Common Names: Mexican tea
Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer that lacks response to hormone therapy. There is a need for targeted molecular therapy for TNBC. The PI3K/AKT/mTOR signaling pathway plays a crucial role in TNBC, and AKT is a promising therapeutic target. In this study, researchers screened 25 compounds from a traditional herbal recipe for their anticancer properties. They found two compounds, cynaroside and epicatechin gallate, to be potent inhibitors of AKT 1 and 2 isoforms. These compounds demonstrate drug-like properties and show structural stability. Computational modeling suggests they could be effective drug candidates for TNBC, but further research is needed for clinical application.