GeoBotanical: Glycyrrhiza uralensis

1.

Total Syntheses and Anti-Inflammatory Studies of Three Natural Coumarins: Glycycoumarin, Glycyrin, and 3-O-Methylglycyrol.

Immunology

Peng T et al (2024).; Molecules.
DOI:: 10.3390/molecules29163942
PubMed:: 39203020

2.

Mechanism of Jizhi syrup's prevention and treatment of acute bronchitis based on LPS-iNOS inflammatory mediators' signalling pathway.

Immunology

Han M et al (2024).; J Ethnopharmacol.
DOI:: 10.1016/j.jep.2024.118708
PubMed:: 39197804

3.

Enhanced salt tolerance in Glycyrrhiza uralensis Fisch. via Bacillus subtilis inoculation alters microbial community.

Xiao J et al (2024).; Microbiol Spectr.
DOI:: 10.1128/spectrum.03812-23
PubMed:: 39189758

4.

Licochalcone A: a review of its pharmacology activities and molecular mechanisms.

Review

Liu M, Du Y and Gao D (2024).; Front Pharmacol.
DOI:: 10.3389/fphar.2024.1453426
PubMed:: 39188947

5.

Effect of Glycyrrhiza uralensis crude water extract on the expression of Nitric Oxide Synthase 2 gene during myogenesis.

Genetics

Fatima Qadri A et al (2024).; Heliyon.
DOI:: 10.1016/j.heliyon.2024.e34747
PubMed:: 39149015

6.

Genome-wide identification of Glycyrrhiza uralensis Fisch. MAPK gene family and expression analysis under salt stress relieved by Bacillus subtilis.

Genetics Immunology

Gao P et al (2024).; Front Genet.
DOI:: 10.3389/fgene.2024.1442277
PubMed:: 39130754

7.

Influence of Habitat and Effects of Salt Stress on Biochemical and Physiological Parameters of Glycyrrhiza uralensis.

Gu J, Jia T and Ma M (2024).; Plants (Basel).
DOI:: 10.3390/plants13152108
PubMed:: 39124226

8.

Injectable Regenerated Silk Fibroin Micro/Nanosphere with Enhanced Permeability and Stability for Osteoarthritis Therapy.

Wang Z et al (2024).; Small.
DOI:: 10.1002/smll.202405049
PubMed:: 39101301

9.

Self-assembly variation of glycyrrhetinic acid epimers: Assembly mechanism and antibacterial efficacy between 18 α-GA and 18 β-GA.

Lin X et al (2024).; Colloids Surf B Biointerfaces.
DOI:: 10.1016/j.colsurfb.2024.114120
PubMed:: 39059147

10.

Neural Circuit Mechanisms of Sinisan formula for the Treatment of adolescent Depression: prefrontal cortex to dorsal raphe nucleus.

Summary

Researchers investigated the Sinisan formula's impact on neuron activity and circuits for treating depression. Understanding its mechanisms can lead to improved treatment options for depression.

Neuroscience

Zhou L et al (2024).; J Ethnopharmacol.
DOI:: 10.1016/j.jep.2024.118529
PubMed:: 38972528

11.

Licochalcone D exhibits cytotoxicity in breast cancer cells and enhances tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis through upregulation of death receptor 5.

Summary

Licochalcone D (LCD) from Glycyrrhiza uralensis Fisch inhibits breast cancer growth, induces DNA damage, and potentiates TRAIL-induced apoptosis via JNK/p38 MAPK-CHOP pathway. Promising natural anticancer agent.

Cancer

Zhang Y et al (2024).; J Biochem Mol Toxicol.
DOI:: 10.1002/jbt.23757
PubMed:: 38937960

12.

Twin Strep-Tag Modified CPT1A Mitochondrial Membrane Chromatography in Screening Lipid Metabolism Regulators.

Phytochemistry

Su W et al (2024).; Anal Chem.
DOI:: 10.1021/acs.analchem.4c02402
PubMed:: 38912707

13.

Study on the material basis and immunological enhancement activity of dangdi oral liquid.

Zhou Z et al (2024).; Heliyon.
DOI:: 10.1016/j.heliyon.2024.e32160
PubMed:: 38912465

14.

Glycyrrhiza uralensis polysaccharides ameliorates cecal ligation and puncture-induced sepsis by inhibiting the cGAS-STING signaling pathway.

Hui S et al (2024).; Front Pharmacol.
DOI:: 10.3389/fphar.2024.1374179
PubMed:: 38904004

15.

Comprehensive reutilization of Glycyrrhiza uralensis residue by extrusion-biological pretreatment for coproduction of flavonoids, cellulase, and ethanol.

Phytochemistry

Chang S et al (2024).; Bioresour Technol.
DOI:: 10.1016/j.biortech.2024.131002
PubMed:: 38889869

16.

A synergistic mechanism of Liquiritin and Licochalcone B from Glycyrrhiza uralensis against COPD.

Dong S et al (2024).; Phytomedicine.
DOI:: 10.1016/j.phymed.2024.155664
PubMed:: 38870751

17.

Glycyrol Relieves Ulcerative Colitis by Promoting the Fusion of ZO-1 with the Cell Membrane through the Enteric Glial Cells GDNF/RET Pathway.

Gastroenterology

Lu S et al (2024).; J Agric Food Chem.
DOI:: 10.1021/acs.jafc.4c00239
PubMed:: 38860840

18.

The alleviation effect and its mechanism of Niuhuang Jiedu prescription on realgar-induced genotoxicity in Mice.

Dong J et al (2024).; J Ethnopharmacol.
DOI:: 10.1016/j.jep.2024.118426
PubMed:: 38844250

19.

Design and optimization of heat pump with infrared drying for Glycyrrhiza uralensis (Licorice) processing.

Zhu L et al (2024).; Front Nutr.
DOI:: 10.3389/fnut.2024.1382296
PubMed:: 38835959

20.

Combining metabolomics and transcriptomics to reveal the potential medicinal value of rare species Glycyrrhiza squamulose.

Genetics

Ma B et al (2024).; Heliyon.
DOI:: 10.1016/j.heliyon.2024.e30868
PubMed:: 38803917

21.

Liquiritigenin Induces Cell Cycle Arrest and Apoptosis in Lung Squamous Cell Carcinoma.

Liu Y et al (2024).; Cell Biochem Biophys.
DOI:: 10.1007/s12013-024-01294-w
PubMed:: 38775930

22.

Chemical quality evaluation and characteristics of interspecific hybrid (G. uralensis × G. glabra) C-18 strain as a new Licorice cultivar.

Shibano M, Matsuda K and Ozaki K (2024).; J Nat Med.
DOI:: 10.1007/s11418-024-01819-w
PubMed:: 38775894

23.

Visualized electrochemiluminescence detection of trace copper in practical food samples.

Wang C et al (2024).; Food Chem.
DOI:: 10.1016/j.foodchem.2024.139461
PubMed:: 38701733

24.

Endophytic Bacillus pumilus G5 Interacting with Silicon to Improve Drought Stress Resilience in Glycyrrhiza uralensis Fisch. by Modulating Nitrogen Absorption, Assimilation, and Metabolism Pathways.

Xu Z et al (2024).; J Agric Food Chem.
DOI:: 10.1021/acs.jafc.4c00282
PubMed:: 38661009

25.

Integrative physiology and transcriptome reveal salt-tolerance differences between two licorice species: Ion transport, Casparian strip formation and flavonoids biosynthesis.

Genetics Phytochemistry

Li X et al (2024).; BMC Plant Biol.
DOI:: 10.1186/s12870-024-04911-1
PubMed:: 38605293

26.

Exploring the effective components of honey-processed licorice (Glycyrrhiza uralensis Fisch.) in attenuating Doxorubicin-induced myocardial cytotoxicity by combining network pharmacology and in vitro experiments.

Summary

Study found honey-processed licorice (HPL) has stronger heart protection than raw licorice. Material basis and mechanism still unclear. Relevant for clinical use of traditional Chinese herb.

Cardiology

Sun P et al (2024).; J Ethnopharmacol.
DOI:: 10.1016/j.jep.2024.118178
PubMed:: 38604511

27.

Efficacy of botanical lozenges in the treatment of chronic pharyngitis: a randomized controlled trial.

Wu Y et al (2024).; Front Pharmacol.
DOI:: 10.3389/fphar.2024.1162883
PubMed:: 38549665

28.

Exploring the dietary and therapeutic potential of licorice (Glycyrrhiza uralensis Fisch.) sprouts.

Park YS et al (2024).; J Ethnopharmacol.
DOI:: 10.1016/j.jep.2024.118101
PubMed:: 38527575

29.

Glycyrrhizic acid treatment ameliorates anxiety-like behaviour via GLT1 and Per1/2-dependent pathways.

Summary

Glycyrrhiza is a traditional Chinese herb with potential health benefits, including anti-inflammatory and anti-viral properties. Research suggests it may be useful in medicinal applications. Scientists should keep it on their radar for future studies.

Neuroscience

Ma S et al (2024).; J Ethnopharmacol.
DOI:: 10.1016/j.jep.2024.118013
PubMed:: 38453099

30.

The polysaccharides from seeds of Glycyrrhiza uralensis ameliorate metabolic disorders and restructure gut microbiota in type 2 diabetic mice.

Summary

GUP from Glycyrrhiza uralensis improves glycemic control, reduces oxidative stress and liver lipid levels, enhances intestinal barrier, kidney function, and gut microbiota diversity in T2D mice. Dietary strategy for diabetes control and overall health improvement.

Diabetes Gastroenterology

Ye J et al (2024).; Int J Biol Macromol.
DOI:: 10.1016/j.ijbiomac.2024.130622
PubMed:: 38447833

31.

Exogenous betaine enhances salt tolerance of Glycyrrhiza uralensis through multiple pathways.

Dong X et al (2024).; BMC Plant Biol.
DOI:: 10.1186/s12870-024-04851-w
PubMed:: 38431542

32.

Bacillus cereus G2 alleviate salt stress in Glycyrrhiza uralensis Fisch. by balancing the downstream branches of phenylpropanoids and activating flavonoid biosynthesis.

Phytochemistry

Xiao X et al (2024).; Ecotoxicol Environ Saf.
DOI:: 10.1016/j.ecoenv.2024.116129
PubMed:: 38430580

33.

Liquiritin reduces chondrocyte apoptosis through P53/PUMA signaling pathway to alleviate osteoarthritis.

Cancer

Qiu M et al (2024).; Life Sci.
DOI:: 10.1016/j.lfs.2024.122536
PubMed:: 38423170

34.

Long COVID-19 gastrointestinal related disorders and traditional Chinese medicine: A network target-based approach.

Summary

Research reviewed nutraceuticals from Traditional Chinese Medicine for relieving Long COVID-19 gastrointestinal symptoms. Identified plants such as Cinnamomum cassia and Salvia miltiorrhiza show promise in reducing inflammation and oxidative stress. These natural remedies may offer multi-target therapeutic benefits for Long COVID-19 complications.

Review COVID-19

Mattioli LB et al (2024).; Phytother Res.
DOI:: 10.1002/ptr.8163
PubMed:: 38421118

35.

Integrated Metabolomics and Transcriptomics Analyses Highlight the Flavonoid Compounds Response to Alkaline Salt Stress in Glycyrrhiza uralensis Leaves.

Summary

Researchers studied how flavonoids in help the plant tolerate alkaline salt stress by analyzing metabolites and gene expression. Flavonoids act as antioxidants, aiding in stress tolerance. Findings offer new insights for improving plant tolerance to environmental stress.

Genetics Phytochemistry

Lv X et al (2024).; J Agric Food Chem.
DOI:: 10.1021/acs.jafc.3c07139
PubMed:: 38416716

36.

Isoliquiritin counteracts cadmium-induced intestinal damage in mice through enhancing intestinal barrier function and inhibiting apoptosis.

Gastroenterology

Zhao L et al (2024).; Food Chem Toxicol.
DOI:: 10.1016/j.fct.2024.114544
PubMed:: 38401882

37.

Lizhong decoction ameliorates ulcerative colitis by inhibiting ferroptosis of enterocytes via the Nrf2/SLC7A11/GPX4 pathway.

Gastroenterology

Li W et al (2024).; J Ethnopharmacol.
DOI:: 10.1016/j.jep.2024.117966
PubMed:: 38401661

38.

Isoliquiritigenin inhibits NLRP3 inflammasome activation with CAPS mutations by suppressing caspase-1 activation and mutated NLRP3 aggregation.

Usui-Kawanishi F et al (2024).; Genes Cells.
DOI:: 10.1111/gtc.13108
PubMed:: 38366709

39.

Mechanistic investigation of the ameliorative effect of liquiritin on hypoxia/reoxygenation‑induced cardiomyocyte injury based on network pharmacology and in vitro validation.

Li H et al (2024).; Exp Ther Med.
DOI:: 10.3892/etm.2024.12405
PubMed:: 38361515

40.

Licochalcone A induces mitochondria-dependent apoptosis and interacts with venetoclax in acute myeloid leukemia.

Summary

Licochalcone A (LCA), from licorice roots, reduces AML cell viability, induces cell death, inhibits signaling pathways, and enhances effectiveness of venetoclax, indicating potential as AML treatment.

Cancer

Li Y et al (2024).; Eur J Pharmacol.
DOI:: 10.1016/j.ejphar.2024.176418
PubMed:: 38350590

41.

Licorice flavonoid ameliorates ethanol-induced gastric ulcer in rats by suppressing apoptosis via PI3K/AKT signaling pathway.

Gastroenterology Phytochemistry

Guo Y et al (2024).; J Ethnopharmacol.
DOI:: 10.1016/j.jep.2024.117739
PubMed:: 38301986

42.

Maternal Effects of Habitats Induce Stronger Salt Tolerance in Early-Stage Offspring of Glycyrrhiza uralensis from Salinized Habitats Compared with Those from Non-Salinized Habitats.

Gu J, Yao S and Ma M (2024).; Biology (Basel).
DOI:: 10.3390/biology13010052
PubMed:: 38275728

43.

Licochalcone A and B enhance muscle proliferation and differentiation by regulating Myostatin.

Ahmad K et al (2024).; Phytomedicine.
DOI:: 10.1016/j.phymed.2024.155350
PubMed:: 38237512

44.

Integrated serum pharmacochemistry and investigation of the anti-influenza A virus pneumonia effect of Qingjin Huatan decoction.

Liu M et al (2024).; J Ethnopharmacol.
DOI:: 10.1016/j.jep.2024.117701
PubMed:: 38185258

45.

Glycyrrhizin Production in Licorice Hairy Roots Based on Metabolic Redirection of Triterpenoid Biosynthetic Pathway by Genome Editing.

Genetics

Chiyo N et al (2023).; Plant Cell Physiol.
DOI:: 10.1093/pcp/pcad161
PubMed:: 38153756

46.

Disruption of a licorice cellulose synthase-derived glycosyltransferase gene demonstrates its in planta role in soyasaponin biosynthesis.

Genetics

Sakanishi M et al (2023).; Plant Cell Rep.
DOI:: 10.1007/s00299-023-03095-6
PubMed:: 38135741

47.

Comprehensive study on genetic and chemical diversity of Asian medicinal plants, aimed at sustainable use and standardization of traditional crude drugs.

Review

Komatsu K et al (2023).; J Nat Med.
DOI:: 10.1007/s11418-023-01770-2
PubMed:: 38133706

48.

Spatial Distribution and Characterization of the Small-Molecule Metabolites and In Situ Hydrolyzed Oligosaccharides in the Rhizome of Glycyrrhiza uralensis by Desorption Electrospray Ionization-Mass Spectrometry Imaging and High-Resolution Liquid Chromatography-Mass Spectrometry.

Phytochemistry

Zhao Y et al (2023).; J Agric Food Chem.
DOI:: 10.1021/acs.jafc.3c04996
PubMed:: 38055271

49.

The Importance of Traditional Chinese Medicine in the Intervention and Treatment of HIV while Considering its Safety and Efficacy.

Shahrajabian MH and Sun W (2023).; Curr HIV Res.
DOI:: 10.2174/011570162X271199231128092621
PubMed:: 38047360

50.

Modulating the gut microbiota is involved in the effect of low-molecular-weight Glycyrrhiza polysaccharide on immune function.

Summary

Low molecular weight polysaccharide (GP) improves gut health and boosts immune system by increasing immune cells, cytokines, and beneficial gut bacteria while reducing harmful bacteria. GP could be a potential treatment for intestinal inflammatory diseases.

Gastroenterology

Song W et al (2023).; Gut Microbes.
DOI:: 10.1080/19490976.2023.2276814
PubMed:: 37948152

51.

The compatibility rationality of Sijunzi decoction based on integrated analysis of tissue distribution and excretion characteristics in spleen deficiency syndrome rats.

Dong B et al (2023).; J Ethnopharmacol.
DOI:: 10.1016/j.jep.2023.117376
PubMed:: 37918551

52.

Investigation of the principle of concoction by using the processing excipient Glycyrrhiza uralensis Fisch. juice to reduce the hepatotoxicity of Dioscorea bulbifera L. and enhance its main efficacy as expectorant and cough suppressant.

Song L et al (2023).; J Ethnopharmacol.
DOI:: 10.1016/j.jep.2023.117372
PubMed:: 37913830

53.

Maimendong decoction regulates M2 macrophage polarization to suppress pulmonary fibrosis via PI3K/Akt/FOXO3a signalling pathway-mediated fibroblast activation.

Summary

Mai Men Dong decoction (MMDD), a traditional Chinese medicine, contains herbs known for treating respiratory conditions. Studying MMDD can enhance understanding and development of ethnopharmacology.

Immunology

Shuangshuang HE et al (2023).; J Ethnopharmacol.
DOI:: 10.1016/j.jep.2023.117308
PubMed:: 37865276

54.

Insights into the missing apiosylation step in flavonoid apiosides biosynthesis of Leguminosae plants.

Summary

Researchers discovered an enzyme that efficiently catalyzes the apiosylation of flavonoid glycosides, identified key sugar-binding motifs, obtained mutants with altered sugar selectivity, and synthesized flavonoid apiosides. This has implications for understanding apioside biosynthesis and phenolic apiosyltransferase applications.

Phytochemistry

Wang HT et al (2023).; Nat Commun.
DOI:: 10.1038/s41467-023-42393-1
PubMed:: 37863881

55.

Isoliquiritigenin suppresses the progression of malignant melanoma via targeting H2A.Z.1-E2F1 pathway.

Xiang S et al (2023).; Biochem Pharmacol.
DOI:: 10.1016/j.bcp.2023.115859
PubMed:: 37863326

56.

Bacillus cereus G2 Facilitates N Cycle in Soil, Further Improves N Uptake and Assimilation, and Accelerates Proline and Glycine Betaine Metabolisms of Glycyrrhiza uralensis Subjected to Salt Stress.

Peng X et al (2023).; J Agric Food Chem.
DOI:: 10.1021/acs.jafc.3c04936
PubMed:: 37828905

57.

Interpretation of the anti-influenza active ingredients and potential mechanisms of Ge Gen Decoction based on spectrum-effect relationships and network analysis.

Liu X et al (2023).; J Ethnopharmacol.
DOI:: 10.1016/j.jep.2023.117290
PubMed:: 37806538

58.

Licochalcone A induces G2/M phase arrest and apoptosis via regulating p53 pathways in esophageal cancer: In-vitro and in-vivo study.

Summary

Licochalcone A (LCA), a compound from Glycyrrhiza uralensis, shows potential for treating esophageal cancer (EC). LCA inhibited EC cell proliferation, migration, and invasion while inducing apoptosis and cell cycle arrest. LCA also inhibited tumor growth in mice without major side effects. LCA can be a promising therapy for EC by regulating the p53 pathway.

Cancer

Liu J et al (2023).; Eur J Pharmacol.
DOI:: 10.1016/j.ejphar.2023.176080
PubMed:: 37758012

59.

Qishen granule attenuates doxorubicin-induced cardiotoxicity by protecting mitochondrial function and reducing oxidative stress through regulation of Sirtuin3.

Immunology

Zhang J et al (2023).; J Ethnopharmacol.
DOI:: 10.1016/j.jep.2023.117134
PubMed:: 37714227

60.

Screening potential treatments for mpox from Traditional Chinese Medicine by using a data-driven approach.

Li L et al (2023).; Medicine (Baltimore).
DOI:: 10.1097/MD.0000000000035116
PubMed:: 37713907

61.

Recruitment of Hippodamia variegata by active volatiles from Glycyrrhiza uralensis and Alhagi sparsifolia plants infested with Aphis atrata.

Jiang Y et al (2023).; Pest Manag Sci.
DOI:: 10.1002/ps.7765
PubMed:: 37691614

62.

Novel Psychopharmacological Herbs Relieve Behavioral Abnormalities and Hippocampal Dysfunctions in an Animal Model of Post-Traumatic Stress Disorder.

Park HR, Cai M and Yang EJ (2023).; Nutrients.
DOI:: 10.3390/nu15173815
PubMed:: 37686847

63.

Zhisou powder displays therapeutic effect on chronic bronchitis through inhibiting PI3K/Akt/HIF-1α/VEGFA signaling pathway and reprograming metabolic pathway of arachidonic acid.

Dong Y et al (2023).; J Ethnopharmacol.
DOI:: 10.1016/j.jep.2023.117110
PubMed:: 37673198

64.

Comparison of halitosis according to herbal mouthwash containing Glycyrrhiza uralensis extract and saline mouthwash: A randomized, double-blind, placebo-controlled study.

Kim YR and Nam SH (2023).; Int J Dent Hyg.
DOI:: 10.1111/idh.12724
PubMed:: 37635655

65.

Potential Antioxidant and Anti-Inflammatory Effects of Lonicera japonica and Citri Reticulatae Pericarpium Polyphenolic Extract (LCPE).

Immunology

Jeong SH et al (2023).; Antioxidants (Basel).
DOI:: 10.3390/antiox12081582
PubMed:: 37627577

66.

Inhibition by components of Glycyrrhiza uralensis of 3CLpro and HCoV-OC43 proliferation.

Summary

Compounds from (name of the source) showed inhibitory activity and binding affinity for the key enzyme 3CLpro in SARS-CoV-2, reducing viral growth and cytotoxicity in cells. This suggests they could be potential treatment options for COVID-19.

COVID-19

Kim JH et al (2023).; J Enzyme Inhib Med Chem.
DOI:: 10.1080/14756366.2023.2242704
PubMed:: 37537881

67.

In Vitro Inhibition of Human Cytochrome P450 Enzymes by Licoisoflavone B from Glycyrrhiza uralensis Fisch. ex DC.

Chen L et al (2023).; Toxicol Sci.
DOI:: 10.1093/toxsci/kfad079
PubMed:: 37535691

68.

Database of space life investigations and information on spaceflight plant biology.

Wang S et al (2023).; Planta.
DOI:: 10.1007/s00425-023-04213-0
PubMed:: 37528331

69.

Therapeutic potential of traditional Chinese medicine for interstitial lung disease.

Review

Zhou YM et al (2023).; J Ethnopharmacol.
DOI:: 10.1016/j.jep.2023.116952
PubMed:: 37487964

70.

Absorption, tissue distribution, and excretion of glycycoumarin, a major bioactive coumarin from Chinese licorice (Glycyrrhiza uralensis Fisch).

Ye L et al (2023).; Front Pharmacol.
DOI:: 10.3389/fphar.2023.1216985
PubMed:: 37484020

71.

Enrichment and qualitative analysis of flavonoid glycosides from the aerial parts of Glycyrrhiza uralensis Fisch.

Phytochemistry

Chang G et al (2023).; Nat Prod Res.
DOI:: 10.1080/14786419.2023.2226296
PubMed:: 37431638

72.

MWCNTs and ZnO-based Ce-MOF nanocomposites as enhanced sensing platform for electrochemical detection of carbendazim in Chinese traditional herbs samples.

Lai H et al (2023).; Mikrochim Acta.
DOI:: 10.1007/s00604-023-05869-x
PubMed:: 37407849

73.

Ameliorative effect of scopolamine-induced cognitive dysfunction by Fufangmuniziqi formula: The roles of alkaloids, saponins, and flavonoids.

Summary

The Fufangmuniziqi formula (FFMN) is a traditional Uyghur medicine in China, composed of 13 herbs. Several of these herbs, including Peganum harmala L., Glycyrrhiza uralensis Fisch., and Nigella glandulifera, have shown potential effects against Alzheimer's disease (AD) by inhibiting acetylcholinesterase (AChE), reducing neuroinflammation, and acting as antioxidants. Despite these promising findings, further research is required to uncover FFMN's precise mechanism of action and to confirm its effectiveness against AD.

Neuroscience Phytochemistry

Zhao X et al (2023).; J Ethnopharmacol.
DOI:: 10.1016/j.jep.2023.116792
PubMed:: 37356745

74.

Qingjin Huatan decoction protects mice against influenza a virus pneumonia via the chemokine signaling pathways.

Liu M et al (2023).; J Ethnopharmacol.
DOI:: 10.1016/j.jep.2023.116745
PubMed:: 37336335

75.

Network pharmacology-based approach to research the effect and mechanism of Si-Miao-Yong-An decoction against thromboangiitis obliterans.

Zou J et al (2023).; Ann Med.
DOI:: 10.1080/07853890.2023.2218105
PubMed:: 37318081

76.

Exploring the effect and mechanism of Haizao Yuhu decoction containing three variants of glycyrrhiza on goiter using an integrated strategy of network pharmacology and RNA sequencing.

Genetics

Li M et al (2023).; J Ethnopharmacol.
DOI:: 10.1016/j.jep.2023.116750
PubMed:: 37295576

77.

Licorice as a herbal extract in periodontal therapy.

Review

Khan SF et al (2023).; Drug Target Insights.
DOI:: 10.33393/dti.2022.2583
PubMed:: 37288311

78.

[Advances in research methods for biosynthetic pathway analysis of active ingredients in traditional Chinese medicine].

Shi WL et al (2023).; Zhongguo Zhong Yao Za Zhi.
DOI:: 10.19540/j.cnki.cjcmm.20230324.101
PubMed:: 37282856

79.

Metagenomics insights into responses of rhizobacteria and their alleviation role in licorice allelopathy.

Liu Y et al (2023).; Microbiome.
DOI:: 10.1186/s40168-023-01511-3
PubMed:: 37211607

80.

Seabuckthorn Wuwei Pulvis attenuates chronic obstructive pulmonary disease in rat through gut microbiota-short chain fatty acids axis.

Gastroenterology

Wang J et al (2023).; J Ethnopharmacol.
DOI:: 10.1016/j.jep.2023.116591
PubMed:: 37146846

81.

Herbs for lochia discharge used among postpartum women in Taiwan.

Huang SS et al (2023).; J Ethnopharmacol.
DOI:: 10.1016/j.jep.2023.116552
PubMed:: 37146845

82.

Plant-beneficial Streptomyces dioscori SF1 potential biocontrol and plant growth promotion in saline soil within the arid and semi-arid areas.

Li X et al (2023).; Environ Sci Pollut Res Int.
DOI:: 10.1007/s11356-023-27362-x
PubMed:: 37145360

83.

Effects of Different Drying Methods on Drying Characteristics and Quality of Glycyrrhiza uralensis (Licorice).

Zhu L et al (2023).; Foods.
DOI:: 10.3390/foods12081652
PubMed:: 37107448

84.

Gut microbiota-based metabolites of Xiaoyao Pills (a typical Traditional Chinese medicine) ameliorate depression by inhibiting fatty acid amide hydrolase levels in brain.

Summary

XYPs are a commonly used Traditional Chinese Medicine (TCM) for treating depression. However, since they are taken orally, they may interact with gut bacteria and affect the therapeutic outcomes of TCMs. The chemical complexity of XYPs makes understanding their biological effects a challenge.

Gastroenterology Neuroscience

Zhang ZW et al (2023).; J Ethnopharmacol.
DOI:: 10.1016/j.jep.2023.116555
PubMed:: 37100263

85.

The pharmacology and mechanisms of platycodin D, an active triterpenoid saponin from Platycodon grandiflorus.

Review Phytochemistry

Xie L et al (2023).; Front Pharmacol.
DOI:: 10.3389/fphar.2023.1148853
PubMed:: 37089949

86.

Inhibition of Soluble Epoxide Hydrolase Activity by Components of Glycyrrhiza uralensis.

Kim JH et al (2023).; Int J Mol Sci.
DOI:: 10.3390/ijms24076485
PubMed:: 37047457

87.

Structure of the O-specific polysaccharide of Ochrobactrum endophyticum KCTC 42485(T) containing 3-(3-hydroxy-2,3-dimethyl-5-oxoprolyl)amino-3,6-dideoxy-d-galactose.

Sigida EN et al (2023).; Carbohydr Res.
DOI:: 10.1016/j.carres.2023.108810
PubMed:: 37040681

88.

Induction of immunogenic cell death effect of licoricidin in cervical cancer cells by enhancing endoplasmic reticulum stress-mediated high mobility group box 1 expression.

Cancer

Wu PJ et al (2023).; Environ Toxicol.
DOI:: 10.1002/tox.23793
PubMed:: 37013980

89.

Liquiritin exhibits anti-acute lung injury activities through suppressing the JNK/Nur77/c-Jun pathway.

Zhou H et al (2023).; Chin Med.
DOI:: 10.1186/s13020-023-00739-3
PubMed:: 37013552

90.

Study of the distribution of Glycyrrhiza uralensis production areas as well as the factors affecting yield and quality.

Cui X et al (2023).; Sci Rep.
DOI:: 10.1038/s41598-023-31946-5
PubMed:: 36991024

91.

Multi-Omics Analysis Provides Crucial Insights into the Drought Adaptation of Glycyrrhiza uralensis Fisch.

Li Y et al (2023).; J Agric Food Chem.
DOI:: 10.1021/acs.jafc.2c07163
PubMed:: 36971245

92.

Efficacy and safety of TCMs with anti-inflammatory effect in patients with rheumatoid arthritis: A network meta-analysis.

Summary

This study analyzed the effectiveness and safety of Traditional Chinese Medicines (TCMs) for treating rheumatoid arthritis. TCMs have anti-inflammatory effects and are widely used in China.

Meta-Analysis Arthritis Immunology

Fang J et al (2023).; Front Immunol.
DOI:: 10.3389/fimmu.2023.1114930
PubMed:: 36969172

93.

The correlation between pharmacological activity and contents of eight constituents of Glycyrrhiza uralensis Fisch.

He R et al (2023).; Heliyon.
DOI:: 10.1016/j.heliyon.2023.e14570
PubMed:: 36967897

94.

Shaoyao-Gancao-Tang regulates the T-helper-type 1/T-helper-type 2 ratio in the lung and gut and alters gut microbiota in rats with ovalbumin-induced asthma.

Summary

Shaoyao-Gancao Tang is a traditional Chinese medicine that effectively treats pain and asthma, but its exact mechanism of action remains unclear.

Asthma Gastroenterology

He R et al (2023).; J Ethnopharmacol.
DOI:: 10.1016/j.jep.2023.116300
PubMed:: 36868437

95.

Abiotic factors and endophytes co-regulate flavone and terpenoid glycoside metabolism in Glycyrrhiza uralensis.

Phytochemistry

Liu Z et al (2023).; Appl Microbiol Biotechnol.
DOI:: 10.1007/s00253-023-12441-3
PubMed:: 36864204

96.

The protective effects of Zhi-Gan-Cao-Tang against diabetic myocardial infarction injury and identification of its effective constituents.

Cardiology Diabetes

Hu M et al (2023).; J Ethnopharmacol.
DOI:: 10.1016/j.jep.2023.116320
PubMed:: 36828197

97.

Immunomodulatory and antioxidant effects of Glycyrrhiza uralensis polysaccharide in Lohmann Brown chickens.

Immunology

Zhou H et al (2022).; Front Vet Sci.
DOI:: 10.3389/fvets.2022.959449
PubMed:: 36090181

98.

Effect of Gan Cao (Glycyrrhiza uralensis Fisch) polysaccharide on growth performance, immune function, and gut microflora of broiler chickens.

Gastroenterology

Zhang S et al (2022).; Poult Sci.
DOI:: 10.1016/j.psj.2022.102068
PubMed:: 36087472

99.

Ethanol Extract of Glycyrrhiza uralensis Fisch: Antidiarrheal Activity in Mice and Contraction Effect in Isolated Rabbit Jejunum.

Wen J et al (2023).; Chin J Integr Med.
DOI:: 10.1007/s11655-022-3536-5
PubMed:: 35997860

100.

Identification of Long Non-coding RNA Transcripts in Glycyrrhiza uralensis.

Genetics

Rostami Azar A and Maroufi A (2022).; Iran J Biotechnol.
DOI:: 10.30498/ijb.2021.205469.2607
PubMed:: 35891954

101.

Multi-omics profiling reveals comprehensive microbe-plant-metabolite regulation patterns for medicinal plant Glycyrrhiza uralensis Fisch.

Zhong C et al (2022).; Plant Biotechnol J.
DOI:: 10.1111/pbi.13868
PubMed:: 35668676

102.

Glycyrrhiza uralensis Fisch. Root-associated microbiota: the multifaceted hubs associated with environmental factors, growth status and accumulation of secondary metabolites.

Gastroenterology

Chen C et al (2022).; Environ Microbiome.
DOI:: 10.1186/s40793-022-00418-0
PubMed:: 35526053

103.

GURFAP: A Platform for Gene Function Analysis in Glycyrrhiza Uralensis.

Genetics

Yang J et al (2022).; Front Genet.
DOI:: 10.3389/fgene.2022.823966
PubMed:: 35495163

104.

Comparative bioactivity evaluation and chemical profiling of different parts of the medicinal plant Glycyrrhiza uralensis.

Shang Z et al (2022).; J Pharm Biomed Anal.
DOI:: 10.1016/j.jpba.2022.114793
PubMed:: 35489249

105.

Effect of Glycyrrhiza uralensis against ulcerative colitis through regulating the signaling pathway of FXR/P-gp.

Gastroenterology

Lu Q et al (2021).; Am J Transl Res.
PubMed:: 34540046

106.

Total Flavonoids of Glycyrrhiza uralensis Alleviates Irinotecan-Induced Colitis via Modification of Gut Microbiota and Fecal Metabolism.

Gastroenterology Phytochemistry

Yue SJ et al (2021).; Front Immunol.
DOI:: 10.3389/fimmu.2021.628358
PubMed:: 34025639

107.

Phenoxychromone and 4-hydroxyisoflavans from the roots of Glycyrrhiza uralensis.

Ali Z et al (2022).; Nat Prod Res.
DOI:: 10.1080/14786419.2021.1892668
PubMed:: 33648400

Glycyrrhiza uralensis

Ethnobotanical Studies

Bairin Area, Inner Mongolia

Studies

Total Syntheses and Anti-Inflammatory Studies of Three Natural Coumarins: Glycycoumarin, Glycyrin, and 3-O-Methylglycyrol.

Mechanism of Jizhi syrup's prevention and treatment of acute bronchitis based on LPS-iNOS inflammatory mediators' signalling pathway.

Enhanced salt tolerance in Glycyrrhiza uralensis Fisch. via Bacillus subtilis inoculation alters microbial community.

Licochalcone A: a review of its pharmacology activities and molecular mechanisms.

Effect of Glycyrrhiza uralensis crude water extract on the expression of Nitric Oxide Synthase 2 gene during myogenesis.

Genome-wide identification of Glycyrrhiza uralensis Fisch. MAPK gene family and expression analysis under salt stress relieved by Bacillus subtilis.

Influence of Habitat and Effects of Salt Stress on Biochemical and Physiological Parameters of Glycyrrhiza uralensis.

Injectable Regenerated Silk Fibroin Micro/Nanosphere with Enhanced Permeability and Stability for Osteoarthritis Therapy.

Self-assembly variation of glycyrrhetinic acid epimers: Assembly mechanism and antibacterial efficacy between 18 α-GA and 18 β-GA.

Neural Circuit Mechanisms of Sinisan formula for the Treatment of adolescent Depression: prefrontal cortex to dorsal raphe nucleus.

Licochalcone D exhibits cytotoxicity in breast cancer cells and enhances tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis through upregulation of death receptor 5.

Twin Strep-Tag Modified CPT1A Mitochondrial Membrane Chromatography in Screening Lipid Metabolism Regulators.

Study on the material basis and immunological enhancement activity of dangdi oral liquid.

Glycyrrhiza uralensis polysaccharides ameliorates cecal ligation and puncture-induced sepsis by inhibiting the cGAS-STING signaling pathway.

Comprehensive reutilization of Glycyrrhiza uralensis residue by extrusion-biological pretreatment for coproduction of flavonoids, cellulase, and ethanol.

A synergistic mechanism of Liquiritin and Licochalcone B from Glycyrrhiza uralensis against COPD.

Glycyrol Relieves Ulcerative Colitis by Promoting the Fusion of ZO-1 with the Cell Membrane through the Enteric Glial Cells GDNF/RET Pathway.

The alleviation effect and its mechanism of Niuhuang Jiedu prescription on realgar-induced genotoxicity in Mice.

Design and optimization of heat pump with infrared drying for Glycyrrhiza uralensis (Licorice) processing.

Combining metabolomics and transcriptomics to reveal the potential medicinal value of rare species Glycyrrhiza squamulose.

Liquiritigenin Induces Cell Cycle Arrest and Apoptosis in Lung Squamous Cell Carcinoma.

Chemical quality evaluation and characteristics of interspecific hybrid (G. uralensis × G. glabra) C-18 strain as a new Licorice cultivar.

Visualized electrochemiluminescence detection of trace copper in practical food samples.

Endophytic Bacillus pumilus G5 Interacting with Silicon to Improve Drought Stress Resilience in Glycyrrhiza uralensis Fisch. by Modulating Nitrogen Absorption, Assimilation, and Metabolism Pathways.

Integrative physiology and transcriptome reveal salt-tolerance differences between two licorice species: Ion transport, Casparian strip formation and flavonoids biosynthesis.

Exploring the effective components of honey-processed licorice (Glycyrrhiza uralensis Fisch.) in attenuating Doxorubicin-induced myocardial cytotoxicity by combining network pharmacology and in vitro experiments.

Efficacy of botanical lozenges in the treatment of chronic pharyngitis: a randomized controlled trial.

Exploring the dietary and therapeutic potential of licorice (Glycyrrhiza uralensis Fisch.) sprouts.

Glycyrrhizic acid treatment ameliorates anxiety-like behaviour via GLT1 and Per1/2-dependent pathways.

The polysaccharides from seeds of Glycyrrhiza uralensis ameliorate metabolic disorders and restructure gut microbiota in type 2 diabetic mice.

Exogenous betaine enhances salt tolerance of Glycyrrhiza uralensis through multiple pathways.

Bacillus cereus G2 alleviate salt stress in Glycyrrhiza uralensis Fisch. by balancing the downstream branches of phenylpropanoids and activating flavonoid biosynthesis.

Liquiritin reduces chondrocyte apoptosis through P53/PUMA signaling pathway to alleviate osteoarthritis.

Long COVID-19 gastrointestinal related disorders and traditional Chinese medicine: A network target-based approach.

Integrated Metabolomics and Transcriptomics Analyses Highlight the Flavonoid Compounds Response to Alkaline Salt Stress in Glycyrrhiza uralensis Leaves.

Isoliquiritin counteracts cadmium-induced intestinal damage in mice through enhancing intestinal barrier function and inhibiting apoptosis.

Lizhong decoction ameliorates ulcerative colitis by inhibiting ferroptosis of enterocytes via the Nrf2/SLC7A11/GPX4 pathway.

Isoliquiritigenin inhibits NLRP3 inflammasome activation with CAPS mutations by suppressing caspase-1 activation and mutated NLRP3 aggregation.

Mechanistic investigation of the ameliorative effect of liquiritin on hypoxia/reoxygenation‑induced cardiomyocyte injury based on network pharmacology and in vitro validation.

Licochalcone A induces mitochondria-dependent apoptosis and interacts with venetoclax in acute myeloid leukemia.

Licorice flavonoid ameliorates ethanol-induced gastric ulcer in rats by suppressing apoptosis via PI3K/AKT signaling pathway.

Maternal Effects of Habitats Induce Stronger Salt Tolerance in Early-Stage Offspring of Glycyrrhiza uralensis from Salinized Habitats Compared with Those from Non-Salinized Habitats.

Licochalcone A and B enhance muscle proliferation and differentiation by regulating Myostatin.

Integrated serum pharmacochemistry and investigation of the anti-influenza A virus pneumonia effect of Qingjin Huatan decoction.

Glycyrrhizin Production in Licorice Hairy Roots Based on Metabolic Redirection of Triterpenoid Biosynthetic Pathway by Genome Editing.

Disruption of a licorice cellulose synthase-derived glycosyltransferase gene demonstrates its in planta role in soyasaponin biosynthesis.

Comprehensive study on genetic and chemical diversity of Asian medicinal plants, aimed at sustainable use and standardization of traditional crude drugs.

Spatial Distribution and Characterization of the Small-Molecule Metabolites and In Situ Hydrolyzed Oligosaccharides in the Rhizome of Glycyrrhiza uralensis by Desorption Electrospray Ionization-Mass Spectrometry Imaging and High-Resolution Liquid Chromatography-Mass Spectrometry.

The Importance of Traditional Chinese Medicine in the Intervention and Treatment of HIV while Considering its Safety and Efficacy.

Modulating the gut microbiota is involved in the effect of low-molecular-weight Glycyrrhiza polysaccharide on immune function.

The compatibility rationality of Sijunzi decoction based on integrated analysis of tissue distribution and excretion characteristics in spleen deficiency syndrome rats.

Investigation of the principle of concoction by using the processing excipient Glycyrrhiza uralensis Fisch. juice to reduce the hepatotoxicity of Dioscorea bulbifera L. and enhance its main efficacy as expectorant and cough suppressant.

Maimendong decoction regulates M2 macrophage polarization to suppress pulmonary fibrosis via PI3K/Akt/FOXO3a signalling pathway-mediated fibroblast activation.

Insights into the missing apiosylation step in flavonoid apiosides biosynthesis of Leguminosae plants.

Isoliquiritigenin suppresses the progression of malignant melanoma via targeting H2A.Z.1-E2F1 pathway.

Bacillus cereus G2 Facilitates N Cycle in Soil, Further Improves N Uptake and Assimilation, and Accelerates Proline and Glycine Betaine Metabolisms of Glycyrrhiza uralensis Subjected to Salt Stress.

Interpretation of the anti-influenza active ingredients and potential mechanisms of Ge Gen Decoction based on spectrum-effect relationships and network analysis.

Licochalcone A induces G2/M phase arrest and apoptosis via regulating p53 pathways in esophageal cancer: In-vitro and in-vivo study.

Qishen granule attenuates doxorubicin-induced cardiotoxicity by protecting mitochondrial function and reducing oxidative stress through regulation of Sirtuin3.

Screening potential treatments for mpox from Traditional Chinese Medicine by using a data-driven approach.

Recruitment of Hippodamia variegata by active volatiles from Glycyrrhiza uralensis and Alhagi sparsifolia plants infested with Aphis atrata.

Novel Psychopharmacological Herbs Relieve Behavioral Abnormalities and Hippocampal Dysfunctions in an Animal Model of Post-Traumatic Stress Disorder.

Zhisou powder displays therapeutic effect on chronic bronchitis through inhibiting PI3K/Akt/HIF-1α/VEGFA signaling pathway and reprograming metabolic pathway of arachidonic acid.

Comparison of halitosis according to herbal mouthwash containing Glycyrrhiza uralensis extract and saline mouthwash: A randomized, double-blind, placebo-controlled study.

Potential Antioxidant and Anti-Inflammatory Effects of Lonicera japonica and Citri Reticulatae Pericarpium Polyphenolic Extract (LCPE).

Inhibition by components of Glycyrrhiza uralensis of 3CLpro and HCoV-OC43 proliferation.

In Vitro Inhibition of Human Cytochrome P450 Enzymes by Licoisoflavone B from Glycyrrhiza uralensis Fisch. ex DC.

Database of space life investigations and information on spaceflight plant biology.

Therapeutic potential of traditional Chinese medicine for interstitial lung disease.

Absorption, tissue distribution, and excretion of glycycoumarin, a major bioactive coumarin from Chinese licorice (Glycyrrhiza uralensis Fisch).

Enrichment and qualitative analysis of flavonoid glycosides from the aerial parts of Glycyrrhiza uralensis Fisch.

MWCNTs and ZnO-based Ce-MOF nanocomposites as enhanced sensing platform for electrochemical detection of carbendazim in Chinese traditional herbs samples.

Ameliorative effect of scopolamine-induced cognitive dysfunction by Fufangmuniziqi formula: The roles of alkaloids, saponins, and flavonoids.

Qingjin Huatan decoction protects mice against influenza a virus pneumonia via the chemokine signaling pathways.

Network pharmacology-based approach to research the effect and mechanism of Si-Miao-Yong-An decoction against thromboangiitis obliterans.

Exploring the effect and mechanism of Haizao Yuhu decoction containing three variants of glycyrrhiza on goiter using an integrated strategy of network pharmacology and RNA sequencing.