Cynara cardunculus

Common Names: cardoon, artichoke, artichoke thistle

Ethnobotanical Studies

Clinical Trials

A Nutraceutical Containing Chlorogenic Acid and Luteolin Improves Cardiometabolic Parameters in Subjects with Pre-Obesity: A 6-Month Randomized, Double-Blind, Placebo-Controlled Study.

A study found that Altilix, a nutraceutical containing chlorogenic acid and luteolin, improved weight, glucose metabolism, lipid profile, hepatic functionality, and cardiovascular health in pre-obesity subjects.

Terzo S et al (2023).
Nutrients.
DOI:
10.3390/nu15020462
PubMed:
36678333

Artichoke and Bergamot Phytosome Alliance: A Randomized Double Blind Clinical Trial in Mild Hypercholesterolemia.

Riva A et al (2021).
Nutrients.
DOI:
10.3390/nu14010108
PubMed:
35010984

Studies

Effect of Different Seasons and Development Stages on the Chemical Composition and Bioactive Potential of Cardoon.

Mandim F et al (2024).
Foods.
DOI:
10.3390/foods13162536
PubMed:
39200463

Onopordum platylepis (Murb.) Murb. as a novel source of thistle rennet: First application to the manufacture of traditional Italian raw ewe's milk cheese.

Rampanti G et al (2024).
Food Res Int.
DOI:
10.1016/j.foodres.2024.114838
PubMed:
39147526

Spotlight on Secondary Metabolites Produced by an Early-Flowering Apulian Artichoke Ecotype Sanitized from Virus Infection by Meristem-Tip-Culture and Thermotherapy.

Spanò R et al (2024).
Antioxidants (Basel).
DOI:
10.3390/antiox13070852
PubMed:
39061920

Antioxidant capacity and peptidomic analysis of in vitro digested Camelina sativa L. Crantz and Cynara cardunculus co-products.

Immunology
Lanzoni D et al (2024).
Sci Rep.
DOI:
10.1038/s41598-024-64989-3
PubMed:
38914602

Novel cold and thermally pasteurized cardoon-enriched functional smoothie formulations: A zero-waste manufacturing approach.

Mandim F et al (2024).
Food Chem.
DOI:
10.1016/j.foodchem.2024.139945
PubMed:
38850604

Globe Artichoke (Cynara scolymus L.) By-Products in Food Applications: Functional and Biological Properties.

Review
Colombo R et al (2024).
Foods.
DOI:
10.3390/foods13101427
PubMed:
38790727

Enhancing Bioactive Compound Classification through the Synergy of Fourier-Transform Infrared Spectroscopy and Advanced Machine Learning Methods.

Sampaio PN and Calado CCR (2024).
Antibiotics (Basel).
DOI:
10.3390/antibiotics13050428
PubMed:
38786156

A new methodology for a rapid and high-throughput comparison of molecular profiles and biological activity of phytoextracts.

Caldeira V et al (2024).
Biotechnol Bioeng.
DOI:
10.1002/bit.28739
PubMed:
38760962

The Dark Side of the pollen: BSA-seq identified genomic regions linked to male sterility in globe artichoke.

Martina M et al (2024).
BMC Plant Biol.
DOI:
10.1186/s12870-024-05119-z
PubMed:
38760683

Cynara cardunculus L. var. scolymus L. Landrace "Carciofo Ortano" as a Source of Bioactive Compounds.

Laghezza Masci V et al (2024).
Plants (Basel).
DOI:
10.3390/plants13060761
PubMed:
38592769

Structural and functional analysis of the active cow rumen's microbial community provides a catalogue of genes and microbes participating in the deconstruction of cardoon biomass.

Genetics
Firrincieli A et al (2024).
Biotechnol Biofuels Bioprod.
DOI:
10.1186/s13068-024-02495-4
PubMed:
38589938

Functional and Therapeutic Potential of Cynara scolymus in Health Benefits.

Review
Porro C et al (2024).
Nutrients.
DOI:
10.3390/nu16060872
PubMed:
38542782

Characterization and Future Distribution Prospects of "Carciofo di Malegno" Landrace for Its In Situ Conservation.

Pedrali D et al (2024).
Plants (Basel).
DOI:
10.3390/plants13050680
PubMed:
38475530

Effect of pre- and postharvest treatments on the quality and storage ability of fresh artichoke heads: opinion article.

El-Mogy MM et al (2024).
Front Plant Sci.
DOI:
10.3389/fpls.2024.1368901
PubMed:
38434441

The Effect of an Innovative Combination of Bergamot Polyphenolic Fraction and Cynara cardunculus L. Extract on Weight Gain Reduction and Fat Browning in Obese Mice.

Summary

Bergamot polyphenolic fraction combined with CyC supplementation reduced weight and fat mass and improved plasma parameters in mice on a high-fat diet, suggesting it may counteract obesity-related effects.

Obesity
Nucera S et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms25010191
PubMed:
38203362

A nutraceutical with Citrus bergamia and Cynara cardunculus improves endothelial function in adults with non-alcoholic fatty liver disease.

Maurotti S et al (2023).
Nutrition.
DOI:
10.1016/j.nut.2023.112294
PubMed:
38042043

Bioactive Compounds from Artichoke and Application Potential.

Review
Feiden T et al (2023).
Food Technol Biotechnol.
DOI:
10.17113/ftb.61.03.23.8038
PubMed:
38022879

Chemical, microbiological, textural, and sensory characteristics of pilot-scale Caciofiore cheese curdled with commercial Cynara cardunculus rennet and crude extracts from spontaneous and cultivated Onopordum tauricum.

Rampanti G et al (2023).
Food Res Int.
DOI:
10.1016/j.foodres.2023.113459
PubMed:
37803784

Insights into the phenolic composition and in vitro bioactivity of cardoon capitulum: A nutraceutical-oriented valorization study.

Summary

Scientists studied the polyphenolic composition and bioactive properties of cardoon cultivars' capitulum constituents. Corolla and bracts of certain cultivars showed strong inhibitory effects on reactive substances, antihaemolytic activity, and antimicrobial potential, suggesting potential medical applications.

Phytochemistry
Mandim F et al (2023).
Food Chem.
DOI:
10.1016/j.foodchem.2023.137480
PubMed:
37774613

Thermal evaluation of plant biomass from the phytostabilisation of soils contaminated by potentially toxic elements.

Gómez X et al (2023).
Chemosphere.
DOI:
10.1016/j.chemosphere.2023.140116
PubMed:
37699457

Future Perspective and Technological Innovation in Cheese Making Using Artichoke (Cynara scolymus) as Vegetable Rennet: A Review.

Review
Bravo Bolívar MS et al (2023).
Foods.
DOI:
10.3390/foods12163032
PubMed:
37628031

Innovative Bioplasticizers from Residual Cynara cardunculus L. Biomass-Derived Levulinic Acid and Their Environmental Impact Assessment by LCA Methodology.

Ruini C et al (2023).
ACS Sustain Chem Eng.
DOI:
10.1021/acssuschemeng.3c02269
PubMed:
37593378

Response Surface Methodology as an Experimental Strategy for Ultrasound-Assisted Extraction of Phenolic Compounds from Artichoke Heads.

Phytochemistry
Melini V, Melini F and Comendador FJ (2023).
Antioxidants (Basel).
DOI:
10.3390/antiox12071360
PubMed:
37507900

Characterization of Targeted Phenolic Compounds in Globe Artichoke Heads and Waste from Vegetatively and "Seed"-Propagated Genotypes.

Phytochemistry
Bonasia A et al (2023).
Plants (Basel).
DOI:
10.3390/plants12132579
PubMed:
37447138

Clotting and Proteolytic Activity of Freeze-Dried Crude Extracts Obtained from Wild Thistles Cynara humilis L. and Onopordum platylepis Murb.

Bande-De León C et al (2023).
Foods.
DOI:
10.3390/foods12122325
PubMed:
37372535

Microbiological Characterization of Protected Designation of Origin Serra da Estrela Cheese.

Rocha R et al (2023).
Foods.
DOI:
10.3390/foods12102008
PubMed:
37238829

Morphological, Molecular, and Nutritional Characterisation of the Globe Artichoke Landrace "Carciofo Ortano".

Alicandri E et al (2023).
Plants (Basel).
DOI:
10.3390/plants12091844
PubMed:
37176903

Ensiling Characteristics, In Vitro Rumen Fermentation Patterns, Feed Degradability, and Methane and Ammonia Production of Berseem (Trifolium alexandrinum L.) Co-Ensiled with Artichoke Bracts (Cynara cardunculus L.).

Ahmed MG et al (2023).
Animals (Basel).
DOI:
10.3390/ani13091543
PubMed:
37174580

Determination of Pesticide Residues in IV Range Artichoke (Cynara cardunculus L.) and Its Industrial Wastes.

Corrias F et al (2023).
Foods.
DOI:
10.3390/foods12091807
PubMed:
37174345

The wide spectrum of industrial applications for cultivated cardoon (Cynara cardunculus L. var. Altilis DC.): A review.

Review
Mandim F et al (2023).
Food Chem.
DOI:
10.1016/j.foodchem.2023.136275
PubMed:
37172504

Effects of Planting Date, Cultivar and Vernalization Using Gibberellic Acid on the Severity of Root-Knot Nematode Damage to Globe Artichoke in Subtropical Sandy Soil.

X Bui H et al (2023).
J Nematol.
DOI:
10.2478/jofnem-2023-0012
PubMed:
37143484

Airborne allergic contact dermatitis to artichoke (Cynara cardunculus L.) in a greengrocer.

Dermatology
Gasparini G et al (2023).
Contact Dermatitis.
DOI:
10.1111/cod.14328
PubMed:
37121580

Gluten-Free Bread Enriched with Artichoke Leaf Extract In Vitro Exerted Antioxidant and Anti-Inflammatory Properties.

Immunology
Vacca M et al (2023).
Antioxidants (Basel).
DOI:
10.3390/antiox12040845
PubMed:
37107220

Safety evaluation of the food enzyme phytepsin from Cynara cardunculus L.

EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP) et al (2023).
EFSA J.
DOI:
10.2903/j.efsa.2023.7909
PubMed:
36969549

Impact of LAB from Serpa PDO Cheese in Cheese Models: Towards the Development of an Autochthonous Starter Culture.

Araújo-Rodrigues H et al (2023).
Foods.
DOI:
10.3390/foods12040701
PubMed:
36832776

Isolation of Pure Lignin and Highly Digestible Cellulose from Defatted and Steam-Exploded Cynara cardunculus.

D'Orsi R et al (2023).
ACS Sustain Chem Eng.
DOI:
10.1021/acssuschemeng.2c06356
PubMed:
36778524

Successive Solvent Extraction, Characterization and Antioxidant Activities of Cardoon Waste (Leaves and Stems) Extracts: Comparative Study.

Hajji Nabih M et al (2023).
Molecules.
DOI:
10.3390/molecules28031129
PubMed:
36770795

Bioguided isolation of potential antitumor agents from the aerial parts of cultivated cardoon (Cynara cardunculus var. altilis).

Cancer
Hamza RA et al (2023).
Saudi Pharm J.
DOI:
10.1016/j.jsps.2022.11.011
PubMed:
36685304

Microbial Dynamics of a Specialty Italian Raw Ewe's Milk Cheese Curdled with Extracts from Spontaneous and Cultivated Onopordum tauricum Willd.

Rampanti G et al (2023).
Microorganisms.
DOI:
10.3390/microorganisms11010219
PubMed:
36677511

Potential Use of Cardunculus Biomass on Pleurotus eryngii Production: Heteroglycans Content and Nutritional Properties (Preliminary Results).

Battaglia V et al (2022).
Foods.
DOI:
10.3390/foods12010058
PubMed:
36613273

Ready-to-Use Nutraceutical Formulations from Edible and Waste Organs of Algerian Artichokes.

Brahmi-Chendouh N et al (2022).
Foods.
DOI:
10.3390/foods11243955
PubMed:
36553698

Safety evaluation of the food enzyme phytepsin from Cynara cardunculus L.

EFSA Panel on Food Contact Materials; Enzymes and Processing Aids (CEP) et al (2022).
EFSA J.
DOI:
10.2903/j.efsa.2022.7678
PubMed:
36507102

Safety evaluation of the food enzyme phytepsin from Cynara cardunculus L.

EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP) et al (2022).
EFSA J.
DOI:
10.2903/j.efsa.2022.7681
PubMed:
36507101

Safety evaluation of the food enzyme phytepsin from Cynara cardunculus L.

EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP) et al (2022).
EFSA J.
DOI:
10.2903/j.efsa.2022.7680
PubMed:
36507100

Microbiological, morpho-textural, and volatile characterization of Portuguese Queijo de Nisa PDO cheese.

Cardinali F et al (2022).
Food Res Int.
DOI:
10.1016/j.foodres.2022.112011
PubMed:
36461236

Cynara cardunculus as a potential source of milk coagulating protease: Effects on physical properties of cow's milk.

Ghribi AM et al (2022).
Food Sci Nutr.
DOI:
10.1002/fsn3.2981
PubMed:
36348785

Antiproliferative Effects of Cynara Cardunculus in Colorectal Cancer Cells Are Modulated by the Circadian Clock.

Cancer
Fuhr L et al (2022).
Int J Mol Sci.
DOI:
10.3390/ijms23169130
PubMed:
36012399

Membrane fractionation of Cynara cardunculus swine blood hydrolysate: Ingredients of high nutritional and nutraceutical value.

Araújo-Rodrigues H et al (2022).
Food Res Int.
DOI:
10.1016/j.foodres.2022.111549
PubMed:
35840243

Chemical composition of cardoon (Cynara cardunculus L. var. altilis) petioles as affected by plant growth stage.

Mandim F et al (2022).
Food Res Int.
DOI:
10.1016/j.foodres.2022.111330
PubMed:
35651080

Effects of Ethanolic Extract of Cynara cardunculus (Artichoke) Leaves on Neuroinflammatory and Neurochemical Parameters in a Diet-Induced Mice Obesity Model.

Summary

A study investigated how Cynara cardunculus leaf ethanol extract affected inflammation and oxidative stress in the brains and liver of obese mice. The extract did not affect body weight but reduced visceral fat. Obesity leads to inflammation and oxidative stress, but treatment with the extract partially reversed these changes and improved antioxidant defense. The extract may contribute to the treatment of obesity.

ImmunologyNeuroscienceObesity
Piccinini A et al (2022).
Neurochem Res.
DOI:
10.1007/s11064-022-03572-6
PubMed:
35426598

Encapsulation of Cynara Cardunculus Guaiane-type Lactones in Fully Organic Nanotubes Enhances Their Phytotoxic Properties.

Mejías FJR et al (2022).
J Agric Food Chem.
DOI:
10.1021/acs.jafc.1c07806
PubMed:
35289164

Cardoon (Cynara cardunculus L. var. altilis) seeds presscake: a natural by-product for pigs feeding.

Zumbo A et al (2022).
Nat Prod Res.
DOI:
10.1080/14786419.2021.1993218
PubMed:
34689664

Biological Effect of Cynara cardunculus on Kidney Status of Hypercholesterolemic Rats.

Alkushi AG et al (2017).
Pharmacogn Mag.
DOI:
10.4103/pm.pm_14_17
PubMed:
29142395