Common Names: Cape jasmine
Geniposide from Gardenia jasminoides Ellis shows potential in managing atherosclerotic cardiovascular disease by reducing inflammation, improving lipid metabolism, and preventing thrombosis. It also has antioxidant and anti-apoptotic effects. This review outlines its pharmacological mechanisms and clinical applications.
Geniposide from gardenia jasminoides shows promise as an antidepressant by regulating arachidonic acid and glucose metabolism, reducing inflammation in depressed mice. This could lead to improved therapeutic options for depression.
ZZCD, a traditional Chinese medicine, is safer and exhibits quicker antidepressant effects compared to Gardenia jasminoides alone. Its mechanism involves the activation of prefrontal PACAP/VIP.
Geniposide (GE) from Gardenia Jasminoides reduces cardiac oxidative stress, inflammation, fibrosis, and metabolic disturbances in heart failure with preserved ejection fraction (HFpEF) models. It targets MMP2/SIRT1/GSK3β pathway, showing potential as a treatment for HFpEF.
Gardenia jasminoides Ellis (Zhi-zi) has potent anti-inflammatory and antioxidant properties, promotes insulin secretion, and protects against diabetes complications. Useful for diabetes treatment and prevention.
Herbal remedies in traditional Chinese medicine show promise in managing SCA3 by targeting oxidative stress. Preclinical studies support their therapeutic roles, suggesting potential alternative treatments to delay disease progression.
Gardenia jasminoides Ellis (GJE) is a plant used in traditional medicine in China. Recent studies show it is effective for treating Alzheimer's, Parkinson's, and major depressive disorder. However, more research is needed.
Study investigated effects of geniposide (GE) on depression-like behavior in prenatal stress-induced male mice. GE had antidepressant effects and may be a potential treatment for prenatal stress-related mental health issues in offspring.
The study showed that an extract could protect and repair white matter damage in the brain. This is important because it promotes the differentiation of brain cells and reduces inflammation, which can have implications for treating neurological conditions.
Shangkehuangshui is a traditional Chinese medicine used for treating injuries. Despite its effectiveness, we still don't know how it works.
Gardenia jasminoides J. Ellis extract (GJ-4) showed neuroprotective effects in a rat model of Alzheimer's disease (AD) by reducing AD-like behaviors, apoptosis, and inflammation in the hippocampus. GJ-4 has potential as a drug for treating AD.
The researchers investigated how a traditional herbal formula called Zhi Zi Chi decoction (ZZCD) regulates the microbiota-gut-brain axis in treating anxious depression. Understanding these mechanisms could lead to improved treatments for neuropsychiatric disorders.
Researchers analyzed the genetic and metabolic makeup of gardenia fruits at different stages of growth, uncovering a network that controls the production of beneficial compounds with antioxidant, anti-inflammatory, and anticancer properties. This study identifies important genes involved in flavonoid synthesis.
Genipin, a compound from Gardenia jasminoides fruit, inhibits growth of oral squamous cell carcinoma (OSCC) cells by inducing apoptosis via caspase-dependent pathway and reducing STAT3 phosphorylation. It may be a potential therapeutic option for OSCC treatment.
Chinese medicinal plant, with high value and genetic diversity, lacks sufficient study on its genetic diversity. Understanding its genetic diversity is important for medicinal and economic purposes.
Gardenia Fructus and Chuanxiong Rhizoma, traditional Chinese medicines, were studied for treating atherosclerosis. They were found to have vascular protective effects, detoxify and activate blood, with potential implications for new AS treatments.
A study identified 50 genipin metabolites in rats, showing that these metabolites can be reabsorbed into the body. This helps understand their pharmacological effects and safety evaluations.
The effectiveness of the Qinzhizhudan Formula (QZZD) in treating vascular dementia (VD) is still unclear, requiring further research to understand its potential therapeutic effects and mechanism of action.
Yueju pill, a Chinese Medicine, up-regulates PACAP to activate PKA-CREB signaling and produce rapid antidepressant effects. Mice with hippocampal PACAP knockdown exhibited depression-like behavior and blunted antidepressant response. Administration of Yueju pill increased PACAP and PKA levels, and reversed depression-like behavior in chronically stressed mice. Iridoids fraction of Gardenia jasminoides was identified as an important component of Yueju pill with rapid antidepressant-like behavior through increased hippocampal PACAP expression. The study suggests that up-regulation of PACAP may represent a novel mechanism for antidepressant effects.
Researchers conducted a systematic review of scientific articles published between 2010 and 2020 that evaluated the anxiolytic, sedative, and/or hypnotic effects of flower extracts in pre-clinical animal models. They found that some flower extracts have an anxiolytic effect comparable to diazepam, but their therapeutic utility in anxiety disorders needs more investigation. The study compiled the characteristics of anxiety studies in animal models, evaluated locomotor activity, and the hypnotic effect of the extracts. The study revealed that matricaria chamomilla had a sedative effect, and 23 other flower plants had anxiolytic effects. However, more reliable behavioral tests and better experimental designs are needed to obtain more conclusive evidence with clinical significance.
This study looked at developing a new way to identify drugs that target a specific receptor involved in Alzheimer's disease. The receptor, called NMDA-2A, plays a role in brain development. The researchers wanted to find natural products that could selectively interact with this receptor, hopefully leading to new drugs for Alzheimer's disease. Their approach could help identify potential treatments that are more precise and effective.
Geniposide (GP) is a compound found in Gardenia jasminoides Ellis that has been found to have anti-depressive activities. Researchers investigated the anti-depressive mechanism of GP in mice with depression-like behaviors induced by chronic unpredictable mild stress (CUMS). GP administration was found to reduce depression-like behaviors in CUMS mice, with transcriptome sequencing identifying Gata2 as a target. GP was found to regulate the circ_0008405/miR-25-3p/Gata2 and Oip5os1/miR-25-3p/Gata2 crosstalk networks, which could lead to potential antidepressant-like effects on CUMS mice.
This review evaluated studies on the role of herbal medicines in managing brain injury. Researchers searched various databases and found 32 studies with medicinal plants like Ginkgo biloba and olive that showed significant improvements in brain injury. The plants worked through different mechanisms, such as reducing free radicals and nitric oxide toxicity and increasing neuronal density. The review summarized the neuroprotective actions and molecular mechanisms of each plant. Overall, herbal medicines show promise in preventing and managing brain injury.
GJ-4, a traditional Chinese medicine extract, has neuroprotective effects on cognitive impairments in Alzheimer's disease mouse models. However, the mechanism behind this is unclear. Previous studies indicate that traditional Chinese medicines can effectively treat various diseases by acting on multiple targets.