Galanthus nivalis

Common Names: snowdrop

Ethnobotanical Studies

Studies

Cell Penetrating Peptide Enhances the Aphidicidal Activity of Spider Venom-Derived Neurotoxin.

Wu W et al (2024).
Toxins (Basel).
DOI:
10.3390/toxins16080358
PubMed:
39195768

Aberrant Mannosylated and Highly Fucosylated Glycoepitopes of Prostatic Acid Phosphatase as Potential Ligands for Dendritic-Cell Specific ICAM-Grabbing Nonintegrin (DC-SIGN) in Human Seminal Plasma-A Step towards Explaining Idiopathic Infertility.

Kałuża A et al (2023).
Biomolecules.
DOI:
10.3390/biom14010058
PubMed:
38254658

The quest for Homer's moly: exploring the potential of an early ethnobotanical complex.

Summary

This study challenges the previous claim that the snowdrop plant is the Homeric moly mentioned in the Odyssey. Instead, the researchers propose that there is an unidentified group of Mediterranean plants with similar properties. The sea daffodil may have influenced the mythical portrayal of moly.

Review Ethnobotany
Molina-Venegas R and Verano R (2024).
J Ethnobiol Ethnomed.
DOI:
10.1186/s13002-024-00650-7
PubMed:
38245738

Spider venom neurotoxin based bioinsecticides: A novel bioactive for the control of the Asian citrus psyllid Diaphorina citri (Hemiptera).

Miranda MP et al (2024).
Toxicon.
DOI:
10.1016/j.toxicon.2024.107616
PubMed:
38218384

Multisite Partial Glycosylation Approach for Preparation of Biologically Relevant Oligomannosyl Branches Contribute to Lectin Affinity Analysis.

Usui R et al (2023).
J Org Chem.
DOI:
10.1021/acs.joc.3c01178
PubMed:
37792638

Evaluation of the yeast phase-specific monoclonal antibody 4D1 and Galanthus nivalis agglutinin sandwich ELISA to detect Talaromyces marneffei antigen in human urine.

Shu F et al (2023).
Front Cell Infect Microbiol.
DOI:
10.3389/fcimb.2023.1163868
PubMed:
37705932

Heterologous production of the insecticidal pea seed albumin PA1 protein by Pichia pastoris and protein engineering to potentiate aphicidal activity via fusion to snowdrop lectin Galanthus nivalis agglutinin; GNA).

De-Thier JS et al (2023).
Microb Cell Fact.
DOI:
10.1186/s12934-023-02176-1
PubMed:
37592258

Quantitation of strain-specific hemagglutinin trimers in mosaic quadrivalent influenza nanoparticle vaccine by ELISA.

Alabanza C et al (2023).
Vaccine.
DOI:
10.1016/j.vaccine.2023.07.009
PubMed:
37451877

Prediction of Mortality in Patients on Peritoneal Dialysis Based on the Fibrinogen Mannosylation.

Baralić M et al (2023).
Cells.
DOI:
10.3390/cells12030351
PubMed:
36766693

Flower angle favors pollen export efficiency in the snowdrop Galanthus nivalis (Linnaeus, 1753) but not in the lesser celandine Ficaria verna (Huds, 1762).

Genetics
Prokop P et al (2023).
Plant Signal Behav.
DOI:
10.1080/15592324.2022.2163065
PubMed:
36635990

Plant lectins as versatile tools to fight coronavirus outbreaks.

Summary

Plant lectins could be used to combat COVID-19 pandemics by masking the non-glycosylated receptor binding domain of the virus and the corresponding region of the receptor. The ability of plant lectins to interact with the N- and O-glycans present on the spike proteins and their receptors have been analyzed, as well as the in vitro and in vivo anti-COVID-19 activity reported for them. Possible ways for delivery of lectins to block the spikes and/or their receptors are also discussed.

Review COVID-19
Simplicien M et al (2023).
Glycoconj J.
DOI:
10.1007/s10719-022-10094-4
PubMed:
36418811

Enhancing the oral and topical insecticidal efficacy of a commercialized spider venom peptide biopesticide via fusion to the carrier snowdrop lectin (Galanthus nivalis agglutinin).

Sukiran NA et al (2023).
Pest Manag Sci.
DOI:
10.1002/ps.7198
PubMed:
36161468

Removal of clinically relevant SARS-CoV-2 variants by an affinity resin containing Galanthus nivalis agglutinin.

Summary

Researchers investigated the effectiveness of plant lectin Galanthus nivalis for binding to the SARS-CoV-2 virus and its variants to develop therapies for severe COVID-19 cases. They tested seven clinically relevant variants and found that viral capture efficiency ranged from 53% to 89%. The study indicated that the use of Galanthus nivalis can be effective and practical in treating severe COVID-19 patients.

COVID-19
Gooldy M et al (2022).
PLoS One.
DOI:
10.1371/journal.pone.0272377
PubMed:
35901224

Expression of Modified Snowdrop Lectin (Galanthus nivalis Agglutinin) Protein Confers Aphids and Plutella xylostella Resistance in Arabidopsis and Cotton.

He P et al (2022).
Genes (Basel).
DOI:
10.3390/genes13071169
PubMed:
35885952

Seed Dispersal by Ants in Three Early-Flowering Plants.

Prokop P, Fančovičová J and Hlúšková Z (2022).
Insects.
DOI:
10.3390/insects13040386
PubMed:
35447828

Isolation and functional analysis of OsAOS1 promoter for resistance to Nilaparvata lugens Stål infestation in rice.

Li H et al (2022).
J Cell Physiol.
DOI:
10.1002/jcp.30653
PubMed:
34908164

Removal of COVID-19 Spike Protein, Whole Virus, Exosomes, and Exosomal MicroRNAs by the Hemopurifier® Lectin-Affinity Cartridge in Critically Ill Patients With COVID-19 Infection.

Summary

Two critically ill COVID-19 patients were treated with a Hemopurifier, which removes mannosylated viruses and exosomes released by activated cells. Both patients tolerated the treatment well. In one patient, removal of exosomes was associated with improved coagulopathy, oxygenation, and clinical recovery. In the second patient, removal of COVID-19 by the Hemopurifier was observed. The Hemopurifier is currently being further investigated in a safety and feasibility study with up to 40 patients in ICU with COVID-19 infection.

COVID-19Genetics
Amundson DE et al (2021).
Front Med (Lausanne).
DOI:
10.3389/fmed.2021.744141
PubMed:
34692735

OdTx12/GNA, a chimeric variant of a β excitatory toxin from Odontobuthus doriae, reveals oral toxicity towards Locusta migratoria and Tenebrio molitor.

Khoshdel Nezamiha F et al (2021).
Toxicon.
DOI:
10.1016/j.toxicon.2021.09.001
PubMed:
34537212

An inexpensive point-of-care immunochromatographic test for Talaromyces marneffei infection based on the yeast phase specific monoclonal antibody 4D1 and Galanthus nivalis agglutinin.

Genetics
Pruksaphon K et al (2021).
PLoS Negl Trop Dis.
DOI:
10.1371/journal.pntd.0009058
PubMed:
33945531

Expression of the Galanthus nivalis agglutinin (GNA) gene in transgenic potato plants confers resistance to aphids.

Mi X et al (2017).
C R Biol.
DOI:
10.1016/j.crvi.2016.10.003
PubMed:
27938939

Synergistic antiviral effect of Galanthus nivalis agglutinin and nelfinavir against feline coronavirus.

Summary

Scientists screened 16 compounds for their antiviral activity against feline coronavirus (FCoV), which causes the fatal disease Feline Infectious Peritonitis (FIP) in cats. They found that Galanthus nivalis agglutinin (GNA) and nelfinavir inhibited FCoV replication. However, when the viral load was increased to mimic FIP, the inhibitors lost their effect. When GNA and nelfinavir were combined, they completely blocked viral replication. This suggests that the combined use of GNA and nelfinavir has therapeutic potential in treating cats with early-diagnosed FIP. These findings are important for developing effective treatments and vaccines against FIP.

AntimicrobialCOVID-19
Hsieh LE et al (2010).
Antiviral Res.
DOI:
10.1016/j.antiviral.2010.06.010
PubMed:
20603153

Binding of the Galanthus nivalis agglutinin to thymocytes reveals alterations in surface glycosylation during T-cell development.

Immunology
Sinkora J et al (2002).
Scand J Immunol.
PubMed:
11896936