Dracocephalum heterophyllum

Ethnobotanical Studies

Studies

The Isolation and Preparation of Samwinol from Dracocephalum heterophyllum and Prevention on Aβ(25-35)-Induced Neuroinflammation in PC-12 Cells.

Summary

Scientists obtained samwinol from traditional Chinese Tibetan medicine by chromatography separation and investigated its effects on protecting cells against neurotoxicity caused by amyloid beta protein fragment. The results showed that samwinol increased cell viability, inhibited the production of reactive oxygen species, and suppressed ERK/AKT phosphorylation while promoting Nrf2/HO-1 signaling. Samwinol has significant anti-neuroinflammatory and antioxidant activities, suggesting its potential use for treating Alzheimer's disease. Further studies are needed to confirm its efficacy.

ImmunologyNeuroscience
Li C et al (2022).
Int J Mol Sci.
DOI:
10.3390/ijms231911572
PubMed:
36232874

Integrated chromatographic approach for the discovery of gingerol antioxidants from Dracocephalum heterophyllum and their potential targets.

Dang J et al (2022).
Anal Methods.
DOI:
10.1039/d2ay01282k
PubMed:
36226573

Preparative isolation of antioxidative furanocoumarins from Dracocephalum heterophyllum and their potential action target.

Lv Y et al (2022).
J Sep Sci.
DOI:
10.1002/jssc.202200309
PubMed:
36222230

Dracocephalum heterophyllum (DH) Exhibits Potent Anti-Proliferative Effects on Autoreactive CD4(+) T Cells and Ameliorates the Development of Experimental Autoimmune Uveitis.

CancerImmunology
Bian J et al (2020).
Front Immunol.
DOI:
10.3389/fimmu.2020.575669
PubMed:
33117376

The Effects of Dracocephalum Heterophyllum Benth Flavonoid on Hypertrophic Cardiomyocytes Induced by Angiotensin II in Rats.

Summary

Researchers studied the effect of Dracocephalum heterophyllum Benth flavonoid (DHBF), a traditional medicine used to treat various disorders, on cardiomyocyte hypertrophy in cultured cells. Neonatal rat cardiomyocytes were cultured and hypertrophy was induced using angiotensin II (Ang II). Ang II treatment reduced cell viability and increased the expression of cardiac hypertrophy genes. DHBF treatment reversed these effects in a concentration-dependent manner and may be related to the release of nitric oxide and regulation of intracellular calcium concentration. This study demonstrates the potential of DHBF in treating cardiomyocyte hypertrophy.

COVID-19Cardiology
Jiang H, Zhang C and He W (2018).
Med Sci Monit.
DOI:
10.12659/MSM.908912
PubMed:
30199522

Preparative isolation of antioxidative compounds from Dracocephalum heterophyllum using off-line two-dimensional reversed-phase liquid chromatography/hydrophilic interaction chromatography guided by on-line HPLC-DPPH assay.

Phytochemistry
Dang J et al (2018).
J Chromatogr B Analyt Technol Biomed Life Sci.
DOI:
10.1016/j.jchromb.2018.08.005
PubMed:
30121456

Anti-hepatitis, antioxidant activities and bioactive compounds of Dracocephalum heterophyllum extracts.

Shi QQ et al (2016).
Bot Stud.
DOI:
10.1186/s40529-016-0133-y
PubMed:
28597426

Protective Effects of Dracocephalum heterophyllum in ConA-Induced Acute Hepatitis.

Zheng W et al (2016).
Mediators Inflamm.
DOI:
10.1155/2016/2684321
PubMed:
27524863