Common Names: Japanese persimmon
Polysaccharide from PLE0 leaves inhibits colon cancer metastasis by reducing cell migration and invasion, suppressing N-cadherin and vimentin expression, upregulating E-cadherin, and inhibiting MMP-2/9 through GSK3β/β-catenin and JNK signaling pathways. This research may lead to potential treatments for colon cancer.
Scientists identified and quantified 75 phenolic compounds in persimmon, showing neuroprotective effects against oxidative stress and neuroinflammation. Fruit extract showed strongest activity, informing targeted selection and development of persimmon for potential health benefits.
The study explores the antioxidant properties of compounds found in the leaves of [unknown plant]. These compounds have the potential to prevent oxidative stress-related diseases, inhibit prostate cancer cell proliferation, and induce apoptosis. This review provides a reference for the development of natural anti-oxidative stress drugs.
Diospyros kaki L.f. leaf extract contains a potent flavonoid compound (9) that reduces brain injury, improves impairments, preserves blood-brain barrier, and suppresses oxidative stress, suggesting its potential for treating ischemic-induced brain damage.
Immature persimmons contain Hederagenin, Ursolic acid, and Quercetin dehydrate, which inhibit α-amylase and α-glucosidase enzymes, reducing hyperglycemia. They have potential for treating diabetes mellitus.
In this study, researchers found that immature persimmon extract (DKE) reduced weight gain and fat tissue in obese mice on a high-fat diet. It also improved lipid levels in the blood, gene expression in the liver, and inhibited enzymes related to fat synthesis. This suggests that DKE can help with obesity by modulating lipid metabolism.