Cyperus rotundus

Common Names: cocograss, purple nutsedge, nutgrass

Ethnobotanical Studies

Clinical Trials

The effectiveness of Cyperus rotundus essential oil in reducing the side effects of laser hair removal.

Cyperus rotundus oil has shown potential as a safe and effective treatment for various ailments due to its anti-inflammatory and pain-relieving properties. However, there is currently no research comparing it to traditional treatments for post-hair removal laser side effects.

Mohammed GF et al (2022).
J Cosmet Dermatol.
DOI:
10.1111/jocd.14301
PubMed:
34132024

Studies

Antifungal Activity of Cyperus articulatus, Cyperus rotundus and Lippia alba Essential Oils against Aspergillus flavus Isolated from Peanut Seeds.

Summary

Three essential oils from different plants were tested for antifungal activity against a fungus contaminating peanut seeds in Senegal. The oil from one plant, had the best inhibitory effect, making it a potential protective agent for groundnuts.

Antimicrobial
Sabaly S et al (2024).
J Fungi (Basel).
DOI:
10.3390/jof10080591
PubMed:
39194916

Treating chronic atrophic gastritis: identifying sub-population based on real-world TCM electronic medical records.

Wang YM et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2024.1444733
PubMed:
39170704

Nanoparticle Encapsulation of the Hexane Fraction of Cyperus Rotundus Extract for Enhanced Antioxidant and Anti-Inflammatory Activities in vitro.

Immunology
Kim C et al (2024).
Int J Nanomedicine.
DOI:
10.2147/IJN.S452636
PubMed:
39165772

Comparative transcriptome analysis of Cyperus esculentus and C. rotundus with contrasting oil contents in tubers defines genes and regulatory networks involved in oil accumulation.

Genetics
Bai X et al (2024).
Plant Sci.
DOI:
10.1016/j.plantsci.2024.112230
PubMed:
39154894

Characterization and antioxidant activity of nano-formulated berberine and cyperus rotundus extracts with anti-inflammatory effects in mastitis-induced rats.

Immunology
Hashem AE et al (2024).
Sci Rep.
DOI:
10.1038/s41598-024-66801-8
PubMed:
39122736

Medicinal Plants Cultivated in Egypt with Antiviral Potential: A Systematic Review.

Summary

Researchers studied antiviral properties of medicinal plants in Egypt, showing potential for treating serious viral diseases. Important due to high mortality rates, lack of cures, and emergence of resistant strains.

Antimicrobial
Elkhouly AM et al (2024).
Altern Ther Health Med.
PubMed:
39110055

Study on the enhanced efficacy mechanism of vinegar-processed Cyperus rotundus in the treatment of primary dysmenorrhea.

Wang F et al (2024).
Biomed Chromatogr.
DOI:
10.1002/bmc.5942
PubMed:
39039792

Comparisons of pharmacokinetics and tissue distribution of six major bioactive components of the herbal pair Alpinia officinarum-Cyperus rotundus in normal and primary dysmenorrhea rats.

Huang Y et al (2024).
J Pharm Biomed Anal.
DOI:
10.1016/j.jpba.2024.116316
PubMed:
38941920

Identification of antidepressant constituents from Xiangfu-chuanxiong herbal medicine pair via spectrum-effect relationship analyses, molecular docking and corticosterone-induced PC12 cells.

Summary

Study evaluated XF-CX herbal medicine pair ratios for antidepressant effects. XF-CX (2:1) most effective. Identified potential antidepressant constituents. Beneficial for depression treatment mechanism and clinical application.

Neuroscience
Li HJ et al (2024).
Fitoterapia.
DOI:
10.1016/j.fitote.2024.106087
PubMed:
38897250

The Impact of Artificial Restoration of Alpine Grasslands in the Qilian Mountains on Vegetation, Soil Bacteria, and Soil Fungal Community Diversity.

Review
Yang X et al (2024).
Microorganisms.
DOI:
10.3390/microorganisms12050854
PubMed:
38792684

Alpha-cyperone mitigates renal ischemic injury via modulation of HDAC-2 expression in diabetes: Insights from molecular dynamics simulations and experimental evaluation.

Summary

Alpha-cyperone from Cyperus rotundus protects kidneys of diabetic rats from injury by reducing oxidative stress, inflammation, and inhibiting HDAC-2 activity. Promising potential treatment for diabetic kidney damage.

Diabetes
Daude RB, Bhadane R and Shah JS (2024).
Eur J Pharmacol.
DOI:
10.1016/j.ejphar.2024.176643
PubMed:
38754539

In silico approach for predicting the bioactive compound of Cyperus rotundus to inhibit NF-kB and iNOS signaling pathways.

Setiawan M et al (2024).
Braz J Biol.
DOI:
10.1590/1519-6984.278323
PubMed:
38747858

Vegetation communities and soil properties along the restoration process of the Jinqianghe mine site in the Qilian Mountains, China.

Yang X et al (2024).
Front Plant Sci.
DOI:
10.3389/fpls.2024.1358309
PubMed:
38711611

From desert flora to cancer therapy: systematic exploration of multi-pathway mechanisms using network pharmacology and molecular modeling approaches.

Summary

Researchers investigated Saudi Arabian flora compounds in treating ovarian cancer, identifying key genes and pathways. Compounds like ascorbic acid and hispidulin showed promising interactions with AKT1 and VEGFA proteins, suggesting potential for future anti-cancer treatments.

Cancer
Alblihy A et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2024.1345415
PubMed:
38666020

Evaluation of Weed Species for Host Status to the Root-Knot Nematodes Meloidogyne enterolobii and M. incognita Race 4.

Schwarz T et al (2024).
J Nematol.
DOI:
10.2478/jofnem-2024-0017
PubMed:
38650601

Diverse effects of a Cyperus rotundus extract on glucose uptake in myotubes and adipocytes and its suppression on adipocyte maturation.

Pichetkun V et al (2024).
Sci Rep.
DOI:
10.1038/s41598-024-59357-0
PubMed:
38641685

Antiobesity and antidiabetes effects of Cyperus rotundus rhizomes presenting protein tyrosine phosphatase, dipeptidyl peptidase 4, metabolic enzymes, stress oxidant and inflammation inhibitory potential.

Summary

"Tubers extract inhibits key enzymes, reduces inflammation in diabetic rats, protects pancreatic beta-cells, and modulates hepatic enzymes. Promising potential for preventing and treating obesity and diabetes."

Immunology
Abdella FIA et al (2024).
Heliyon.
DOI:
10.1016/j.heliyon.2024.e27598
PubMed:
38486768

Effect of the number of Cyperus rotundus and medium height on the performance of batch-constructed wetland in treating aquaculture effluent.

Imron MF et al (2024).
Chemosphere.
DOI:
10.1016/j.chemosphere.2024.141595
PubMed:
38438021

The Herbal Combination Shu Gan Jie Yu Regulates the SNCG/ER-a/AKT-ERK Pathway in DMBA-Induced Breast Cancer and Breast Cancer Cell Lines Based on RNA-Seq and IPA Analysis.

Summary

Researchers identified 3 liver-soothing herbs for breast cancer therapy in TCM. This herbal combination (SGJY) may offer potential benefits, worth investigating further for therapeutic applications.

CancerGenetics
Zhao Y et al (2024).
Integr Cancer Ther.
DOI:
10.1177/15347354241233258
PubMed:
38369762

Assessment of heavy metal concentrations in roadside soils and plants around the Dexing copper mine: implications for environmental management and remediation.

Wan Y, Peng M and Wang YP (2024).
Environ Monit Assess.
DOI:
10.1007/s10661-024-12422-7
PubMed:
38340265

Effects of Dietary Tuber Ethanolic Extract of Nut Grass (Cyperus rotundus Linn.) on Growth, Immune Response, and Disease Resistance in Nile Tilapia (Oreochromis niloticus).

Wigraiboon S et al (2024).
Animals (Basel).
DOI:
10.3390/ani14030503
PubMed:
38338145

Cyperus rotundus L.: Invasive weed plant with insecticidal potential against Aphis craccivora Koch and Planococcus lilacinus (Cockerell).

Singh R et al (2024).
Pestic Biochem Physiol.
DOI:
10.1016/j.pestbp.2023.105720
PubMed:
38225075

Phytostabilization of metal(loid)s by ten emergent macrophytes following a 90-day exposure to industrially contaminated groundwater.

Velasco-Arroyo B et al (2023).
N Biotechnol.
DOI:
10.1016/j.nbt.2023.12.003
PubMed:
38128697

Weed spatial distribution as a function of soil properties in two distinct environments of the Brazilian semi-arid region.

Lessa BFDT et al (2023).
An Acad Bras Cienc.
DOI:
10.1590/0001-3765202320190182
PubMed:
38088692

Plant-plant interactions vary greatly along a flooding gradient in a dam-induced riparian habitat.

Ying L et al (2023).
Front Plant Sci.
DOI:
10.3389/fpls.2023.1290776
PubMed:
38078102

Components study on gastroprotective effect and holistic mechanism of the herbal pair Alpinia officinarum - Cyperus rotundus based on spectrum-effect relationship and integrated transcriptome and metabolome analyses.

Summary

HPAC, an herbal pair used to treat gastric ulcers, has a proven history of success. Consider implementing it in your lab to improve treatment options for ulcers.

Genetics
Qu H et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117494
PubMed:
38012972

In Vitro and In Vivo Evaluation for Antioxidant and Anti-Diabetic Properties of Cyperus rotundus L. Kombucha.

Summary

Kombucha is a fermented beverage with antioxidants that lower oxidative stress, lipid peroxidation, and alpha-glucosidase activity, making it a potential functional food for health.

DiabetesImmunology
Dechakhamphu A et al (2023).
Foods.
DOI:
10.3390/foods12224059
PubMed:
38002116

Polyherbal and Multimodal Treatments: Kaempferol- and Quercetin-Rich Herbs Alleviate Symptoms of Alzheimer's Disease.

Summary

A review identified potential herbal treatments for Alzheimer's Disease (AD). Common herbs rich in kaempferol and quercetin show promise in reducing plaque formation, suppressing oxidative stress, and modulating signaling pathways. A polyherbal cocktail of these compounds could be a potential alternative treatment for AD.

Review Neuroscience
Alexander C, Parsaee A and Vasefi M (2023).
Biology (Basel).
DOI:
10.3390/biology12111453
PubMed:
37998052

Interplay between edaphic and climatic factors unravels plant and microbial diversity along an altitudinal gradient.

Aqeel M et al (2023).
Environ Res.
DOI:
10.1016/j.envres.2023.117711
PubMed:
37995997

Pyrethroids toxicity in vertebrates and invertebrates and amelioration by bioactive compounds: A review.

Review
Kumar A et al (2023).
Pestic Biochem Physiol.
DOI:
10.1016/j.pestbp.2023.105615
PubMed:
37945252

Classification and rapid non-destructive quality evaluation of different processed products of Cyperus rotundus based on near-infrared spectroscopy combined with deep learning.

Shi Y et al (2023).
Talanta.
DOI:
10.1016/j.talanta.2023.125266
PubMed:
37832457

Herbal therapeutics for female infertility: A systematic review and meta-analysis: Herbal medicine for female infertility.

Review
Hyun JY, Jung HS and Park JY (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117258
PubMed:
37778518

Molecular characterization of oleosin genes in Cyperus esculentus, a Cyperaceae plant producing oil in underground tubers.

Summary

Researchers discovered highly expressed genes (CeOLE) in tigernut tubers correlated with oil accumulation. Overexpressing these genes increased oil content in tobacco leaves, offering insights into improving tigernut oil production.

Genetics
Zou Z et al (2023).
Plant Cell Rep.
DOI:
10.1007/s00299-023-03066-x
PubMed:
37747544

Managing Weed-Crop Interactions Enhances Chickpea (Cicer arietinum L.) Chemical Components.

Khan I et al (2023).
Plants (Basel).
DOI:
10.3390/plants12173073
PubMed:
37687320

Effects of Traditional Chinese Herbal Feed Additive on Production Performance, Egg Quality, Antioxidant Capacity, Immunity and Intestinal Health of Laying Hens.

Summary

A Chinese herbal feed additive (TCM) improved egg production, quality, antioxidant capacity, immunity, and intestinal health in Roman laying hens compared to control and antibiotic groups.

GastroenterologyImmunology
Liu B et al (2023).
Animals (Basel).
DOI:
10.3390/ani13152510
PubMed:
37570319

Phytochemistry, data mining, pharmacology, toxicology and the analytical methods of Cyperus rotundus L. (Cyperaceae): a comprehensive review.

Summary

This review summarizes the various uses and effects of in traditional medicine, including its phytochemistry, pharmacology, and analytical methods. It also highlights its safety profile and potential for further scientific research and clinical use.

Review Phytochemistry
Xue BX et al (2023).
Phytochem Rev.
DOI:
10.1007/s11101-023-09870-3
PubMed:
37359712

Implication of Scanning Electron Microscopy and Light Microscopy for Morphology of Some Selected Seed Drugs: As a Tool for Authentication.

Munir R et al (2023).
J Microsc Ultrastruct.
DOI:
10.4103/jmau.jmau_104_22
PubMed:
37144167

Ecological importance and sociological characters of fourteen widespread weeds and their contribution to the observed (dis)similarity between weed communities.

Mahgoub AMMA et al (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e13638
PubMed:
37025790

An efficient high-speed counter-current chromatography method for the preparative separation of sesquiterpenoids from the rhizomes of Cyperus rotundus L. combined with evaluation the anti-inflammation activity in vitro and molecular docking.

ImmunologyPhytochemistry
Pan S et al (2023).
J Sep Sci.
DOI:
10.1002/jssc.202300042
PubMed:
36939191

Study on the quality difference of Cyperus rotundus before and after vinegar processing based on ultra-high-performance liquid chromatography-quadrupole-time of flight-mass spectrometry and molecular network combined with color parameters.

Phytochemistry
Shi Y et al (2023).
J Sep Sci.
DOI:
10.1002/jssc.202200990
PubMed:
36827079

In vitro and in vivo anthelmintic and chemical studies of Cyperus rotundus L. extracts.

El-Wakil ES et al (2023).
BMC Complement Med Ther.
DOI:
10.1186/s12906-023-03839-7
PubMed:
36658562

A Quantitative Study on the Ethnobotanical Knowledge about Wild Edible Plants among the Population of Messiwa.

Ethnobotany
Ghanimi R et al (2022).
Ethiop J Health Sci.
DOI:
10.4314/ejhs.v32i6.22
PubMed:
36475263

Qi Gong Wan ameliorates adipocyte hypertrophy and inflammation in adipose tissue in a PCOS mouse model through the Nrf2/HO-1/Cyp1b1 pathway: Integrating network pharmacology and experimental validation in vivo.

Immunology
Zheng R et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2022.115824
PubMed:
36273747

Phytoremediation potential of indigenous plants growing in soils affected by mine activities in Gejiu City, Yunnan Province.

Niu X et al (2022).
Int J Phytoremediation.
DOI:
10.1080/15226514.2022.2117789
PubMed:
36048899

Cyperus rotundus L. drives arable soil infertile by changing the structure of soil bacteria in the rhizosphere, using a maize field as an example.

Liu SY et al (2022).
Environ Sci Pollut Res Int.
DOI:
10.1007/s11356-022-21480-8
PubMed:
35715673

Genital whitening with topical Cyperus rotundus oil enhances sexuality and quality of life.

Mohammed GF, Al-Dhubaibi MS and Mohamed ML (2022).
J Cosmet Dermatol.
DOI:
10.1111/jocd.14918
PubMed:
35290702

The association study of chemical compositions and their pharmacological effects of Cyperi Rhizoma (Xiangfu), a potential traditional Chinese medicine for treating depression.

Review
Lu J et al (2022).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2021.114962
PubMed:
34968659

Integrated Network Pharmacology and GC-MS-Based Metabolomics to Investigate the Effect of Xiang-Su Volatile Oil Against Menopausal Depression.

Li Y et al (2021).
Front Pharmacol.
DOI:
10.3389/fphar.2021.765638
PubMed:
34925022

Cyperus rotundus L. reverses the olanzapine-induced weight gain and metabolic changes-outcomes from network and experimental pharmacology.

Kanagali SN et al (2022).
Comput Biol Med.
DOI:
10.1016/j.compbiomed.2021.105035
PubMed:
34802711

Cyperus rotundus: a safe forage or hyper phytostabilizer species in copper contaminated soils.

Jahan-Nejati S, Jowkar-Tangkarami M and Taei-Semiromi J (2021).
Int J Phytoremediation.
DOI:
10.1080/15226514.2021.1888072
PubMed:
33825562

Characterization of the complete plastome of Cyperus rotundus L. (Cyperaceae).

Wu R, Yu C and Wu Y (2021).
Mitochondrial DNA B Resour.
DOI:
10.1080/23802359.2020.1845999
PubMed:
33521266