Decalepis hamiltonii

Ethnobotanical Studies

Studies

In-vitro cell migration enhancing constituents from Decalepis hamiltonii, a plant used in the preparation of 'Pinda oil', a medicinal oil used in Ayurveda for wound management.

Kulatunge DR et al (2024).
Nat Prod Res.
DOI:
10.1080/14786419.2024.2305220
PubMed:
38235612

Decalepis hamiltonii root fraction alleviates CCl(4) hepatotoxicity in a rat model.

Labhade S et al (2023).
J Ayurveda Integr Med.
DOI:
10.1016/j.jaim.2023.100818
PubMed:
38011760

Antimicrobial, antioxidant, anticancer, and antithrombotic, competency of saponins from the root of Decalepis hamiltonii.

Summary

Crude saponin from D. hamiltonii root has excellent antioxidant, antibacterial, antithrombotic, and anticancer properties, making it suitable for pharmaceutical formulations.

AntimicrobialCancerImmunologyPhytochemistry
Gitanjali J et al (2023).
Environ Res.
DOI:
10.1016/j.envres.2023.116096
PubMed:
37172679

In vitro-derived plants grown from low nitrate medium produced quality tubers in Decalepis hamiltonii Wight & Arn.

Koppada U, Matam P and Parvatam G (2022).
3 Biotech.
DOI:
10.1007/s13205-022-03256-6
PubMed:
35935545

Fabrication and in vitro Evaluation of 4-HIA Encapsulated PLGA Nanoparticles on PC12 Cells.

Ravikiran T et al (2021).
Int J Nanomedicine.
DOI:
10.2147/IJN.S317986
PubMed:
34429603

Proteomic approach to identify the differentially abundant proteins during flavour development in tuberous roots of Decalepis hamiltonii Wight & Arn.

Kamireddy K et al (2021).
3 Biotech.
DOI:
10.1007/s13205-021-02714-x
PubMed:
33927964

Natural bioactive 4-Hydroxyisophthalic acid (4-HIPA) exhibited antiproliferative potential by upregulating apoptotic markers in in vitro and in vivo cancer models.

Cancer
Zarei M, Shivanandappa T and Zarei M (2020).
Mol Biol Rep.
DOI:
10.1007/s11033-020-05617-x
PubMed:
32607952

Pharmacore maping based on docking, ADME/toxicity, virtual screening on 3,5-dimethyl-1,3,4-hexanetriol and dodecanoic acid derivates for anticancer inhibitors.

Cancer
Prakash P et al (2021).
J Biomol Struct Dyn.
DOI:
10.1080/07391102.2020.1778533
PubMed:
32567489

Cyclophosphamide, a cancer chemotherapy drug-induced early onset of reproductive senescence and alterations in reproductive performance and their prevention in mice.

Cancer
Athira VR, Shivanandappa T and Yajurvedi HN (2022).
Drug Chem Toxicol.
DOI:
10.1080/01480545.2020.1774773
PubMed:
32536211

Disruption of galectin-3 and galectin-3 binding protein (G3BP) interaction by dietary pectic polysaccharides (DPP) - Arrest of metastasis, inhibition of proliferation and induction of apoptosis.

Cancer
Natarajamurthy SH, Sistla S and Dharmesh SM (2019).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2019.07.180
PubMed:
31356934

Expression profile of phenylpropanoid pathway genes in Decalepis hamiltonii tuberous roots during flavour development.

Genetics
Kiran K et al (2018).
3 Biotech.
DOI:
10.1007/s13205-018-1388-7
PubMed:
30105190

Neuroprotective effect of Decalepis hamiltonii aqueous root extract and purified 2-hydroxy-4-methoxy benzaldehyde on 6-OHDA induced neurotoxicity in Caenorhabditis elegans.

Summary

Scientists investigated the potential for Decalepis hamiltonii to protect against neurotoxicity induced by 6-hydroxy dopamine in Caenorhabditis elegans. They tested two types of extracts, finding the best results with D. hamiltonii Fresh Tuber Extract (DHFE) and D. hamiltonii purified 2H4MB fraction (DHPF). The team observed that both DHFE and DHPF had significant neuroprotective properties against 6-OHDA-induced toxicity, improving mitochondrial function, dopamine content, and antioxidant defence mechanisms. This indicates a potential use for Decalepis hamiltonii in the treatment of neurodegenerative disorders.

Neuroscience
Kamireddy K et al (2018).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2018.06.002
PubMed:
30021395

Modulatory Effects of Decalepis hamiltonii Extract and Its Compounds on the Antioxidant Status of the Aging Rat Brain.

Summary

Researchers examined the potential neuroprotective benefits of Dh root extract on age-related oxidative stress in certain regions of rat brains. They achieved this through experiments on rats and examining significant differences in certain regions of their brains. Findings suggest that Dh root extract has neuroprotective properties that can help reduce the effects of aging on certain parts of the brain.

ImmunologyNeuroscience
Sowbhagya R et al (2017).
J Pharm Bioallied Sci.
DOI:
10.4103/0975-7406.206219
PubMed:
28584487

Biochemical characterization of a key step involved in 2H4MB production in Decalepis hamiltonii.

Kamireddy K et al (2017).
J Plant Physiol.
DOI:
10.1016/j.jplph.2017.04.006
PubMed:
28460278

Antimetastatic pectic polysaccharide from Decalepis hamiltonii; galectin-3 inhibition and immune-modulation.

Venkateshaiah SU et al (2017).
Clin Exp Metastasis.
DOI:
10.1007/s10585-017-9836-z
PubMed:
28160109

Decalepis hamiltonii inhibits tumor progression and metastasis by regulating the inflammatory mediators and nuclear factor κB subunits.

CancerImmunology
Shathish K and Guruvayoorappan C (2014).
Integr Cancer Ther.
DOI:
10.1177/1534735413502075
PubMed:
24013642

Insecticidal activity of the root extract of Decalepis hamiltonii against stored-product insect pests and its application in grain protection.

Rajashekar Y, Gunasekaran N and Shivanandappa T (2010).
J Food Sci Technol.
DOI:
10.1007/s13197-010-0049-6
PubMed:
23572643

Chemoprotective effect of Decalepis hamiltonii against cyclophosphamide induced toxicity.

Shathish K, Reena D and Guruvayoorappan C (2012).
J Exp Ther Oncol.
PubMed:
22545422

Hepatoprotective potential of Decalepis hamiltonii (Wight and Arn) against carbon tetrachloride-induced hepatic damage in rats.

Harish R and Shivanandappa T (2010).
J Pharm Bioallied Sci.
DOI:
10.4103/0975-7406.72137
PubMed:
21180469

Anti inflammatory potential of Decalepis hamiltonii (Wight and Arn) as evidenced by down regulation of pro inflammatory cytokines-TNF-alpha and IL-2.

Immunology
Ashalatha K et al (2010).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2010.04.022
PubMed:
20434534