Elephantopus scaber

Ethnobotanical Studies

Studies

Synergistic modulation of proinflammatory mediators and cytokines in lipopolysaccharide-activated RAW 264.7 macrophages: The therapeutic potential of Elephantopus scaber and Sauropus androgynus ethanol extract.

Summary

Combining ES and SA extracts showed potential anti-inflammatory effects on LPS-activated macrophage cells. This may lead to new treatments for inflammatory conditions.

Immunology
Djati MS et al (2024).
Vet World.
DOI:
10.14202/vetworld.2024.728-734
PubMed:
38680152

Elephantopus scaber L. Polysaccharides Alleviate Heat Stress-Induced Systemic Inflammation in Mice via Modulation of Characteristic Gut Microbiota and Metabolites.

GastroenterologyImmunology
Wang C et al (2024).
Nutrients.
DOI:
10.3390/nu16020262
PubMed:
38257155

Ethyl caffeate combined with fluconazole exhibits efficacy against azole-resistant oropharyngeal candidiasis via the EFGR/JNK/c-JUN signaling pathway.

Wang T et al (2023).
Med Mycol.
DOI:
10.1093/mmy/myad114
PubMed:
37947257

Structurally diverse terpenoids from Elephantopus scaber L. and their acetylcholinesterase inhibitory activities.

Summary

Researchers isolated three new compounds, elephantopuscabers A-C, and a known compound spirowallichiione from Elephantopus scaber L. Their structures were determined using extensive analysis techniques. Elephantopuscaber B and C showed potential as acetylcholinesterase inhibitors. Molecular docking predicted the binding sites.

Neuroscience
Li JY et al (2023).
Phytochemistry.
DOI:
10.1016/j.phytochem.2023.113892
PubMed:
37813132

[Prediction and analysis of Q-markers of Elephantopus scaber based on its UPLC fingerprint, content determination of components, and in vitro a nti-tumor activity].

Summary

This study analyzed Elephantopus scaber using UPLC to determine its quality markers and identified 13 major components. The main components showed strong anti-cancer activity against lung cancer cells, making them potential quality markers for E. scaber.

Cancer
Jia CC et al (2023).
Zhongguo Zhong Yao Za Zhi.
DOI:
10.19540/j.cnki.cjcmm.20230526.201
PubMed:
37802868

The medicinal plant used in the Guangxi Fangcheng Golden Camellias national nature reserve, a coastal region in southern China.

Hu R et al (2023).
J Ethnobiol Ethnomed.
DOI:
10.1186/s13002-023-00605-4
PubMed:
37501198

Anticancer activity of gold nanobioconjugates synthesized from Elephantopus scaber (linn.) leaf extract.

Summary

Researchers studied the potential of synthesized nanoscale particles made from plant extracts as a possible anti-cancer agent, offering a safer alternative to current treatments.

Cancer
Shinde AS and Mendhulkar VD (2023).
J Cancer Res Ther.
DOI:
10.4103/jcrt.JCRT_1043_20
PubMed:
37147946

The combination of Elephantopus scaber and Phaleria macrocarpa leaves extract promotes anticancer activity via downregulation of ER-α, Nrf2 and PI3K/AKT/mTOR pathway.

Cancer
Christina YI et al (2022).
J Ayurveda Integr Med.
DOI:
10.1016/j.jaim.2022.100674
PubMed:
36502785

Scabertopin Derived from Elephantopus scaber L. Mediates Necroptosis by Inducing Reactive Oxygen Species Production in Bladder Cancer In Vitro.

Cancer
Gao Y et al (2022).
Cancers (Basel).
DOI:
10.3390/cancers14235976
PubMed:
36497458

Deoxyelephantopin, a germacrane-type sesquiterpene lactone from Elephantopus scaber, induces mitochondrial apoptosis of hepatocarcinoma cells by targeting Hsp90α in vitro and in vivo.

Phytochemistry
Chen JJ et al (2023).
Phytother Res.
DOI:
10.1002/ptr.7654
PubMed:
36420857

Deoxyelephantopin alleviates lipopolysaccharide-induced septic lung injury through inhibiting NF-ĸB/STAT3 axis.

Immunology
Wang S and Chen Y (2022).
Allergol Immunopathol (Madr).
DOI:
10.15586/aei.v50i5.626
PubMed:
36086962

Chemical structures and anti-tyrosinase activity of the constituents from Elephantopus scaber L.

Xu W et al (2022).
Fitoterapia.
DOI:
10.1016/j.fitote.2022.105259
PubMed:
35931288

Deoxyelephantopin Suppresses Pancreatic Cancer Progression In Vitro and In Vivo by Targeting linc00511/miR-370-5p/p21 Promoter Axis.

Cancer
Ji D et al (2022).
J Oncol.
DOI:
10.1155/2022/3855462
PubMed:
35794978

Effects of Elephantopus scaber extract on growth, proximate composition, immunity, intestinal microbiota and resistance of the GIFT strain of Nile tilapia Oreochromis niloticus to Streptococcus agalactiae.

Gastroenterology
Xu JR et al (2022).
Fish Shellfish Immunol.
DOI:
10.1016/j.fsi.2022.06.032
PubMed:
35752371

Synergistic Cytotoxicity between Elephantopus scaber and Tamoxifen on MCF-7-Derived Multicellular Tumor Spheroid.

Cancer
Ho WY et al (2021).
Evid Based Complement Alternat Med.
DOI:
10.1155/2021/6355236
PubMed:
34712346

Deoxyelephantopin Induces Reactive Oxygen Species-Mediated Apoptosis and Autophagy in Human Osteosarcoma Cells.

Zou J et al (2017).
Cell Physiol Biochem.
DOI:
10.1159/000479537
PubMed:
28750364

A review on pharmacology and toxicology of Elephantopus scaber Linn.

Review
Hiradeve SM and Rangari VD (2014).
Nat Prod Res.
DOI:
10.1080/14786419.2014.883394
PubMed:
24499355