Diospyros lotus

Common Names: date plum

Ethnobotanical Studies

Studies

Diospyros lotus leaf extract and its main component myricitrin inhibit itch‑related IL‑6 and IL‑31 by suppressing microglial inflammation and microglial‑mediated astrocyte activation.

Summary

Researchers investigated the effects of a plant extract and its component on itch-related processes in the central nervous system. They found that the extract and component suppressed itch-related cytokines in microglia, potentially offering relief for pruritus.

ImmunologyNeuroscience
Shin JY et al (2024).
Mol Med Rep.
DOI:
10.3892/mmr.2024.13303
PubMed:
39129303

Muscle relaxant and antipyretic effects of pentacyclic triterpenes isolated from the roots of Diospyros lotus L.

Khan A et al (2024).
Heliyon.
DOI:
10.1016/j.heliyon.2024.e30547
PubMed:
38726163

Osteogenic Effects of the Diospyros lotus L. Leaf Extract on MC3T3-E1 Pre-Osteoblasts and Ovariectomized Mice via BMP2/4 and TGF β Pathways.

Hong S et al (2024).
Nutrients.
DOI:
10.3390/nu16081247
PubMed:
38674937

The evolution history of an allotetraploid mangrove tree analysed with a new tool Allo4D.

Wang Y et al (2023).
Plant Biotechnol J.
DOI:
10.1111/pbi.14281
PubMed:
38157253

Ongoing Rapid Evolution of a Post-Y Region Revealed by Chromosome-Scale Genome Assembly of a Hexaploid Monoecious Persimmon (Diospyros kaki).

Genetics
Horiuchi A et al (2023).
Mol Biol Evol.
DOI:
10.1093/molbev/msad151
PubMed:
37414545

Conflicting selection pressures on seed size and germination caused by carnivorous seed dispersers.

Cui J et al (2023).
Integr Zool.
DOI:
10.1111/1749-4877.12743
PubMed:
37394984

Diospyros lotus leaf extract and its main component myricitrin regulate pruritus through the inhibition of astrocyte activation.

Summary

The study focuses on the potential use of the plant extract and its main component, myricetin, in alleviating histamine-independent pruritus (itching). By evaluating the effects on signal transducer and activator of transcription 3 (STAT3) activation, glial fibrillary acidic protein (GFAP) expression, and lipocalin-2 (LCN2) production in astrocytes, as well as scratching behavior, mast cell infiltration, and IL-6 levels in mice, the researchers found that the extract and myricetin inhibited STAT3 activation, GFAP expression, and LCN2 release in astrocytes. Moreover, they also ameliorated scratching behavior and other allergic responses in mice. These findings suggest that the plant extract and myricetin could be potential therapeutic agents for the treatment of pruritus.

Neuroscience
Shin JY et al (2023).
Exp Ther Med.
DOI:
10.3892/etm.2023.12022
PubMed:
37346401

Nutritional and mineral analysis of the ultimate wild food plants of Lotkuh, Chitral, the Eastern Hindukush Pakistan.

Ullah H and Badshah L (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e14449
PubMed:
36950657

Rapid Characterization and Action Mechanism of the Antidiabetic Effect of Diospyros lotus L Using UHPLC-Q-Exactive Orbitrap MS and Network Pharmacology.

Diabetes
Qin S et al (2022).
J Anal Methods Chem.
DOI:
10.1155/2022/8000126
PubMed:
36624749

Cloning and expression analysis of SERK1 gene in Diospyros lotus.

Zhou R et al (2022).
Open Life Sci.
DOI:
10.1515/biol-2022-0490
PubMed:
36249531

The antioxidant system response to drought-stressed Diospyros lotus treated with exogenous melatonin.

Zhang P et al (2022).
PeerJ.
DOI:
10.7717/peerj.13936
PubMed:
36157056

Drying date plum (Diospyros lotus L.) fruit: Assessing rehydration properties, antioxidant activity, and phenolic compounds.

Phytochemistry
Hassan AMA et al (2022).
J Food Sci.
DOI:
10.1111/1750-3841.16322
PubMed:
36112569

[Water repellent characteristics of physical and biological crusts and their effects on water infiltration].

Zhong XY et al (2022).
Ying Yong Sheng Tai Xue Bao.
DOI:
10.13287/j.1001-9332.202207.013
PubMed:
36052787

Integrated Metabolomic-Transcriptomic Analysis Reveals Diverse Resource of Functional Ingredients From Persimmon Leaves of Different Varieties.

Yu XM et al (2022).
Front Plant Sci.
DOI:
10.3389/fpls.2022.904208
PubMed:
35693179

Population Analysis of Diospyros lotus in the Northwestern Caucasus Based on Leaf Morphology and Multilocus DNA Markers.

Genetics
Samarina LS et al (2022).
Int J Mol Sci.
DOI:
10.3390/ijms23042192
PubMed:
35216308

Sedative-hypnotic effect and in silico study of dinaphthodiospyrols isolated from Diospyros lotus Linn.

Al-Awthan YS et al (2021).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2021.111745
PubMed:
34020246

Protective effect of fermented Diospyros lotus L. extracts against the high glucose-induced apoptosis of MIN6 cells.

Yin H et al (2021).
J Food Biochem.
DOI:
10.1111/jfbc.13685
PubMed:
33682148

Antioxidant and hypoglycemic effects of Diospyros lotus fruit fermented with Microbacterium flavum and Lactobacillus plantarum.

Diabetes
Zhang ZP et al (2018).
J Biosci Bioeng.
DOI:
10.1016/j.jbiosc.2018.01.005
PubMed:
29395958