Erigeron breviscapus

Ethnobotanical Studies

Studies

Scutellarin ameliorates mitochondrial dysfunction and apoptosis in OGD/R-insulted HT22 cells through mitophagy induction.

Yang L et al (2024).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2024.117340
PubMed:
39191025

Scutellarin inhibits inflammatory PANoptosis by diminishing mitochondrial ROS generation and blocking PANoptosome formation.

Immunology
Yuan T et al (2024).
Int Immunopharmacol.
DOI:
10.1016/j.intimp.2024.112710
PubMed:
39029229

Traceability Research on Geographic Erigeron breviscapus Based on High-Resolution Mass Spectrometry and Chemometric Analysis.

Zhang J et al (2024).
Molecules.
DOI:
10.3390/molecules29122930
PubMed:
38930993

Scutellarein Suppresses the Production of ROS and Inflammatory Mediators of LPS-Activated Bronchial Epithelial Cells and Attenuates Acute Lung Injury in Mice.

Immunology
Li X et al (2024).
Antioxidants (Basel).
DOI:
10.3390/antiox13060710
PubMed:
38929149

Research progress on anti-tumor mechanisms of scutellarin.

Summary

Scutellarin, a flavonoid, shows promising anti-tumor effects by inhibiting growth/metastasis, inducing apoptosis/autophagy, and enhancing sensitivity to chemotherapy. Further research can explore its potential in cancer treatment.

Review Cancer
Ge HC and Zhong XH (2024).
J Asian Nat Prod Res.
DOI:
10.1080/10286020.2024.2362375
PubMed:
38910315

Investigation of the efficacy of Dengzhan Shengmai capsule against heart failure with preserved ejection fraction.

Summary

Chinese medicine DZSMC may treat HFpEF effectively. Research on its mechanism is growing. Potential safe and effective treatment worth exploring further for high mortality condition.

Cardiology
Kang Z et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118419
PubMed:
38838924

Breviscapine ameliorates autophagy by activating the JAK2/STAT5/BCL2 pathway in a transient cerebral ischemia rat model.

Summary

Breviscapine (Bre) from Erigeron breviscapus reduces ischemic brain damage by decreasing excessive autophagy. Activating JAK2/STAT5/BCL2 pathway improves neural recovery. Potential therapy for cerebral ischemia.

CardiologyImmunology
Cun Y et al (2024).
J Neuropathol Exp Neurol.
DOI:
10.1093/jnen/nlae045
PubMed:
38804899

Scutellarein alleviates osteoarthritis progression through the PI3K/Akt/NF-kappaB signaling pathway: In vitro and in vivo studies.

Ye Z et al (2024).
Phytother Res.
DOI:
10.1002/ptr.8232
PubMed:
38695125

Scutellarin ameliorates diabetic nephropathy via TGF-β1 signaling pathway.

Summary

Scutellarin from breviscapine improves diabetic nephropathy by reducing proteinuria, glomerular expansion, and renal fibrosis. Works through TGF-β1, Erk, and Wnt/β-catenin pathways. Important for treating DN.

Diabetes
Huang B et al (2024).
Nat Prod Bioprospect.
DOI:
10.1007/s13659-024-00446-y
PubMed:
38656633

Exploring the neuroprotection of the combination of astragaloside A, chlorogenic acid and scutellarin in treating chronic cerebral ischemia via network analysis and experimental validation.

Summary

The combination of Astragalus and Salvia extracts can help improve cognitive function and neurological impairments in chronic cerebral ischemia by activating the PI3K/AKT pathway, offering potential as a therapeutic medication.

Cardiology
Cheng F et al (2024).
Heliyon.
DOI:
10.1016/j.heliyon.2024.e29162
PubMed:
38655299

Anti-Inflammatory, Analgesic, Functional Improvement, and Chondroprotective Effects of Erigeron breviscapus (Vant.) Hand.-Mazz. Extract in Osteoarthritis: An In Vivo and In Vitro Study.

Summary

East Asian herbal medicine EB shows potential as a treatment for osteoarthritis by reducing inflammation and pain, and inhibiting cartilage destruction. Further research is needed to confirm its efficacy.

ImmunologyPain
Jo HG et al (2024).
Nutrients.
DOI:
10.3390/nu16071035
PubMed:
38613068

Development of a stable genetic transformation system in Erigeron breviscapus: a case study with EbYUC2 in relation to leaf number and flowering time.

Zhu Q et al (2024).
Planta.
DOI:
10.1007/s00425-024-04351-z
PubMed:
38522041

Pharmacodynamics and mechanism of Erigeron breviscapus granules in the treatment of ischemic stroke in mice by regulating sphingolipid metabolism based on metabolomics.

Summary

They studied how Erigeron breviscapus (EB) granules treat ischemic stroke (IS) by examining its metabolic effects. Understanding the mechanism can lead to better treatment options for IS.

CardiologyNeuroscience
Liu C et al (2024).
J Pharm Biomed Anal.
DOI:
10.1016/j.jpba.2024.116058
PubMed:
38422673

Preparation, Characterization, and Evaluation of Mesoporous Silica Nanoparticles in Enhancing Oral Bioavailability of Poorly Water-Soluble Drugs.

Zhang H et al (2024).
Curr Drug Deliv.
DOI:
10.2174/0115672018273792240101062603
PubMed:
38310438

A sport supplement candidate of Erigeron breviscapus extract regulates lipogenesis in vitro and in vivo.

Kim K et al (2023).
Phys Act Nutr.
DOI:
10.20463/pan.2023.0039
PubMed:
38297478

Effects of scutellarin on the mechanism of cardiovascular diseases: a review.

Summary

Researchers studied scutellarin, a compound found in a plant, for its potential to treat heart diseases. Finding safe and effective treatments for cardiovascular diseases is crucial due to their increasing prevalence and risks of side effects from current medications.

Review Cardiology
Zhang X et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2023.1329969
PubMed:
38259289

Scutellarin alleviates tensile stress-induced proliferation and migration of venous smooth muscle cells via mediating the p38 MAPK pathway.

Immunology
Zhang H et al (2024).
Tissue Cell.
DOI:
10.1016/j.tice.2024.102300
PubMed:
38211409

Scutellarin Alleviates Ovalbumin-Induced Airway Remodeling in Mice and TGF-β-Induced Pro-fibrotic Phenotype in Human Bronchial Epithelial Cells via MAPK and Smad2/3 Signaling Pathways.

Immunology
Li M et al (2024).
Inflammation.
DOI:
10.1007/s10753-023-01947-7
PubMed:
38168709

Corrigendum to "Study on the anti-mitochondrial apoptosis mechanism of Erigeron breviscapus injection based on UPLC-Q-TOF-MS metabolomics and molecular docking in rats with cerebral ischemia-reperfusion injury" [J. Ethnopharmacol. 319 (Part 2) (2024) 117310].

Cardiology
Zhang J et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117596
PubMed:
38141517

Scutellarin alleviates liver injury in type 2 diabetic mellitus by suppressing hepatocyte apoptosis in vitro and in vivo.

Diabetes
Fan X et al (2023).
Chin Herb Med.
DOI:
10.1016/j.chmed.2023.03.007
PubMed:
38094008

Study on the anti-mitochondrial apoptosis mechanism of Erigeron breviscapus injection based on UPLC-Q-TOF-MS metabolomics and molecular docking in rats with cerebral ischemia-reperfusion injury.

Cardiology
Zhang J et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117310
PubMed:
37827296

Induction of RIPK3/MLKL-mediated necroptosis by Erigeron breviscapus injection exhibits potent antitumor effect.

Cancer
Guo X et al (2023).
Front Pharmacol.
DOI:
10.3389/fphar.2023.1219362
PubMed:
37397499

Caffeoylquinic acids protect against alcoholic liver injury and rare C(10) acetylenic acids from Erigeron breviscapus.

Hou X et al (2024).
Nat Prod Res.
DOI:
10.1080/14786419.2023.2201886
PubMed:
37070421

Dengzhan Xixin injection derived from a traditional Chinese herb Erigeron breviscapus ameliorates cerebral ischemia/reperfusion injury in rats via modulation of mitophagy and mitochondrial apoptosis.

Cardiology
Yang L et al (2022).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2022.114988
PubMed:
35032588

Complete Chloroplast Genome Sequence of Erigeron breviscapus and Characterization of Chloroplast Regulatory Elements.

Genetics
Yu Y et al (2021).
Front Plant Sci.
DOI:
10.3389/fpls.2021.758290
PubMed:
34899783

Breviscapine alleviates NASH by inhibiting TGF-β-activated kinase 1-dependent signaling.

Lan T et al (2022).
Hepatology.
DOI:
10.1002/hep.32221
PubMed:
34717002

PK-PD Correlation of Erigeron Breviscapus Injection in the Treatment of Cerebral Ischemia-Reperfusion Injury Model Rats.

Cardiology
Liu G et al (2021).
J Mol Neurosci.
DOI:
10.1007/s12031-020-01651-3
PubMed:
32757108

Systematic investigation of the Erigeron breviscapus mechanism for treating cerebrovascular disease.

Wang J et al (2018).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2018.05.022
PubMed:
29783016