Study examined gene expression in Gleditsia plants after grafting, revealing specific mRNA and miRNA in different graft combinations. Results enhance understanding of plant hormone signaling and rootstock effects for potential resource development in breeding.
Study analyzed Professor Xu Zhiyin's treatment of thyroid nodules to identify patterns in symptoms, causes, and treatments. Provides valuable clinical insights and scholarly perspectives for managing this condition.
Tossers studied how drought affects G. sinensis growth, impacting industry. RNA-seq analyzed gene expression in resistant vs susceptible seedlings, providing insights for improving tolerance.
The dried spines of Gleditsia sinensis Lam, known as "Gleditsiae Spina," contain various chemical components. This study used network pharmacology, molecular docking, and molecular dynamics simulations to investigate the potential of Gleditsiae Spina for treating pancreatic cancer. The study identified common targets such as AKT1, TP53, TNFα, IL6, and VEGFA. Critical pathways involved fisetin, eriodyctiol, kaempferol, and quercetin. The MD simulations showed that eriodyctiol and kaempferol had stable hydrogen bonds and high binding free energy for TP53. These findings can help explore leading compounds and potential drugs for pancreatic cancer.