Common Names: gumhar
This study looked at using naturally occurring substances (phytochemicals) as potential treatments for COVID-19. The researchers tested these substances against specific proteins in the SARS-CoV-2 virus and identified some promising candidates for further research. Given the persistent threat of COVID-19 and the need for additional prevention and treatment options, this work could have significant implications for future efforts to control the spread of the disease.
Researchers screened a library of phytochemicals for their potential to inhibit the binding of ACE2 receptors to the spike protein of SARS-CoV-2. Out of 686 compounds, 20 were found to bind with energy ranging from -11.8 to -6.9 kcal/mol. Four compounds were found to be non-toxic and stable in molecular dynamics simulations and may prevent SARS-CoV-2 infection by inhibiting viral entry into host cells. These compounds are Hinokinin, Gmelanone, Isocolumbin, and Tinocordioside.