Common Names: cultivated licorice
Researchers studied Lupiwighteone (Lup) in drug-resistant leukemia cells. Lup reversed Multidrug Resistance (MDR) in K562 cells. Potential mechanism for cancer treatment. Important for overcoming chemotherapy resistance.
Researchers studied antiviral properties of medicinal plants in Egypt, showing potential for treating serious viral diseases. Important due to high mortality rates, lack of cures, and emergence of resistant strains.
Glabridin from liquorice roots effectively disinfects L. monocytogenes, especially on stainless steel surfaces. Efficacy may vary with different food residues. Potential as a natural surface disinfectant.
G. glabra can modulate immune cells to suppress TH1 and activate Treg cells, potentially inhibiting tumor development. Important for understanding and developing new cancer treatments.
Scientists evaluated the binding affinities of phytoestrogens from medicinal plants for estrogen receptor β, using a yeast-based fluorescent assay. This can help identify potential treatments for gynecological diseases and assess environmental substances affecting the female reproductive system.
Research suggests natural products may offer alternative, cost-effective treatments for cardiovascular diseases, with potential benefits including anti-oxidant and anti-cholesterol effects. Explore their potential alongside conventional therapies.
GG extract reduced anxiety behavior and salt preference in rats under chronic stress conditions by altering gene expression of barrier proteins in the prefrontal cortex. GG may be a beneficial therapy for depression and anxiety disorders with high aldosterone levels and inflammation.
Study on neuroprotective effects of plant extracts on rats exposed to vacuum gas oil in their diet. Shows potential to counteract negative neurological effects of VGO consumption. Utilizes biochemical assays to evaluate antioxidant and lipid levels in the brain.
This review examines current research on Ayurvedic rasayanas in oncology. It aims to summarize the literature, identify knowledge gaps, and highlight the adaptogenic effects of these natural products. Read it for insights on using rasayanas in your lab.
Glycyrrhizin and its derivative Enoxolone show potential as antiviral treatments. This clinical trial focuses on evaluating the safety and effectiveness of a nebulized GA/18β drug for treating COVID-19 patients.
Glycyrrhiza glabra (liquorice) might have therapeutic effects in treating acute pancreatitis by interacting with the protein MAPK3, according to computational biology methods and in vitro experiments.
Immunosenescence and age-related immune system changes contribute to the severity of COVID-19. Glycyrrhiza glabra in a polyherbal formulation boosts immunity and has antiviral properties. Phytoconstituents, particularly liquiritigenin, inhibit the major protease protein of SARS-CoV-2, highlighting potential for clinical drug development.
Researchers formulated and characterized remdesivir and licorice extract nanoemulsions for subcutaneous injection against coronavirus. Licorice extract nanoemulsion showed better release and stability, making it a potential treatment for mild to moderate coronavirus.
This study analyzed metal content and composition of compounds in licorice roots from Armenia. Results showed safe metal levels and highlighted the impact of soil characteristics on compound composition. The licorice extract from all regions exhibited significant antioxidant properties.
Researchers found that TC + PL extract reduced insulin resistance and liver weight in mice, while Saroglitazar reversed body weight and lipid level changes. These extracts hold promise for preventing obesity-related complications.
Matrine and oxymatrine, alkaloids found in Sophora plants and sometimes in liquorice products, were found unlikely to cause gene mutations. The study highlights the need for further research on secondary plant metabolites. (41 words)
This study tested licorice extract as a treatment for COVID-19. The results showed that licorice did not significantly improve symptoms like body temperature and respiratory rate, but it did improve levels of CRP and ALT. Licorice was found to be safe, but larger trials are needed to confirm these results.
Scientists modified genistein, a compound found in licorice, to enhance its anticancer effects against breast and lung cancer. Computational studies showed improved antineoplastic activity, acceptable ADME profiles, and increased binding affinities to cancer proteins. Further experimental investigation is needed.
Researchers investigated the effects of Licochalcone A (LCA) on myocardial ischemia-reperfusion (I/R) injury. LCA demonstrated cardioprotective effects by inhibiting ferroptosis and reducing markers of damage. This suggests a potential new treatment strategy for I/R injury.
Favipiravir didn't work against SARS-CoV-2, but Cridanimod showed promising results in suppressing its replication. Tilorone stimulated replication, while licorice extract inhibited replication but with low activity. Cridanimod is a potential candidate for clinical trials, while licorice extract could be further developed as a safe adjunctive therapy.
Glabridin, a compound found in licorice roots, has anti-inflammatory and antioxidant properties. It can reduce inflammation, oxidative stress, and IgE antibodies in rats with allergic asthma. Further research and clinical trials are needed to evaluate its potential as a treatment for this condition.
Glabridin, extracted from Glycyrrhiza glabra, protects zebrafish brains from the negative effects of Titanium dioxide nanoparticles by reducing oxidative stress and inflammation. This suggests glabridin has potential neuroprotective properties.
Glabridin, a compound found in Glycyrrhiza glabra, has shown potential in the treatment of Triple-negative breast cancer (TNBC). In a mouse model, glabridin enhanced the effectiveness of the front-line therapy, paclitaxel, by reducing tumor burden and inhibiting the formation of lung nodules. It also reversed the traits of hostile cancer cells and promoted apoptosis in tumor tissue. Furthermore, glabridin improved the pharmacokinetics of paclitaxel by slowing down its metabolism in the liver. With its dual role in enhancing anti-metastatic activity and limiting tumorigenesis, glabridin shows promise as a potential neoadjuvant therapy for paclitaxel chemoresistance and cancer recurrence. Further research is needed to fully explore its potential.
Researchers studied the antiviral properties of Glycyrrhiza glabra, a herbal remedy, to develop new, safe, and effective drugs for various viral infections.