Fallopia multiflora

Common Names: tuber fleeceflower

Ethnobotanical Studies

Studies

Evaluating the anticancer potential of Polygonum multiflorum root-derived stilbenes against H2452 malignant pleural mesothelioma cells.

Cancer
Ngo TH et al (2024).
Fitoterapia.
DOI:
10.1016/j.fitote.2024.106135
PubMed:
39047845

[Widely targeted metabolomics reveals differential metabolites between root tuber and leaf of Fallopia multiflora].

Wang J, Zhao YJ and Peng HS (2024).
Zhongguo Zhong Yao Za Zhi.
DOI:
10.19540/j.cnki.cjcmm.20240414.101
PubMed:
39041120

Research progress on hepatotoxicity mechanism of polygonum multiflorum and its main components.

Review
Gong L et al (2024).
Toxicon.
DOI:
10.1016/j.toxicon.2024.108040
PubMed:
39038664

HLA-B*35:01-mediated activation of emodin-specific T cells contributes to Polygonum multiflorum thunb. -induced liver injury in mice.

Zeng X et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118523
PubMed:
38969149

Study on the differential hepatotoxicity of raw polygonum multiflorum and polygonum multiflorum praeparata and its mechanism.

Huang C et al (2024).
BMC Complement Med Ther.
DOI:
10.1186/s12906-024-04463-9
PubMed:
38632548

[A case of the syndrome of disappearing intrahepatic bile ducts caused by Polygonum multiflorum].

Guan SB, Zhang WT and Guo H (2024).
Zhonghua Gan Zang Bing Za Zhi.
DOI:
10.3760/cma.j.cn501113-20231203-00260
PubMed:
38584108

Alleviation of Glucocorticoid-Induced Osteoporosis in Rats by Ethanolic Reynoutria multiflora (Thunb.) Moldenke Extract.

Arthritis
Liu Y et al (2024).
J Med Food.
DOI:
10.1089/jmf.2023.K.0105
PubMed:
38442325

2,3,5,4'- tetrahydroxystilbene-2-O-β-D- glucopyranoside (TSG)-Driven immune response in the hepatotoxicity of Polygonum multiflorum.

Liu W et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.117865
PubMed:
38369066

Mechanistic study of the anti-excitatory amino acid toxicity of Bushen Zhichan decoction for Parkinson's disease based on the transcriptional regulation of EAAT1 by YY1.

Summary

Bushen Zhichan decoction (BSZCF) is a traditional Chinese herbal formula derived from Liuwei Dihuang Pill. It is used to treat Parkinson's disease by nourishing and tonifying the liver and kidneys. More research is needed to understand how it works.

Neuroscience
Liu L, Tian X and Li W (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.117857
PubMed:
38350506

A comprehensive investigation on the chemical changes of traditional Chinese medicine with classic processing technology: Polygonum multiflorum under nine cycles of steaming and sunning as a case study.

Fan X et al (2024).
Anal Bioanal Chem.
DOI:
10.1007/s00216-024-05177-0
PubMed:
38347251

Characterization of the physiological parameters, effective components, and transcriptional profiles of Polygonum multiflorum Thunb. Under pH stress.

Wu Y et al (2024).
Plant Physiol Biochem.
DOI:
10.1016/j.plaphy.2023.108279
PubMed:
38128226

Anti-aging activities of neutral and acidic polysaccharides from Polygonum multiflorum Thunb in Caenorhabditis elegans.

Fan J et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2023.128724
PubMed:
38103673

Hydrophobic constituents of Polygonum multiflorum roots promote renal erythropoietin expression in healthy mice.

Shirako S et al (2023).
J Nat Med.
DOI:
10.1007/s11418-023-01737-3
PubMed:
37587329

The first chromosome-level Fallopia multiflora genome assembly provides insights into stilbene biosynthesis.

Genetics
Zhao Y et al (2023).
Hortic Res.
DOI:
10.1093/hr/uhad047
PubMed:
37213683

Enhanced TSG stability through co-assembly with C3G: the mechanism behind processing Polygonum multiflorum Thunb with black beans via supramolecular analysis.

Liu Y et al (2023).
Food Funct.
DOI:
10.1039/d2fo03402f
PubMed:
37067244

Dianthrone derivatives from Polygonum multiflorum Thunb: Anti-diabetic activity, structure-activity relationships (SARs), and mode of action.

Diabetes
Yang JB et al (2023).
Bioorg Chem.
DOI:
10.1016/j.bioorg.2023.106491
PubMed:
37011521

Comparisons of physicochemical features and hepatoprotective potentials of unprocessed and processed polysaccharides from Polygonum multiflorum Thunb.

Phytochemistry
Wang Y et al (2023).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2023.123901
PubMed:
36871693

Cytochrome P450-mediated herb-drug interaction (HDI) of Polygonum multiflorum Thunb. based on pharmacokinetic studies and in vitro inhibition assays.

Xing Y et al (2023).
Phytomedicine.
DOI:
10.1016/j.phymed.2023.154710
PubMed:
36805481

Potential biomarkers screening of Polygonum multiflorum radix-induced liver injury based on metabonomics analysis of clinical samples.

Hu Y et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116217
PubMed:
36758914

In vivo recognition of bioactive substances of Polygonum multiflorum for protecting mitochondria against metabolic dysfunction-associated fatty liver disease.

Yu LP et al (2023).
World J Gastroenterol.
DOI:
10.3748/wjg.v29.i1.171
PubMed:
36683716

Discovery of Hepatotoxic Equivalent Markers and Mechanism of Polygonum multiflorum Thunb. by Metabolomics Coupled with Molecular Docking.

Zhang Y et al (2022).
Molecules.
DOI:
10.3390/molecules28010025
PubMed:
36615221

Molecular identification and functional characterization of two glycosyltransferases genes from Fallopia multiflora.

Genetics
Cai Q et al (2022).
Front Plant Sci.
DOI:
10.3389/fpls.2022.1017122
PubMed:
36561458

A Network-Pharmacology-Combined Integrated Pharmacokinetic Strategy to Investigate the Mechanism of Potential Liver Injury due to Polygonum multiflorum.

Jia Z et al (2022).
Molecules.
DOI:
10.3390/molecules27238592
PubMed:
36500685

A Comparative Phylogenetic Analysis on the Chloroplast Genome in Different Reynoutria japonica Populations.

Genetics
Chen J et al (2022).
Genes (Basel).
DOI:
10.3390/genes13111979
PubMed:
36360217

Integrated spatially resolved metabolomics and network toxicology to investigate the hepatotoxicity mechanisms of component D of Polygonum multiflorum Thunb.

Jiang HY et al (2022).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2022.115630
PubMed:
35987407

Identification of intrinsic hepatotoxic compounds in Polygonum multiflorum Thunb. using machine-learning methods.

Hu X et al (2022).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2022.115620
PubMed:
35963419

Assessing potential liver injury induced by Polygonum multiflorum using potential biomarkers via targeted sphingolipidomics.

Jia Z et al (2022).
Pharm Biol.
DOI:
10.1080/13880209.2022.2099908
PubMed:
35949191

Tissue-specific metabolite profiling of Fallopia multiflora (Heshouwu) and Fallopia multiflora var. angulata by mass spectrometry imaging and laser microdissection combined with UPLC-Q/TOF-MS.

Zhao Y et al (2021).
J Pharm Biomed Anal.
DOI:
10.1016/j.jpba.2021.114070
PubMed:
33878622

Polygonum multiflorum: Recent updates on newly isolated compounds, potential hepatotoxic compounds and their mechanisms.

Review
Teka T et al (2021).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2021.113864
PubMed:
33485980

The hepatotoxicity of Polygonum multiflorum: The emerging role of the immune-mediated liver injury.

Review
Rao T et al (2021).
Acta Pharmacol Sin.
DOI:
10.1038/s41401-020-0360-3
PubMed:
32123300

Aloe-emodin: A review of its pharmacology, toxicity, and pharmacokinetics.

Review
Dong X et al (2020).
Phytother Res.
DOI:
10.1002/ptr.6532
PubMed:
31680350

Emodin-induced autophagy against cell apoptosis through the PI3K/AKT/mTOR pathway in human hepatocytes.

Zheng XY et al (2019).
Drug Des Devel Ther.
DOI:
10.2147/DDDT.S204958
PubMed:
31564833

Determination of the species status of Fallopia multiflora, Fallopia multiflora var. angulata and Fallopia multiflora var. ciliinervis based on morphology, molecular phylogeny, and chemical analysis.

Xie HQ et al (2019).
J Pharm Biomed Anal.
DOI:
10.1016/j.jpba.2019.01.040
PubMed:
30711810

[Molecular authentication of Fallopia multiflora by PCR-RFLP based on the trnL-trnF analysis].

Zheng CJ, Sheng SJ and Zhao SJ (2012).
Zhong Yao Cai.
PubMed:
23019899

[Analysis and authentication of Fallopia multiflora and its adulterants by matK sequence].

Sheng SJ et al (2010).
Zhong Yao Cai.
PubMed:
21434430