induced colitis by activation of KEAP1‑NRF2 interaction to inhibit oxidative damage and autophagy of intestinal epithelium barrier.

Summary

Curculigoside (CUR) has anti-inflammatory effects and helps maintain intestinal barrier function. It activates Nrf2 via Keap1/Nrf2 interaction, reducing oxidative stress and promoting autophagy. CUR can effectively treat colitis and may be used in UC therapy.

Gastroenterology
Li F et al (2023).
Int J Mol Med.
DOI:
10.3892/ijmm.2023.5310
PubMed:
37772380

Molecular networking-assisted isolation of chlorophenolic glycosides from the rhizomes of Curculigo orchioides and their Inhibitory effect on α-glucosidase.

Summary

Researchers used molecular networking analysis and in silico tools to explore bioactive constituents in Curculigo orchioides. They identified new compounds with inhibitory effects on α-glucosidase, providing potential for drug development.

Phytochemistry
Kim JG et al (2023).
Phytochemistry.
DOI:
10.1016/j.phytochem.2023.113820
PubMed:
37562563

Curculigo orchioides polysaccharide COP70-1 stimulates osteogenic differentiation of MC3T3-E1 cells by activating the BMP and Wnt signaling pathways.

Wang J et al (2023).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2023.125879
PubMed:
37473884

Production of the antidepressant orcinol glucoside in Yarrowia lipolytica with yields over 6,400-fold higher than plant extraction.

Summary

Researchers used a screening pipeline to identify the genes responsible for biosynthesis of the antidepressant compound orcinal glucoside in a Chinese herb. They then improved production of the compound 100-fold by optimizing fermentation in Y. lipolytica. The final yield was 6,400 times higher than from the natural root source. This approach can be used to identify genes for other natural products and improve their production.

Neuroscience
Chen B et al (2023).
PLoS Biol.
DOI:
10.1371/journal.pbio.3002131
PubMed:
37279234

Protective Effect of Curculigo orchioides Gaertn. Extract on Heat Stress-Induced Spermatogenesis Complications in Murine Model.

Bui-Le TN et al (2023).
Curr Issues Mol Biol.
DOI:
10.3390/cimb45040212
PubMed:
37185736

Decipher the pharmacological mechanisms of raw and wine-processed Curculigo orchioides Gaertn. on bone destruction in rheumatoid arthritis rats using metabolomics.

Arthritis
Liu X et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116395
PubMed:
36958673

Toxicity Assessment of Curculigo orchioides Leaf Extract Using Drosophila melanogaster: A Preliminary Study.

Kushalan S et al (2022).
Int J Environ Res Public Health.
DOI:
10.3390/ijerph192215218
PubMed:
36429955

In vitro somatic embryo productions from Curculigo orchioides derived gold nanoparticles: Synthesis, characterization, its biomedical applications, and their eco-friendly approaches to degradation of methylene blue under solar light irradiations.

Thamilchelvan K et al (2023).
Environ Res.
DOI:
10.1016/j.envres.2022.114774
PubMed:
36403654

Molecular Networking-Guided Isolation of Cycloartane-type Triterpenoids from Curculigo orchioides and Their Inhibitory Effect on Nitric Oxide Production.

Kim JG et al (2022).
ACS Omega.
DOI:
10.1021/acsomega.2c03243
PubMed:
35936480

Discrimination of Curculigo orchioides Rhizoma and Curculigo glabrescens Rhizoma using stable isotope and mineral element analyses coupled with chemometrics.

Liu Y et al (2022).
Sci Rep.
DOI:
10.1038/s41598-022-16851-7
PubMed:
35869256

Structural characterization and anti-osteoporosis activity of two polysaccharides extracted from the rhizome of Curculigo orchioides.

Yu Y et al (2022).
Food Funct.
DOI:
10.1039/d2fo00720g
PubMed:
35661847

Orcinol Glucoside Improves Senile Osteoporosis through Attenuating Oxidative Stress and Autophagy of Osteoclast via Activating Nrf2/Keap1 and mTOR Signaling Pathway.

ArthritisImmunology
Gong W et al (2022).
Oxid Med Cell Longev.
DOI:
10.1155/2022/5410377
PubMed:
35585885

GC-MS analysis of curculigo orchiodes and medicinal herbs with cytotoxic, hepatoprotective attributes of ethanolic extract from Indian origin.

Singh V et al (2022).
J Complement Integr Med.
DOI:
10.1515/jcim-2020-0545
PubMed:
35320638

Curculigo orchioides Gaertn Effectively Ameliorates the Uro- and Nephrotoxicities Induced by Cyclophosphamide Administration in Experimental Animals.

Murali VP and Kuttan G (2016).
Integr Cancer Ther.
DOI:
10.1177/1534735415607319
PubMed:
26424815

Protective effect of curculigo orchioides extract on cyclophosphamide-induced neurotoxicity in murine model.

Summary

Curculigo orchioides (Kali Musli) is a plant known for its adaptogenic and anti-osteoporotic activities. This study evaluated its potential neuroprotective effect in animals treated with cyclophosphamide to induce neurotoxicity. The plant was extracted using methanol and phytochemical studies were performed. Results showed that C. orchioides at 400mg/kg significantly restored levels of catalase, superoxide dismutase, and glutathione as well as decreased levels of malondialdehyde. It was also observed that the plant extract is rich in phytochemicals such as flavonoids and polyphenols, which have a reputed neuroprotective effect. These findings suggest that C. orchioides may hold potential for the prevention or treatment of neurodegenerative disorders.

Neuroscience
Ramchandani D et al (2014).
Toxicol Int.
DOI:
10.4103/0971-6580.155323
PubMed:
25948959

Curculigo orchioides, natural compounds for the treatment of noise-induced hearing loss in mice.

Hong BN, You YO and Kang TH (2011).
Arch Pharm Res.
DOI:
10.1007/s12272-011-0416-5
PubMed:
21544731