Central Europe
- PubMed:
- 36616265
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Researchers developed a wound dressing using fumaria officinalis extract-loaded chitosan nanoparticles in a hydrogel. In vitro and in vivo studies showed it promoted cell viability, migration, and wound healing potential comparable to a marketed product. This research suggests potential use in diabetic wound treatment.
Researchers isolated two new alkaloids, fumaranine and fumarostrejdine, and 18 known alkaloids from Fumaria officinalis. They determined the structure of the compounds through spectroscopic analysis and compared them with literature data. The absolute configuration of fumaranine was determined by comparing its circular dichroism spectra with known analogs. Some of the isolated compounds were evaluated for their inhibition of acetylcholinesterase, butyrylcholinesterase, prolyl oligopeptidase (POP), and glycogen synthase kinase-3β activities. Parfumidine and sinactine were found to have potent POP inhibition activities.