Ginkgo biloba

Common Names: maidenhair tree, common ginkgo

Ethnobotanical Studies

Clinical Trials

Efficacy and safety evaluation of Ginkgo biloba dropping pill (GBDP) on stable angina pectoris complicated with depression: A placebo-controlled, randomized, double-blind, multicenter study.

The study looked at using Ginkgo biloba dropping pill (GBDP) as a treatment for stable angina pectoris (SAP) patients with depressive disorders. Results showed it was effective and safe. Consider using GBDP as an adjuvant therapy for SAP and depression.

He X et al (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2023.155264
PubMed:
38430820

A randomized, open-label clinical trial in mild cognitive impairment with EGb 761 examining blood markers of inflammation and oxidative stress.

Researchers are studying the effects of Ginkgo biloba extract (EGb 761) on mild cognitive impairment (MCI) by examining blood markers before and after a 12-month treatment period in 100 patients. They are also assessing cognitive test scores. The study is expected to be complete by 2023.

Morató X et al (2023).
Sci Rep.
DOI:
10.1038/s41598-023-32515-6
PubMed:
37012306

Studies

Exploring the multifaceted role of ginkgolides and bilobalide from Ginkgo biloba in mitigating metabolic disorders.

Review
Kim H, Kang S and Go GW (2024).
Food Sci Biotechnol.
DOI:
10.1007/s10068-024-01656-3
PubMed:
39234277

Use of Herbal Drugs in Cardiovascular Disease- A Review.

Summary

Researchers studied the use of phytochemicals from medicinal plants to prevent cardiovascular diseases, including lowering cholesterol and controlling diabetes. More research is needed to fully understand their effectiveness.

Cardiology
Kaur A and Kumar R (2024).
Curr Cardiol Rev.
DOI:
10.2174/011573403X323724240830075719
PubMed:
39229989

Fabrication of bio-inspired carbon nanodot-corn starch nanocomposite films via extrusion process for sustainable active food packaging applications.

Lyu JS and Han J (2024).
Carbohydr Polym.
DOI:
10.1016/j.carbpol.2024.122502
PubMed:
39174146

Selective capture of PM(2.5) by urban trees: The role of leaf wax composition and physiological traits in air quality enhancement.

Chen D et al (2024).
J Hazard Mater.
DOI:
10.1016/j.jhazmat.2024.135428
PubMed:
39137544

Genome-wide identification of the EIN3/EIL gene family in Ginkgo biloba and functional study of a GbEIL in the ethylene signaling pathway.

Genetics
Chai S et al (2024).
Gene.
DOI:
10.1016/j.gene.2024.148800
PubMed:
39067545

Ginkgo biloba leaf polysaccharide-stabled selenium nanozyme as an efficient glutathione peroxidase mimic for the preservation of bananas and cherry tomatoes.

Zou J et al (2024).
Food Chem.
DOI:
10.1016/j.foodchem.2024.140443
PubMed:
39003861

Ginkgo biloba for Tardive Dyskinesia and Plasma MnSOD Activity: Association with MnSOD Ala-9Val Variant.

Wang D et al (2024).
Curr Neuropharmacol.
DOI:
10.2174/1570159X22666240530095721
PubMed:
38919004

Combinative effect of pulsed-light irradiation and solid-state fermentation on ginkgolic acids, ginkgols, ginkgolides, bilobalide, flavonoids, product quality and sensory assessment of Ginkgo biloba dark tea.

Phytochemistry
Boateng ID et al (2024).
Food Chem.
DOI:
10.1016/j.foodchem.2024.139979
PubMed:
38852441

Mini-encyclopedia of mitochondria-relevant nutraceuticals protecting health in primary and secondary care-clinically relevant 3PM innovation.

Golubnitschaja O et al (2024).
EPMA J.
DOI:
10.1007/s13167-024-00358-4
PubMed:
38841620

Anti-oxidative and anti-inflammatory effects of Ginkgo biloba extract (EGb761) on hindlimb skeletal muscle ischemia-reperfusion injury in rats.

Summary

Researchers found that Ginkgo biloba extract can protect muscles from injury during spine surgery by reducing inflammation and oxidative stress. This could improve surgical outcomes and recovery.

CardiologyImmunology
Chen LY et al (2024).
Physiol Rep.
DOI:
10.14814/phy2.16050
PubMed:
38839736

Research progress on the types, functions, biosynthesis, and metabolic regulation of ginkgo terpenoids.

Review
Guo J et al (2024).
Plant Physiol Biochem.
DOI:
10.1016/j.plaphy.2024.108754
PubMed:
38824693

Ginkgolic acids induce liver injury in mice through cell cycle arrest and immune stress under specific condition.

Yang Z et al (2024).
Toxicon.
DOI:
10.1016/j.toxicon.2024.107788
PubMed:
38823652

Thermal fixation technologies affect phenolic profile, ginkgolides, bilobalide, product quality, and ginkgolic acids in Ginkgo biloba leaf tea.

Phytochemistry
Soetanto DA et al (2024).
J Food Sci.
DOI:
10.1111/1750-3841.17126
PubMed:
38783591

Therapeutic effect of ginkgetin on smoke-induced airway inflammation by down-regulating the c/EBPβ signaling pathway and CCL2 expression.

Immunology
Tao Z et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118284
PubMed:
38735420

Efficacy and safety of Ginkgo biloba extract in the treatment of unstable angina pectoris: A systematic review and network meta-analysis.

Meta-Analysis
Liu Y et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118297
PubMed:
38718890

Acaricidal Efficacy of Thirty-Five Egyptian Plants Against the Camel Tick, Hyalomma Dromedarii.

Khater HF et al (2024).
Acta Parasitol.
DOI:
10.1007/s11686-024-00801-6
PubMed:
38671280

Ginkgo biloba and Its Chemical Components in the Management of Alzheimer's Disease.

Summary

Chinese medicine compound Gb has promising effects on Alzheimer's disease, offering alternative treatment options. Bioactive plant ingredients can provide antioxidant, anti-inflammatory benefits and improve symptoms. Consider Gb extracts as a potential therapy for neurodegenerative diseases like AD.

Neuroscience
Peng Y et al (2024).
Am J Chin Med.
DOI:
10.1142/S0192415X24500277
PubMed:
38654507

Optimization of α-L-arabinofuranosidase CcABF on clarification and beneficial active substances in fermented ginkgo kernel juice by artificial neural network and genetic algorithm.

Chen J et al (2024).
Food Chem.
DOI:
10.1016/j.foodchem.2024.139386
PubMed:
38653057

Separation and purification of polyprenols from Ginkgo biloba leaves by silver ion anchored on imidazole-based ionic liquid functionalized mesoporous MCM-41 sorbent.

Boateng ID et al (2024).
Food Chem.
DOI:
10.1016/j.foodchem.2024.139284
PubMed:
38640543

Bacillus-derived consortium enhances Ginkgo biloba's health and resistance to Alternaria tenuissima.

Ji S et al (2024).
Pest Manag Sci.
DOI:
10.1002/ps.8118
PubMed:
38578650

Development of a loop-mediated isothermal amplification assay for the rapid detection of Styphnolobium japonicum (L.) Schott as an adulterant of Ginkgo biloba (L.).

Rodrigues V et al (2023).
Phytomedicine.
DOI:
10.1016/j.phymed.2023.155322
PubMed:
38569291

Cytisine-N-methylene-(5,7,4(')-trihydroxy)- isoflavone ameliorates ischemic stroke-induced brain injury in mouse by regulating the oxidative stress and BDNF-Trkb/Akt pathway.

Summary

LY01, from Sophora alopecuroides L, shows neuroprotection and potential for ischemic stroke treatment. Further research needed for mechanism and efficacy.

CardiologyImmunologyNeuroscience
Li Y, Fan F and Liu Q (2024).
Eur J Pharmacol.
DOI:
10.1016/j.ejphar.2024.176512
PubMed:
38493912

Ginkgo biloba L. exocarp petroleum ether extract inhibits methicillin-resistant Staphylococcus aureus by modulating ion transport, virulence, and biofilm formation in vitro and in vivo.

Wei PW et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.117957
PubMed:
38493904

Tailoring the physicochemical properties of starch: impact of integrated ultrasonic and ethanol pretreatment on the oil uptake of infrared fried ginkgo seeds.

Phytochemistry
Su Y et al (2024).
J Sci Food Agric.
DOI:
10.1002/jsfa.13417
PubMed:
38477402

LC-MS based untargeted metabolomics studies of the metabolic response of Ginkgo biloba extract on arsenism patients.

Li W et al (2024).
Ecotoxicol Environ Saf.
DOI:
10.1016/j.ecoenv.2024.116183
PubMed:
38471343

Development of pollinated and unpollinated ovules in Ginkgo biloba: unravelling the role of pollen in ovule tissue maturation.

Muto A et al (2024).
J Exp Bot.
DOI:
10.1093/jxb/erae102
PubMed:
38459807

The anti-apoptotic role of Ginkgolide B via mitochondrial permeability transition pore inhibition in retinal ischemia-reperfusion.

Summary

Ginkgolide B from Ginkgo biloba protects mitochondria in glaucoma, reducing cell death. Could be a treatment for acute primary angle-closure glaucoma.

Cardiology
Wang X et al (2024).
Biochem Biophys Res Commun.
DOI:
10.1016/j.bbrc.2024.149722
PubMed:
38442447

Efficacy and safety of standardized Ginkgo biloba extract as adjuvant therapy for intracerebral hemorrhage in China: A systematic review and meta-analysis.

Chen S et al (2024).
Heliyon.
DOI:
10.1016/j.heliyon.2024.e26861
PubMed:
38439880

Correction to: Ginkgo biloba Extract 50 (GBE50) Exerts Antifibrotic and Antioxidant Effects on Pulmonary Fibrosis in Mice by Regulating Nrf2 and TGF-β1/Smad Pathways.

Immunology
Liang W et al (2024).
Appl Biochem Biotechnol.
DOI:
10.1007/s12010-024-04852-3
PubMed:
38421573

Sea hedgehog-inspired surface-enhanced Raman scattering biosensor probe for ultrasensitive determination of Staphylococcus aureus in food supplements.

Tao Y, Liu Q and Cheng N (2024).
Biosens Bioelectron.
DOI:
10.1016/j.bios.2024.116146
PubMed:
38417286

Self-assembly of CuAuTA nanozymes for intelligent detection of ginkgolic acids.

Zhong H et al (2024).
Anal Bioanal Chem.
DOI:
10.1007/s00216-024-05221-z
PubMed:
38416157

Fungal, but not bacterial, diversity and network complexity promote network stability during roadside slope restoration.

Wang M et al (2024).
Sci Total Environ.
DOI:
10.1016/j.scitotenv.2024.171007
PubMed:
38401731

Ginkgo biloba extract alleviates CCl(4)-induced acute liver injury by regulating PI3K/AKT signaling pathway.

Pu X et al (2024).
Heliyon.
DOI:
10.1016/j.heliyon.2024.e26093
PubMed:
38390084

Genome-wide analyses of the GbAP2 subfamily reveal the function of GbTOE1a in salt and drought stress tolerance in Ginkgo biloba.

Summary

Scientists discovered that GbTOE1a, an AP2 gene in Ginkgo biloba, regulates stress responses and flavonoid synthesis. GbTOE1a overexpression increased flavonoid content, while its silencing reduced it. This research lays the foundation for studying AP2's role in flavonoid synthesis and stress tolerance.

Genetics
Chang B et al (2024).
Plant Sci.
DOI:
10.1016/j.plantsci.2024.112027
PubMed:
38354754

Transcriptome analysis of the bloom-forming dinoflagellate Prorocentrum donghaiense exposed to Ginkgo biloba leaf extract, with an emphasis on photosynthesis.

Summary

Ginkgo biloba leaf extract (GBE) inhibits photosynthesis in Prorocentrum donghaiense, leading to a decline in algal cell photosynthesis. Understanding this mechanism is crucial for preventing and controlling harmful algal blooms.

Genetics
Shen A et al (2024).
Environ Sci Pollut Res Int.
DOI:
10.1007/s11356-024-32409-8
PubMed:
38351353

Multi-target drugs for the treatment of cognitive impairment and fatigue in post-COVID syndrome: focus on Ginkgo biloba and Rhodiola rosea.

Summary

Post-COVID syndrome leads to cognitive impairment, depression, and fatigue due to neuroinflammation, oxidative stress, and mitochondrial dysfunction. Herbal drugs like Ginkgo biloba and Rhodiola rosea may improve cognition, reduce fatigue and depression, but more research is required.

Review COVID-19Neuroscience
Mueller JK and Müller WE (2024).
J Neural Transm (Vienna).
DOI:
10.1007/s00702-024-02749-3
PubMed:
38347175

Ginkgolide C inhibits ROS-mediated activation of NLRP3 inflammasome in chondrocytes to ameliorate osteoarthritis.

Jia L et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.117887
PubMed:
38346525

The molecular mechanisms of ginkgo (Ginkgo biloba) activity in signaling pathways: A comprehensive review.

Review
Mohammadi Zonouz A, Ghasemzadeh Rahbardar M and Hosseinzadeh H (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2024.155352
PubMed:
38342017

Green Synthesis of Narrow-Size Silver Nanoparticles Using Ginkgo biloba Leaves: Condition Optimization, Characterization, and Antibacterial and Cytotoxic Activities.

Ni Q et al (2024).
Int J Mol Sci.
DOI:
10.3390/ijms25031913
PubMed:
38339192

Harnessing the potential of ginkgo biloba extract: Boosting denitrification performance through accelerated electron transfer.

Gao H et al (2024).
Chemosphere.
DOI:
10.1016/j.chemosphere.2024.141368
PubMed:
38316282

Effects and safety of Ginkgo biloba on blood metabolism in type 2 diabetes mellitus: a systematic review and meta-analysis.

Summary

This study analyzed the effects and safety of Ginkgo biloba on patients with type 2 diabetes mellitus. It helps determine if Ginkgo biloba is beneficial for blood metabolism in these patients.

Meta-Analysis Diabetes
Zou H et al (2024).
Front Endocrinol (Lausanne).
DOI:
10.3389/fendo.2023.1231053
PubMed:
38264278

Anti-atherosclerotic effects and molecular targets of ginkgolide B from Ginkgo biloba.

Review
Ye W et al (2024).
Acta Pharm Sin B.
DOI:
10.1016/j.apsb.2023.09.014
PubMed:
38239238

Portable paper-based probe for on-site ratiometric fluorescence determination of total flavonol glycosides in plant extract using smartphone imaging.

Phytochemistry
Gao J et al (2024).
Mikrochim Acta.
DOI:
10.1007/s00604-023-06166-3
PubMed:
38165510

Shuxuening Injection Inhibits Apoptosis and Reduces Myocardial Ischemia-Reperfusion Injury in Rats through PI3K/AKT Pathway.

Cardiology
Yue TT et al (2024).
Chin J Integr Med.
DOI:
10.1007/s11655-023-3650-z
PubMed:
38153596

Bilobalide attenuates lipopolysaccharide‑induced HepG2 cell injury by inhibiting TLR4‑NF‑κB signaling via the PI3K/Akt pathway.

Mao S et al (2023).
Exp Ther Med.
DOI:
10.3892/etm.2023.12312
PubMed:
38125341

Ginkgo Biloba Extract Can Antagonize Subchronic Arsenite Exposure-Induced Hepatocyte Senescence by Inhibiting Oxidative Damage and Inflammation in Rats.

Immunology
Chen X et al (2023).
Biol Trace Elem Res.
DOI:
10.1007/s12011-023-04021-3
PubMed:
38110608

Clinical effectiveness of pharmacological and non-pharmacological treatments for the management of anxiety in community dwelling people living with dementia: A systematic review and meta-analysis.

Summary

Music therapy, cognitive activities, and non-drug interventions effectively reduce anxiety in dementia patients. Ginkgo biloba, probiotics, olanzapine, loxapine, and citalopram may also show promise in managing anxiety.

Review Neuroscience
Nimmons D et al (2023).
Neurosci Biobehav Rev.
DOI:
10.1016/j.neubiorev.2023.105507
PubMed:
38097097

Transplanted Ginkgo growth rates indicate common Chinese nursery techniques may severely limit urban ecosystem services.

Laffitte B et al (2024).
Sci Total Environ.
DOI:
10.1016/j.scitotenv.2023.168977
PubMed:
38036147

Facile fabrication and antibacterial properties of chitosan/acrylamide/gold nanocomposite hydrogel incorporated with Chaetomium globosium extracts from Gingko biloba leaves.

Oladipo A et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2023.128194
PubMed:
37984578

Ginkgo biloba Extract 50 (GBE50) Exerts Antifibrotic and Antioxidant Effects on Pulmonary Fibrosis in Mice by Regulating Nrf2 and TGF-β1/Smad Pathways.

Summary

GBE50, a standardized Ginkgo biloba extract, shows potential as a protective agent against pulmonary fibrosis (PF), a severe lung disorder. Further research is needed to understand its mechanism of action.

Immunology
Liang W et al (2023).
Appl Biochem Biotechnol.
DOI:
10.1007/s12010-023-04755-9
PubMed:
37971580

Pharmacological Treatment of Acute Unilateral Vestibulopathy: A Review.

Sousa FA et al (2023).
J Audiol Otol.
DOI:
10.7874/jao.2023.00066
PubMed:
37953517

Radioprotective effect of Ginkgolide B on brain: The mediating role of DCC/MST1 signaling.

Summary

Ginkgolide B (GB) from ginkgo biloba leaves shows potential protective effects on radiation-induced brain injury (RBI) by regulating the Hippo signaling pathway, suggesting its value for mitigating neurological complications and developing treatments.

Neuroscience
Yang T, Du X and Xu L (2023).
Int J Radiat Biol.
DOI:
10.1080/09553002.2023.2281515
PubMed:
37934907

Safety Assessment of Ginkgo biloba-Derived Ingredients as Used in Cosmetics.

Burnett CL et al (2023).
Int J Toxicol.
DOI:
10.1177/10915818231210792
PubMed:
37930133

Genome-wide identification of the Pinus tabuliformis CONSTANS-like gene family and their potential roles in reproductive cone development.

Genetics
Yang W et al (2023).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2023.127621
PubMed:
37890750

Genome-wide identification and expression analysis of the NRT genes in Ginkgo biloba under nitrate treatment reveal the potential roles during calluses browning.

Genetics
Feng J et al (2023).
BMC Genomics.
DOI:
10.1186/s12864-023-09732-4
PubMed:
37872493

Modeling the Antiviral Activity of Ginkgo Biloba Polyphenols Against Variola: In Silico Exploration of Inhibitory Candidates for Vartmpk and Hsstmpk Enzymes.

Summary

This study used modeling to evaluate the antiviral properties of Ginkgo biloba extracts against variola, a dangerous disease with potential for bioterrorism. Discovering effective and safe antiviral therapies is crucial due to the global threat and increasing spread of variola.

Antimicrobial
Hamdani S, Bouchentouf S and Allali H (2023).
Curr Drug Discov Technol.
DOI:
10.2174/0115701638261541230922095853
PubMed:
37861017

Signal Detection and Assessment of Herb-Drug Interactions: Saudi Food and Drug Authority SFDA Experience.

Alghamdi W et al (2023).
Drugs Real World Outcomes.
DOI:
10.1007/s40801-023-00388-w
PubMed:
37857794

New insight into the mechanisms of Ginkgo biloba leaves in the treatment of cancer.

Summary

Ginkgo biloba leaves have been used for centuries as a traditional medicine. They have shown potential in preventing cancer, but the exact mechanism is not well understood.

Review Cancer
Yu J et al (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2023.155088
PubMed:
37844377

Large-Scale Identification and Characterization Analysis of VQ Family Genes in Plants, Especially Gymnosperms.

Genetics
Tian J, Zhang J and Francis F (2023).
Int J Mol Sci.
DOI:
10.3390/ijms241914968
PubMed:
37834416

Traditional Chinese medicine for neonatal hypoxic-ischemic encephalopathy: A Bayesian network meta-analysis.

Review
Zhang C et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117317
PubMed:
37832809

Evaluating the role of Ginkgo biloba extract in the secondary prevention of Acute Ischemic Stroke with cerebral microbleeds by Quantitative Susceptibility Mapping（QSM）.

Summary

EGb 761, a Ginkgo biloba extract, has anti-inflammatory and thrombotic effects. In a study, EGb combined with Aspirin improved blood oxygen saturation in ischemic stroke patients with microbleeds. This combo could be effective for long-term secondary prevention.

CardiologyNeuroscience
Lan W et al (2023).
Int J Neurosci.
DOI:
10.1080/00207454.2023.2268264
PubMed:
37812205

Early treatment for benign paroxysmal positional vertigo secondary to sudden sensorineural hearing loss.

Li GF et al (2023).
Medicine (Baltimore).
DOI:
10.1097/MD.0000000000035480
PubMed:
37800834

Composites made of Ginkgo biloba fibers and polylactic acid exhibit non-isothermal crystallization kinetics.

Yang H and Du J (2023).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2023.127232
PubMed:
37793533

Bimetallic nanocubes embedded in biomass-derived porous carbon to construct magnetic/carbon dual-mechanism layered structures for efficient microwave absorption.

Zheng H et al (2024).
J Colloid Interface Sci.
DOI:
10.1016/j.jcis.2023.09.121
PubMed:
37774656

Study on network pharmacology of Ginkgo biloba extract against ischaemic stroke mechanism and establishment of UPLC-MS/MS methods for simultaneous determination of 19 main active components.

Summary

Ginkgo biloba extract (GBE) is effective for treating stroke, but we don't know the active ingredients or how it works. You should care because understanding its mechanism can help us develop better treatments.

CardiologyNeuroscience
Yin CY et al (2023).
Phytochem Anal.
DOI:
10.1002/pca.3286
PubMed:
37758241

Preparation and functional characteristics of protein from Ginkgo endophytic Pseudomonas R6 and Ginkgo seed.

Zhang D et al (2023).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2023.127063
PubMed:
37748587

The role of Ginkgo Folium on antitumor: Bioactive constituents and the potential mechanism.

Review Cancer
Hu D et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117202
PubMed:
37742878

Comprehensive analysis of JAZ family members in Ginkgo biloba reveals the regulatory role of the GbCOI1/GbJAZs/GbMYC2 module in ginkgolide biosynthesis.

Du JF et al (2023).
Tree Physiol.
DOI:
10.1093/treephys/tpad121
PubMed:
37741055

Attention-deficit/hyperactivity disorder and inflammation: natural product-derived treatments-a review of the last ten years.

Summary

This review explores herbal treatments for ADHD, examining their effects on humans and animals and their potential to modify inflammation. It may offer non-pharmacological options with fewer side effects for ADHD treatment.

Review ImmunologyNeuroscience
Martins A et al (2023).
Inflammopharmacology.
DOI:
10.1007/s10787-023-01339-1
PubMed:
37740887

A structural similarity networking assisted collision cross-section prediction interval filtering strategy for multi-compound identification of complex matrix by ion-mobility mass spectrometry.

Wen JH et al (2023).
Anal Chim Acta.
DOI:
10.1016/j.aca.2023.341720
PubMed:
37709461

In Vitro, In Vivo, and In Silico Activities of Ginkgolic Acid C15:1 against Streptococcus agalactiae Clinical Isolates.

Wen Z et al (2023).
ACS Infect Dis.
DOI:
10.1021/acsinfecdis.3c00188
PubMed:
37696007

Uncovering the anti-obesity constituents in Ginkgo biloba extract and deciphering their synergistic effects.

Summary

Ginkgo biloba extract (GBE50) contains bioflavonoids and several flavonoids that inhibit human pancreatic lipase (hPL), potentially enhancing its anti-obesity effects.

Obesity
Zhang M et al (2023).
Fitoterapia.
DOI:
10.1016/j.fitote.2023.105669
PubMed:
37683877

Ultrasound-assisted fermentation of ginkgo kernel juice by Lactiplantibacillus plantarum: Microbial response and juice composition development.

Chen J et al (2023).
Ultrason Sonochem.
DOI:
10.1016/j.ultsonch.2023.106587
PubMed:
37683418

Enhanced expression of RAGE/NADPH oxidase signaling pathway and increased level of oxidative stress in brains of rats with chronic fluorosis and the protective effects of blockers.

Immunology
Ma YL et al (2023).
J Trace Elem Med Biol.
DOI:
10.1016/j.jtemb.2023.127288
PubMed:
37659123

Ginkgo biloba extract promotes Treg differentiation to ameliorate ischemic stroke via inhibition of HIF-1α/HK2 pathway.

Summary

Ginkgo biloba extract (EGb) has beneficial effects on ischemic stroke by reducing neurobehavioral scores, infarct volume, inflammation, and increasing Treg cells. EGb can be used as part of future stroke therapy.

CardiologyNeuroscience
Hui W et al (2023).
Phytother Res.
DOI:
10.1002/ptr.7988
PubMed:
37655539

Poleward shifts in the maximum of spring phenological responsiveness of Ginkgo biloba to temperature in China.

Wu Z et al (2023).
New Phytol.
DOI:
10.1111/nph.19229
PubMed:
37632265

[Dynamic regulation using a quorum-sensing circuit enhances the production of tyrosol by Escherichia coli].

Shen Y et al (2023).
Sheng Wu Gong Cheng Xue Bao.
DOI:
10.13345/j.cjb.230136
PubMed:
37622367

Data Base similarity (DBsimilarity) of natural products to aid compound identification on MS and NMR pipelines, similarity networking, and more.

Summary

DBsimilarity is a tool that helps natural product chemists easily organize structure databases into similarity networks, aiding in information visualization without requiring coding skills.

Phytochemistry
Borges RM et al (2023).
Phytochem Anal.
DOI:
10.1002/pca.3277
PubMed:
37592443

A systematic review of the safety and efficacy on cognitive function of herbal and nutritional medicines in older adults with and without subjective cognitive impairment.

Summary

This review examines herbal and nutritional medicines' effectiveness and safety in improving cognitive function for older adults with and without subjective cognitive impairment (SCI). It also assesses study characteristics and methodological quality.

Neuroscience
Cave AE et al (2023).
Syst Rev.
DOI:
10.1186/s13643-023-02301-6
PubMed:
37592293

Efficient removal of both heavy metal ion and dyes from wastewater using magnetic response adsorbent of block polymer brush-grafted N-doped biochar.

Li B and Li K (2023).
Chemosphere.
DOI:
10.1016/j.chemosphere.2023.139811
PubMed:
37586497

Neurovascular glial unit: A target of phytotherapy for cognitive impairments.

Summary

Herbal medicines may be useful for treating cognitive impairment in Alzheimer's disease and vascular dementia, by targeting dysfunction in the neurovascular glial unit.

Neuroscience
Chen L et al (2023).
Phytomedicine.
DOI:
10.1016/j.phymed.2023.155009
PubMed:
37573807

Syndrome of inappropriate antidiuresis and Ginkgo biloba: An overlooked relationship.

Guerrero-Pérez F, Peiró I and Villabona C (2023).
Med Clin (Barc).
DOI:
10.1016/j.medcli.2023.06.037
PubMed:
37567826

Genetic diversity, population structure, and genome-wide association analysis of ginkgo cultivars.

Summary

Scientists used genotyping-by-sequencing (GBS) and genome-wide association analysis to study the genetic diversity of ginkgo trees. They found that most germplasms have no genetic relationship and identified candidate genes related to seed traits. This information can improve conservation and utilization efforts.

Genetics
Hu Y et al (2023).
Hortic Res.
DOI:
10.1093/hr/uhad136
PubMed:
37564270

Ginkgo biloba extract (EGb-761) confers neuroprotection against ischemic stroke by augmenting autophagic/lysosomal signaling pathway.

Summary

Ginkgo biloba extract (EGb-761) promotes autophagic/lysosomal signaling in neurons and reduces infarction size, neurological deficits, and neuron death in ischemic stroke. It could be a potential new treatment target.

CardiologyNeuroscience
Zang R et al (2023).
J Neuroimmunol.
DOI:
10.1016/j.jneuroim.2023.578101
PubMed:
37536050

Ginkgolide K delays the progression of osteoarthritis by regulating YAP to promote the formation of cartilage extracellular matrix.

Liu R et al (2023).
Phytother Res.
DOI:
10.1002/ptr.7953
PubMed:
37527970

The D14 and KAI2 Orthologs of Gymnosperms Sense Strigolactones and KL Mimics, Respectively, and the Signals Are Transduced to Control Downstream Genes.

Genetics
Kodama K, Xie X and Kyozuka J (2023).
Plant Cell Physiol.
DOI:
10.1093/pcp/pcad072
PubMed:
37489639

Sodium alginate coating of Ginkgo biloba leaves extract containing phenylpropanoids as an ecofriendly preserving agent to maintain the quality of peach fruit.

Mou L et al (2023).
J Food Sci.
DOI:
10.1111/1750-3841.16708
PubMed:
37477272

Critical analysis of ginkgo preparations: comparison of approved drugs and dietary supplements marketed in Germany.

Trabert M and Seifert R (2023).
Naunyn Schmiedebergs Arch Pharmacol.
DOI:
10.1007/s00210-023-02602-6
PubMed:
37470803

Molecular Characterization and Genetic Diversity of Ginkgo (Ginkgo biloba L.) Based on Insertions and Deletions (InDel) Markers.

Wang D et al (2023).
Plants (Basel).
DOI:
10.3390/plants12132567
PubMed:
37447128

Treating Severe Adverse Drug Reactions Caused by Ischemic Optic Neuropathy with Ginkgo Biloba Extract Injection: A Case Report.

Yan L, Wei Q and Gao Y (2023).
Altern Ther Health Med.
PubMed:
37392195

The enzymatic modification of whey-proteins for spray drying encapsulation of Ginkgo-biloba extract.

Kalajahi SG et al (2023).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2023.125548
PubMed:
37356680

Screening and Evaluation of Novel α-Glucosidase Inhibitory Peptides from Ginkgo biloba Seed Cake Based on Molecular Docking Combined with Molecular Dynamics Simulation.

Wang X et al (2023).
J Agric Food Chem.
DOI:
10.1021/acs.jafc.3c00826
PubMed:
37288757

Exploring the mechanism of Ginkgo biloba L. leaves in the treatment of vascular dementia based on network pharmacology, molecular docking, and molecular dynamics simulation.

Summary

Researchers explored how Ginkgo biloba L. leaves treat vascular dementia. The study's methods and results remain undisclosed, and no broader implications were discussed.

Neuroscience
Pan J et al (2023).
Medicine (Baltimore).
DOI:
10.1097/MD.0000000000033877
PubMed:
37233418

A Novel Extract From Ginkgo biloba Inhibits Neuroinflammation and Maintains White Matter Integrity in Experimental Stroke.

Summary

Pinitol added to GBE reduces brain damage, improves function, promotes white matter repair, and inhibits inflammation in stroke mice, suggesting potential as a treatment for stroke patients.

CardiologyNeuroscience
Dong W et al (2023).
Neuroscience.
DOI:
10.1016/j.neuroscience.2023.05.015
PubMed:
37225050

Ginkgo biloba supplement abates lead-induced endothelial and testicular dysfunction in Wistar rats via up-regulation of Bcl-2 protein expression, pituitary-testicular hormones and down-regulation of oxido-inflammatory reactions.

Immunology
Asiwe JN et al (2023).
J Trace Elem Med Biol.
DOI:
10.1016/j.jtemb.2023.127216
PubMed:
37224746

Bilobalide Prevents Apoptosis and Improves Cardiac Function in Myocardial Infarction.

Summary

Bilobalide from Ginkgo biloba leaves has cardioprotective effects in myocardial infarction by reducing cardiomyocyte apoptosis and myocardial fibrosis via the inactivation of JNK/p38 MAPK signaling pathways. It may be an effective treatment.

Cardiology
Song W et al (2023).
Mol Biotechnol.
DOI:
10.1007/s12033-023-00753-8
PubMed:
37199885

Ginkgetin suppresses ovarian cancer growth through inhibition of JAK2/STAT3 and MAPKs signaling pathways.

Summary

Ginkgetin, found in Ginkgo biloba leaves, has shown various beneficial effects, but its impact on ovarian cancer remains unclear.

CancerEndocrinologyImmunology
Wu L et al (2023).
Phytomedicine.
DOI:
10.1016/j.phymed.2023.154846
PubMed:
37172479

Efficacy and safety of Ginkgo biloba dropping pills in the treatment of coronary heart disease with stable angina pectoris and depression: study protocol for a randomised, placebo-controlled, parallel-group, double-blind and multicentre clinical trial.

Summary

A study found that GBDPs derived from GBE can improve angina frequency and quality of life in patients with stable angina pectoris and depression symptoms, suggesting potential usefulness as treatment.

CardiologyNeuroscience
Wu T et al (2023).
BMJ Open.
DOI:
10.1136/bmjopen-2021-055263
PubMed:
37164472

Natural antioxidant formula ameliorates lipopolysaccharide-induced impairment of hippocampal neurogenesis and contextual fear memory through suppression of neuroinflammation in rats.

Summary

A natural antioxidant formula (NAF) composed of several beneficial compounds was given to rats in this study, who were also induced with lipopolysaccharide (LPS)-induced cognitive dysfunction. The NAF decreased inflammation in the brain and increased the number of neural progenitor cells, ultimately ameliorating the detrimental effects on neurogenesis and fear memory caused by LPS-induced inflammation. These findings suggest that NAF could be utilized to prevent neuroinflammation, which is thought to contribute to cognitive dysfunction.

ImmunologyNeuroscience
Zeng W et al (2023).
J Chem Neuroanat.
DOI:
10.1016/j.jchemneu.2023.102285
PubMed:
37150363

Ginkgolide C attenuates cerebral ischemia/reperfusion-induced inflammatory impairments by suppressing CD40/NF-κB pathway.

Summary

Ginkgo biloba has been used in Chinese medicine for cardiovascular diseases. Ginkgolide C shows promise in reducing inflammation in cerebral ischemia/reperfusion injury.

CardiologyImmunology
Li B et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116537
PubMed:
37094696

Ginkgo biloba extract attenuates cisplatin-induced renal interstitial fibrosis by inhibiting the activation of renal fibroblasts through down-regulating the HIF-1α/STAT3/IL-6 pathway in renal tubular epithelial cells.

Immunology
Zhang Y et al (2023).
Phytomedicine.
DOI:
10.1016/j.phymed.2023.154809
PubMed:
37087791

Ginkgolide B facilitates muscle regeneration via rejuvenating osteocalcin-mediated bone-to-muscle modulation in aged mice.

Wang BY et al (2023).
J Cachexia Sarcopenia Muscle.
DOI:
10.1002/jcsm.13228
PubMed:
37076950

Ginkgo biloba Leaves Extract's Cosmeceutical Evaluation: A Preliminary Assessment of Human Volunteers towards Achieving Improved Skin Conditions and Rejuvenation.

Abdellatif AAH et al (2023).
Drug Dev Ind Pharm.
DOI:
10.1080/03639045.2023.2204374
PubMed:
37074796

Standardized extract of Ginkgo biloba treatment and novelty on the weak encoding of spatial recognition memory in rats.

de Andrade CV, Soliani AG and Cerutti SM (2023).
Learn Mem.
DOI:
10.1101/lm.053755.123
PubMed:
37072140

Real-time quality control of dripping pill's weight based on laser detection technology.

Wang X et al (2023).
Sci Rep.
DOI:
10.1038/s41598-023-32805-z
PubMed:
37061566

An Evaluation of Tertiary Drug Resources' Consistency Regarding Drug-Drug Interactions Between Tricyclic Antidepressants and Herbal Supplements.

Engel E, Friedt CT and Reinert JP (2023).
J Pharm Technol.
DOI:
10.1177/87551225231154405
PubMed:
37051281

Discovery and characterization of the covalent SARS-CoV-2 3CL(pro) inhibitors from Ginkgo biloba extract via integrating chemoproteomic and biochemical approaches.

Summary

Study investigates how natural and synthetic compounds modify coronavirus proteases. Identifying herbal constituents that target these proteases is challenging but holds potential for COVID-19 treatment.

COVID-19
Zhang YN et al (2023).
Phytomedicine.
DOI:
10.1016/j.phymed.2023.154796
PubMed:
37037086

Efficacy and safety of Ginkgo biloba extract as an adjuvant in the treatment of Chinese patients with sudden hearing loss: a meta-analysis.

Yuan C et al (2023).
Pharm Biol.
DOI:
10.1080/13880209.2023.2190782
PubMed:
36999358

Polyprenols in Ginkgo biloba; a review of their chemistry (synthesis of polyprenols and their derivatives), extraction, purification, and bioactivities.

Review
Boateng ID et al (2023).
Food Chem.
DOI:
10.1016/j.foodchem.2023.136006
PubMed:
36996648

Neuroprotective potential of Ginkgo biloba on alteration of rat cerebellum following prenatal exposure to cyclophosphamide.

Summary

This study investigated the effects of prenatal exposure to the chemotherapeutic drug cyclophosphamide on the cerebellar tissues of rats. The researchers found that exposure caused significant decreases in the number and volume of certain cells, and histopathological evaluation confirmed these findings. They also tested the neuroprotective potential of Ginkgo biloba and found that it significantly attenuated the negative effects of the drug. These results suggest that prenatal exposure to chemotherapeutic drugs can have significant impacts on brain development, but that neuroprotective agents may offer some degree of protection.

Neuroscience
Weli SHW and Yahyazadeh A (2023).
J Chem Neuroanat.
DOI:
10.1016/j.jchemneu.2023.102268
PubMed:
36989922

Effects of processing methods on quality, antioxidant capacity, and cytotoxicity of Ginkgo biloba leaf tea product.

Immunology
Li F et al (2023).
J Sci Food Agric.
DOI:
10.1002/jsfa.12577
PubMed:
36973882

Polysucrose hydrogel loaded with natural molecules/extracts for multiphase-directed sustainable wound healing.

Chummun Phul I et al (2023).
RSC Med Chem.
DOI:
10.1039/d2md00402j
PubMed:
36970144

Ginkgo biloba modulates ET-I/NO signalling in Lead Acetate induced rat model of endothelial dysfunction: Involvement of oxido-inflammatory mediators.

Immunology
Asiwe JN et al (2023).
Int J Environ Health Res.
DOI:
10.1080/09603123.2023.2194612
PubMed:
36960596

Ginkgolide A targets forkhead box O1 to protect against lipopolysaccharide-induced septic cardiomyopathy.

Cardiology
Wang L et al (2023).
Phytother Res.
DOI:
10.1002/ptr.7802
PubMed:
36932920

Efficacy of a mixture of Ginkgo biloba, sesame, and turmeric on cognitive function in healthy adults: Study protocol for a randomized, double-blind, placebo-controlled trial.

Summary

Researchers investigated the cognitive benefits of Ginkgo biloba extract (GBE) supplemented with sesame seed and turmeric (GBE/MST) in healthy adults. Results showed that GBE/MST improved cognitive function more significantly than GBE alone, possibly due to increased terpene lactone concentrations in the brain. These findings suggest that GBE/MST could be a promising natural intervention for cognitive enhancement in healthy adults.

Neuroscience
Nakase T et al (2023).
PLoS One.
DOI:
10.1371/journal.pone.0280549
PubMed:
36921003

Study protocol for a phase III randomised controlled trial of Sailuotong (SLT) for vascular dementia and Alzheimer's disease with cerebrovascular disease.

Summary

A new herbal formulation called Sailuotong (SLT) consisting of extracts from Panax ginseng, Ginkgo biloba, and Crocus sativus was developed and found to enhance cognition in patients with vascular dementia (VaD) in early clinical trials. A phase III clinical trial has been developed to confirm the efficacy and safety of SLT in 238 patients with mild to moderate VaD or VaD mixed with Alzheimer’s disease. Participants will be randomly allocated to receive SLT or placebo capsules for 52 weeks, and primary outcome measures include cognitive and functional assessments. The study aims to provide important data on this novel treatment approach to VaD.

Neuroscience
Karamacoska D et al (2023).
PLoS One.
DOI:
10.1371/journal.pone.0265285
PubMed:
36920949

Effect of Ginkgo biloba extract on pharmacology and pharmacokinetics of atorvastatin in rats with hyperlipidaemia.

Wang Q et al (2023).
Food Funct.
DOI:
10.1039/d2fo03238d
PubMed:
36916480

Co-delivery of doxorubicin/sorafenib by DNA-decorated green ZIF-67-based nanocarriers for chemotherapy and hepatocellular carcinoma treatment.

CancerGenetics
Farasati Far B et al (2023).
Environ Res.
DOI:
10.1016/j.envres.2023.115589
PubMed:
36858304

Protective effects of curcumin and Ginkgo biloba extract combination on a new model of Alzheimer's disease.

Summary

A study evaluated the effects of a combination of curcumin and Ginkgo biloba extract on Alzheimer's disease (AD). Results showed that the combination achieved higher levels of curcumin in the brain and plasma, compared to curcumin alone. The combination treatment reversed cognitive impairment induced by AD in rats, with a more pronounced effect on inhibiting various neurological markers and pro-inflammatory cytokines. The combination therapy might be an alternative therapy in the management/prevention of neurological disorders, and future research should focus on synergic effects of herbal drugs.

Neuroscience
Assi AA et al (2023).
Inflammopharmacology.
DOI:
10.1007/s10787-023-01164-6
PubMed:
36856916

γ-Aminobutyric acid promotes the inhibition of hair growth induced by chronic restraint stress.

Wang X et al (2023).
Life Sci.
DOI:
10.1016/j.lfs.2023.121439
PubMed:
36731645

Ginkgolide B caused the activation of the Akt/eNOS pathway through the antioxidant effect of SOD1 in the diabetic aorta.

Diabetes
Taguchi K et al (2023).
Pflugers Arch.
DOI:
10.1007/s00424-023-02790-3
PubMed:
36715760

Differences in in vivo absorption of flavone glycosides, flavone aglycones and terpene lactones under different dosage forms and physiological conditions.

Phytochemistry
Luo J et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116159
PubMed:
36649852

Coagulation effect of atmospheric submicron particles on plant leaves: Key functional characteristics and a comparison with dry deposition.

Lyu J et al (2023).
Sci Total Environ.
DOI:
10.1016/j.scitotenv.2023.161582
PubMed:
36640873

Investigating the mechanism of action of ginkgolides and bilobalide on absence seizures in male WAG/Rij rats.

Gedikli Ö, Akca M and Yildirim M (2023).
J Neurosci Res.
DOI:
10.1002/jnr.25166
PubMed:
36634122

Overexpression of the Ginkgo biloba dihydroflavonol 4-reductase gene GbDFR6 results in the self-incompatibility-like phenotypes in transgenic tobacco.

Zhang N et al (2023).
Plant Signal Behav.
DOI:
10.1080/15592324.2022.2163339
PubMed:
36630727

Ginkgo biloba extracts protect human retinal Müller glial cells from t-BHP induced oxidative damage by activating the AMPK-Nrf2-NQO-1 axis.

Li Y et al (2023).
J Pharm Pharmacol.
DOI:
10.1093/jpp/rgac095
PubMed:
36583518

Novel bioactive peptides from ginkgo biloba seed protein and evaluation of their α-glucosidase inhibition activity.

Wang X et al (2023).
Food Chem.
DOI:
10.1016/j.foodchem.2022.134481
PubMed:
36240562

Comparative Inhibitory Effects of Natural Biflavones from Ginkgo against Human CYP1B1 in Recombinant Enzymes and MCF-7 Cells.

Chen X et al (2023).
Planta Med.
DOI:
10.1055/a-1936-4807
PubMed:
36064115

Ginkgo biloba extract mitigates the neurotoxicity of AlCl(3) in alzheimer rat's model: role of apolipoprotein E4 and clusterin genes in stimulating ROS generation and apoptosis.

GeneticsNeuroscience
Batawi AH et al (2024).
Int J Neurosci.
DOI:
10.1080/00207454.2022.2082968
PubMed:
35634646

Neuroprotective and Antioxidant Effect of Ginkgo biloba Extract Against AD and Other Neurological Disorders.

Summary

This abstract discusses the potential use of Ginkgo biloba extract (GBE) in the prevention of Alzheimer's disease (AD). GBE is a popular herbal remedy taken by elderly people to improve memory and cognitive function. However, its effectiveness in the prevention and treatment of dementia is controversial. The review summarizes recent advancements on the study of the antioxidant properties of GBE in the prevention of AD, including its potential use in patients who are already undergoing conventional anti-dementia treatments. Understanding the mechanisms of action of GBE against AD will help to design therapeutic strategies and gain a better understanding of the underlying neurodegenerative processes.

Review Neuroscience
Singh SK et al (2019).
Neurotherapeutics.
DOI:
10.1007/s13311-019-00767-8
PubMed:
31376068

Ginkgo Biloba.

Nguyen T and Alzahrani T (2022).
PubMed:
31082068

Ginkgo biloba in the treatment of tinnitus: An updated literature review.

Review
Mahmoudian-Sani MR et al (2017).
Int Tinnitus J.
DOI:
10.5935/0946-5448.20170011
PubMed:
28723603

Ginkgo biloba Extract in Vascular Protection: Molecular Mechanisms and Clinical Applications.

Review
Tian J, Liu Y and Chen K (2017).
Curr Vasc Pharmacol.
DOI:
10.2174/1570161115666170713095545
PubMed:
28707602

Review of Ginkgo biloba-induced toxicity, from experimental studies to human case reports.

Review
Mei N et al (2017).
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev.
DOI:
10.1080/10590501.2016.1278298
PubMed:
28055331

Ginkgo biloba: indications, mechanisms, and safety.

Review
Diamond BJ and Bailey MR (2013).
Psychiatr Clin North Am.
DOI:
10.1016/j.psc.2012.12.006
PubMed:
23538078

Ginkgo biloba.

Review
Sierpina VS, Wollschlaeger B and Blumenthal M (2003).
Am Fam Physician.
PubMed:
13678141