Dendrobium nobile

Ethnobotanical Studies

Studies

Systematic Characterization of Sesquiterpenes from Dendrobium nobile through Offline Two-Dimensional Chromatography Tandem Mass Spectrometry and Target Isolation.

Phytochemistry
Wang HZ et al (2024).
J Agric Food Chem.
DOI:
10.1021/acs.jafc.4c02305
PubMed:
39190823

Dendrobium nobile-derived polysaccharides stimulate the glycolytic pathway by activating SIRT2 to regulate insulin resistance in polycystic ovary syndrome granulosa cells.

Summary

"DNP improved insulin resistance in PCOS rats by enhancing estrous cycle, follicle development, and glycolytic pathway via SIRT2 activation. Potential treatment for PCOS patients."

Endocrinology
Hu R et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.134780
PubMed:
39153683

Genome-wide identification of Ankyrin (ANK) repeat gene families in three Dendrobium species and the expression of ANK genes in D. officinale under gibberellin and abscisic acid treatments.

Genetics
Li L et al (2024).
BMC Plant Biol.
DOI:
10.1186/s12870-024-05461-2
PubMed:
39123107

Integrated metabolomic and transcriptomic analysis reveals variation in the metabolites of Dendrobium officinale, Dendrobium huoshanense, Dendrobium nobile.

Chen L et al (2024).
Phytochem Anal.
DOI:
10.1002/pca.3429
PubMed:
39118423

Colonization by the endophytic fungus Phyllosticta fallopiae combined with the element Si promotes the growth of Dendrobium nobile.

Chen W et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.133343
PubMed:
38925191

Dendrobium nobile active ingredient Dendrobin A against hepatocellular carcinoma via inhibiting nuclear factor kappa-B signaling.

Yu Y et al (2024).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2024.117013
PubMed:
38901205

New natural protein tyrosine phosphatase 1B inhibitors from Gynostemma pentaphyllum.

Wang X et al (2024).
J Enzyme Inhib Med Chem.
DOI:
10.1080/14756366.2024.2360063
PubMed:
38873930

Metabolic and Transcriptomic Profile Revealing the Differential Accumulating Mechanism in Different Parts of Dendrobium nobile.

Zhao R et al (2024).
Int J Mol Sci.
DOI:
10.3390/ijms25105356
PubMed:
38791394

Dendrobium nobile Polysaccharide Attenuates Blue Light-Induced Injury in Retinal Cells and In Vivo in Drosophila.

Hsu WH et al (2024).
Antioxidants (Basel).
DOI:
10.3390/antiox13050603
PubMed:
38790708

Exploring the mechanism of dendrobine in treating metabolic associated fatty liver disease based on network pharmacology and experimental validation.

Li F et al (2024).
Hereditas.
DOI:
10.1186/s41065-024-00322-2
PubMed:
38755697

Chemical characterization and comparative analysis of different parts of Cocculus orbiculatus through UHPLC-Q-TOF-MS.

Wang XR et al (2024).
Anal Methods.
DOI:
10.1039/d3ay02251j
PubMed:
38752456

Structure of Polysaccharide from Dendrobium nobile Lindl. and Its Mode of Action on TLR4 to Exert Immunomodulatory Effects.

Immunology
Li L et al (2024).
Foods.
DOI:
10.3390/foods13091356
PubMed:
38731727

Inhibition of mitochondrial ROS-mediated necroptosis by Dendrobium nobile Lindl. alkaloids in carbon tetrachloride induced acute liver injury.

Summary

DNLA in Dendrobium nobile Lindl. protects liver from CCl-induced damage by reducing oxidative stress and improving mitochondrial function. Signaling pathways need further study. Important for potential liver protective therapies.

Phytochemistry
Xian S et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118253
PubMed:
38679400

Quantitative analysis of six sesquiterpene glycosides from Dendrobium nobile Lindl. under different growth conditions by high-performance liquid chromatography coupled with triple quadrupole tandem mass spectrometry in MRM mode.

Phytochemistry
Gao C et al (2024).
Phytochem Anal.
DOI:
10.1002/pca.3356
PubMed:
38659238

First Report of Brown Leaf Rot Disease on Dendrobium nobile Caused by Xylaria flabelliformis in Guizhou Province, China.

Sarsaiya S et al (2024).
Plant Dis.
DOI:
10.1094/PDIS-08-23-1701-PDN
PubMed:
38587802

Effects of the epiphytic patterns on endophytes and metabolites of Dendrobium nobile Lindl.

Yu C et al (2024).
Front Plant Sci.
DOI:
10.3389/fpls.2024.1326998
PubMed:
38550286

Mechanism of Dendrobium Nobile Polysaccharide Inhibition of Ferroptosis in Rats with Spinal Cord Injury.

Huang J et al (2024).
J Integr Neurosci.
DOI:
10.31083/j.jin2303065
PubMed:
38538216

Metabolites rapid-annotation in mice by comprehensive method of virtual polygons and Kendric mass loss filtering: A case study of Dendrobium nobile Lindl.

Wu X et al (2024).
J Pharm Biomed Anal.
DOI:
10.1016/j.jpba.2024.116106
PubMed:
38492511

Construction of in vitro liver-on-a-chip models and application progress.

Review
Liu J et al (2024).
Biomed Eng Online.
DOI:
10.1186/s12938-024-01226-y
PubMed:
38491482

Bibenzyl-phenylpropane Hybrids with Immunosuppressive Activities from Dendrobium nobile Lindl.

Wang QT et al (2024).
Chem Biodivers.
DOI:
10.1002/cbdv.202400283
PubMed:
38485665

Isolation and characterization of Paenibacillus peoriae JC-3jx from Dendrobium nobile.

Li Z et al (2024).
Biotechniques.
DOI:
10.2144/btn-2023-0083
PubMed:
38469872

Dendrobium Nobile Alcohol Extract Extends the Lifespan of Caenorhabditis elegans via hsf-1 and daf-16.

Li L et al (2024).
Molecules.
DOI:
10.3390/molecules29040908
PubMed:
38398658

Genome-wide identification and characterization of TCP gene family in Dendrobium nobile and their role in perianth development.

Genetics
Wei X et al (2024).
Front Plant Sci.
DOI:
10.3389/fpls.2024.1352119
PubMed:
38375086

Enhancing dendrobine production in Dendrobium nobile through mono-culturing of endophytic fungi, Trichoderma longibrachiatum (MD33) in a temporary immersion bioreactor system.

Sarsaiya S et al (2024).
Front Plant Sci.
DOI:
10.3389/fpls.2024.1302817
PubMed:
38348269

Hypoglycemic Effects and Quality Marker Screening of Dendrobium nobile Lindl. at Different Growth Years.

Summary

The researchers compared the effects of Lindl. cultivated at year 1 and year 3 on hyperglycemic syndrome in mice. They found that Lindl. from year 1 had a better effect and identified alkaloids as potential quality markers for treating hyperglycemic syndrome.

Diabetes
Luo Y et al (2024).
Molecules.
DOI:
10.3390/molecules29030699
PubMed:
38338442

Dendrobine: A neuroprotective Sesquiterpenic Alkaloid for the Prevention and Treatment of Diseases: A Review.

Summary

Dendrobine, a compound extracted from Dendrobium nobile Lindl, has neuroprotective effects and potential in treating cognitive disorders, anxiety, depression, Alzheimer's disease, Parkinson's disease, and inflammation. It activates neuro synapses and neurotransmission pathways.

NeurosciencePhytochemistry
Bhardwaj K et al (2024).
Mini Rev Med Chem.
DOI:
10.2174/0113895575274314240125105120
PubMed:
38321903

Genome-Wide Identification of R2R3-MYB Family Genes and Their Response to Stress in Dendrobium nobile.

Genetics
Wu L et al (2024).
Front Biosci (Landmark Ed).
DOI:
10.31083/j.fbl2901001
PubMed:
38287794

PPARα is one of the key targets for dendrobine to improve hepatic steatosis in NAFLD.

Xu Y et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117684
PubMed:
38171466

Age-dependent dendrobine biosynthesis in Dendrobium nobile: insights into endophytic fungal interactions.

Zhao Y et al (2023).
Front Microbiol.
DOI:
10.3389/fmicb.2023.1294402
PubMed:
38149273

Dendrobium nobile Lindl. alkaloid decreases Tau hyperphosphorylation via regulating PI3K/Akt/GSK-3β pathway in vitro and in vivo.

Phytochemistry
Huang J et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117592
PubMed:
38097026

The Integration of the Metabolome and Transcriptome for Dendrobium nobile Lindl. in Response to Methyl Jasmonate.

Genetics
Gong D et al (2023).
Molecules.
DOI:
10.3390/molecules28237892
PubMed:
38067620

Gibberellic Acid Inhibits Dendrobium nobile-Piriformospora Symbiosis by Regulating the Expression of Cell Wall Metabolism Genes.

Genetics
Chen H et al (2023).
Biomolecules.
DOI:
10.3390/biom13111649
PubMed:
38002331

Dendrobium nobile Lindl ameliorates learning and memory deficits in scopolamine-treated mice.

Zhang Q et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117416
PubMed:
37981114

New dammarane-type triterpenoids from hydrolyzate of total Gynostemma pentaphyllum saponins with protein tyrosine phosphatase 1B inhibitory activity.

Summary

Researchers found that nine dammarane triterpenoids have significant inhibitory activity on protein tyrosine phosphatase 1B, indicating their potential as treatments for type 2 diabetes.

Phytochemistry
Tan D et al (2023).
J Enzyme Inhib Med Chem.
DOI:
10.1080/14756366.2023.2281263
PubMed:
37965892

Reducing myocardial infarction by combination of irisin and Dendrobium nobile Lindl through inhibiting nod-like receptor protein-3-related pyroptosis and activating PINK1/Parkin-mitophagy during aging.

Summary

Irisin/Dendrobium nobile Lindl combination therapy protects against myocardial IR injury in aged rats by suppressing pyroptosis and enhancing mitophagy. This therapy improves cardiac function, decreases LDH and cTn-I levels, and reduces inflammation. Further studies needed for potential use in aging-related heart disease.

Cardiology
Ding C and Zhang C (2023).
Chin J Physiol.
DOI:
10.4103/cjop.CJOP-D-23-00032
PubMed:
37929346

Species of associated bryophytes and their effects on the yield and quality of Dendrobium nobile.

Li M et al (2023).
BMC Plant Biol.
DOI:
10.1186/s12870-023-04503-5
PubMed:
37880597

Heat Stress Alleviation by Exogenous Calcium in the Orchid Dendrobium nobile Lindl: A Biochemical and Transcriptomic Analysis.

Fan Y et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms241914692
PubMed:
37834139

A signal R3-type, CAPRICE-like MYB transcription factor from Dendrobium nobile controls trichome and root-hair development in Arabidopsis.

Xu W et al (2023).
Plant Sci.
DOI:
10.1016/j.plantsci.2023.111878
PubMed:
37777017

Involvement of the Sch9/Rim15/Msn2 signaling pathway in the anti-aging activity of dendrobine from Dendrobium nobile Lindl. via modification of oxidative stress and autophagy.

Immunology
Wu E et al (2023).
Chin Med.
DOI:
10.1186/s13020-023-00827-4
PubMed:
37670345

Multi‑omics‑based analysis of the regulatory mechanism of gypenosides on bile acids in hypercholesterolemic mice.

Feng C et al (2023).
Exp Ther Med.
DOI:
10.3892/etm.2023.12136
PubMed:
37614436

Transcriptome analysis reveals the role of polysaccharide biosynthesis in the detoxification of Dendrobium nobile under zinc stress.

Genetics
Fan Y et al (2023).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2023.126406
PubMed:
37598828

Therapeutic potential of the chemical composition of Dendrobium nobile Lindl.

Review
Fan C et al (2023).
Front Pharmacol.
DOI:
10.3389/fphar.2023.1163830
PubMed:
37497110

Dendrobium nobile Lindl Polysaccharides Attenuate UVB-induced Photodamage by Regulating Oxidative Stress, Inflammation and MMPs Expression in Mice Model.

Immunology
Long Y et al (2023).
Photochem Photobiol.
DOI:
10.1111/php.13780
PubMed:
36651803

Dendrobium nobile Lindl. Polysaccharides protect fibroblasts against UVA-induced photoaging via JNK/c-Jun/MMPs pathway.

Li W et al (2022).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2022.115590
PubMed:
35973631

Chromosome-Scale Assembly of the Dendrobium nobile Genome Provides Insights Into the Molecular Mechanism of the Biosynthesis of the Medicinal Active Ingredient of Dendrobium.

Genetics
Xu Q et al (2022).
Front Genet.
DOI:
10.3389/fgene.2022.844622
PubMed:
35299950

Anti-aging properties of Dendrobium nobile Lindl.: From molecular mechanisms to potential treatments.

Review
Nie X et al (2020).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2020.112839
PubMed:
32268205