Cynanchum paniculatum

Ethnobotanical Studies

Studies

Cynanchum paniculatum (Bunge) Kitag. ex H.Hara inhibits pancreatic cancer progression by inducing caspase-dependent apoptosis and suppressing TGF-β-mediated epithelial-mesenchymal transition.

Summary

Study explores potential anti-cancer effects of (Bunge) Kitag. ex H.Hara in pancreatic cancer. CPAE inhibits proliferation, induces apoptosis, and suppresses metastasis. Promising herbal medicine for pancreatic cancer treatment.

Cancer
Cheng CS et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2024.1284371
PubMed:
38881872

Development and evaluation of a Chinese herbal gel for analgesic and anti-inflammatory effects.

Summary

This study developed a gel containing three Chinese herbal extracts and tested its pain-relieving and anti-inflammatory effects. Results showed that the gel effectively reduced pain and inflammation. It could be beneficial for developing pain medications or treatments for rheumatoid arthritis.

ImmunologyPain
Yang C et al (2023).
Pak J Pharm Sci.
PubMed:
37606015

Paeonol, the active component of Cynanchum paniculatum, ameliorated schizophrenia-like behaviors by regulating the PI3K-Akt-GSK3β-NF-κB signalling pathway in MK-801-treated mice.

Summary

Cynanchum paniculatum has been traditionally utilized in East Asia as an analgesic or antiviral. Some traditional medicinal books also mention its use in treating psychotic symptoms. The study explores its potential benefits for treating schizophrenia-like symptoms in rats. The extracts showed a promising reduction in behavioral abnormalities, leading to the possibility of this plant being a useful resource in the development of antipsychotic medicines.

ImmunologyNeuroscience
Bae HJ et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116627
PubMed:
37164258

Cynapanoside A exerts protective effects against obesity-induced diabetic nephropathy through ameliorating TRIM31-mediated inflammation, lipid synthesis and fibrosis.

ImmunologyObesity
Luo J et al (2022).
Int Immunopharmacol.
DOI:
10.1016/j.intimp.2022.109395
PubMed:
36375322

Network Pharmacological Study on the Mechanism of Cynanchum paniculatum (Xuchangqing) in the Treatment of Bungarus multicinctus Bites.

Zeng L et al (2022).
Biomed Res Int.
DOI:
10.1155/2022/3887072
PubMed:
35837378

Paeonol inhibits inflammatory response and protects chondrocytes by upregulating sirtuin 1.

Immunology
Shang P, Liu Y and Jia J (2022).
Can J Physiol Pharmacol.
DOI:
10.1139/cjpp-2021-0319
PubMed:
35235465

Effects of Water Extract of Cynanchum paniculatum (Bge.) Kitag. on Different Breast Cancer Cell Lines.

Cancer
Yang SY et al (2021).
Evid Based Complement Alternat Med.
DOI:
10.1155/2021/6665949
PubMed:
34122605

Combinatorial Synthesis of Novel 3/5(3,5)-(Di)nitro/chloropaeonol Carbonyl Hydrazone Derivatives as Nematicidal Agents.

Chen G et al (2022).
Comb Chem High Throughput Screen.
DOI:
10.2174/1386207324666210324145627
PubMed:
33761851

Cynanchum paniculatum and Its Major Active Constituents for Inflammatory-Related Diseases: A Review of Traditional Use, Multiple Pathway Modulations, and Clinical Applications.

Review Immunology
Chen JX et al (2020).
Evid Based Complement Alternat Med.
DOI:
10.1155/2020/7259686
PubMed:
32774428

Paeonol Inhibits Pancreatic Cancer Cell Migration and Invasion Through the Inhibition of TGF-β1/Smad Signaling and Epithelial-Mesenchymal-Transition.

Cancer
Cheng CS et al (2020).
Cancer Manag Res.
DOI:
10.2147/CMAR.S224416
PubMed:
32099461

Comparison of the Analgesic and Anti-Inflammatory Effects of Xiaoyuningkun Decoction with Cynanchum Paniculatum and Fukeqianjin in a Mouse Model of Pelvic Inflammatory Disease.

ImmunologyPain
Tang B et al (2019).
Med Sci Monit.
DOI:
10.12659/MSM.916070
PubMed:
31784502

ANTI-VIRAL EFFECT OF HERBAL MEDICINE KOREAN TRADITIONAL CYNANCHUM PANICULATUM (BGE.) KITAG EXTRACTS.

Antimicrobial
Kim W, Oh TS and Park YJ (2017).
Afr J Tradit Complement Altern Med.
DOI:
10.21010/ajtcam.v14i3.21
PubMed:
28480431

Neuroprotective compounds isolated from Cynanchum paniculatum.

Summary

Scientists isolated ten compounds from Cynanchum paniculatum Kitagawa roots and tested their ability to protect nerve cells from damage. Compound 4, called 2,3-dihydroxy-4-methoxyacetophenone, was the most effective at preventing damage, with a 47.55% protection rate. These findings suggest that the compound may have neuroprotective effects against glutamate-induced neurotoxicity.

Neuroscience
Weon JB et al (2012).
Arch Pharm Res.
DOI:
10.1007/s12272-012-0404-4
PubMed:
22553053