Forsythia suspensa

Common Names: weeping forsythia

Ethnobotanical Studies

Studies

Analysis of Forsythia suspensa fruit and leaf extracts using UHPLC-Q-Exactive-Orbitrap/MS: In vivo antioxidant activity on D-galactose-induced aging mice.

Immunology
Wang X et al (2024).
Food Chem.
DOI:
10.1016/j.foodchem.2024.141002
PubMed:
39216371

Phillyrin and its metabolites exert antipyretic effects by targeting the NAD(+) binding domain of GAPDH, MDH2 and IDH2.

Liu W et al (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2024.155955
PubMed:
39191169

Forsythiaside A ameliorates bleomycin-induced pulmonary fibrosis by inhibiting oxidative stress and apoptosis.

Summary

FA, from Forsythia plant, shows anti-inflammatory, antioxidant, and antiviral properties. It may help treat pulmonary fibrosis (PF), a serious disease with high morbidity and mortality.

Immunology
Yang F et al (2024).
Immun Inflamm Dis.
DOI:
10.1002/iid3.70006
PubMed:
39172055

Mechanism investigation of Forsythoside A against esophageal squamous cell carcinoma in vitro and in vivo.

Yang Y et al (2024).
Cancer Biol Ther.
DOI:
10.1080/15384047.2024.2380023
PubMed:
39046082

Network Pharmacology Analysis of Traditional Chinese Medicine for Treating Psoriasis: Identifying Core Components, Mechanisms, and Dosing Patterns.

Dermatology
Yang S, Hu X and Wang Z (2024).
Altern Ther Health Med.
PubMed:
39038330

Distribution of active ingredients and quality control of Forsythia suspensa with AP-MALDI mass spectrometry imaging.

Liu Y et al (2024).
J Mass Spectrom.
DOI:
10.1002/jms.5073
PubMed:
38989767

Chemical Compositions of Lianqiao (Forsythia suspensa) Extracts and Their Potential Health Benefits.

Gao B et al (2024).
Pharmaceuticals (Basel).
DOI:
10.3390/ph17060740
PubMed:
38931407

Current and future distribution of Forsythia suspensa in China under climate change adopting the MaxEnt model.

Wang E et al (2024).
Front Plant Sci.
DOI:
10.3389/fpls.2024.1394799
PubMed:
38887460

Enzymatic and ultrasound assisted β-cyclodextrin extraction of active ingredients from Forsythia suspensa and their antioxidant and anti-inflammatory activities.

Immunology
Xiao X et al (2024).
Ultrason Sonochem.
DOI:
10.1016/j.ultsonch.2024.106944
PubMed:
38878712

Phillyrin and its metabolites treat pulmonary embolism by targeting PLCβ3 to inhibit platelet activation.

Li J et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118457
PubMed:
38866117

Forsythoside A regulates pulmonary fibrosis by inhibiting endothelial-to-mesenchymal transition and lung fibroblast proliferation via the PTPRB signaling.

Zhang Q et al (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2024.155715
PubMed:
38788399

[Single extract of Forsythia Suspense versus the prepared drug in pieces: comparison of their anti-inflammatory, antitumor and antibacterial effects in zebrafish].

Summary

Researchers evaluated the effects of Forsythia Suspense extract on inflammation, tumors, and bacteria. Results can guide potential use in medicine.

CancerImmunology
Guo X et al (2024).
Nan Fang Yi Ke Da Xue Xue Bao.
DOI:
10.12122/j.issn.1673-4254.2024.03.22
PubMed:
38597452

Combination of tenuigenin-based Polygala tenuifolia willd. root extract and forsythoside a improved Alzheimer's disease.

Summary

Tenuigenin and forsythoside A extracts from specific plants show neuro-protective effects individually. When combined in a 2:1 ratio, they synergistically protect against Alzheimer's disease symptoms in cell models. Shows potential for future treatment development.

Neuroscience
Liang G et al (2024).
Nat Prod Res.
DOI:
10.1080/14786419.2024.2332945
PubMed:
38529756

Efficacy of Forsythia suspensa (Thunb.) Vahl on mouse and rat models of inflammation-related diseases: a meta-analysis.

Immunology
Zhou C et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2024.1288584
PubMed:
38500762

Isolation and Identification of Allelopathic Substances from Forsythia suspensa Leaves, and Their Metabolism and Activity.

Kato-Noguchi H et al (2024).
Plants (Basel).
DOI:
10.3390/plants13050575
PubMed:
38475422

Protective role of forsythoside B in Kawasaki disease-induced cardiac injury: Inhibition of pyroptosis via the SIRT1-NF-κB-p65 signaling pathway.

Summary

FTS-B from Forsythia suspensa inhibits NF-κB through SIRT1, reducing inflammatory damage in Kawasaki disease models. SIRT1-NF-κB-p65 pathway may be a promising therapeutic target for KD treatment.

CardiologyImmunology
Yang Y et al (2024).
Chem Biol Interact.
DOI:
10.1016/j.cbi.2024.110953
PubMed:
38471628

Phillyrin improves myocardial remodeling in salt-sensitive hypertensive mice by reducing endothelin1 signaling.

Summary

Phillyrin from Forsythia suspensa protects the heart from strain caused by chronic hypertension. This study explores how phillyrin can prevent hypertension-induced myocardial remodeling in mice.

Cardiology
Luo Q et al (2024).
J Pharm Pharmacol.
DOI:
10.1093/jpp/rgae018
PubMed:
38447186

Modulation of macrophages by a phillyrin-loaded thermosensitive hydrogel promotes skin wound healing in mice.

Summary

Researchers studied a new treatment combining PF-127 and phillyrin to enhance wound healing by modulating macrophages. This has potential for treating traumatic skin injuries.

Immunology
Huang C et al (2024).
Cytokine.
DOI:
10.1016/j.cyto.2024.156556
PubMed:
38417214

Phillygenin prevents osteoclast differentiation and bone loss by targeting RhoA.

Zhang J et al (2024).
Phytother Res.
DOI:
10.1002/ptr.8074
PubMed:
38358766

Synergistic anti-infectious bronchitis virus activity of Phillygenin combined Baicalin by modulating respiratory microbiota and improving metabolic disorders.

Gastroenterology
Feng H et al (2024).
Poult Sci.
DOI:
10.1016/j.psj.2023.103371
PubMed:
38150830

An integrated approach for studying the metabolic profiling of herbal medicine in mice using high-resolution mass spectrometry and metabolomics data processing tools.

Zhang H et al (2024).
J Chromatogr A.
DOI:
10.1016/j.chroma.2023.464505
PubMed:
37976901

Phillyrin sensitizes lung cancer cells to ferroptosis through inhibiting FTH1/SLC7A11 axis.

Cancer
Tang X, Teng J and Lu K (2024).
Int J Clin Pharmacol Ther.
DOI:
10.5414/CP204475
PubMed:
37942927

Review of the therapeutic potential of Forsythiae Fructus on the central nervous system: Active ingredients and mechanisms of action.

Review Neuroscience
Zhang L et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117275
PubMed:
37797873

Synergy of different leaf traits determines the particulate matter retention capacity and its susceptibility to rain wash-off.

Xu L et al (2024).
Sci Total Environ.
DOI:
10.1016/j.scitotenv.2023.167365
PubMed:
37769719

Forsythoside A Mitigates Alzheimer's-like Pathology by Inhibiting Ferroptosis-mediated Neuroinflammation via Nrf2/GPX4 Axis Activation.

Neuroscience
Wang C et al (2022).
Int J Biol Sci.
DOI:
10.7150/ijbs.69714
PubMed:
35342364

UPLC/Q-TOF MS Screening and Identification of Antibacterial Compounds in Forsythia suspensa (Thunb.) Vahl Leaves.

Review
Zhou M et al (2022).
Front Pharmacol.
DOI:
10.3389/fphar.2021.704260
PubMed:
35153732

Different effects of Forsythia suspensa metabolites on bovine serum albumin (BSA).

Li Y et al (2019).
Spectrochim Acta A Mol Biomol Spectrosc.
DOI:
10.1016/j.saa.2019.02.076
PubMed:
30798212