Delphinium brunonianum

Ethnobotanical Studies

Ladakh, Trans-Himalayan Region, India

Uses: Stem is used to treat skin diseases, Leaves are used against evil spirits, poisoning, epidemic fever, itching, cold, cough, and snakebite.

DOI:: 10.3390/biology10090827
PubMed:: 34571704

Studies

Brunonianines D-F, three new C19-diterpenoid alkaloids from the Delphinium brunonianum, with therapeutic effect on ovarian cancer in vitro and in vivo.

Summary

Researchers isolated novel compounds from Delphinium brunonianum, a traditional Tibetan medicine, that show potent anti-tumor effects on ovarian cancer cells. These compounds offer potential as a natural alternative to chemotherapy with fewer side effects.

Cancer Endocrinology Phytochemistry

Li Q et al (2024).; Bioorg Chem.
DOI:: 10.1016/j.bioorg.2024.107478
PubMed:: 38788366

Cross-cultural ethnobotany of the Baltis and Shinas in the Kharmang district, Trans-Himalaya India-Pakistan border.

Ethnobotany

Hussain B et al (2024).; Heliyon.
DOI:: 10.1016/j.heliyon.2024.e28613
PubMed:: 38586350

Brunonianines A-C, C(20)-diterpenoid alkaloids with cyano group from Delphinium brunonianum Royle.

Summary

Researchers isolated three rare C-diterpenoid alkaloids with a cyano functional group from a plant. One compound showed better inhibitory activity against cancer cells than a current drug. It also arrested cells in the G2/M phase and induced apoptosis by activating a specific signaling pathway.

Phytochemistry

Li Q et al (2024).; Phytochemistry.
DOI:: 10.1016/j.phytochem.2024.113987
PubMed:: 38218306

Protective Effect of Butanolic Fraction of Delphinium brunonianum on Fructose-Mediated Metabolic Alterations in Rats.

Bukhari SNA et al (2022).; Metabolites.
DOI:: 10.3390/metabo12060481
PubMed:: 35736413

Diterpenoid Alkaloids Isolated from Delphinium brunonianum and Their Inhibitory Effects on Hepatocytes Lipid Accumulation.

Phytochemistry

Ma H et al (2022).; Molecules.
DOI:: 10.3390/molecules27072257
PubMed:: 35408656

Integrating metabolomics and network pharmacology to reveal the mechanisms of Delphinium brunonianum extract against nonalcoholic steatohepatitis.

Zhang K et al (2022).; J Ethnopharmacol.
DOI:: 10.1016/j.jep.2022.115268
PubMed:: 35398502

Two Alkaloids From Delphinium brunonianum Royle, Their Anti-inflammatory and Anti-oxidative Stress Activity via NF-κB Signaling Pathway.

Immunology Phytochemistry

Tang Q et al (2022).; Front Nutr.
DOI:: 10.3389/fnut.2021.826957
PubMed:: 35127798

Plant Resources Utilization among Different Ethnic Groups of Ladakh in Trans-Himalayan Region.

Haq SM et al (2021).; Biology (Basel).
DOI:: 10.3390/biology10090827
PubMed:: 34571704

Comparative Assessment of Medicinal Plant Utilization among Balti and Shina Communities in the Periphery of Deosai National Park, Pakistan.

Abbas Z et al (2021).; Biology (Basel).
DOI:: 10.3390/biology10050434
PubMed:: 34068859

10.

Phytochemical analysis and reappraisal of diuretic activity of Delphinium brunonianum Royle and its mode of action in experimental rats.

Phytochemistry

Asif H et al (2020).; Pak J Pharm Sci.
PubMed:: 33612467

11.

Characterization of the complete chloroplast genome of the Musk Larkspur Delphinium brunonianum (Ranunculales: Ranunculaceae).

Genetics

Li Q et al (2020).; Mitochondrial DNA B Resour.
DOI:: 10.1080/23802359.2020.1775522
PubMed:: 33503075

12.

Phytochemical analysis of crude extract of Delphinium brunonianum and its effect on hypertension and metabolic perturbations in fructose fed rats.

Cardiology Phytochemistry

Asif H et al (2021).; Nat Prod Res.
DOI:: 10.1080/14786419.2019.1679134
PubMed:: 31674843

13.

New amide alkaloids from Delphinium brunonianum.

Phytochemistry

Zou YS et al (2019).; Fitoterapia.
DOI:: 10.1016/j.fitote.2019.104186
PubMed:: 31150769