Dipsacus asper

Ethnobotanical Studies

Studies

[Material basis of kidney Yang deficiency rats before and after salt processing of Dipsacus asper based on spectrum-effect relationship].

Fang KE et al (2024).
Zhongguo Zhong Yao Za Zhi.
DOI:
10.19540/j.cnki.cjcmm.20240325.302
PubMed:
39041083

Dipsacoside B ameliorates cognitive impairment in sepsis-associated encephalopathy by reducing Th17 cell infiltration and neuroinflammation.

Summary

Study showed Dipsacoside B (DB) from Chuan Xu Duan plant alleviates cognitive decline in sepsis-associated encephalopathy (SAE) mice by reducing blood-brain barrier impairment and Th17 cell infiltration. Potential treatment for SAE-related cognitive deficits.

Neuroscience
Peng S et al (2024).
Biochem Pharmacol.
DOI:
10.1016/j.bcp.2024.116428
PubMed:
39009096

An exploratory metabolomic study reveals the Dipsacus asper-Achyranthes bidentate herb pair against osteoarthritis by modulating imbalance in polyunsaturated fatty acids and energy metabolism.

Hu C et al (2024).
J Pharm Biomed Anal.
DOI:
10.1016/j.jpba.2024.116196
PubMed:
38723559

A novel strategy for the multi-components division and discovering pharmacodynamic material basis of Chinese herbal compounds: A case study of Xian-Ling-Gu-Bao capsule.

Guan Y et al (2024).
J Pharm Biomed Anal.
DOI:
10.1016/j.jpba.2024.116112
PubMed:
38513502

Analysis of Quality Differences in Radix Dipsaci before and after Processing with Salt Based on Quantitative Control of HPLC Multi-Indicator Components Combined with Chemometrics.

Wu H et al (2024).
Int J Anal Chem.
DOI:
10.1155/2024/2109127
PubMed:
38357676

Akebia saponin D attenuates allergic airway inflammation through AMPK activation.

Summary

Akebia saponin D (ASD), extracted from Dipsacus asper Wall, inhibits inflammation in lung cells and mice through AMPK activation, suggesting ASD as a potential treatment for allergic airway inflammation.

ImmunologyPhytochemistry
Xuan L et al (2024).
J Nat Med.
DOI:
10.1007/s11418-023-01762-2
PubMed:
38175326

Unraveling the potential mechanisms of the anti-osteoporotic effects of the Achyranthes bidentata-Dipsacus asper herb pair: a network pharmacology and experimental study.

Li T et al (2023).
Front Pharmacol.
DOI:
10.3389/fphar.2023.1242194
PubMed:
37849727

Asperosaponin VI protects alcohol-induced hepatic steatosis and injury via regulating lipid metabolism and ER stress.

Wei L et al (2023).
Phytomedicine.
DOI:
10.1016/j.phymed.2023.155080
PubMed:
37757711

Metabolomic and microbiomic insights into color changes during the sweating process in Dipsacus asper.

He H et al (2023).
Front Microbiol.
DOI:
10.3389/fmicb.2023.1195088
PubMed:
37711689

Akebia saponin D from Dipsacus asper wall. Ex C.B. Clarke ameliorates skeletal muscle insulin resistance through activation of IGF1R/AMPK signaling pathway.

Summary

Dipsacus asper is a popular herb in Traditional Chinese Medicine for improving musculoskeletal health. Akebia saponin D, derived from this herb, has potential benefits for osteoporosis, liver protection, and heart health.

Phytochemistry
Shu Y et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117049
PubMed:
37591362

Potential Therapeutic Mechanism of Radix Angelicae Biseratae and Dipsaci Radix Herb Pair against Osteoarthritis: Based on Network Pharmacology and Molecular Docking.

Xi Y et al (2023).
Evid Based Complement Alternat Med.
DOI:
10.1155/2023/2140327
PubMed:
37089716

Research on the effect of Dipsaci Radix before and after salt-processed on kidney yang deficiency syndrome rats and the preliminary mechanism study through the BMP-Smad signaling pathway.

Du W et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116480
PubMed:
37061069

Exploring active ingredients of anti-osteoarthritis in raw and wine-processed Dipsaci Radix based on spectrum-effect relationship combined with chemometrics.

Arthritis
Lv Y et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116281
PubMed:
36828196

Comparative analysis of anti-osteoporosis efficacy in Radix Dipsaci before and after processing with salt based on spectrum-effect relationship.

Wu H et al (2022).
J Pharm Biomed Anal.
DOI:
10.1016/j.jpba.2022.115078
PubMed:
36183633

Protective effect of Du-Zhong-Wan against osteoporotic fracture by targeting the osteoblastogenesis and angiogenesis couple factor SLIT3.

Genetics
Tian S et al (2022).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2022.115399
PubMed:
35649495

Safety Evaluation of Natural Drugs in Chronic Skeletal Disorders: A Literature Review of Clinical Trials in the Past 20 years.

Review
Zhou D et al (2022).
Front Pharmacol.
DOI:
10.3389/fphar.2021.801287
PubMed:
35095508

Polycaprolactone/Polyethylene Glycol Blended with Dipsacus asper Wall Extract Nanofibers Promote Osteogenic Differentiation of Periodontal Ligament Stem Cells.

Huang TY et al (2021).
Polymers (Basel).
DOI:
10.3390/polym13142245
PubMed:
34301001

In the presence of TGF-β1, Asperosaponin VI promotes human mesenchymal stem cell differentiation into nucleus pulposus like- cells.

Phytochemistry
Niu YT et al (2021).
BMC Complement Med Ther.
DOI:
10.1186/s12906-020-03169-y
PubMed:
33446173

Traditional uses, processing methods, phytochemistry, pharmacology and quality control of Dipsacus asper Wall. ex C.B. Clarke: A review.

Review Phytochemistry
Tao Y, Chen L and Yan J (2020).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2020.112912
PubMed:
32348843

Protective effects of Dipsacus asper polysaccharide on osteoporosis in vivo by regulating RANKL/RANK/OPG/VEGF and PI3K/Akt/eNOS pathway.

Sun X et al (2019).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2019.02.022
PubMed:
30735778

Authentication of Herbal Medicines Dipsacus asper and Phlomoides umbrosa Using DNA Barcodes, Chloroplast Genome, and Sequence Characterized Amplified Region (SCAR) Marker.

Genetics
Park I et al (2018).
Molecules.
DOI:
10.3390/molecules23071748
PubMed:
30018232

Integrating UHPLC-MS/MS quantification and DAS analysis to investigate the effects of wine-processing on the tissue distributions of bioactive constituents of herbs in rats: Exemplarily shown for Dipsacus asper.

Tao Y et al (2017).
J Chromatogr B Analyt Technol Biomed Life Sci.
DOI:
10.1016/j.jchromb.2017.04.035
PubMed:
28467948

[Study of anti-aging effect and its mechanism of total saponins of Wu-He Dipsacus asper on skin of mouse-aging model].

Phytochemistry
Wan QY and Song LJ (2015).
Zhongguo Ying Yong Sheng Li Xue Za Zhi.
PubMed:
26248427

[Study on identification of wild Dipsacus asper and cultivated Dipsacus asper at different growth years by organization structure].

Yang J et al (2012).
Zhong Yao Cai.
PubMed:
23705356

The herbal medicine Dipsacus asper wall extract reduces the cognitive deficits and overexpression of beta-amyloid protein induced by aluminum exposure.

Summary

In this study, researchers tested the potential for an herbal extract called Dipsacus asper to protect against cognitive impairment caused by chronic exposure to aluminum chloride in rats. The animals showed significant declines in memory and increases in beta-amyloid protein, a hallmark of Alzheimer's disease, after 90 days of exposure to aluminum chloride. Treatment with Dipsacus asper or vitamin E for up to five months improved the rats' performance on memory tasks and reduced the levels of beta-amyloid in their brains. The researchers suggest that Dipsacus asper may have therapeutic benefits for Alzheimer's disease.

Neuroscience
Zhang ZJ et al (2003).
Life Sci.
PubMed:
12954453