Diplazium esculentum

Common Names: vegetable fern

Ethnobotanical Studies

Studies

Box-Behnken Design-Based Optimization of Phytochemical Extraction from Diplazium esculentum (Retz.) Sw. Associated with Its Antioxidant and Anti-Alzheimer's Properties.

Summary

Researchers optimized extraction of a fern extract for Alzheimer's disease treatment. It showed high BACE-1 inhibition, antioxidant properties, and synergy with AD drug, improving brain function in a fly model. The extract contains beneficial phytochemicals.

ImmunologyNeurosciencePhytochemistry
Kongsung S et al (2024).
Molecules.
DOI:
10.3390/molecules29102204
PubMed:
38792065

Enhancing Therapeutic Efficacy of Donepezil, an Alzheimer's Disease Drug, by Diplazium esculentum (Retz.) Sw. and Its Phytochemicals.

Summary

The edible fern extract showed synergistic effects with donepezil against key enzymes in Alzheimer's disease pathogenesis, improving eye phenotypes in a model of AD without genotoxic effects. This combination therapy may reduce adverse side effects of AD drugs.

Neuroscience
Inthachat W et al (2024).
Pharmaceuticals (Basel).
DOI:
10.3390/ph17030341
PubMed:
38543127

The traditional utilization, biological activity and chemical composition of edible fern species.

Review
Dvorakova M et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.117818
PubMed:
38296173

Phytochemical profiling and biological activities of Diplazium esculentum (Retz.) Sw.: an edible vegetable fern.

Review Phytochemistry
Raina K et al (2023).
Drug Metab Pers Ther.
DOI:
10.1515/dmpt-2023-0035
PubMed:
37535427

Nutritional Profiles of Four Promising Wild Edible Plants Commonly Consumed by the Semai in Malaysia.

Tharmabalan RT et al (2023).
Curr Dev Nutr.
DOI:
10.1016/j.cdnut.2023.100054
PubMed:
37304850

Experimental investigation of modified indirect solar dryer with integrated thermal storage material for drying of dhekia (Diplazium esculentum) fern.

Saikia D et al (2023).
Environ Sci Pollut Res Int.
DOI:
10.1007/s11356-023-25310-3
PubMed:
36656481

Steroids from Diplazium esculentum: Antiplasmodial activity and molecular docking studies to investigate their binding modes.

Safar HF et al (2022).
Trop Biomed.
DOI:
10.47665/tb.39.4.011
PubMed:
36602215

Antioxidant Potential of Selected Wild Edible Leafy Vegetables of Sikkim Himalayan Region: Effects of Cooking Methods and Gastrointestinal Digestion on Activity.

Immunology
Sharma S et al (2022).
Front Nutr.
DOI:
10.3389/fnut.2022.861347
PubMed:
35529464

Impact of Drying Processes on Phenolics and In Vitro Health-Related Activities of Indigenous Plants in Thailand.

Sirichai P et al (2022).
Plants (Basel).
DOI:
10.3390/plants11030294
PubMed:
35161275

Diplazium esculentum (Retz.) Sw. reduces BACE-1 activities and amyloid peptides accumulation in Drosophila models of Alzheimer's disease.

Neuroscience
Kunkeaw T et al (2021).
Sci Rep.
DOI:
10.1038/s41598-021-03142-w
PubMed:
34893659

Toxicological assessment of Diplazium esculentum on the reproductive functions of male Swiss albino mouse.

Roy S and Chaudhuri TK (2017).
Drug Chem Toxicol.
DOI:
10.1080/01480545.2016.1190739
PubMed:
27308970

In vitro assessment of anticholinesterase and NADH oxidase inhibitory activities of an edible fern, Diplazium esculentum.

Roy S, Dutta S and Chaudhuri TK (2015).
J Basic Clin Physiol Pharmacol.
DOI:
10.1515/jbcpp-2014-0100
PubMed:
25719308

Assessment of the immunosuppressive and hemolytic activities of an edible fern, Diplazium esculentum.

Roy S et al (2013).
Immunopharmacol Immunotoxicol.
DOI:
10.3109/08923973.2013.775588
PubMed:
23672523