Eleutherococcus senticosus

Common Names: Siberian ginseng

Ethnobotanical Studies

Studies

Vigeo Promotes Myotube Differentiation and Protects Dexamethasone-Induced Skeletal Muscle Atrophy via Regulating the Protein Degradation, AKT/mTOR, and AMPK/Sirt-1/PGC1α Signaling Pathway In Vitro and In Vivo.

Cheon YH et al (2024).
Nutrients.
PubMed:
39203823

Predicting the impact of climate change and land use change on the potential distribution of two economic forest trees in Northeastern China.

Lin X et al (2024).
Front Plant Sci.
PubMed:
39070907

An improved Trizol method for extracting total RNA from Eleutherococcus senticosus (Rupr. & Maxim.) Maxim leaves.

Xiao S et al (2024).
Phytochem Anal.
PubMed:
38952075

Quantitative analysis of anthocyanins and flavonoids in purple and green leaves of Eleutherococcus senticosus by UPLC-MS/MS techniques.

Summary

Researchers used UPLC-MS/MS to quantify anthocyanins and flavonoids in purple and green leaves of Ulmus pumila. Purple leaves had higher anthocyanin and flavonoid levels, with cyanidin-3galactoside and delphinidin as main compounds. Findings are important for potential health benefits of these plants.

Hua M et al (2024).
Nat Prod Res.
PubMed:
38847179

Identification of Eleutherococcus senticosus NAC transcription factors and their mechanisms in mediating DNA methylation of EsFPS, EsSS, and EsSE promoters to regulate saponin synthesis.

Dong J et al (2024).
BMC Genomics.
PubMed:
38816704

State-of-the-Art Review on Botanical Hybrid Preparations in Phytomedicine and Phytotherapy Research: Background and Perspectives.

Review
Panossian A, Lemerond T and Efferth T (2024).
Pharmaceuticals (Basel).
PubMed:
38675443

Vigeo attenuates cartilage and bone destruction in a collagen‑induced arthritis mouse model by reducing production of pro‑inflammatory cytokines.

Cheon YH et al (2024).
Exp Ther Med.
PubMed:
38590570

DNA methylation regulates the secondary metabolism of saponins to improve the adaptability of Eleutherococcus senticosus during drought stress.

Summary

Researchers investigated drought stress effects on plant growth and secondary metabolite synthesis, focusing on DNA methylation changes in Eleutherococcus senticosus. Results highlighted DNA demethylation's role in gene expression and saponin synthesis for plant adaptation to drought stress.

Wang S et al (2024).
BMC Genomics.
PubMed:
38565995

Comprehensive analysis of Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. fruits based on UPLC-MS/MS and GC-MS: A rapid qualitative analysis.

Chang Y et al (2023).
Food Sci Nutr.
PubMed:
38455163

Anti-Neuroinflammatory Effects of Adaptogens: A Mini-Review.

Summary

Adaptogens are plants that help the body adapt to stress and promote resilience. They have anti-inflammatory effects and may improve conditions in central nervous system disorders. Research aims to understand their benefits on neuroinflammation.

Wróbel-Biedrawa D and Podolak I (2024).
Molecules.
PubMed:
38398618

Integrating serum pharmacochemistry and network pharmacology to explore the molecular mechanisms of Acanthopanax senticosus (Rupr. & Maxim.) Harms on attenuating doxorubicin-induced myocardial injury.

Summary

Acanthopanax, or Siberian ginseng, may help reduce the cardiotoxicity of chemotherapeutic drug doxorubicin, potentially enhancing its anticancer effects. This could lead to safer and more effective cancer treatments.

Zhang X et al (2024).
J Ethnopharmacol.
PubMed:
38380572

The Eleutherococcus senticosus fruits' intractum affects changes in the transepithelial electric potential in the distal section of the rabbit's large intestine and inhibits hyaluronidase.

Graczyk F et al (2024).
J Ethnopharmacol.
PubMed:
38307357

Plant-Derived Extracts Plus Vitamin E and/or Aloe Vera Protect Against Intrinsic/Extrinsic Stressor in Human Skin: In Vitro and Clinical Evidence.

Diwakar G et al (2023).
Front Biosci (Landmark Ed).
PubMed:
38179774

Harder, better, faster, stronger? Retrospective chart review of adverse events of interactions between adaptogens and antidepressant drugs.

Summary

This study evaluated the prevalence and characteristics of adverse events associated with adaptogen-antidepressant interactions. Adaptogens were involved in 9% of adverse events. Clinicians should monitor these interactions due to the potential for clinically significant adverse events.

Siwek M et al (2023).
Front Pharmacol.
PubMed:
37829299

Efficacy of Kan Jang(®) in Patients with Mild COVID-19: A Randomized, Quadruple-Blind, Placebo-Controlled Trial.

Summary

Kan Jang reduced severe cases and virus detection in mild COVID-19 patients. Improved symptoms and reduced inflammatory markers. Effective treatment for mild/moderate cases.

Ratiani L et al (2023).
Pharmaceuticals (Basel).
PubMed:
37765004

Identification of the AP2/ERF transcription factor family of Eleutherococcus senticosus and its expression correlation with drought stress.

Jiao MY et al (2023).
3 Biotech.
PubMed:
37405267

Nootropic Herbs, Shrubs, and Trees as Potential Cognitive Enhancers.

Summary

Plant-based nootropics are natural drugs that can improve cognitive abilities through various mechanisms. They enhance erythrocyte plasticity, inhibit aggregation, and possess antioxidant activity that protects brain tissue from neurotoxicity. They induce the synthesis of neuronal proteins, nucleic acids, and phospholipids for constructing and repairing neurohormonal membranes. The study provides brief descriptions of representative species, their chemical composition, uses, dosages, and contraindications. These plant nootropics have potential therapeutic benefits for treating cognitive disorders, but must be taken at optimal doses for extended periods, and their psychoactive properties are produced by a synergistic combination of several compounds.

Malík M and Tlustoš P (2023).
Plants (Basel).
PubMed:
36987052

Screening of anti-fatigue active ingredients of Eleutherococcus senticosus via spectrum-effect relationship based on factor analysis and LC-MS/MS.

Cheng J et al (2023).
Nat Prod Res.
PubMed:
36718097

Pharmacological effects of Eleutherococcus senticosus on the neurological disorders.

Review
Li XT et al (2022).
Phytother Res.
PubMed:
35844057

Plant Adaptogens-History and Future Perspectives.

Meta-Analysis
Todorova V et al (2021).
Nutrients.
PubMed:
34445021

Chromosomal-scale genome assembly of Eleutherococcus senticosus provides insights into chromosome evolution in Araliaceae.

Yang Z et al (2021).
Mol Ecol Resour.
PubMed:
33891787

The Chemical Characterization of Eleutherococcus senticosus and Ci-wu-jia Tea using UHPLC-UV-QTOF/MS.

Wang YH et al (2019).
Int J Mol Sci.
PubMed:
30678313

Eleuthero.

Review
(2021).
PubMed:
30000865

Acanthopanax senticosus: Photochemistry and Anticancer Potential.

Review Cancer
Li T et al (2016).
Am J Chin Med.
PubMed:
27852123

Assessment of the effects of eleutherococcus senticosus on endurance performance.

Review
Goulet ED and Dionne IJ (2005).
Int J Sport Nutr Exerc Metab.
PubMed:
15902991

Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. (Araliaceae) as an adaptogen: a closer look.

Review
Davydov M and Krikorian AD (2000).
J Ethnopharmacol.
PubMed:
10996277