Ecballium elaterium

Common Names: squirting cucumber, exploding cucumber

Ethnobotanical Studies

Studies

Cucurbitacin E shows synergistic effect with sorafenib by inducing apoptosis in hepatocellular carcinoma cells and regulates Jak/Stat3, ERK/MAPK, PI3K/Akt/mTOR signaling pathways.

Immunology
Mehdi Üremiş M, Üremiş N and Türköz Y (2023).
Steroids.
DOI:
10.1016/j.steroids.2023.109261
PubMed:
37355001

Tomato Leaf Curl New Delhi Virus Spain Strain Is Not Transmitted by Trialeurodes vaporariorum and Is Inefficiently Transmitted by Bemisia tabaci Mediterranean between Zucchini and the Wild Cucurbit Ecballium elaterium.

Farina A et al (2023).
Insects.
DOI:
10.3390/insects14040384
PubMed:
37103199

Okadaic Acid-Induced Alzheimer's in Rat Brain: Phytochemical Cucurbitacin E Contributes to Memory Gain by Reducing TAU Protein Accumulation.

Summary

Phytochemical cucurbitacin E (CuE) may be a promising drug discovery treatment in Alzheimer's disease (AD). This study investigated CuE's effects on TAU fibril formation in okadaic acid-induced AD in rats. Results suggest that CuE contributes to memory gain by reducing TAU protein accumulation. Further evaluations in future preclinical and clinical studies are warranted.

NeurosciencePhytochemistry
Yılmaz ŞG et al (2023).
OMICS.
DOI:
10.1089/omi.2022.0175
PubMed:
36594931

Effect of Leaf Trichomes in Different Species of Cucurbitaceae on Attachment Ability of the Melon Ladybird Beetle Chnootriba elaterii.

Saitta V et al (2022).
Insects.
DOI:
10.3390/insects13121123
PubMed:
36555032

Inhibitory effect of phenolic extract from squirting cucumber (Ecballium elaterium (L.) A. Rich) seed oil on integrin-mediated cell adhesion, migration and angiogenesis.

GeneticsPhytochemistry
Touihri-Barakati I et al (2022).
RSC Adv.
DOI:
10.1039/d2ra02593k
PubMed:
36380921

The Determination of Molecular and Toxicological Mechanisms of Cucurbitacine E in Model Organism Drosophila melanogaster and Various Cancer Cell Lines: Molecular modelling, docking and dynamic simulation studies.

Cancer
Tunçbilek AŞ, Azarkan SY and Ercan FS (2022).
Curr Comput Aided Drug Des.
DOI:
10.2174/1573409919666221031112223
PubMed:
36321227

Detection of Ecballium elaterium in hedgerow olive orchards using a low-cost uncrewed aerial vehicle and open-source algorithms.

Torres-Sánchez J et al (2023).
Pest Manag Sci.
DOI:
10.1002/ps.7233
PubMed:
36223137

Genetic Differentiation and Migration Fluxes of Viruses from Melon Crops and Crop Edge Weeds.

Maachi A et al (2022).
J Virol.
DOI:
10.1128/jvi.00421-22
PubMed:
35924924

Cucurbitacin I exhibits anticancer efficacy through induction of apoptosis and modulation of JAK/STAT3, MAPK/ERK, and AKT/mTOR signaling pathways in HepG2 cell line.

Immunology
Üremiş N et al (2022).
J Food Biochem.
DOI:
10.1111/jfbc.14333
PubMed:
35866877

Ecballium elaterium improved stimulatory effects of tissue-resident NK cells and ameliorated liver fibrosis in a thioacetamide mice model.

Ghanim M et al (2022).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2022.112942
PubMed:
35429743

Ecballium elaterium attenuates neuroinflammation in an animal model of Alzheimer's disease through modulation of nuclear factor κB pathway.

Summary

This study evaluated the potential of a Mediterranean plant as a treatment for Alzheimer's disease by testing its anti-inflammatory properties in rats with AD symptoms. They found that the plant had positive effects on both biochemical markers and behavior in the rats. Additionally, the researchers investigated the plant's impact on the NF-κB pathway, which is responsible for inflammation, and found that the plant could potentially reduce inflammation in individuals with AD.

ImmunologyNeuroscience
Heysieattalab S and Sadeghi L (2022).
Avicenna J Phytomed.
DOI:
10.22038/AJP.2021.18881
PubMed:
35145898

Study of Aqueous Ecballium Elaterium as Fibrinolytic in The Rabbit Model of Intrapleural Empyema.

Sahin A et al (2021).
Niger J Clin Pract.
DOI:
10.4103/njcp.njcp_360_20
PubMed:
34531345

Histopathologic evaluation of Ecballium elaterium applied to nasal mucosa in a rat rhinosinusitis model.

Eti CM et al (2018).
Ear Nose Throat J.
PubMed:
30036418

Ecballium Elaterium for Gastrointestinal Cancer.

Cancer
Mazokopakis EE et al (2018).
Asian Pac J Cancer Prev.
PubMed:
29579786

Effects of Ecballium elaterium on brain in a rat model of sepsis-associated encephalopathy.

Summary

Researchers studied the effects of Ecballium elaterium (EE) on sepsis-associated encephalopathy (SAE), a major clinical challenge in intensive care units. They induced SAE in 30 rats with cecal ligation and puncture (CLP), then divided them into three groups: control, sepsis, and treatment. The treatment group received 2.5 mg/kg of EE. After 24 hours, the brain tissue was analyzed for levels of cytokines, antioxidants, and inflammation. The treatment group showed a statistically significant reduction in brain tissue levels of proinflammatory cytokines and a decrease in histopathologic changes associated with SAE. EE contains components that may help protect against SAE by reducing inflammation.

Neuroscience
Arslan D et al (2017).
Libyan J Med.
DOI:
10.1080/19932820.2017.1369834
PubMed:
28859554

Intra-peritoneal administration of Ecballium elaterium diminishes postoperative adhesions.

Okur MH et al (2014).
Acta Cir Bras.
PubMed:
25317995

Effect of ethanolic extract of Ecballium elaterium against Staphylococcus aureus and Candida albicans.

Adwan G, Salameh Y and Adwan K (2011).
Asian Pac J Trop Biomed.
DOI:
10.1016/S2221-1691(11)60100-7
PubMed:
23569813