Gastrodin protects against stroke-induced inflammation and mitochondrial dysfunction by inhibiting JAK2/STAT3 signaling pathway, making it a potential therapy for cerebral ischemia.
Gastrodin from orchid plant reduces cardiac injury caused by sleep deprivation by inhibiting ferroptosis through SIRT6 pathway. Important for understanding sleep deprivation effects on heart health.
Researchers found that dysregulation of VMAT2 leads to DA neurotoxicity and motor deficits in Parkinson's disease, but treatment with GTD derived from Gastrodia elata Blume may help regulate this dysfunction. This suggests GTD could be a potential treatment for PD.
Research showed that the herbal extract gastrodin relieved depression in stroke patients by restoring synaptic proteins and spine density in the brain. This effect is mediated by CB1R, PKA, and RhoA signaling pathways, suggesting Gas could be a potential treatment for post-stroke depression.
Researchers studied the effects of -hydroxybenzaldehyde (-HBA) from on Alzheimer's disease treatment using animal models. -HBA has shown anti-inflammatory, antioxidative stress, and neuroprotective effects. This research may lead to new treatments for Alzheimer's.
Herbal remedies in traditional Chinese medicine show promise in managing SCA3 by targeting oxidative stress. Preclinical studies support their therapeutic roles, suggesting potential alternative treatments to delay disease progression.
GEP from is a potential treatment for Parkinson's disease, reducing motor dysfunction and neuroinflammation by preventing apoptosis and regulating gut microbiota. Promising for future functional products.
DCXD, a Chinese herbal extract, is traditionally used to treat cardiovascular disease. This study explores its potential to lower blood pressure in hypertension and the mechanisms involved.
Researchers investigated the effects of Parishin C, a compound found in Gastrodia elata Blume plant, on depression. It is safe and has neuroprotective properties. Its potential benefits for depression need further exploration.
The researchers studied a traditional herbal formula called Da Chuanxiong (DCX) that improves blood circulation and protects the brain, potentially beneficial for treating Vascular Cognitive Impairment (VCI).
Researchers found that a specific miRNA from a traditional Chinese medicine targets GSK-3β, a key factor in Alzheimer's disease. This miRNA showed neuroprotective effects in cell and mouse models. Their findings offer insights into potential treatments for Alzheimer's disease.
Researchers studied Gastrodia elata Blume (a Chinese herbal medicine) and its effects on insomnia and depressive symptoms. It was found to have sedative-hypnotic and antidepressant effects, suggesting it could be a potential treatment option with fewer side effects.
Gas-miR2-3p, derived from oral administration, reduces inflammatory factors TNF-α, IL-6, and IL-1β in both cells and animals. It also downregulates p-p65 and p-IκBα, alleviating neuroinflammation by modulating the NF-κB signaling pathway. MiRNAs have potential as novel regulators for neuroinflammation.
Gastrodin, a Chinese herb extract, has anti-inflammatory, antioxidant, and antiviral properties, outperforming diabetes medications with fewer side effects. It protects lung function, improves antiviral activity, and inhibits a factor in COVID-19 complications. Promising as a diabetes and COVID-19 treatment.
Para-hydroxybenzaldehyde (PHBA) protected against cerebral ischemia in rats by improving neurological function, reducing infarction area, and increasing neuron number. Metabolic analysis identified key pathways and PHBA increased autophagy, offering potential stroke therapies.
This study looked at how a polysaccharide from Gastrodia elata called NPGE affects the interaction between ferroptosis and neuroinflammation during cerebral ischemia-reperfusion injury. It found that NPGE has potential effects against oxidative stress and inflammation in CIRI neuropathology.
Banxia baizhu tianma decoction (BBTD) is a traditional Chinese medicine with a long history of use for treating excessive phlegm-dampness hypertension. However, the specific effects of each herb in BBTD are unclear, limiting its full understanding and potential for hypertension treatment.
G. elata, a plant commonly used in Asian countries, has various applications in medicine, food, and health care products.
Scientists found that a compound called 20C derived from Gastrodia elata inhibits the aggregation of α-synuclein, a protein linked to Parkinson's disease. In tests on mice, 20C reduced α-synuclein levels, improved behavior, and protected mitochondrial function. Promising for PD treatment.
Zebrafish study shows two Chinese herbal products had behavioral effects, suggesting combination assays as useful for safety assessment.
Benzaldehyde, found in Gastrodia elata, improves body weight and cognitive function in rats with angiostrongyliasis. It reduces blood-brain barrier breakdown and cell apoptosis, offering a potential therapy for this disease.
Blume (traditional Chinese medicine) has various benefits including anti-inflammation, anti-oxidation, neuroprotection. This study shows EEGE's ability to reduce Aβ toxicity and delay nematode paralysis through gene regulation.
In this study, researchers investigated different modifications of a polysaccharide derived from the "Tian Ma" plant used in traditional Chinese medicine to enhance its anti-breast cancer activity. By analyzing the physicochemical properties and structure of the modified polysaccharides, they found that the modifications improved solubility and anti-breast cancer activity while decreasing the size of the polysaccharides. They also discovered that one of the modifications allowed for better uptake of the polysaccharide by breast cancer cells. These findings suggest that structural modifications can enhance the therapeutic potential of polysaccharides and provide a starting point for further research in this area.
Blume, a traditional medicinal plant, has been used to treat neurological diseases due to its neuroprotective effect. To study its effect on cognition impaired by simulated weightlessness, mice subjected to hindlimb unloading were given fresh Blume orally. Behavioral tests showed significant improvement in short- and long-term spatial memory, while biochemical tests demonstrated a reduction in oxidative stress levels and maintenance of pro-inflammatory and anti-inflammatory factor balance in the hippocampus. Fresh Blume also corrected abnormal changes in synapse- and glutamate neurotransmitter-related protein. These results suggest a potential application of fresh Blume in the prevention of cognitive impairment in space.
Gastrodia elata Bl. is a Chinese medicinal material with various chemical components. It has medicinal and edible value and is used for various diseases. Its composition and pharmacological activity are of scientific interest.
Article compiles information on business intelligence (BI) from various sources. Useful for understanding and making informed decisions about BI in the lab.
Researchers used network pharmacology to study the potential protective effect of Blume against Alzheimer's disease. They identified key targets of Blume and conducted protein-protein interaction and molecular docking analyses, finding that the components 4,4'-dihydroxydiphenyl methane and protocatechuic aldehyde were most strongly associated with AD, along with five core targets including GAPDH, EP300, HSP90AB1, KDM6B, and CREBBP. Both components were found to delay paralysis and inhibit aggregation of Aβ plaques in a model, with DM upregulating the expression of KDM6B and both components upregulating HSP90AB1. These results suggest that DM and PA may be potential active components of Blume in the treatment of AD.
Gastrodia elata Blume (Tianma) is used in Chinese medicine to treat various disorders. Its compounds show potential for neuroprotection, pain relief, anxiety, depression, blood pressure control, liver protection, anti-tumor effects, and immunity enhancement in cardiovascular diseases.
This study explored the effects of two bioactive components of a traditional Chinese herbal medicine, GEB, on cognitive dysfunction in vascular dementia. The effectiveness of Gastrodin and Gastrodigenin was tested using various methods, including a water maze test and immunohistochemistry. The study showed that these components attenuated learning memory dysfunction and neuronal damage, reduced protein accumulation in the brain tissue and improved energy metabolism disorders in rats. This suggests that these components may provide neuroprotective effects by regulating energy metabolism and mitochondrial function in vascular dementia.
Gastrodin, previously shown to improve cerebral ischemia-reperfusion and hypoperfusion injury and cognitive deficit in Alzheimer's disease, was administered orally to rats for 7 days to examine its effects on REM sleep deprivation. Results showed that gastrodin improved sleep disturbance, cognitive deficits, and neuron damage in the hippocampus and cerebral cortex. It did so by regulating the TLR4/NF-κB and Wnt/β-catenin signaling pathways. Gastrodin shows potential as a treatment for REM sleep deprivation.
In a study investigating the effects of microgravity on cognitive function, Gastrodia elata Blume (GEB) was found to have a significant protective effect on memory decline. Mice receiving daily treatment with GEB and Huperzine A showed improved learning and memory, associated with changes in biochemical markers and protein expressions in the hippocampus. The study suggests that GEB may have potential uses in preventing memory decline associated with long-term spaceflight and other conditions.
Gastrodia elata Blume (GE) is a traditional Chinese treatment for neurological disorders. Recent tests with a water extract of GE showed it can reduce inflammation and enhance social behavior in mice. But, it wasn't known if the extract could also alleviate depression-like symptoms and cognitive issues in mice with gut microbiome problems.
A Chinese medicinal herb called Gastrodia elata Blume is used to treat conditions such as headaches, epilepsy, and depression.
Researchers studied the effect of water extracts from the herbal medicine Blume (GE) on G2019S-induced Parkinson's disease (PD) in flies and mice. The study found that treatment with GE improved locomotion and protected dopaminergic neurons. GE suppressed the hyperactivation of G2019S proteins in dopaminergic neurons and activated the antioxidation and detoxification factor Nrf2 mainly in astrocyte-like and ensheathing glia. This glial activation antagonized G2019S-induced Mad/Smad signaling and prevented locomotion defects and neuronal loss in transgenic mice. These findings may offer a potential therapeutic avenue for PD.
Physician-scientists are searching for new ways to treat aging-related diseases like dementia. Traditional Chinese medicine (TCM) may provide a promising approach. One TCM, Blume (tianma), has been studied for treating cerebrocardiovascular diseases (CCVDs) like Alzheimer's disease (AD). Studies examined its potential efficacy and safety in well-characterized aging-related disease models, with positive results. Other related herbal preparations and natural products have also shown potential in treating CCVDs and dementia. Overall, data suggest that tianma treatment could be a promising complementary therapy for AD.
Gastrodin, a compound found in the Chinese herb , has been traditionally used for treating various disorders. Recent studies have investigated its effects on the central nervous system (CNS) and found that it has beneficial effects on diseases such as epilepsy, Alzheimer's disease, and Parkinson's disease through several mechanisms. These mechanisms include modulating neurotransmitters, antioxidative and anti-inflammatory effects, and regulating neurotrophins. Despite the promising preclinical data, more clinical studies are needed to determine its effectiveness in treating neurological disorders.
The traditional Chinese herb Gastrodia elata Blume has been used for centuries in folk medicine and is being researched for its anticonvulsant properties and safety. Its biological activity is being studied to deepen our understanding of its effects.