Dioscorea bulbifera

Common Names: air potato, bitter yam, air yam

Ethnobotanical Studies

Studies

Exploring the genetic diversity and population structure of aerial yams (Dioscorea bulbifera L.) DArT-seq and agronomic traits.

Ekaette E et al (2024).
PLoS One.
DOI:
10.1371/journal.pone.0306631
PubMed:
39178185

Chemopreventive effect of modified zeng-sheng-ping on oral squamous cell carcinoma by regulating tumor associated macrophages through targeting tnf alpha induced protein 6.

Summary

Researchers developed a modified anti-cancer drug, ZSP-M, based on Zeng-Sheng-Ping, with high efficacy and low toxicity for oral cancer. They aim to understand its pharmacodynamic material basis and its effect on tumor-associated macrophages. This could lead to potentially effective treatments for oral squamous cell carcinoma.

CancerImmunology
Wang J et al (2024).
BMC Complement Med Ther.
DOI:
10.1186/s12906-024-04593-0
PubMed:
39068492

The anti-non-small cell lung cancer effect of Diosbulbin B: Targeting YY1 induced cell cycle arrest and apoptosis.

Summary

Scientists studied Diosbulbin B (DIOB) from Dioscorea bulbifera L. as a potential anti-cancer drug. DIOB shows promise in treating non-small cell lung cancer (NSCLC) at safe doses, but further research is needed.

Cancer
Zhao JQ et al (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2024.155734
PubMed:
38761775

Antibacterial activity of Dioscorea bulbifera Linn. extract and its active component flavanthrinin against skin-associated bacteria.

Sanguansermsri D et al (2024).
BMC Complement Med Ther.
DOI:
10.1186/s12906-024-04480-8
PubMed:
38698382

Low-coverage whole genome sequencing of diverse Dioscorea bulbifera accessions for plastome resource development, polymorphic nuclear SSR identification, and phylogenetic analyses.

Genetics
Lu R et al (2024).
Front Plant Sci.
DOI:
10.3389/fpls.2024.1373297
PubMed:
38510439

Anti-papillary thyroid carcinoma effects of dioscorea bulbifera L. through ferroptosis and the PI3K/AKT pathway based on network pharmacology and experimental validation.

Summary

Study examines DBL effects on PTC. DBL, a Chinese medicine, shows potential for treating thyroid cancer. Research could lead to new, effective therapies.

Endocrinology
Gao Y et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.117912
PubMed:
38387682

DbGTi: Thermostable trypsin inhibitor from Dioscorea bulbifera L. ground tubers: assessment of antioxidant and antibacterial properties and cytotoxicity evaluation using zebrafish model.

Immunology
Jegadheeshwari S et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.130244
PubMed:
38387638

Yams (Dioscorea spp.) in shellmounds and swiddens: ancient history in Babitonga Bay, Santa Catarina State, southern Brazil.

da Silva Souza DA, da Bandeira DR and Peroni N (2024).
J Ethnobiol Ethnomed.
DOI:
10.1186/s13002-024-00653-4
PubMed:
38308263

Biological Activities and Nanoparticle Synthesis of Dioscorea bulbifera and its Mechanistic Action - An Extensive Review.

Yadav SA et al (2024).
Pharm Nanotechnol.
DOI:
10.2174/0122117385284106240110065809
PubMed:
38265372

Thermal Properties and Dynamic Rheological Characterization of Dioscorea Starch Gels.

Otegbayo BO et al (2024).
Gels.
DOI:
10.3390/gels10010051
PubMed:
38247774

SP-Max- A Herbomineral Formulation Attenuates Busulfan-Induced Oligospermia in Mice by Preventing Loss of Reproductive Hormones.

Laddha AP, Joshi S and Kulkarni YA (2023).
Reprod Toxicol.
DOI:
10.1016/j.reprotox.2023.108525
PubMed:
38123000

Diosbulbin C, a novel active ingredient in Dioscorea bulbifera L. extract, inhibits lung cancer cell proliferation by inducing G0/G1 phase cell cycle arrest.

Summary

Scientists discovered that diosbulbin C, a natural compound found in traditional Chinese medicine, has strong anti-cancer properties against non-small cell lung cancer. This finding is important for developing new therapeutic interventions for the disease.

Cancer
Zhu Z et al (2023).
BMC Complement Med Ther.
DOI:
10.1186/s12906-023-04245-9
PubMed:
38049779

Investigation of the principle of concoction by using the processing excipient Glycyrrhiza uralensis Fisch. juice to reduce the hepatotoxicity of Dioscorea bulbifera L. and enhance its main efficacy as expectorant and cough suppressant.

Song L et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117372
PubMed:
37913830

Glycyrrhizin protects against diosbulbin B-induced hepatotoxicity by inhibiting the metabolic activation of diosbulbin B.

Yang B et al (2023).
J Biochem Mol Toxicol.
DOI:
10.1002/jbt.23549
PubMed:
37794747

Integrating network pharmacology and experimental studies for uncovering the molecular mechanisms of Dioscorea bulbifera L. in the treatment of thyroid cancer.

Summary

HYZ, a traditional Chinese medicine, shows promise in treating thyroid cancer by improving symptoms and reducing tumor volume. However, the exact mechanism of HYZ's action is still unknown.

CancerEndocrinology
Liu Z et al (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e18886
PubMed:
37600377

Attraction of the Air Potato Leaf Beetle, Lilioceris Cheni, (Coleoptera: Chrysomelidae) to leaf Volatiles of the Air Potato, Dioscorea bulbifera.

Griesheimer JL et al (2023).
J Chem Ecol.
DOI:
10.1007/s10886-023-01436-z
PubMed:
37278905

Glycyrrhetinic acid ameliorates diosbulbin B-induced hepatotoxicity in mice by modulating metabolic activation of diosbulbin B.

Lin D et al (2023).
J Appl Toxicol.
DOI:
10.1002/jat.4450
PubMed:
36807597

Expression of concern: Protective role of air potato (Dioscorea bulbifera) of yam family in myocardial ischemic reperfusion injury.

Cardiology
Ross P et al (2022).
Food Funct.
DOI:
10.1039/d2fo90065c
PubMed:
36018292

Pennogenin-3-O-α-L-Rhamnopyranosyl-(1→2)-[α-L-Rhamnopyranosyl-(1→3)]-β-D-Glucopyranoside (Spiroconazol A) Isolated from Dioscorea bulbifera L. var. sativa Induces Autophagic Cell Death by p38 MAPK Activation in NSCLC Cells.

Ki YS et al (2022).
Pharmaceuticals (Basel).
DOI:
10.3390/ph15070893
PubMed:
35890190

Asparagine and Glutamine Residues Participate in Protein Covalent Binding by Epoxide Metabolite of 8-Epidiosbulbin E Acetate In Vitro and In Vivo.

Zhang N et al (2022).
Chem Res Toxicol.
DOI:
10.1021/acs.chemrestox.2c00130
PubMed:
35839447

Development of an efficient micropropagation system for Dioscorea bulbifera L. and phytochemical profile of regenerated plants.

Phytochemistry
Bhat MH et al (2022).
J Genet Eng Biotechnol.
DOI:
10.1186/s43141-022-00382-9
PubMed:
35838925

Formulation and Optimal Design of Dioscorea bulbifera and Honey-Loaded Gantrez(®)/Xyloglucan Hydrogel as Wound Healing Patches.

Eakwaropas P et al (2022).
Pharmaceutics.
DOI:
10.3390/pharmaceutics14061302
PubMed:
35745874

Evidence for adduction of biologic amines with reactive metabolite of 8-epidiosbulbin E acetate in vitro and in vivo.

Zhang N et al (2022).
Toxicol Lett.
DOI:
10.1016/j.toxlet.2022.05.008
PubMed:
35680040

Diosbulbin B: An important component responsible for hepatotoxicity and protein covalent binding induced by Dioscorea bulbifera L.

Tan R et al (2022).
Phytomedicine.
DOI:
10.1016/j.phymed.2022.154174
PubMed:
35660353

Development of a mechanism-based biomarker for Dioscorea bulbifera L. exposure and hepatotoxicity in rats.

Hu Z et al (2022).
Phytomedicine.
DOI:
10.1016/j.phymed.2022.154172
PubMed:
35609388

NMR-based metabolomic approach to understanding Zeng-Sheng-Ping-induced hepatotoxicity, and identifying possible toxic constituents by LC-MS profiles.

Phytochemistry
Wu Y et al (2022).
J Pharm Biomed Anal.
DOI:
10.1016/j.jpba.2022.114833
PubMed:
35594777

Isolation, modification and characterisation of cellulose from wild Dioscorea bulbifera.

Ogunjobi JK and Balogun OM (2021).
Sci Rep.
DOI:
10.1038/s41598-020-78533-6
PubMed:
33441616

Dioscorea bulbifera L.-induced hepatotoxicity and involvement of metabolic activation of furanoterpenoids.

Review
Li H, Peng Y and Zheng J (2020).
Drug Metab Rev.
DOI:
10.1080/03602532.2020.1800724
PubMed:
32757959

Dioscorea bulbifera induced apoptosis through inhibition of ERK 1/2 and activation of JNK signaling pathways in HCT116 human colorectal carcinoma cells.

Ahmad Hidayat AF et al (2018).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2018.05.073
PubMed:
29860114

Study of the hepatotoxicity induced by Dioscorea bulbifera L. rhizome in mice.

Wang J et al (2010).
Biosci Trends.
PubMed:
20448345