Gelsemium elegans

Ethnobotanical Studies

Studies

Gelselegine-gelsedine type bisindoles as well as the units from Gelsemium elegans with promoting proliferation of oral mucosa fibroblast cells.

Lin J et al (2024).
Phytochemistry.
DOI:
10.1016/j.phytochem.2024.114077
PubMed:
38615925

An efficient method for the preparative isolation and purification of alkaloids from Gelsemium by using high speed counter-current chromatography and preparative HPLC.

Phytochemistry
Liang LL et al (2024).
Prep Biochem Biotechnol.
DOI:
10.1080/10826068.2024.2336990
PubMed:
38592940

Identification of toxic Gelsemium elegans in processed food and honey based on real-time PCR analysis.

Wang G et al (2024).
Food Res Int.
DOI:
10.1016/j.foodres.2024.114188
PubMed:
38519193

Understanding the toxicity mechanism of gelsemine in zebrafish.

Ma C et al (2024).
Comp Biochem Physiol C Toxicol Pharmacol.
DOI:
10.1016/j.cbpc.2024.109886
PubMed:
38447648

Koumine inhibits IL-1β-induced chondrocyte inflammation and ameliorates extracellular matrix degradation in osteoarthritic cartilage through activation of PINK1/Parkin-mediated mitochondrial autophagy.

Summary

Koumine, an alkaloid found in Gelsemium elegans, alleviates osteoarthritis in rats by increasing mitochondrial autophagy and reducing inflammation and cartilage erosion. This suggests potential for treating OA in humans.

Immunology
Kong X et al (2024).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2024.116273
PubMed:
38412715

Molecular identification and functional characterization of a transcription factor GeRAV1 from Gelsemium elegans.

Cui T et al (2024).
BMC Genomics.
DOI:
10.1186/s12864-023-09919-9
PubMed:
38166591

New Monoterpenoid Indole Hybrids from Gelsemium elegans with Anti-Inflammatory and Osteoclast Inhibitory Activities.

Summary

Researchers discovered two new alkaloids, along with six known analogues, in Gelsemium elegans. These compounds showed anti-inflammatory activity and inhibited osteoclast formation, suggesting potential therapeutic applications for G. elegans.

Immunology
Zhang PP et al (2023).
Chem Biodivers.
DOI:
10.1002/cbdv.202301665
PubMed:
37968250

Reference Genes Screening and Gene Expression Patterns Analysis Involved in Gelsenicine Biosynthesis under Different Hormone Treatments in Gelsemium elegans.

Summary

Scientists studied the reference genes in a medicinal plant under different hormone treatments to understand gelsenicine synthesis. They found three genes that strongly correlated with gelsenicine levels. This research will help future molecular analyses of this plant.

EndocrinologyGenetics
Zhang Y et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms242115973
PubMed:
37958955

Toxic Effects of Koumine on the Early-Life Development Stage of Zebrafish.

Wang D et al (2023).
Toxics.
DOI:
10.3390/toxics11100853
PubMed:
37888703

Koumine ameliorates neuroinflammation by regulating microglia polarization via activation of Nrf2/HO-1 pathway.

Summary

Gelsemium elegans, a traditional medicine, contains Koumine, which can reduce inflammation by modulating macrophage activation and polarization. This research might have potential applications in treating inflammatory conditions.

Neuroscience
Wang L et al (2023).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2023.115608
PubMed:
37801902

Antinociceptive effect of gelsenicine, principal toxic alkaloids of gelsemium, on prostaglandin E2-induced hyperalgesia in mice: Comparison with gelsemine and koumine.

Phytochemistry
Xu WB et al (2023).
Biochem Biophys Res Commun.
DOI:
10.1016/j.bbrc.2023.09.037
PubMed:
37757667

Effect of Dietary Gelsemium elegans Benth. Extract on the Growth, Slaughter Performance, Meat Quality, Intestinal Morphology, and Microflora of Yellow-Feathered Chickens.

Gastroenterology
Cao YH et al (2023).
J Poult Sci.
DOI:
10.2141/jpsa.2023023
PubMed:
37691877

Genus Gelsemium and its endophytic fungi - Comprehensive review of their traditional uses, phytochemistry, pharmacology, and toxicology.

Summary

Gelsemium plants are popular for their medicinal properties, treating various issues like skin problems, neuralgia, fractures, and cancer. They are also used to reduce inflammation and blood flow to spinal and cerebrospinal centers.

Phytochemistry
Peng YL et al (2023).
Curr Top Med Chem.
DOI:
10.2174/1568026623666230825105233
PubMed:
37642181

D-Optimal Design and Development of a Koumine-Loaded Microemulsion for Rheumatoid Arthritis Treatment: In vivo and in vitro Evaluation.

Arthritis
Hu Q et al (2023).
Int J Nanomedicine.
DOI:
10.2147/IJN.S406641
PubMed:
37304972

Regulation of microglia related neuroinflammation contributes to the protective effect of Gelsevirine on ischemic stroke.

Summary

Gelsevirine reduces stroke damage by decreasing inflammation and apoptotic cells, improving neurobiological function, and downregulating microglia activity and JAK-STAT signal pathway.

CardiologyNeuroscience
Xing C et al (2023).
Front Immunol.
DOI:
10.3389/fimmu.2023.1164278
PubMed:
37063929

Structural Elucidation and Cytotoxic Activity of New Monoterpenoid Indoles from Gelsemium elegans.

Song D et al (2023).
Molecules.
DOI:
10.3390/molecules28062531
PubMed:
36985503

Modulation of GABA(A) receptors and of GABAergic synapses by the natural alkaloid gelsemine.

Summary

Gelsemine, an alkaloid found in plants with therapeutic and toxic effects, may be involved in the modulation of GABA receptors (GABARs) responsible for the properties of benzodiazepines (BDZs), drugs used to treat anxiety, insomnia, and pain. Through electrophysiological recordings in HEK293 cells and cortical neurons, researchers discovered that gelsemine acts as a negative modulator of GABARs and GABAergic synaptic function, leading to toxicity. However, its presynaptic effects also provide a potential mechanism for its therapeutic effects. These findings improve understanding of gelsemine's effects in the nervous system and suggest potential new targets for therapeutic agents.

NeurosciencePhytochemistry
Marileo AM et al (2023).
Front Mol Neurosci.
DOI:
10.3389/fnmol.2022.1083189
PubMed:
36733271

The multicomponent residue depletion of Gelsemium elegans in pig tissues, urine, and plasma.

Wu Y et al (2023).
Front Vet Sci.
DOI:
10.3389/fvets.2022.1111782
PubMed:
36713860

Sex Differences in the In Vivo Exposure Process of Multiple Components of Gelsemium elegans in Rats.

Zuo MT et al (2022).
Metabolites.
DOI:
10.3390/metabo13010033
PubMed:
36676958

Assembly of the Complete Mitochondrial Genome of Gelsemium elegans Revealed the Existence of Homologous Conformations Generated by a Repeat Mediated Recombination.

Genetics
You C et al (2022).
Int J Mol Sci.
DOI:
10.3390/ijms24010527
PubMed:
36613970

PI3K/AKT/mTOR, NF-κB and ERS pathway participated in the attenuation of H(2)O(2)-induced IPEC-J2 cell injury by koumine.

Yuan Z et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2022.116028
PubMed:
36529250

Genomic evidence supports the genetic convergence of a supergene controlling the distylous floral syndrome.

Genetics
Zhao Z et al (2023).
New Phytol.
DOI:
10.1111/nph.18540
PubMed:
36239093

Effects of Dietary Koumine on Growth Performance, Intestinal Morphology, Microbiota, and Intestinal Transcriptional Responses of Cyprinus carpio.

Gastroenterology
Wang Q et al (2022).
Int J Mol Sci.
DOI:
10.3390/ijms231911860
PubMed:
36233179

Excretion, Metabolism, and Tissue Distribution of Gelsemium elegans (Gardn. & Champ.) Benth in Pigs.

Ma X et al (2022).
Molecules.
DOI:
10.3390/molecules27082605
PubMed:
35458803

Gelsemium elegans cyclic peptide induces human cervical carcinoma cells apoptosis through intrinsic and extrinsic pathways.

Liu J et al (2022).
J Pept Sci.
DOI:
10.1002/psc.3410
PubMed:
35307909

Gelsemium elegans Benth: Chemical Components, Pharmacological Effects, and Toxicity Mechanisms.

Review
Lin H et al (2021).
Molecules.
DOI:
10.3390/molecules26237145
PubMed:
34885727

Gelsemium poisoning mediated by the non-toxic plant Cassytha filiformis parasitizing Gelsemium elegans.

Cheung WL et al (2018).
Toxicon.
DOI:
10.1016/j.toxicon.2018.09.009
PubMed:
30273705