Differences in composition of Ganoderma lucidum spore powder from different origins. OE-GLSP contains bioactive substances with potential biological activity. Improves intestinal barrier function, needs more research.
Researchers studied the use of phytochemicals from medicinal plants to prevent cardiovascular diseases, including lowering cholesterol and controlling diabetes. More research is needed to fully understand their effectiveness.
Scientists synthesized triterpenoids from a fungus for potential cancer treatment. Endertiin B showed strong anti-tumor activity by blocking cell cycle and inducing apoptosis. Relevant for cancer drug development.
GPG, a glucan from Ganoderma lucidum, improves immune response in breast cancer. Combining with Gemcitabine reduces tumor burden, alters TME, and inhibits MDSC expansion. GPG reverses immunosuppression induced by chemotherapy.
Ganoderic acid D from Ganoderma lucidum may reverse gemcitabine resistance in triple-negative breast cancer, potentially expanding treatment options for patients.
Fermentation of Tartary buckwheat increased enzyme activity, bioactive compounds, and metabolite diversity. Results show improved antioxidant and anti-glycemic properties. Fermentation could enhance health benefits of Tartary buckwheat.
Ganoderma lucidum contains compounds that may help manage diabetes and its complications by improving glucose metabolism and protecting pancreatic cells. More research needed for potential treatment with fewer side effects.
Scientists studied how natural compounds can enhance anti-tumor effects by boosting CD8 T cells' immune response. This research is important for improving cancer immunotherapy and overcoming therapeutic failure.
Tossers investigated GLP and HP for their anti-inflammatory and antioxidant effects on ovarian tissue in rats with PCOS. Results could help understand and potentially treat inflammation-related aspects of PCOS.
Researchers isolated a polysaccharide from Ganoderma lucidum, GLP70-1-2, which improved spatial learning and memory, reduced anxiety in an Alzheimer's disease model, and decreased inflammatory factors in cells. GLP70-1-2 shows potential as a drug for Alzheimer's disease.
Study demonstrates Ganoderma lucidum extracts inhibit endometrial cancer by activating Rap1 signaling pathway, inhibiting proliferation, promoting apoptosis, and blocking cell cycle. Important for potential cancer treatment research.
Researchers are studying the bioactive compounds in a versatile mushroom for potential disease treatments, including their antimicrobial and antioxidant properties.
COP-22, a curcumin derivative, shows potential in protecting the brain from aging-induced damage by reducing oxidative stress, improving cholinergic system dysfunction, and protecting nerve cells. It also demonstrates the ability to reduce oxidative stress in the liver and kidney. It could be used in aging therapy and to treat diseases like Alzheimer's.
Ganoderma lucidum, a medicinal mushroom, shows potential as an adjuvant for Alzheimer's disease (AD) treatment. It can delay AD progression, improve cognitive function, and inhibit various mechanisms involved in AD pathology. More research and clinical trials are needed to fully understand its therapeutic potential.
Researchers developed a hydrogel using Ganoderma lucidum polysaccharide, sodium alginate, and carboxymethyl chitosan. The hydrogel improves wound healing in diabetic patients by promoting macrophage polarization, reducing inflammation, and enhancing tissue regeneration.
Ganoderma lucidum is a Chinese herbal medicine with potential as additional cancer therapy, but its specific effects and mechanisms are still unknown.
Scientists discovered that Ganoderma lucidum polysaccharides (GLPs) have anti-cancer effects, reducing chemotherapy toxicity and aiding drug delivery. GLPs-based nanoparticles were examined for targeted delivery. This research suggests GLPs could inhibit cancer, minimize chemo side effects, and complement combination therapies.
The study found that Ganoderma lucidum polysaccharide, when used in combination with Docetaxel and Flutamide, significantly enhanced apoptosis, reduced cell migration and colonization, and decreased the expression of prostate cancer biomarkers. This suggests that Ganoderma lucidum polysaccharide could be a new potential therapy for prostate cancer.
Scientists sequenced the genome of a fungus that can produce potentially effective pharmaceutical compounds. The study provides valuable information on the genes involved in polysaccharide biosynthesis and expands our understanding of fungal genomics.
TCM can influence the gut microbiome to combat osteoporosis. This is because the gut microbiome affects inflammation, hormone levels, nutrient absorption, and bone mass. TCM herbs can regulate the gut microbiome and indirectly impact bone health. Puerarin specifically improves intestinal health and reduces inflammation caused by estrogen deficiency.
Scientists studied the anti-obesity effect of chenpi tea, made from citri reticulatae pericarpium, Ganoderma lucidum, and pu-erh tea, in mice on a high-fat diet. They used RNA sequencing and metabolomic analysis to identify potential mechanisms.