Ferula communis

Ethnobotanical Studies

Clinical Trials

Evaluation of the Potential Beneficial Effects of Ferula communis L. Extract Supplementation in Postmenopausal Discomfort.

Researchers found that L. extract containing ferutinin improved sexual behavior and reduced postmenopausal symptoms in women. This natural hormone therapy could potentially improve quality of life during menopause.

Macrì R et al (2024).
Nutrients.
DOI:
10.3390/nu16162651
PubMed:
39203788

Studies

Author Correction: Comprehensive analysis of different solvent extracts of Ferula communis L. fruit reveals phenolic compounds and their biological properties via in vitro and in silico assays.

Phytochemistry
Nouioura G et al (2024).
Sci Rep.
DOI:
10.1038/s41598-024-63023-w
PubMed:
38821991

Therapeutic Promises of Ferulic Acid and Its Derivatives on Hepatic damage Related with Oxidative Stress and Inflammation: A Review with Mechanisms.

Immunology
Bhuia MS et al (2024).
Chem Biodivers.
DOI:
10.1002/cbdv.202400443
PubMed:
38757848

Comprehensive analysis of different solvent extracts of Ferula communis L. fruit reveals phenolic compounds and their biological properties via in vitro and in silico assays.

Phytochemistry
Nouioura G et al (2024).
Sci Rep.
DOI:
10.1038/s41598-024-59087-3
PubMed:
38594363

Dauferulins A-L, daucane-type sesquiterpenes from the roots of Ferula communis: Their structures and biological activities.

Yoshino Y et al (2024).
Fitoterapia.
DOI:
10.1016/j.fitote.2024.105877
PubMed:
38417680

Effects of silver nanoparticle prepared by aqueous extract of Ferula communis on the developing mice embryo after maternal exposure.

Seleem AA and Hussein BH (2023).
Toxicol Ind Health.
DOI:
10.1177/07482337231209094
PubMed:
37871157

In Vitro Evaluation of Ferutinin Rich-Ferula communis L., ssp. glauca, Root Extract on Doxorubicin-Induced Cardiotoxicity: Antioxidant Properties and Cell Cycle Modulation.

Immunology
Macrì R et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms241612735
PubMed:
37628916

Assessment of the acute and subacute toxicity of the aqueous extract of Moroccan Ferula communis fruit in a mouse model.

Nouioura G et al (2023).
Saudi Pharm J.
DOI:
10.1016/j.jsps.2023.101701
PubMed:
37576855

Preliminary phytochemical screening and antibacterial effects of root bark of Ferula communis (Apiaceae).

Phytochemistry
Yirdaw B and Kassa T (2023).
Vet Med Sci.
DOI:
10.1002/vms3.1170
PubMed:
37392454

Ferula communis Root Extract: In Vitro Evaluation of the Potential Additive Effect with Chemotherapy Tamoxifen in Breast Cancer (MCF-7) Cells Part II.

Cancer
Maiuolo J et al (2023).
Plants (Basel).
DOI:
10.3390/plants12051194
PubMed:
36904054

Communiferulins, farnesylated coumarins from the roots of Ferula communis and their anti-neuroinflammatory activity.

Summary

Four compounds were isolated from Ferula communis roots and characterized using spectroscopic analysis and NMR data calculation. Three new farnesylated coumarins and a farnesylated chromone were identified, and their structures were determined. The compounds were found to have inhibitory activities on IL-1β production from stimulated microglial cells.

ImmunologyNeuroscience
Yoshino Y et al (2023).
J Nat Med.
DOI:
10.1007/s11418-022-01657-8
PubMed:
36289185

Anaemia in Ruminants Caused by Plant Consumption.

Review
Ruiz H et al (2022).
Animals (Basel).
DOI:
10.3390/ani12182373
PubMed:
36139233

Composition of Algerian Propolis, Plant Origin, and Its Antiangiogenic Activity In Vitro.

Hosoya T et al (2021).
Molecules.
DOI:
10.3390/molecules26216510
PubMed:
34770923

The Effect of Ferula communis Extract in Escherichia coli Lipopolysaccharide-Induced Neuroinflammation in Cultured Neurons and Oligodendrocytes.

Summary

Ferutinin, a compound found in the plant genus L., has properties that may benefit the treatment of neurodegenerative and demyelinating diseases. In an experimental system, human neurons and oligodendrocytes were treated with a pro-inflammatory agent and then pretreated with ferutinin. Results suggested that ferutinin may act as an antioxidant and anti-inflammatory agent. However, further studies are needed to confirm its potential use as a treatment strategy for diseases characterized by inflammation and oxidative stress.

ImmunologyNeuroscience
Maiuolo J et al (2021).
Int J Mol Sci.
DOI:
10.3390/ijms22157910
PubMed:
34360675

In vitro Antileishmanial Activity of Some Ethiopian Medicinal Plants.

Nigatu H et al (2021).
J Exp Pharmacol.
DOI:
10.2147/JEP.S285079
PubMed:
33488126

Ferula L. Plant Extracts and Dose-Dependent Activity of Natural Sesquiterpene Ferutinin: From Antioxidant Potential to Cytotoxic Effects.

Review Phytochemistry
Macrì R et al (2020).
Molecules.
DOI:
10.3390/molecules25235768
PubMed:
33297504

Antibacterial and antioxidant activities of traditional medicinal plants from the Erzurum region of Turkey.

Ceylan S et al (2019).
Ir J Med Sci.
DOI:
10.1007/s11845-019-01993-x
PubMed:
30805769

Hepatoprotective potential of Ferula communis extract for carbon tetrachloride induced hepatotoxicity and oxidative damage in rats.

Deniz GY et al (2019).
Biotech Histochem.
DOI:
10.1080/10520295.2019.1566831
PubMed:
30712392

Review of the traditional uses, phytochemistry, pharmacology and toxicology of giant fennel (Ferula communis L. subsp. communis).

Review Phytochemistry
Akaberi M, Iranshahy M and Iranshahi M (2015).
Iran J Basic Med Sci.
PubMed:
26949491

Metabolite profiles of essential oils and molecular markers analysis to explore the biodiversity of Ferula communis: Towards conservation of the endemic giant fennel.

Phytochemistry
Rahali FZ et al (2016).
Phytochemistry.
DOI:
10.1016/j.phytochem.2016.01.012
PubMed:
26826740

Comparative inhibitory effect of prenylated coumarins, ferulenol and ferprenin, contained in the 'poisonous chemotype' of Ferula communis on mammal liver microsomal VKORC1 activity.

Louvet MS et al (2015).
Phytochemistry.
DOI:
10.1016/j.phytochem.2015.08.012
PubMed:
26314757

Experimental Ferula communis (giant fennel) toxicosis in sheep.

Shlosberg A and Egyed MN (1985).
Zentralbl Veterinarmed A.
PubMed:
3937384