Dichroa febrifuga

Ethnobotanical Studies

Studies

Dichroa febrifuga Lour.: A review of its botany, traditional use, phytochemistry, pharmacological activities, toxicology, and progress in reducing toxicity.

Summary

Scientists studied the toxic plant Dichroa febrifuga Lour., often used in traditional Chinese medicine as a treatment for malaria and parasitic diseases. Results may provide insights for future drug development.

Review Phytochemistry
Wang M et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118093
PubMed:
38537842

Inhibition of IL-17 signaling in macrophages underlies the anti-arthritic effects of halofuginone hydrobromide: Network pharmacology, molecular docking, and experimental validation.

Summary

HF, derived from Chinese herb, shows promise in treating RA with anti-inflammatory effects. Further research needed to understand how HF works to benefit RA patients.

ArthritisImmunology
Zhu J et al (2024).
BMC Complement Med Ther.
DOI:
10.1186/s12906-024-04397-2
PubMed:
38413973

Design, Synthesis and Antitumor Activity of FAK/PLK1 Dual Inhibitors with Quinazolinone as the Skeleton.

Cancer
Sun J et al (2023).
Chem Biodivers.
DOI:
10.1002/cbdv.202300146
PubMed:
36919922

First Report of Top Blight of Cunninghamia lanceolata Caused by Diaporthe unshiuensis and Diaporthe hongkongensis in China.

Liao YC et al (2022).
Plant Dis.
DOI:
10.1094/PDIS-06-22-1467-PDN
PubMed:
35876759

Halofuginone Sensitizes Lung Cancer Organoids to Cisplatin via Suppressing PI3K/AKT and MAPK Signaling Pathways.

Cancer
Li H et al (2021).
Front Cell Dev Biol.
DOI:
10.3389/fcell.2021.773048
PubMed:
34901018

Preparative separation of two isomeric antimalaria alkaloids febrifugine and isofebrifugine from Dichroa febrifuga roots by countercurrent chromatography.

Phytochemistry
Sheng LQ and Ma JL (2021).
J Sep Sci.
DOI:
10.1002/jssc.202001257
PubMed:
33811736

In vitro effects of febrifugine on Schistosoma mansoni adult worms.

Mitsui Y, Miura M and Kato K (2020).
Trop Med Health.
DOI:
10.1186/s41182-020-00230-x
PubMed:
32518498

Involvement of eIF2α in halofuginone-driven inhibition of TGF-β1-induced EMT.

Duan M et al (2020).
J Biosci.
DOI:
pii: 71
PubMed:
32457283

Synergistic effect of halofuginone and dexamethasone on LPS‑induced acute lung injury in type II alveolar epithelial cells and a rat model.

Du HL, Zhai AD and Yu H (2020).
Mol Med Rep.
DOI:
10.3892/mmr.2019.10865
PubMed:
31974595

Chemical synthesis of febrifugine and analogues.

Review
Smullen S, McLaughlin NP and Evans P (2018).
Bioorg Med Chem.
DOI:
10.1016/j.bmc.2018.04.027
PubMed:
29681487

[Simultaneous determination of febrifugine and isofebrifugine in Dichroa febrifuga root by HPLC method].

Zhang JY et al (2017).
Zhongguo Zhong Yao Za Zhi.
DOI:
10.19540/j.cnki.cjcmm.20170224.017
PubMed:
29082694

Anticoccidial activity of traditional Chinese herbal Dichroa febrifuga Lour. extract against Eimeria tenella infection in chickens.

Zhang DF et al (2012).
Parasitol Res.
DOI:
10.1007/s00436-012-3071-y
PubMed:
22898876

Dichroa febrifuga Lour. inhibits the production of IL-1beta and IL-6 through blocking NF-kappaB, MAPK and Akt activation in macrophages.

Immunology
Park SY et al (2009).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2009.07.003
PubMed:
19607899

Alkaloids of Dichroa febrifuga Lour.

Phytochemistry
KUEHL FA Jr, SPENCER CF and FOLKERS K (1948).
J Am Chem Soc.
PubMed:
18863804