Datura stramonium

Common Names: Jamestown weed, jimsonweed, mad apple, moonflower, stinkwort, thorn apple

Ethnobotanical Studies

Studies

Sugar-binding profiles of the mesothelial glycocalyx in frozen tissues of mice revealed by lectin staining.

Taniguchi T et al (2024).
Pathol Res Pract.
DOI:
10.1016/j.prp.2024.155538
PubMed:
39191196

Plasticity in biomass allocation underlies tolerance to leaf damage in native and non-native populations of Datura stramonium.

Liñán-Vigo F and Núñez-Farfán J (2024).
Oecologia.
DOI:
10.1007/s00442-024-05585-0
PubMed:
39048862

Crystal structure of the cytotoxic macrocyclic trichothecene Isororidin A.

Asmaey MA et al (2024).
Acta Crystallogr C Struct Chem.
DOI:
10.1107/S2053229624006144
PubMed:
38984909

First report of Alternaria crassa causing yellow spots on Datura stramonium in China.

Yang S and Liu YL (2024).
Plant Dis.
DOI:
10.1094/PDIS-08-23-1494-PDN
PubMed:
38885028

The use and potential abuse of psychoactive plants in southern Africa: an overview of evidence and future potential.

Review
Nyazema NZ, Chanyandura JT and Egan B (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2024.1269247
PubMed:
38855756

Deaddicta® for maintenance treatment of Opioid-dependence: A six-month follow-up.

Moosavyzadeh A et al (2024).
Caspian J Intern Med.
DOI:
10.22088/cjim.15.2.318
PubMed:
38807734

Modulation of Tropane Alkaloids' Biosynthesis and Gene Expression by Methyl Jasmonate in Datura stramonium L.: A Comparative Analysis of Scopolamine, Atropine, and Hyoscyamine Accumulation.

GeneticsPhytochemistry
Rasi A et al (2024).
Life (Basel).
DOI:
10.3390/life14050618
PubMed:
38792639

Unveiling the Dark Side of Datura in Pediatric Poisoning With Insights From Jordanian Experience: A Retrospective Clinical Study.

Tarawneh A et al (2024).
Pediatr Emerg Care.
DOI:
10.1097/PEC.0000000000003189
PubMed:
38718809

Evaluation of Weed Species for Host Status to the Root-Knot Nematodes Meloidogyne enterolobii and M. incognita Race 4.

Schwarz T et al (2024).
J Nematol.
DOI:
10.2478/jofnem-2024-0017
PubMed:
38650601

Applications of Liquid Chromatography-Tandem Mass Spectrometry in Natural Products Research: Tropane Alkaloids as a Case Study.

Phytochemistry
Cinelli MA, Cline J and Watson T (2024).
J Vis Exp.
DOI:
10.3791/66620
PubMed:
38526072

Medicinal Plants Used by Oromo Community in Kofale District, West-Arsi Zone, Oromia Regional State, Ethiopia.

Nuro GB, Tolossa K and Giday M (2024).
J Exp Pharmacol.
DOI:
10.2147/JEP.S449496
PubMed:
38476311

Biodiesel production and exploring properties of Datura stramonium L. oil with its optimization using combined approaches-Taguchi, grey relational analysis, and response surface methodology.

Singh Y et al (2024).
Environ Sci Pollut Res Int.
DOI:
10.1007/s11356-024-32665-8
PubMed:
38430436

An appraisal of traditional knowledge of plant poisoning of livestock and its validation through acute toxicity assay in rats.

Rasool F et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2024.1328133
PubMed:
38420196

Ethnoveterinary medicinal plants and their utilization by the people of Soro District, Hadiya Zone, southern Ethiopia.

Ethnobotany
Hankiso M et al (2024).
J Ethnobiol Ethnomed.
DOI:
10.1186/s13002-024-00651-6
PubMed:
38389077

A Trip Back Home: Resistance to Herbivores of Native and Non-Native Plant Populations of Datura stramonium.

Núñez-Farfán J et al (2024).
Plants (Basel).
DOI:
10.3390/plants13010131
PubMed:
38202439

Effects of Datura stramonium L. Invasion into Different Habitats on Native Plant Functional Traits and Soil Carbon, Nitrogen and Phosphorus Stoichiometric Characteristics.

Lv J et al (2023).
Biology (Basel).
DOI:
10.3390/biology12121497
PubMed:
38132323

The chromosome-scale genome and the genetic resistance machinery against insect herbivores of the Mexican Toloache, Datura stramonium.

Genetics
De-la-Cruz IM, Oyama K and Núñez-Farfán J (2023).
G3 (Bethesda).
DOI:
10.1093/g3journal/jkad288
PubMed:
38113048

Inter-annual variation in the abundance of specialist herbivores determines plant resistance in Datura stramonium.

De-la-Cruz IM and Núñez-Farfán J (2023).
Ecol Evol.
DOI:
10.1002/ece3.10794
PubMed:
38077505

In Situ Green Synthesis of Co(3)O(4)@ZnO Core-Shell Nanoparticles Using Datura stramonium Leaf Extract: Antibacterial and Antioxidant Studies.

Immunology
Tadesse G et al (2023).
Bioinorg Chem Appl.
DOI:
10.1155/2023/5019838
PubMed:
38075557

Efficacy and toxicity of different plant extracts over the period of time in Bracon hebetor (Say) (Hymenoptera: Braconidae).

Asrar M et al (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e21631
PubMed:
38027796

Anti-Diabetic Effects of the 80% Methanolic Extract of Datura Stramonium Linn (Solanaceae) Leaves in Streptozotocin- Induced Diabetic Mice.

Summary

Researchers investigated the anti-diabetic effects of Solanaceae leaves extract in diabetic mice and found it to be effective. This could lead to the development of affordable, plant-based medications with fewer side effects for managing diabetes.

Diabetes
Baylie T et al (2023).
J Exp Pharmacol.
DOI:
10.2147/JEP.S426925
PubMed:
37873553

Unintentional Jimson Weed Poisoning in a Family: A Case Report.

Ahmed M and Mridha D (2023).
Cureus.
DOI:
10.7759/cureus.45604
PubMed:
37868440

The Plant Virus Tomato Spotted Wilt Orthotospovirus Benefits Its Vector Frankliniella occidentalis by Decreasing Plant Toxic Alkaloids in Host Plant Datura stramonium.

Phytochemistry
Zhang Z et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms241914493
PubMed:
37833941

Simultaneous quantification of hyoscyamine and scopolamine using HPLC-DAD in four Solanaceae: Hyoscyamus niger, Datura stramonium, Atropa belladonna and Mandragora officinarum.

Piatti D et al (2023).
Nat Prod Res.
DOI:
10.1080/14786419.2023.2269595
PubMed:
37830795

Development of a novel lectin-based gold nanoparticle point-of-care immunoassay for rapid diagnosis of patients with severe Dengue infection.

Paul M, Saha B and Mukhopadhyay S (2023).
J Immunoassay Immunochem.
DOI:
10.1080/15321819.2023.2260480
PubMed:
37789768

Nephroprotective effects of Datura stramonium leaves against methotrexate nephrotoxicity via attenuation of oxidative stress-mediated inflammation and apoptosis in rats.

Summary

Researchers investigated whether a leaf extract could counteract the kidney-damaging side effects of the anticancer drug methotrexate in rats. This study is relevant for improving the clinical application of methotrexate in cancer treatments.

Immunology
Alum EU et al (2023).
Avicenna J Phytomed.
DOI:
10.22038/AJP.2023.21903
PubMed:
37663387

Exploring the antibacterial potential of plant extracts and essential oils against Bacillus thermophilus in beet sugar for enhanced sucrose retention: a comparative assessment and implications.

Yousef MM et al (2023).
Front Microbiol.
DOI:
10.3389/fmicb.2023.1219823
PubMed:
37547698

Selective targeting of lectins and their macropinocytosis in urothelial tumours: translation from in vitro to ex vivo.

Resnik N et al (2023).
Histochem Cell Biol.
DOI:
10.1007/s00418-023-02224-2
PubMed:
37535087

Datura stramonium Flowers as a Potential Natural Resource of Bioactive Molecules: Identification of Anti-Inflammatory Agents and Molecular Docking Analysis.

Immunology
Damergi B et al (2023).
Molecules.
DOI:
10.3390/molecules28135195
PubMed:
37446858

The Role of Long-Acting Antimuscarinic Agents in the Treatment of Asthma.

Summary

This review discusses the history and effectiveness of antimuscarinic agents in asthma treatment. Tiotropium, glycopyrronium, and umeclidinium are recommended as add-on therapies for patients with severe asthma.

Review Asthma
Arslan B, Çetin GP and Yilmaz İ (2023).
J Aerosol Med Pulm Drug Deliv.
DOI:
10.1089/jamp.2022.0059
PubMed:
37428619

Identification and complete genome sequence of iris potyvirus A, which causes dwarfing and foliar chlorosis with mosaic or mottle disease symptoms on lily (Lilium lancifolium Thunb.) in China.

Genetics
Wang F et al (2023).
Virus Res.
DOI:
10.1016/j.virusres.2023.199141
PubMed:
37355176

Determination of Atropine by HPLC in Plant of Datura by Liquid-Liquid Extraction and Magnet Solid-Phase Extraction.

Mahmoudi S et al (2023).
J Chromatogr Sci.
DOI:
10.1093/chromsci/bmad041
PubMed:
37316168

Habitat suitability evaluation of invasive plant species Datura stramonium in Liaoning Province: Based on Biomod2 combination model.

Wang ZW et al (2023).
Ying Yong Sheng Tai Xue Bao.
DOI:
10.13287/j.1001-9332.202305.017
PubMed:
37236944

Accidental ingestion of jimsonweed by an adolescent.

Forno FJ and Terry RA (2023).
J Osteopath Med.
DOI:
10.1515/jom-1998-0091
PubMed:
37043796

Impact of wild solanaceae rootstocks on morphological and physiological response, yield, and fruit quality of tomato (Solanum lycopersicum L.) grown under deficit irrigation conditions.

Tejada-Alvarado JJ et al (2022).
Heliyon.
DOI:
10.1016/j.heliyon.2022.e12755
PubMed:
36685469

The pattern of coding sequences in the chloroplast genome of Atropa belladonna and a comparative analysis with other related genomes in the nightshade family.

Genetics
Sahoo S and Rakshit R (2022).
Genomics Inform.
DOI:
10.5808/gi.22045
PubMed:
36617650

Priming by Insects: Differential Effects of Sympatric and Allopatric Priming upon Plant Performance and Tolerance to Herbivory.

Garrido E et al (2022).
Plants (Basel).
DOI:
10.3390/plants11243567
PubMed:
36559679

Growing your own food is like printing money, don't let it make you mad as a hatter.

Ghys T et al (2022).
Clin Chem Lab Med.
DOI:
10.1515/cclm-2022-1137
PubMed:
36542485

Isolation, Purification, and Characterization of Homogenous Novel Bioactive Protein from Datura stramonium Stem Exhibited Larvicidal Activity against Anopheles stephensi.

Kirar M, Singh SP and Sehrawat N (2022).
J Trop Med.
DOI:
10.1155/2022/1637896
PubMed:
36518638

Elicitation of Hyoscyamine Production in Datura stramonium L. Plants Using Tobamoviruses.

Mihálik D et al (2022).
Plants (Basel).
DOI:
10.3390/plants11233319
PubMed:
36501358

Germination Response of Datura stramonium L. to Different pH and Salinity Levels under Different Temperature Conditions.

Nikolić N et al (2022).
Plants (Basel).
DOI:
10.3390/plants11233259
PubMed:
36501298

Host biology and genomic properties of Plumeria mosaic virus, a tobamovirus discovered in a temple tree in India co-infecting with frangipani mosaic virus.

Genetics
Kumar A et al (2022).
Front Microbiol.
DOI:
10.3389/fmicb.2022.1030042
PubMed:
36406428

The modulatory effects of alkaloid extracts of Cannabis sativa, Datura stramonium, Nicotiana tabacum and male Carica papaya on neurotransmitter, neurotrophic and neuroinflammatory systems linked to anxiety and depression.

Summary

This study examined the effects of extracts from different plants on anxiety and depression in rats. The extracts were administered orally in varying doses for 90 days. The results showed that extracts from Cannabis sativa, Nicotiana tabacum, and male Carica papaya had anxiolytic and antidepressant properties. These extracts reduced inflammation and promoted the activity of certain neurotransmitters linked to mood regulation. However, extracts from Datura stramonium and high doses of the other extracts had adverse effects. Overall, these extracts may have therapeutic potential, but may also lead to dependence and addiction.

ImmunologyNeurosciencePhytochemistry
Fasakin OW et al (2022).
Inflammopharmacology.
DOI:
10.1007/s10787-022-01006-x
PubMed:
35665872

Light and scanning electron microscopy of Datura stramonium L. extract and its biological applications.

Rehman SU et al (2022).
Microsc Res Tech.
DOI:
10.1002/jemt.24148
PubMed:
35555838

Datura stramonium abrogates depression- and anxiety-like disorders in mice: possible involvement of monoaminergic pathways in its antidepressant activity.

Summary

Researchers investigated the antidepressant and anxiolytic properties of a certain plant called HLDS, which is traditionally used to manage mental health issues. They studied its effects on mice and tried to understand how it works. The findings suggest that HLDS has therapeutic potential for mental health disorders in humans.

Neuroscience
Akanji MA et al (2022).
Drug Metab Pers Ther.
DOI:
10.1515/dmpt-2021-0166
PubMed:
35218173

Datura stramonium intoxication in two children.

Rakotomavo F et al (2014).
Pediatr Int.
DOI:
10.1111/ped.12363
PubMed:
24894939

Pharmacological properties of Datura stramonium L. as a potential medicinal tree: an overview.

Review
Soni P et al (2012).
Asian Pac J Trop Biomed.
DOI:
10.1016/S2221-1691(13)60014-3
PubMed:
23593583

Datura stramonium lectin.

Crowley JF and Goldstein IJ (1982).
Methods Enzymol.
PubMed:
7098940